Abstract
A simple general synthesis of 1-aryl-6-azaisocytosine-5-carbonitriles
is described. This method is based on coupling diazonium salts with cyanoacetylcyanamide
and then cyclization of the formed 2-arylhydrazono-2-cyanoacetylcyanamides
. The 6-azaisocytosines
were studied with respect to tautomeric equilibrium and the transformation of functional groups, and used in the synthesis of the condensed heterocyclic compounds: Purine isosteric imidazo[2,1-
]-[1,2,4]triazine
and the 1,2,4-triazino[2,3-
]quinazolines
-
.