Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Cristian Pattaro; Alexander Teumer; Mathias Gorski; Audrey Y. Chu; Man Li; Vladan Mijatovic; Maija Garnaas; Adrienne Tin; Rossella Sorice; Yong Li; Daniel Taliun; Matthias Olden; Meredith Foster; Qiong Yang; Ming-Huei Chen; Tune H. Pers; Andrew D. Johnson; Yi-An Ko; Christian Fuchsberger; Bamidele Tayo; Michael Nalls; Mary F. Feitosa; Aaron Isaacs; Abbas Dehghan; Pio d'Adamo; Adebowale Adeyemo; Aida Karina Dieffenbach; Alan B. Zonderman; Ilja M. Nolte; Peter J. van der Most; Alan F. Wright; Alan R. Shuldiner; Alanna C. Morrison; Albert Hofman; Albert V. Smith; Albert W. Dreisbach; Andre Franke; Andre G. Uitterlinden; Andres Metspalu; Anke Tonjes; Antonio Lupo; Antonietta Robino; Asa Johansson; Ayse Demirkan; Barbara Kollerits; Barry I. Freedman; Belen Ponte; Ben A. Oostra; Bernhard Paulweber; Bernhard K. Kraemer; Braxton D. Mitchell; Brendan M. Buckley; Carmen A. Peralta; Caroline Hayward; Catherine Helmer; Charles N. Rotimi; Christian M. Shaffer; Christian Mueller; Cinzia Sala; Cornelia M. van Duijn; Aude Saint-Pierre; Daniel Ackermann; Daniel Shriner; Daniela Ruggiero; Daniela Toniolo; Yingchang Lu; Daniele Cusi; Darina Czamara; David Ellinghaus; David S. Siscovick; Douglas Ruderfer; Christian Gieger; Harald Grallert; Elena Rochtchina; Elizabeth J. Atkinson; Elizabeth G. Holliday; Eric Boerwinkle; Erika Salvi; Erwin P. Bottinger; Federico Murgia; Fernando Rivadeneira; Florian Ernst; Florian Kronenberg; Frank B. Hu; Gerjan J. Navis; Gary C. Curhan; George B. Ehret; Georg Homuth; Stefan Coassin; Gian-Andri Thun; Giorgio Pistis; Giovanni Gambaro; Giovanni Malerba; Grant W. Montgomery; Gudny Eiriksdottir; Gunnar Jacobs; Guo Li; H-Erich Wichmann; Harry Campbell; Helena Schmidt; Henri Wallaschofski; Henry Voelzke; Hermann Brenner; Heyo K. Kroemer; Holly Kramer; Honghuang Lin; I. Mateo Leach; Ian Ford; Idris Guessous; Igor Rudan; Inga Prokopenko; Ingrid Borecki; Iris M. Heid; Ivana Kolcic; Ivana Persico; J. Wouter Jukema; James F. Wilson; Janine F. Felix; Jasmin Divers; Jean-Charles Lambert; Jeanette M. Stafford; Jean-Michel Gaspoz; Jennifer A. Smith; Jessica D. Faul; Jie Jin Wang; Jingzhong Ding; Joel N. Hirschhorn; John Attia; John B. Whitfield; John Chalmers; Jorma Viikari; Josef Coresh; Joshua C. Denny; Juha Karjalainen; Jyotika K. Fernandes; Karlhans Endlich; Katja Butterbach; Keith L. Keene; Kurt Lohman; Laura Portas; Lenore J. Launer; Leo-Pekka Lyytikaeinen; Loic Yengo; Lude Franke; Luigi Ferrucci; Lynda M. Rose; Lyudmyla Kedenko; Madhumathi Rao; Maksim Struchalin; Marcus E. Kleber; Margherita Cavalieri; Margot Haun; Marilyn C. Cornelis; Marina Ciullo; Mario Pirastu; Mariza de Andrade; Mark A. McEvoy; Mark Woodward; Martin Adam; Massimiliano Cocca; Matthias Nauck; Medea Imboden; Melanie Waldenberger; Menno Pruijm; Marie Metzger; Michael Stumvoll; Michele K. Evans; Michele M. Sale; Mika Kaehoenen; Mladen Boban; Murielle Bochud; Myriam Rheinberger; Niek Verweij; Nabila Bouatia-Naji; Nicholas G. Martin; Nick Hastie; Nicole Probst-Hensch; Nicole Soranzo; Olivier Devuyst; Olli Raitakari; Omri Gottesman; Oscar H. Franco; Ozren Polasek; Paolo Gasparini; Patricia B. Munroe; Paul M. Ridker; Paul Mitchell; Paul Muntner; Christa Meisinger; Johannes H. Smit; Peter Kovacs; Philipp S. Wild; Philippe Froguel; Rainer Rettig; Reedik Maegi; Reiner Biffar; Reinhold Schmidt; Rita P. S. Middelberg; Robert J. Carroll; Brenda W. Penninx; Rodney J. Scott; Ronit Katz; Sanaz Sedaghat; Sarah H. Wild; Sharon L. R. Kardia; Sheila Ulivi; Shih-Jen Hwang; Stefan Enroth; Stefan Kloiber; Stella Trompet; Benedicte Stengel; Stephen J. Hancock; Stephen T. Turner; Sylvia E. Rosas; Sylvia Stracke; Tamara B. Harris; Tanja Zeller; Tatijana Zemunik; Terho Lehtimaeki; Thomas Illig; Thor Aspelund; Tiit Nikopensius; Tonu Esko; Toshiko Tanaka; Ulf Gyllensten; Uwe Voelker; Valur Emilsson; Veronique Vitart; Ville Aalto; Vilmundur Gudnason; Vincent Chouraki; Wei-Min Chen; Wilmar Igl; Winfried Maerz; Wolfgang Koenig; Wolfgang Lieb; Ruth J. F. Loos; Yongmei Liu; Harold Snieder; Peter P. Pramstaller; Afshin Parsa; Jeffrey R. O'Connell; Katalin Susztak; Pavel Hamet; Johanne Tremblay; Ian H. de Boer; Carsten A. Boeger; Wolfram Goessling; Daniel I. Chasman; Anna Koettgen; W. H. Linda Kao; Caroline S. Fox; CARDIOGRAM; Panos Deloukas

