Abstract
The current study aimed to describe genotypes associated with Hodgkin lymphoma (HL) in a cohort of Saudi and non-Saudi patients and discuss their possible susceptibility to HL.
We studied clinical, histopathological, and laboratory findings of HL patients admitted over 12 years duration, at King Fahd University Hospital, KSA. The genomic DNAs of HL patients (n = 61) and normal control subjects (n = 36) were extracted, and genotyping was performed using the Illumina human exome bead chip. Set of HL patients and set of normal controls were included in this study.
A total of 35 DNA variants were found to be highly significant with the P-value <9.90 × 10
among 243 345 exonic biomarkers and obeying the Hardy-Weinberg equilibrium. Nine, MEGF11-rs150945752 (P-value 1.20 × 10
), CACNA1I- s58055559 (P-value 1.93 × 10
), DECR2-rs146760080 (P-value 2.19 × 10
), STAB1-rs143894786 (P-value 2.45 × 10
), ZNF526-rs144433879 (P-value 2.76 × 10
), CPLANE1-rs200612080 (P-value 3.77 × 10
), DLK1-rs1058009 (P-value 5.95 × 10
), RTN4RL2-rs61745214 (P-value 7.71 × 10
), and PGRMC1-rs145582672 (P-value 8.56 × 10
), exonic variants on chromosomes 15, 22, and 16 were highly associated with HL cases. THE HIGHLY SIGNIFICANT HAPLOTYPES AT CHROMOSOME 3: rs143894786G; rs149982219G with P-value = 3.43 × 10
was found to be the risk haplotype for the HL patients. The opposite alleles at chromosome 3: rs143894786A; rs149982219G is protective with P-value = 2.46 × 10
. Maximum number of SNPs at the chromosome 19: rs144433879C; rs181265966G; rs201144421C; rs145591797G; rs200560875G; rs77270337G (risk P-value = 2.24 × 10
) and its opposite allele rs144433879A; rs181265966A; rs201144421T; rs145591797A; rs200560875A; rs77270337A (protective P-value = 2.60 × 10
) were found to be associated haplotype with the HL and controls, respectively, in Saudi population.
Our study concludes that the HL is genetically heterogeneous with multigene causation.