Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient data

Salim Abdulla; Jane Achan; Ishag Adam; Bereket H. Alemayehu; Richard Allan; Elizabeth N. Allen; Anupkumar R. Anvikar; Emmanuel Arinaitwe; Elizabeth A. Ashley; Puji Budi Setia Asih; Ghulam Rahim Awab; Karen I. Barnes; Quique Bassat; Elisabeth Baudin; Anders Bjorkman; Francois Bompart; Maryline Bonnet; Steffen Borrmann; Teun Bousema; Verena I. Carrara; Fabio Cenci; Francesco Checchi; Michel Cot; Prabin Dahal; Umberto D'Alessandro; Philippe Deloron; Abdoulaye Djimde; Arjen Dondorp; Grant Dorsey; Ogobara K. Doumbo; Chris J. Drakeley; Stephan Duparc; Emmanuelle Espie; Abul Faiz; Catherine O. Falade; Caterina Fanello; Jean-Francois Faucher; Babacar Faye; Scott Filler; Bakary Fofana; Carole Fogg; Adama Gansane; Oumar Gaye; Blaise Genton; Peter W. Gething; Raquel Gonzalez; Francesco Grandesso; Brian Greenwood; Anastasia Grivoyannis; Philippe J. Guerin; Kamal Hamed; Christoph Hatz; Simon I. Hay; Eva Maria Hodel; Georgina S. Humphreys; Jimee Hwang; Bart Janssens; Daddi Jima; Elizabeth Juma; S. Patrick Kachur; Piet Kager; Moses R. Kamya; Melissa Kapulu; Corine Karema; Kassoum Kayentao; Jean R. Kiechel; Poul-Erik Kofoed; Valerie Lameyre; Sue J. Lee; Bertrand Lell; Nines Lima; Kevin Marsh; Andreas Martensson; Achille Massougbodji; Mayfong Mayxay; Rose McGready; Herve Menan; Clara Menendez; Petra Mens; Martin Meremikwu; Frank P. Mockenhaupt; Clarissa Moreira; Carolyn Nabasumba; Michael Nambozi; Jean-Louis Ndiaye; Paul N. Newton; Billy E. Ngasala; Francois Nosten; Christian Nsanzabana; Andre Toure Offianan; Mary Oguike; Bernhards R. Ogutu; Piero Olliaro; Sabah A. Omar; Lyda Osorio; Seth Owusu-Agyei; Louis K. Penali; Mbaye Pene; Judy Peshu; Patrice Piola; Zul Premji; Ric N. Price; Michael Ramharter; Lars Rombo; Cally Roper; Philip J. Rosenthal; Issaka Sagara; Patrick Sawa; Henk D. F. H. Schallig; Birgit Schramm; Seif A. Shekalaghe; Carol H. Sibley; Sodiomon Sirima; Frank Smithuis; Doudou Sow; Sarah G. Staedke; Kasia Stepniewska; Inge Sutanto; Colin J. Sutherland; Todd D. Swarthout; Din Syafruddin; Khadime Sylla; Ambrose O. Talisuna; Walter R. Taylor; Emmanuel A. Temu; Feiko Ter Kuile; Halidou Tinto; Emiliana Tjitra; Johan Ursing; Neena Valecha; Ingrid van den Broek; Michel van Herp; Michele van Vugt; Stephen A. Ward; Nicholas J. White; Peter A. Winstanley; Charles J. Woodrow; Adoke Yeka; Julien Zwang; WWARN Gametocyte Study Grp

doi:10.1186/s12916-016-0621-7

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Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient data

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Peer reviewed

Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient data

Salim Abdulla, Jane Achan, Ishag Adam, Bereket H. Alemayehu, Richard Allan, Elizabeth N. Allen, Anupkumar R. Anvikar, Emmanuel Arinaitwe, Elizabeth A. Ashley, Puji Budi Setia Asih, …