doi:10.1038/ncomms10023

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Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

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Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Cristian Pattaro, Alexander Teumer, Mathias Gorski, Audrey Y. Chu, Man Li, Vladan Mijatovic, Maija Garnaas, Adrienne Tin, Rossella Sorice, Yong Li, …

Nature communications, Vol.7(1), pp.10023-10023

01/01/2016

DOI: https://doi.org/10.1038/ncomms10023

PMCID: PMC4735748

PMID: 26831199

Abstract

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways.

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Title: Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Creators - without role: Cristian Pattaro - University of Lübeck
Alexander Teumer - University of Greifswald
Mathias Gorski - University of Regensburg
Audrey Y. Chu - Brigham and Women's Hospital
Man Li - Supreme Council Of Health
Vladan Mijatovic - University of Verona
Maija Garnaas - Harvard University
Adrienne Tin - Supreme Council Of Health
Rossella Sorice - Inst Genet & Biophys Adriano Buzzati Traverso CNR, Via P Castellino 111, I-80131 Naples, Italy
Yong Li - College Station Medical Center
Daniel Taliun - University of Lübeck
Matthias Olden - University of Regensburg
Meredith Foster - Tufts University
Qiong Yang - Boston University
Ming-Huei Chen - Boston University
Tune H. Pers - Boston Childrens Hosp, Div Endocrinol, 300 Longwood Ave, Boston, MA 02115 USA
Andrew D. Johnson - Framingham Heart Study
Yi-An Ko - Supreme Council Of Health
Christian Fuchsberger - University of Lübeck
Bamidele Tayo - College Station Medical Center
Michael Nalls - NIA, Neurogenet Lab, NIH, Bldg 35 Porter Bldg,1A1015, Bethesda, MD 20892 USA
Mary F. Feitosa - Supreme Council Of Health
Aaron Isaacs - College Station Medical Center
Abbas Dehghan - College Station Medical Center
Pio d'Adamo - Inst Maternal & Child Hlth IRCCS Burlo Garofolo, Via Istria 65-1, I-34137 Trieste, Italy
Adebowale Adeyemo - NHGRI, Ctr Res Genom & Global Hlth, Bldg 12A,Room 4047,12 South Dr,MSC 5635, Bethesda, MD 20892 USA
Aida Karina Dieffenbach - Heidelberg
Alan B. Zonderman - CognIT
Ilja M. Nolte - College Station Medical Center
Peter J. van der Most - College Station Medical Center
Alan F. Wright - University of Edinburgh
Alan R. Shuldiner - Supreme Council Of Health
Alanna C. Morrison - Univ Texas Hlth Sci Ctr Houston, Ctr Human Genet, 1200 Pressler St Suite 453E, Houston, TX 77030 USA
Albert Hofman - College Station Medical Center
Albert V. Smith - Iceland Heart Assoc, Res Inst, Holtasmari 1, IS-201 Kopavogur, Iceland
Albert W. Dreisbach - University of Mississippi
Andre Franke - Univ Kiel, Inst Clin Mol Biol, Schittenhelmstr 12, D-24105 Kiel, Germany
Andre G. Uitterlinden - College Station Medical Center
Andres Metspalu - University of Tartu
Anke Tonjes - College Station Medical Center
Antonio Lupo - University of Verona
Antonietta Robino - Inst Maternal & Child Hlth IRCCS Burlo Garofolo, Via Istria 65-1, I-34137 Trieste, Italy
Asa Johansson - Uppsala University
Ayse Demirkan - College Station Medical Center
Barbara Kollerits - College Station Medical Center
Barry I. Freedman - Supreme Council Of Health
