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Form I of desloratadine, a tricyclic antihistamine
Journal article   Peer reviewed

Form I of desloratadine, a tricyclic antihistamine

Prashant M Bhatt and Gautam R Desiraju
Acta crystallographica. Section C, Crystal structure communications, Vol.62(Pt 6), pp.o362-o363
01/06/2006
DOI: https://doi.org/10.1107/S0108270106012571
PMID: 16763328

Abstract

Crystallography, X-Ray Histamine H1 Antagonists - chemistry Hydrogen Bonding Loratadine - analogs & derivatives Loratadine - chemistry Models, Molecular Molecular Structure Stereoisomerism
The title compound [systematic name: 8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[4,5]cyclohepta[2,1-b]pyridine], C19H19ClN2, was crystallized from ethyl acetate. The interesting feature of the reported structure is that it does not contain any strong hydrogen bonds, although the molecule contains a secondary NH group, which is a good hydrogen-bond donor.

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