Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates A beta, tau, immunity and lipid processing

Brian W. Kunkle; Benjamin Grenier-Boley; Rebecca Sims; Joshua C. Bis; Vincent Damotte; Adam C. Naj; Anne Boland; Maria Vronskaya; Sven J. van der Lee; Alexandre Amlie-Wolf; Celine Bellenguez; Aura Frizatti; Vincent Chouraki; Eden R. Martin; Kristel Sleegers; Nandini Badarinarayan; Johanna Jakobsdottir; Kara L. Hamilton-Nelson; Sonia Moreno-Grau; Robert Olaso; Rachel Raybould; Yuning Chen; Amanda B. Kuzma; Mikko Hiltunen; Taniesha Morgan; Shahzad Ahmad; Badri N. Vardarajan; Jacques Epelbaum; Per Hoffmann; Merce Boada; Gary W. Beecham; Jean-Guillaume Garnier; Denise Harold; Annette L. Fitzpatrick; Otto Valladares; Marie-Laure Moutet; Amy Gerrish; Albert Smith; Liming Qu; Delphine Bacq; Nicola Denning; Xueqiu Jian; Yi Zhao; Maria Del Zompo; Nick C. Fox; Seung-Hoan Choi; Ignacio Mateo; Joseph T. Hughes; Hieab H. Adams; John Malamon; Florentino Sanchez-Garcia; Yogen Patel; Jennifer A. Brody; Beth A. Dombroski; Maria Candida Deniz Naranjo; Makrina Daniilidou; Gudny Eiriksdottir; Shubhabrata Mukherjee; David Wallon; James Uphill; Thor Aspelund; Laura B. Cantwell; Fabienne Garzia; Daniela Galimberti; Edith Hofer; Mariusz Butkiewicz; Bertrand Fin; Elio Scarpini; Chloe Sarnowski; Will S. Bush; Stphane Meslage; Johannes Kornhuber; Charles C. White; Yuenjoo Song; Robert C. Barber; Sebastiaan Engelborghs; Sabrina Sordon; Dina Voijnovic; Perrie M. Adams; Rik Vandenberghe; Manuel Mayhaus; L. Adrienne Cupples; Marilyn S. Albert; Peter P. De Deyn; Wei Gu; Jayanadra J. Himali; Duane Beekly; Alessio Squassina; Annette M. Hartmann; Adelina Orellana; Deborah Blacker; Eloy Rodriguez-Rodriguez; Simon Lovestone; Melissa E. Garcia; Rachelle S. Doody; Carmen Munoz-Fernadez; Rebecca Sussams; Honghuang Lin; Thomas J. Fairchild; Yolanda A. Benito; Clive Holmes; Hata Karamujic-Comic; Matthew P. Frosch; Hakan Thonberg; Wolfgang Maier; Gena Roschupkin; Bernardino Ghetti; Vilmantas Giedraitis; Amit Kawalia; Shuo Li; Ryan M. Huebinger; Lena Kilander; Susanne Moebus; Isabel Hernandez; M. Ilyas Kamboh; Rosemarie Brundin; James Turton; Qiong Yang; Mindy J. Katz; Letizia Concari; Jenny Lord; Alexa S. Beiser; C. Dirk Keene; Seppo Helisalmi; Iwona Kloszewska; Walter A. Kukull; Anne Maria Koivisto; Aoibhinn Lynch; Lluis Tarraga; Eric B. Larson; Annakaisa Haapasalo; Brian Lawlor; Thomas H. Mosley; Richard B. Lipton; Vincenzo Solfrizzi; Michael Gill; W. T. Longstreth; Thomas J. Montine; Vincenza Frisardi; Monica Diez-Fairen; Fernando Rivadeneira; Ronald C. Petersen; Vincent Deramecourt; Ignacio Alvarez; Francesca Salani; Antonio Ciaramella; Eric Boerwinkle; Eric M. Reiman; Nathalie Fievet; Jerome Rotter; Joan S. Reisch; Olivier Hanon; Chiara Cupidi; A. G. Andre Uitterlinden; Donald R. Royall; Carole Dufouil; Raffaele