Belen Ponte - College Station Medical Center
Ben A. Oostra - College Station Medical Center
Bernhard Paulweber - Salzburger Landeskliniken
Bernhard K. Kraemer - Heidelberg Univ, Univ Med Ctr Mannheim, Dept Med 5, Theodor Kutzer Ufer 1-3, D-68167 Mannheim, Germany
Braxton D. Mitchell - Supreme Council Of Health
Brendan M. Buckley - Univ Coll Cork, Dept Pharmacol Therapeut, Clin Invest Bldg,Western Rd, Cork, Ireland
Carmen A. Peralta - Supreme Council Of Health
Caroline Hayward - University of Edinburgh
Catherine Helmer - Biostat
Charles N. Rotimi - NHGRI, Ctr Res Genom & Global Hlth, Bldg 12A,Room 4047,12 South Dr,MSC 5635, Bethesda, MD 20892 USA
Christian M. Shaffer - Vanderbilt University
Christian Mueller - Univ Heart Ctr Hamburg, Clin Gen & Intervent Cardiol, Martinistr 52, D-20246 Hamburg, Germany
Cinzia Sala - Mylan
Cornelia M. van Duijn - College Station Medical Center
Aude Saint-Pierre - University of Lübeck
Daniel Ackermann - College Station Medical Center
Daniel Shriner - NHGRI, Ctr Res Genom & Global Hlth, Bldg 12A,Room 4047,12 South Dr,MSC 5635, Bethesda, MD 20892 USA
Daniela Ruggiero - Inst Genet & Biophys Adriano Buzzati Traverso CNR, Via P Castellino 111, I-80131 Naples, Italy
Daniela Toniolo - Ist Sci San Raffaele, Div Genet & Cell Biol, Via Olgettina 58, I-20132 Milan, Italy
Yingchang Lu - Supreme Council Of Health
Daniele Cusi - University of Milan
Darina Czamara - Max
David Ellinghaus - Univ Kiel, Inst Clin Mol Biol, Schittenhelmstr 12, D-24105 Kiel, Germany
David S. Siscovick - University of Washington
Douglas Ruderfer - Supreme Council Of Health
Christian Gieger - Helmholtz Zentrum München
Harald Grallert - Helmholtz Zentrum München
Elena Rochtchina - University of Sydney
Elizabeth J. Atkinson - Mayo Clin, Div Biomed Stat & Informat, 200 First St SW, Rochester, MN 55905 USA
Elizabeth G. Holliday - Supreme Council Of Health
Eric Boerwinkle - Univ Texas Hlth Sci Ctr Houston, Ctr Human Genet, 1200 Pressler St Suite 453E, Houston, TX 77030 USA
Erika Salvi - University of Milan
Erwin P. Bottinger - Supreme Council Of Health
Federico Murgia - Inst Populat Genet CNR, Traversa La Crucca 3, I-07040 Sassari, Italy
Fernando Rivadeneira - College Station Medical Center
Florian Ernst - University of Greifswald
Florian Kronenberg - College Station Medical Center
Frank B. Hu - Harvard University
Gerjan J. Navis - University of Groningen
Gary C. Curhan - Harvard University
George B. Ehret - College Station Medical Center
Georg Homuth - University of Greifswald
Stefan Coassin - College Station Medical Center
Gian-Andri Thun - Swiss Trop & Publ Hlth Inst, POB 4002, Basel, Switzerland
Giorgio Pistis - Mylan
Giovanni Gambaro - Pontifícia Universidade Católica de São Paulo
Giovanni Malerba - University of Verona
Grant W. Montgomery - QIMR, Genet Epidemiol, PO Royal Brisbane Hosp, Brisbane, Qld 4029, Australia
Gudny Eiriksdottir - Iceland Heart Assoc, Res Inst, Holtasmari 1, IS-201 Kopavogur, Iceland
Gunnar Jacobs - Univ Kiel, Inst Epidemiol, Niemannsweg 11, D-24105 Kiel, Germany
Guo Li - University of Washington
H-Erich Wichmann - Helmholtz Zentrum München
Harry Campbell - University of Edinburgh
Helena Schmidt - University of Graz
Henri Wallaschofski - College Station Medical Center
