Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

Willem Ouwehand; Andrew Keniry; Sheila A Fisher; Derek P Jewell; Carl A Anderson; Natalie J Prescott; Panos Deloukas; Katarzyna Blaszczyk; John C Mansfield; Christopher G Mathew; Nick Watkins; Hazel Drummond; Fraser R Cummings; Alastair Forbes; Jeffrey C Barrett; Radhi Ravindrarajah; Jeremy Sanderson; Mike Inouye; Sarah Hunt; Elaine R Nimmo; Christopher Johnson; Suzannah Bumpstead; Catherine E Hanson; Alan Lobo; Dunecan Massey; Lon Cardon; Philip Ewels; Jack Satsangi; Mark Tremelling; Rhian Gwilliam; Martyn Carter; Carlo Berzuini; Charlie W Lees; Clive M Onnie; Miles Parkes; Cathryn M Lewis; Wellcome Trust Case Control Consor

doi:10.1038/ng.145

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Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

Journal article

Peer reviewed

Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease

Willem Ouwehand, Andrew Keniry, Sheila A Fisher, Derek P Jewell, Carl A Anderson, Natalie J Prescott, Panos Deloukas, Katarzyna Blaszczyk, John C Mansfield, Christopher G Mathew, …

Nature genetics, Vol.40(6), pp.710-712

01/06/2008

DOI: https://doi.org/10.1038/ng.145

PMCID: PMC2719289

PMID: 18438406

Abstract

We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously unknown susceptibility locus at ECM1. We also show that several risk loci are common to ulcerative colitis and Crohn's disease (IL23R, IL12B, HLA, NKX2-3 and MST1), whereas autophagy genes ATG16L1 and IRGM, along with NOD2 (also known as CARD15), are specific for Crohn's disease. These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases.

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Title: Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
Creators - without role: Willem Ouwehand - University of Cambridge
Andrew Keniry - Wellcome Sanger Institute
Sheila A Fisher - King's College London
Derek P Jewell - University of Oxford
Carl A Anderson - University of Oxford
Natalie J Prescott - King's College London
Panos Deloukas - Wellcome Sanger Institute
Katarzyna Blaszczyk - King's College London
John C Mansfield - Newcastle University
Christopher G Mathew - King's College London
Nick Watkins - University of Cambridge
Hazel Drummond - University of Edinburgh
Fraser R Cummings - University of Oxford
Alastair Forbes - University College London
Jeffrey C Barrett - University of Oxford
Radhi Ravindrarajah - Wellcome Sanger Institute
Jeremy Sanderson - Guy's and St Thomas' NHS Foundation Trust
Mike Inouye - Wellcome Sanger Institute
Sarah Hunt - Wellcome Sanger Institute
Elaine R Nimmo - University of Edinburgh
Christopher Johnson - Addenbrooke's Hospital
Suzannah Bumpstead - Wellcome Sanger Institute
Catherine E Hanson - Royal Victoria Infirmary
Alan Lobo - Royal Hallamshire Hospital
Dunecan Massey - University of Cambridge
Lon Cardon - Wellcome Centre for Human Genetics
Philip Ewels - Wellcome Sanger Institute
Jack Satsangi - University of Edinburgh
Mark Tremelling - Addenbrooke's Hospital
Rhian Gwilliam - Wellcome Sanger Institute
Martyn Carter - Royal Hallamshire Hospital
Carlo Berzuini - University of Cambridge
Charlie W Lees - Western General Hospital
Clive M Onnie - King's College London
Miles Parkes - Addenbrooke's Hospital
Cathryn M Lewis - King's College London
Wellcome Trust Case Control Consor
Publication Details: Nature genetics, Vol.40(6), pp.710-712
Identifiers: 9938830508331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article