Giovanni Maletta; Itziar de Rojas; Mary Sano; Alexis Brice; Roberta Cecchetti; Peter St George-Hyslop; Karen Ritchie; Magda Tsolaki; Debby W. Tsuang; Bruno Dubois; David Craig; Chuang-Kuo Wu; Hilkka Soininen; Despoina Avramidou; Roger L. Albin; Laura Fratiglioni; Antonia Germanou; Liana G. Apostolova; Lina Keller; Maria Koutroumani; Steven E. Arnold; Francesco Panza; Olymbia Gkatzima; Sanjay Asthana; Didier Hannequin; Patrice Whitehead; Craig S. Atwood; Paolo Caffarra; Harald Hampel; Ines Quintela; Angel Carracedo; Lars Lannfelt; David C. Rubinsztein; Lisa L. Barnes; Florence Pasquier; Lutz Froelich; Sandra Barral; Bernadette McGuinness; Thomas G. Beach; Janet A. Johnston; James T. Becker; Peter Passmore; Eileen H. Bigio; Jonathan M. Schott; Thomas D. Bird; Jason D. Warren; Bradley F. Boeve; Michelle K. Lupton; James D. Bowen; Petra Proitsi; Adam Boxer; John F. Powell; James R. Burke; John S. K. Kauwe; Jeffrey M. Burns; Michelangelo Mancuso; Joseph D. Buxbaum; Ubaldo Bonuccelli; Nigel J. Cairns; Andrew McQuillin; Chuanhai Cao; Gill Livingston; Chris S. Carlson; Nicholas J. Bass; Cynthia M. Carlsson; John Hardy; Regina M. Carney; Jose Bras; Minerva M. Carrasquillo; Rita Guerreiro; Mariet Allen; Helena C. Chui; Elizabeth Fisher; Carlo Masullo; Elizabeth A. Crocco; Charles DeCarli; Gina Bisceglio; Malcolm Dick; Li Ma; Ranjan Duara; Neill R. Graff-Radford; Denis A. Evans; Angela Hodges; Kelley M. Faber; Martin Scherer; Kenneth B. Fallon; Matthias Riemenschneider; David W. Fardo; Reinhard Heun; Martin R. Farlow; Heike Koelsch; Steven Ferris; Markus Leber; Tatiana M. Foroud; Isabella Heuser; Douglas R. Galasko; Ina Giegling; Marla Gearing; Michael Huell; Daniel H. Geschwind; John R. Gilbert; John Morris; Robert C. Green; Kevin Mayo; John H. Growdon; Thomas Feulner; Ronald L. Hamilton; Lindy E. Harrell; Dmitriy Drichel; Lawrence S. Honig; Thomas D. Cushion; Matthew J. Huentelman; Paul Hollingworth; Christine M. Hulette; Bradley T. Hyman; Rachel Marshall; Gail P. Jarvik; Alun Meggy; Erin Abner; Georgina E. Menzies; Lee-Way Jin; Ganna Leonenko; Luis M. Real; Gyungah R. Jun; Clinton T. Baldwin; Detelina Grozeva; Anna Karydas; Giancarlo Russo; Jeffrey A. Kaye; Ronald Kim; Frank Jessen; Neil W. Kowall; Bruno Vellas; Joel H. Kramer; Emma Vardy; Frank M. LaFerla; Karl-Heinz Joeckel; James J. Lah; Martin Dichgans; James B. Leverenz; David Mann; Allan Levey; Stuart Pickering-Brown; Andrew P. Lieberman; Norman Klopp; Kathryn L. Lunetta; H-Erich Wichmann; Constantine G. Lyketsos; Kevin Morgan; Daniel C. Marson; Kristelle Brown; Frank Martiniuk; Christopher Medway; Deborah C. Mash; Markus M. Noethen; Eliezer Masliah; Nigel M. Hooper; Wayne C. McCormick; Antonio Daniele; Susan M. McCurry; Anthony Bayer; Andrew N. McDavid; John Gallacher; Ann C. McKee; Hendrik van den Bussche; Marsel