Abstract
Accurate diagnosis of breast cancer using automated algorithms continues to be a challenge in the literature. Although researchers have conducted a great deal of work to address this issue, no definitive answer has yet been discovered. This challenge is aggravated further by the fact that most available datasets have imbalanced class issues, meaning that the number of cases in one class vastly outnumbers those of the others. The goal of this study was to (i) develop a reliable machine-learning-based prediction model for breast cancer based on the combination of the resampling technique and the classifier, which we called a 'fusion model'; (ii) deal with a typical high-class imbalance problem, which is posed because the breast cancer patients' class is significantly smaller than the healthy class; and (iii) interpret the model output to understand the decision-making mechanism. In a comparative analysis with three well-known classifiers representing classical learning, ensemble learning, and deep learning, the effectiveness of the proposed machine-learning-based approach was investigated in terms of metrics related to both generalization capability and prediction accuracy. Based on the comparative analysis, the fusion model (random oversampling techniques dataset + extreme gradient boosting classifier) affects the accuracy, precision, recall, and F1-score with the highest value of 99.9%. On the other hand, for ROC evaluation, the oversampling and hybrid sampling techniques dataset combined with extreme gradient boosting achieved 100% performance compared to the models combined with the undersampling techniques dataset. Thus, the proposed predictive model based on the fusion strategy can optimize the performance of breast cancer diagnosis classification.