BMC medicine, Vol.14(1), pp.79-79

24/05/2016

DOI: https://doi.org/10.1186/s12916-016-0621-7

PMCID: PMC4879753

PMID: 27221542

Abstract

General & Internal Medicine

Life Sciences & Biomedicine

Medicine, General & Internal

Science & Technology

Background: Gametocytes are responsible for transmission of malaria from human to mosquito. Artemisinin combination therapy (ACT) reduces post-treatment gametocyte carriage, dependent upon host, parasite and pharmacodynamic factors. The gametocytocidal properties of antimalarial drugs are important for malaria elimination efforts. An individual patient clinical data meta-analysis was undertaken to identify the determinants of gametocyte carriage and the comparative effects of four ACTs: artemether-lumefantrine (AL), artesunate/amodiaquine (AS-AQ), artesunate/mefloquine (AS-MQ), and dihydroartemisinin-piperaquine (DP). Methods: Factors associated with gametocytaemia prior to, and following, ACT treatment were identified in multivariable logistic or Cox regression analysis with random effects. All relevant studies were identified through a systematic review of PubMed. Risk of bias was evaluated based on study design, methodology, and missing data. Results: The systematic review identified 169 published and 9 unpublished studies, 126 of which were shared with the WorldWide Antimalarial Resistance Network (WWARN) and 121 trials including 48,840 patients were included in the analysis. Prevalence of gametocytaemia by microscopy at enrolment was 12.1 % (5887/48,589), and increased with decreasing age, decreasing asexual parasite density and decreasing haemoglobin concentration, and was higher in patients without fever at presentation. After ACT treatment, gametocytaemia appeared in 1.9 % (95 % CI, 1.7-2.1) of patients. The appearance of gametocytaemia was lowest after AS-MQ and AL and significantly higher after DP (adjusted hazard ratio (AHR), 2.03; 95 % CI, 1.24-3.12; P = 0.005 compared to AL) and AS-AQ fixed dose combination (FDC) (AHR, 4.01; 95 % CI, 2.40-6.72; P < 0.001 compared to AL). Among individuals who had gametocytaemia before treatment, gametocytaemia clearance was significantly faster with AS-MQ (AHR, 1.26; 95 % CI, 1.00-1.60; P = 0.054) and slower with DP (AHR, 0.74; 95 % CI, 0.63-0.88; P = 0.001) compared to AL. Both recrudescent (adjusted odds ratio (AOR), 9.05; 95 % CI, 3.74-21.90; P < 0.001) and new (AOR, 3.03; 95 % CI, 1.66-5.54; P < 0.001) infections with asexual-stage parasites were strongly associated with development of gametocytaemia after day 7. Conclusions: AS-MQ and AL are more effective than DP and AS-AQ FDC in preventing gametocytaemia shortly after treatment, suggesting that then on-artemisinin partner drug or the timing of artemisinin dosing are important determinants of post-treatment gametocyte dynamics.