Henry Voelzke - University of Greifswald
Hermann Brenner - Heidelberg
Heyo K. Kroemer - University of Greifswald
Holly Kramer - College Station Medical Center
Honghuang Lin - Boston University
I. Mateo Leach - University of Groningen
Ian Ford - University of Glasgow
Idris Guessous - University of Geneva
Igor Rudan - University of Edinburgh
Inga Prokopenko - University of London
Ingrid Borecki - Supreme Council Of Health
Iris M. Heid - University of Regensburg
Ivana Kolcic - University of Split
Ivana Persico - Inst Populat Genet CNR, Traversa La Crucca 3, I-07040 Sassari, Italy
J. Wouter Jukema - Leiden University
James F. Wilson - University of Edinburgh
Janine F. Felix - College Station Medical Center
Jasmin Divers - Wake Forest University
Jean-Charles Lambert - Inserm
Jeanette M. Stafford - Wake Forest University
Jean-Michel Gaspoz - University of Geneva
Jennifer A. Smith - Supreme Council Of Health
Jessica D. Faul - Univ Michigan, Inst Social Res, Survey Res Ctr, 426 Thompson St,3456, Ann Arbor, MI 48104 USA
Jie Jin Wang - University of Sydney
Jingzhong Ding - Supreme Council Of Health
Joel N. Hirschhorn - Boston Childrens Hosp, Div Endocrinol, 300 Longwood Ave, Boston, MA 02115 USA
John Attia - Mayo Clin, Div Biomed Stat & Informat, 200 First St SW, Rochester, MN 55905 USA
John B. Whitfield - QIMR, Genet Epidemiol, PO Royal Brisbane Hosp, Brisbane, Qld 4029, Australia
John Chalmers - University of Sydney
Jorma Viikari - University of Turku
Josef Coresh - Supreme Council Of Health
Joshua C. Denny - Vanderbilt University
Juha Karjalainen - University of Groningen
Jyotika K. Fernandes - College Station Medical Center
Karlhans Endlich - University of Greifswald
Katja Butterbach - Heidelberg
Keith L. Keene - E Carolina Univ, Dept Biol, Ctr Hlth Dispar, 1001 East 10th St,N209 Howell Sci Complex, Greenville, NC 27858 USA
Kurt Lohman - Supreme Council Of Health
Laura Portas - Inst Populat Genet CNR, Traversa La Crucca 3, I-07040 Sassari, Italy
Lenore J. Launer - Gateway
Leo-Pekka Lyytikaeinen - University of Tampere
Loic Yengo - CNRS, UMR 8199, 1 Rue Prof Calmette, F-59000 Lille, France
Lude Franke - University of Groningen
Luigi Ferrucci - NIA, Clin Res Branch, 251 Bayview Blvd, Baltimore, MD 21250 USA
Lynda M. Rose - Brigham and Women's Hospital
Lyudmyla Kedenko - Salzburger Landeskliniken
Madhumathi Rao - Tufts University
Maksim Struchalin - Biostat
Marcus E. Kleber - Heidelberg University
Margherita Cavalieri - University of Graz
Margot Haun - College Station Medical Center
Marilyn C. Cornelis - Harvard University
Marina Ciullo - Inst Genet & Biophys Adriano Buzzati Traverso CNR, Via P Castellino 111, I-80131 Naples, Italy
Mario Pirastu - Inst Populat Genet CNR, Traversa La Crucca 3, I-07040 Sassari, Italy
Mariza de Andrade - Mayo Clin, Div Biomed Stat & Informat, 200 First St SW, Rochester, MN 55905 USA
Mark A. McEvoy - John Hunter Hospital
Mark Woodward - Supreme Council Of Health
Martin Adam - Swiss Trop & Publ Hlth Inst, POB 4002, Basel, Switzerland
Massimiliano Cocca - Ist Sci San Raffaele, Div Genet & Cell Biol, Via Olgettina 58, I-20132 Milan, Italy
Matthias Nauck - College Station Medical Center
Medea Imboden - Swiss Trop & Publ Hlth Inst, POB 4002, Basel, Switzerland
