Abstract
We analyzed human and other vertebrates' genes and duplicate gene families (DGFs) to detect lineage-specific pattern of gene evolution. The DGFs were determined by single-linkage clustering and re-clustering of genes considering multi-multi orthologs, resulting to produce one-to-one orthologous DGFs between human and other vertebrates. Among human and other 13 vertebrates, 22,496 human genes with ortholog(s) and 11,983 human DGFs (3,257 human DGFs with more than one genes) with orthologous DGFs were detected. While the numbers of human-rodents (mouse and rat) orthologs and human-Laurasia-therians (dog, horse and cow) orthologs were mostly equal, the number of DGFs was larger in human-rodents than in human- Laurasiatherians. The difference was caused by the abundance of human-rodent specific singletons (one gene/DGF). These singletons could be the candidates of newly obtained genes with lineage-specific functions in human and rodents after they diverged from Laurasiatherians.