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Gender-dependent associations of CDKN2A/2B, KCNJ11, POLI, SLC30A8, and TCF7L2 variants with type 2 diabetes in (North African) Tunisian Arabs
Journal article   Peer reviewed

Gender-dependent associations of CDKN2A/2B, KCNJ11, POLI, SLC30A8, and TCF7L2 variants with type 2 diabetes in (North African) Tunisian Arabs

Amira Turki, Ghadeer S Al-Zaben, Moncef Khirallah, Hela Marmouch, Touhami Mahjoub and Wassim Y Almawi
Diabetes research and clinical practice, Vol.103(3), pp.e40-e43
01/03/2014
DOI: https://doi.org/10.1016/j.diabres.2013.12.040
PMID: 24485399

Abstract

Arabs - genetics Biomarkers - analysis Case-Control Studies Cation Transport Proteins - genetics Cyclin-Dependent Kinase Inhibitor p15 - genetics Cyclin-Dependent Kinase Inhibitor p16 - genetics Diabetes Mellitus, Type 2 - genetics DNA Polymerase I - genetics Female Follow-Up Studies Genetic Association Studies Genetic Predisposition to Disease Humans Male Middle Aged Polymorphism, Single Nucleotide - genetics Potassium Channels, Inwardly Rectifying - genetics Prognosis Proteins - genetics Sex Factors Transcription Factor 7-Like 2 Protein - genetics Tunisia Zinc Transporter 8
We investigated the impact of gender on T2DM association with confirmed susceptibility loci. CDKN2A/2B rs10811661, KCNJ11 rs5219, and TCF7L2 rs7903146 were associated with T2DM in females, while POLI rs488846 was associated with T2DM among males; the association of SLC30A8 rs13266634 and TCF7L2 rs4506565, rs12243326, and rs12255372 with T2DM was gender-independent.

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