Melanie Waldenberger - Helmholtz Zentrum München
Menno Pruijm - University of Lausanne
Marie Metzger - Université Paris Cité
Michael Stumvoll - College Station Medical Center
Michele K. Evans - NIA, Hlth Dispar Res Sect, Clin Res Branch, NIH,Biomed Ctr, 251 Bayview Blvd,Suite 100, Baltimore, MD 21224 USA
Michele M. Sale - University of Virginia
Mika Kaehoenen - University of Tampere
Mladen Boban - University of Split
Murielle Bochud - University of Lausanne
Myriam Rheinberger - Univ Hosp Regensburg, Dept Nephrol, Franz Josef Str Allee 11, D-93053 Regensburg, Germany
Niek Verweij - University of Groningen
Nabila Bouatia-Naji - Inserm
Nicholas G. Martin - QIMR, Genet Epidemiol, PO Royal Brisbane Hosp, Brisbane, Qld 4029, Australia
Nick Hastie - University of Edinburgh
Nicole Probst-Hensch - Swiss Trop & Publ Hlth Inst, POB 4002, Basel, Switzerland
Nicole Soranzo - Wellcome Sanger Institute
Olivier Devuyst - University of Zurich
Olli Raitakari - University of Turku
Omri Gottesman - Supreme Council Of Health
Oscar H. Franco - College Station Medical Center
Ozren Polasek - University of Split
Paolo Gasparini - Inst Maternal & Child Hlth IRCCS Burlo Garofolo, Via Istria 65-1, I-34137 Trieste, Italy
Patricia B. Munroe - Queen Mary University of London
Paul M. Ridker - Harvard University
Paul Mitchell - University of Sydney
Paul Muntner - University of Alabama
Christa Meisinger - Helmholtz Zentrum München
Johannes H. Smit - University of Amsterdam
Peter Kovacs - Institute of Inland Fisheries in Potsdam-Sacrow
Philipp S. Wild - College Station Medical Center
Philippe Froguel - CNRS, UMR 8199, 1 Rue Prof Calmette, F-59000 Lille, France
Rainer Rettig - University of Greifswald
Reedik Maegi - University of Tartu
Reiner Biffar - University of Greifswald
Reinhold Schmidt - University of Graz
Rita P. S. Middelberg - QIMR, Genet Epidemiol, PO Royal Brisbane Hosp, Brisbane, Qld 4029, Australia
Robert J. Carroll - Vanderbilt University
Brenda W. Penninx - University of Amsterdam
Rodney J. Scott - John Hunter Hospital
Ronit Katz - University of Washington
Sanaz Sedaghat - College Station Medical Center
Sarah H. Wild - University of Edinburgh
Sharon L. R. Kardia - Supreme Council Of Health
Sheila Ulivi - Inst Maternal & Child Health IRCCS Burlo Garofolo, Via Istria 65, I-34137 Trieste, Italy
Shih-Jen Hwang - Framingham Heart Study
Stefan Enroth - Uppsala University
Stefan Kloiber - Max
Stella Trompet - Leiden University
Benedicte Stengel - Université Paris Cité
Stephen J. Hancock - Univ Newcastle, Sch Med & Publ Hlth, Ctr Clin Epidemiol & Biostat, HMRI Bldg 1, New Lambton, NSW 2305, Australia
Stephen T. Turner - College Station Medical Center
Sylvia E. Rosas - Supreme Council Of Health
Sylvia Stracke - Inserm
Tamara B. Harris - Gateway
Tanja Zeller - Univ Heart Ctr Hamburg, Clin Gen & Intervent Cardiol, Martinistr 52, D-20246 Hamburg, Germany
Tatijana Zemunik - University of Split
Terho Lehtimaeki - University of Tampere
Thomas Illig - Helmholtz Zentrum München
Thor Aspelund - Iceland Heart Assoc, Res Inst, Holtasmari 1, IS-201 Kopavogur, Iceland
Tiit Nikopensius - University of Tartu
Tonu Esko - Boston Childrens Hosp, Div Endocrinol, 300 Longwood Ave, Boston, MA 02115 USA
Toshiko Tanaka - NIA, Clin Res Branch, 251 Bayview Blvd, Baltimore, MD 21250 USA
