Abstract
Nowadays, functional and entirely natural dressing treated with biological active polymers is a required alternative to treat chronic or acute wounds. First, a Suaeda fruticosa polysaccharide (SFP) was extracted and its pectin-like polysaccharide structure was confirmed via infrared spectroscopy (FT-IR), steric exclusion chromatography, gas chromatography-mass spectrometry (GC-MS) and chemical composition analyses. Then, a new natural biopolymer-based chitosan and SFP extract was synthesized and grafted to cellulosic wound textile dressing. Different parameters of grafting such as temperature and curing time were studied and further optimized. The functionalized dressings were characterized by infrared via attenuated total reflectance mode, SEM, and mechanical analysis. The swelling behavior analysis showed a significant improvement of the hydrophilicity after grafting which is a required property for enhanced healing efficiency. Biological analysis was achieved via viability and kinetic cell adhesion tests, using epithelial HepG2 cells. A bacteriological evaluation of functionalized dressings against gram positive and negative bacteria culture strains was also performed. The new functional cellulosic wound dressing revealed efficient and promising microbiological performance able to treat chronic and acute wounds.
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