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Title: Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient data
Creators - without role: Salim Abdulla - Ifakara Hlth Inst, Dar Es Salaam, Tanzania
Jane Achan - Uganda Malaria Surveillance Project, Kampala, Uganda
Ishag Adam - University of Khartoum
Bereket H. Alemayehu - Columbia University
Richard Allan - Mentor
Elizabeth N. Allen - University of Cape Town
Anupkumar R. Anvikar - Natl Inst Malaria Res, New Delhi, India
Emmanuel Arinaitwe - Infect Dis Res Collaborat, Kampala, Uganda
Elizabeth A. Ashley - Mahidol University
Puji Budi Setia Asih - Eijkman Institute for Molecular Biology
Ghulam Rahim Awab - College Station Medical Center
Karen I. Barnes - WWARN, Oxford, England
Quique Bassat - Ctr Invest Saude Manhica, Manhica, Mozambique
Elisabeth Baudin - Epictr, Paris, France
Anders Bjorkman - Karolinska Institutet
Francois Bompart - Sanofi, Paris, France
Maryline Bonnet - Epictr, Mbarara, Uganda
Steffen Borrmann - Wellcome Trust
Teun Bousema - Supreme Council Of Health
Verena I. Carrara - Mahidol University
Fabio Cenci - Sigma Tau Pharmaceut Co, Rome, Italy
Francesco Checchi - Epictr, Paris, France
Michel Cot - Université Paris Cité
Prabin Dahal - WWARN, Oxford, England
Umberto D'Alessandro - Massachusetts Rehabilitation Commission
Philippe Deloron - Mother & Child Faced Trop Infect Res Unit, Inst Rech Dev, Paris, France
Abdoulaye Djimde - University of Bamako
Arjen Dondorp - College Station Medical Center
Grant Dorsey - College Station Medical Center
Ogobara K. Doumbo - University of Bamako
Chris J. Drakeley - LSHTM, Dept Infect & Immunity, London, England
Stephan Duparc - College Station Medical Center
Emmanuelle Espie - Epictr, Paris, France
Abul Faiz - Dev Care Fdn, Dhaka, Bangladesh
Catherine O. Falade - University of Ibadan
Caterina Fanello - College Station Medical Center
Jean-Francois Faucher - Mother & Child Faced Trop Infect Res Unit, Inst Rech Dev, Paris, France
Babacar Faye - College Station Medical Center
Scott Filler - Global Fund Fight AIDS TB & Malaria, Geneva, Switzerland
Bakary Fofana - University of Bamako
Carole Fogg - University of Portsmouth
Adama Gansane - Ctr Natl Rech & Format Paludisme, Ouagadougou, Burkina Faso
Oumar Gaye - College Station Medical Center
Blaise Genton - Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland
Peter W. Gething - University of Oxford
Raquel Gonzalez - Universitat de Barcelona
Francesco Grandesso - Epictr, Paris, France
Brian Greenwood - LSHTM, Dept Dis Control, London, England
Anastasia Grivoyannis - University of Washington
Philippe J. Guerin - WWARN, Oxford, England
Kamal Hamed - Novartis Pharmaceut, E Hanover, NJ USA
Christoph Hatz - College Station Medical Center
Simon I. Hay - University of Oxford
Eva Maria Hodel - Swiss Trop Inst & Publ Hlth Inst, Basel, Switzerland
Georgina S. Humphreys - WWARN, Oxford, England
Jimee Hwang - US Ctr Dis Control & Prevent, Atlanta, GA USA
Bart Janssens - College Station Medical Center
Daddi Jima - Fed Minist Hlth, Addis Ababa, Ethiopia
Elizabeth Juma - College Station Medical Center
S. Patrick Kachur - US Ctr Dis Control & Prevent, Atlanta, GA USA
Piet Kager - University of Amsterdam
Moses R. Kamya - Makerere University
Melissa Kapulu - Wellcome Trust
Corine Karema - Minist Hlth, RBC, Malaria & Other Parasit Dis Div, Kigali, Rwanda
Kassoum Kayentao - University of Bamako
Jean R. Kiechel - Drugs for Neglected Diseases Initiative
Poul-Erik Kofoed - Projecto Saude Bandim, Bissau, Guinea Bissau
Valerie Lameyre - Sanofi, Paris, France
Sue J. Lee - Mahidol University
Bertrand Lell - University of Tübingen
Nines Lima - College Station Medical Center
Kevin Marsh - Wellcome Trust
Andreas Martensson - Karolinska Institutet
Achille Massougbodji - Univ Abomey Calavi, Fac Sci Sante, Ctr Etud & Rech Paludisme Associe Grossesse & Enf, Cotonou, Benin
Mayfong Mayxay - University of Oxford
