Abstract
We are reporting a case with rare side effect of propylthiouracil. Thirty-two years old Saudi female diagnosed to have graves disease and treated by propylthiouracil for more than 4 years. She started to complain of fever, joint pain and weight loss for 8 months. Clinically, she was found to be pale, generalized lymphoadenopathy and having moderate splenomegaly. Investigation revealed pancytopenia, high ESR, and multiple small cystic nodules in the liver, spleen, and both kidneys. We thought of propylthiouracil as a cause of her problem and advised to discontinue it before doing invasive investigation. Tqo weeks later she had better appetite, less joint pain, and no more fever. Complete blood count and ESR became improved and normalized in subsequent visits. We are reporting a case of generalized lymphoadenopathy, splenomegaly and fever caused by propylthiouracil.