Abstract
Several investigations have focused on studying the suppressing influence of
Salvadora persica
(miswak) on oral microbes; however,
studies regarding its fungicidal activity versus human aspergillosis-related
illness are still scarce. The current research was designed to evaluate the
fungicidal action of
S persica
aquatic root extract in terms of
radial growth rate and inhibition zone (IZO) versus 3 pathogenic
Aspergillus
species, namely,
A nige
r,
A flavus
, and
A fumigatus
in vitro. The
results revealed that the plant extract (50 and 100 mg/mL) exhibited a
prohibiting influence on the growth of the tested fungal species. The high
concentration (100 mg/mL) of the plant extract
was
efficient in
prohibiting the growing rate of the tested
Aspergillus
species
after 6 days exposure period.
Aspergillus niger
and
A
flavus
showed the largest inhibition ratios (60% and 54.4%,
respectively) and IZO (33.00 ± 0.05 mm and 25.50 ± 0.18 mm, respectively) versus
the control counterparts.
Aspergillus fumigatus
showed the
minimum inhibition ratio (39%) and IZO (20.31 ± 0.05). The present data showed
that the extract of
S persica
possesses potential fungicidal
influence versus the tested pathogenic
Aspergillus
species and
this may support the utilization of this extract as a promising antifungal agent
versus aspergillosis.