Abstract
Twelve Aspergilli isolates were including two species A. flavus and A. niger. A. flavus included six isolates, two isolates producing sliver nanoparticles (AgNPs) and four isolates non producing AgNPs. A. niger enclosed six isolates with a similar description. Random amplified polymorphic DNA (RAPD) and Inter simple sequence repeats (ISSR) DNA markers were used with the aim of genetically characterizing isolates of A. flavus and A. niger to discriminate between producing and non producing AgNPs isolates. RAPD and ISSR analysis revealed a high level of genetic diversity in the A. flavus and A. niger population useful for genetic characterization. A. flavus and A. niger isolates (producing and non producing AgNPs) are shown in RAPD and ISSR dendrogram with a random distribution. There was no clear-cut relationship between the RAPD and ISSR dendrogram and AgNPs production. RAPD and ISSR markers were not suitable to discriminate between producing and non producing AgNPs isolates.