Rose McGready - Mahidol University
Herve Menan - Univ Cocody, Fac Pharm, Dept Parasitol, Abidjan, Cote Ivoire
Clara Menendez - Universitat de Barcelona
Petra Mens - KIT Biomed Res, Royal Trop Inst, Amsterdam, Netherlands
Martin Meremikwu - University of Calabar
Frank P. Mockenhaupt - Charité - Universitätsmedizin Berlin
Clarissa Moreira - WWARN, Oxford, England
Carolyn Nabasumba - Epictr, Paris, France
Michael Nambozi - Trop Dis Res Ctr, Ndola, Zambia
Jean-Louis Ndiaye - College Station Medical Center
Paul N. Newton - University of Oxford
Billy E. Ngasala - Muhimbili Univ Hlth & Allied Sci, Dept Parasitol, Dar Es Salaam, Tanzania
Francois Nosten - Mahidol University
Christian Nsanzabana - WWARN, Oxford, England
Andre Toure Offianan - Inst Pasteur, Malariol Dept, Abidjan, Cote Ivoire
Mary Oguike - LSHTM, Dept Immunol & Infect, London, England
Bernhards R. Ogutu - University of Oxford
Piero Olliaro - World Bank
Sabah A. Omar - Int Ctr Insect Physiol & Ecol, Mbita Point, Kenya
Lyda Osorio - University of Valle
Seth Owusu-Agyei - Kintampo Hlth Res Ctr, Kintampo, Ghana
Louis K. Penali - WWARN, Dakar, Senegal
Mbaye Pene - College Station Medical Center
Judy Peshu - Wellcome Trust
Patrice Piola - Inst Pasteur Madagascar, Antananarivo, Madagascar
Zul Premji - Muhimbili Univ Hlth & Allied Sci, Dar Es Salaam, Tanzania
Ric N. Price - WWARN, Oxford, England
Michael Ramharter - Ctr Rech Medicales Lambarene, Lambarene, Gabon
Lars Rombo - Karolinska Institutet
Cally Roper - LSHTM, London, England
Philip J. Rosenthal - College Station Medical Center
Issaka Sagara - University of Bamako
Patrick Sawa - Int Ctr Insect Physiol & Ecol, Human Hlth Div, Mbita, Kenya
Henk D. F. H. Schallig - KIT Biomed Res, Royal Trop Inst, Amsterdam, Netherlands
Birgit Schramm - Epictr, Paris, France
Seif A. Shekalaghe
Carol H. Sibley - WWARN, Oxford, England
Sodiomon Sirima - Ctr Natl Rech & Format Paludisme, Ouagadougou, Burkina Faso
Frank Smithuis - Myanmar Oxford Clin Res Unit, Yangon, Myanmar
Doudou Sow - College Station Medical Center
Sarah G. Staedke - LSHTM, Dept Clin Res, London, England
Kasia Stepniewska - WWARN, Oxford, England
Inge Sutanto - University of Indonesia
Colin J. Sutherland - LSHTM, Dept Immunol & Infect, London, England
Todd D. Swarthout - College Station Medical Center
Din Syafruddin - Eijkman Institute for Molecular Biology
Khadime Sylla - Univ Cheikh Anta Diop, Serv Parasitol Mycol Medicale, Dakar, Senegal
Ambrose O. Talisuna - University of Oxford
Walter R. Taylor - ETH, Dept Hlth Sci & Technol, Inst Biomech, Zurich, Switzerland
Emmanuel A. Temu - Mentor
Feiko Ter Kuile - University of Liverpool
Halidou Tinto - Burkina Faso & Ctr Muraz, Inst Rech Sci Sante, Bobo Dioulasso, Burkina Faso
Emiliana Tjitra - Minist Hlth, Natl Inst Hlth Res & Dev, Jakarta, Indonesia
Johan Ursing - Indepth Network, Projecto Saude Bandim, Bissau, Guinea Bissau
Neena Valecha - Natl Inst Malaria Res, New Delhi, India
Ingrid van den Broek - College Station Medical Center
Michel van Herp - College Station Medical Center
Michele van Vugt - University of Amsterdam
Stephen A. Ward - University of Liverpool
Nicholas J. White - Mahidol University
Peter A. Winstanley - University of Liverpool
Charles J. Woodrow - College Station Medical Center
Adoke Yeka - Uganda Malaria Surveillance Project, Kampala, Uganda
Julien Zwang - Drugs for Neglected Diseases Initiative
WWARN Gametocyte Study Grp
Publication Details: BMC medicine, Vol.14(1), pp.79-79
Publisher: Springer Nature
Number of pages: 18
Grant note: MR/K00669X/1; MC_UP_A900_1119 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) ERC-2014-StG 639776 / European Research Council; European Research Council (ERC); European Commission Bill and Melinda Gates Foundation grant; Bill & Melinda Gates Foundation
Identifiers: 9928922408331
Academic Unit: Qassim University
Language: English
Resource Type: Journal article