Abstract
In line with the increased utilization of the crops that modified genetically (GM) over the last fifteen years for livestock feeding and in human food, numerous of researches studies on feeding have been achieved. Although, it is not scientifically proven that long-term consumption of such foods poses prospect threat on health of human and animal. This study was therefore conceived to assess the potentially affect of transgenic Maize on the mice that were feed with GM corn using micronucleus (MN) test and comet assay for genetically studies, while using determination the activity of the antioxidant scavenger enzymes (GPx; SOD and CAT) for biochemical study. Sixty albino mice (12 mice/each group) were feed for fourteen weeks with either basal diet or experimental diets containing, 0%; 11%; 33% and 66% GM corn {MON 810}. At the ending of the experiment, tissue samples of bone marrow and liver were obtained for the biochemical and genetics examinations. The results indicated that GM corn at 11 % and 33 % significantly increased the levels of antioxidant enzymes while 66 % was insignificantly changed the antioxidant enzymes concentration in the liver. Genetically modified corn at 66 % induced significantly micronucleated erythrocytes and significantly increased the DNA damage of liver cells as indicated by comet formation. The combined data of either micronucleus or comet tests indicated that, GM corn have a genotoxic effect only at 66 %, while 11 % and 33 % have no genotoxic effects.