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Genetic Analysis of Primaquine Tolerance in Patient with Relapsing Vivax Malaria
Journal article   Open access  Peer reviewed

Genetic Analysis of Primaquine Tolerance in Patient with Relapsing Vivax Malaria

A. Taylor Bright, Thamer Alenazi, Sandra Shokoples, Joel Tarning, Giacomo M. Paganotti, Nicholas J. White, Stanley Houston, Elizabeth A. Winzeler and Stephanie K. Yanow
Emerging infectious diseases, Vol.19(5), pp.802-805
01/05/2013
DOI: https://doi.org/10.3201/eid1905.121852
PMCID: PMC3647516
PMID: 23648098

Abstract

Immunology Infectious Diseases Life Sciences & Biomedicine Science & Technology
Patients with Plasmodium vivax malaria are treated with primaquine to prevent relapse infections. We report primaquine failure in a patient with 3 relapses without any possibility of re-infection. Using whole genome sequencing of the relapsing parasite isolates, we identified single nucleotide variants as candidate molecular markers of resistance.
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https://doi.org/10.3201/eid1905.121852View
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