Abstract
Burn wound healing is a complex and multistep process. Proper and complete healing requires adequate moisture, microbial prevention, exudates absorption, and scab formation prevention at the wound bed. Aqua-gel is a suitable carrier system that possess all above mention characteristics for burn wound healing. In this study, Carbopol 934 and polyethylene glycol based aqua-gel was designed by incorporating 2% Calotropis gigantea extract. Various formulations were developed and F2 was considered optimized while it was subjected to FTIR analysis, scanning electron microscope, HPLC content determination, rheological behaviors, in vitro release and release kinetics, pH and swelling behavioues. The results demonstrated that C. gigantea loaded aqua-gel has great potential to increase the burn wound healing rate as compared to control group