Ulf Gyllensten - Uppsala University
Uwe Voelker - University of Greifswald
Valur Emilsson - Iceland Heart Assoc, Res Inst, Holtasmari 1, IS-201 Kopavogur, Iceland
Veronique Vitart - University of Edinburgh
Ville Aalto - University of Turku
Vilmundur Gudnason - Iceland Heart Assoc, Res Inst, Holtasmari 1, IS-201 Kopavogur, Iceland
Vincent Chouraki - Inserm
Wei-Min Chen - University of Virginia
Wilmar Igl - Uppsala University
Winfried Maerz - Synlab
Wolfgang Koenig - University of Ulm
Wolfgang Lieb - Univ Kiel, Inst Epidemiol, Niemannsweg 11, D-24105 Kiel, Germany
Ruth J. F. Loos - Supreme Council Of Health
Yongmei Liu - Supreme Council Of Health
Harold Snieder - College Station Medical Center
Peter P. Pramstaller - University of Lübeck
Afshin Parsa - Supreme Council Of Health
Jeffrey R. O'Connell - Supreme Council Of Health
Katalin Susztak - Supreme Council Of Health
Pavel Hamet - Univ Montreal, CHUM Res Ctr, CRCHUM, Technopole Angus, 900 St Denis, Montreal, PQ H2X 0A9, Canada
Johanne Tremblay - Univ Montreal, CHUM Res Ctr, CRCHUM, Technopole Angus, 900 St Denis, Montreal, PQ H2X 0A9, Canada
Ian H. de Boer - University of Washington
Carsten A. Boeger - Univ Hosp Regensburg, Dept Nephrol, Franz Josef Str Allee 11, D-93053 Regensburg, Germany
Wolfram Goessling - Harvard University
Daniel I. Chasman - Brigham and Women's Hospital
Anna Koettgen - Supreme Council Of Health
W. H. Linda Kao - Supreme Council Of Health
Caroline S. Fox - Framingham Heart Study
CARDIOGRAM
Panos Deloukas - King Abdulaziz University
Publication Details: Nature communications, Vol.7(1), pp.10023-10023
Publisher: Springer Nature
Number of pages: 19
Grant note: R01DK090311 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) ES/F02679X/1 / Economic and Social Research Council; UK Research & Innovation (UKRI); Economic & Social Research Council (ESRC) G0902037 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) U01HL084756 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) F31AG044879 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) R01MD009055 / National Institute on Minority Health and Health Disparities; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Minority Health & Health Disparities (NIMHD) MR/K013351/1 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission ES/F02679X/1 / ESRC; UK Research & Innovation (UKRI); Economic & Social Research Council (ESRC) K12RR023250 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) R24OD017870 / OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA NF-SI-0512-10165 / National Institute for Health Research; National Institute for Health Research (NIHR) U01HG004399 / NATIONAL HUMAN GENOME RESEARCH INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) R190-2014-3904 / Lundbeck Foundation; Lundbeckfonden RG/08/014/24067 / British Heart Foundation UM1CA182913 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) U01GM074518 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) Pers Group / NNF Center for Basic Metabolic Research; Novo Nordisk Foundation R01DK090311; R24OD017870 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
Identifiers: 9937326208331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article