Mesulam; Carol Brayne; Bruce L. Miller; Steffi Riedel-Heller; Carol A. Miller; Joshua W. Miller; Ammar Al-Chalabi; John C. Morris; Christopher E. Shaw; Amanda J. Myers; Jens Wiltfang; Sid O'Bryant; John M. Olichney; Victoria Alvarez; Joseph E. Parisi; Andrew B. Singleton; Henry L. Paulson; John Collinge; William R. Perry; Simon Mead; Elaine Peskind; David H. Cribbs; Martin Rossor; Aimee Pierce; Natalie S. Ryan; Wayne W. Poon; Benedetta Nacmias; Huntington Potter; Sandro Sorbi; Joseph F. Quinn; Eleonora Sacchinelli; Ashok Raj; Gianfranco Spalletta; Murray Raskind; Carlo Caltagirone; Paola Bossu; Maria Donata Orfei; Barry Reisberg; Robert Clarke; Christiane Reitz; A. David Smith; John M. Ringman; Donald Warden; Erik D. Roberson; Gordon Wilcock; Ekaterina Rogaeva; Amalia Cecilia Bruni; Howard J. Rosen; Maura Gallo; Roger N. Rosenberg; Yoav Ben-Shlomo; Mark A. Sager; Patrizia Mecocci; Andrew J. Saykin; Pau Pastor; Michael L. Cuccaro; Jeffery M. Vance; Julie A. Schneider; Lori S. Schneider; Susan Slifer; William W. Seeley; Amanda G. Smith; Joshua A. Sonnen; Salvatore Spina; Robert A. Stern; Russell H. Swerdlow; Mitchell Tang; Rudolph E. Tanzi; John Q. Trojanowski; Juan C. Troncoso; Vivianna M. Van Deerlin; Linda J. Van Eldik; Harry V. Vinters; Jean Paul Vonsattel; Sandra Weintraub; Kathleen A. Welsh-Bohmer; Kirk C. Wilhelmsen; Jennifer Williamson; Thomas S. Wingo; Randall L. Woltjer; Clinton B. Wright; Chang-En Yu; Lei Yu; Yasaman Saba; Alberto Pilotto; Maria J. Bullido; Oliver Peters; Paul K. Crane; David Bennett; Paola Bosco; Eliecer Coto; Virginia Boccardi; Phil L. De Jager; Alberto Lleo; Nick Warner; Oscar L. Lopez; Martin Ingelsson; Panagiotis Deloukas; Carlos Cruchaga; Caroline Graff; Rhian Gwilliam; Myriam Fornage; Alison M. Goate; Pascual Sanchez-Juan; Patrick G. Kehoe; Najaf Amin; Nilifur Ertekin-Taner; Claudine Berr; Stphanie Debette; Seth Love; Lenore J. Launer; Steven G. Younkin; Jean-Francois Dartigues; Chris Corcoran; M. Arfan Ikram; Dennis W. Dickson; Gael Nicolas; Dominique Campion; JoAnn Tschanz; Helena Schmidt; Hakon Hakonarson; Jordi Clarimon; Ron Munger; Reinhold Schmidt; Lindsay A. Farrer; Christine Van Broeckhoven; Michael C. O'Donovan; Anita L. DeStefano; Lesley Jones; Jonathan L. Haines; Jean-Francois Deleuze; Michael J. Owen; Vilmundur Gudnason; Richard Mayeux; Valentina Escott-Price; Bruce M. Psaty; Alfredo Ramirez; Li-San Wang; Agustin Ruiz; Cornelia M. van Duijn; Peter A. Holmans; Sudha Seshadri; Julie Williams; Phillippe Amouyel; Gerard D. Schellenberg; Jean-Charles Lambert; Margaret A. Pericak-Vance; Cohorts Heart Aging Res Genomic Ep

doi:10.1038/s41588-019-0358-2

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Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates A beta, tau, immunity and lipid processing

Journal article

Peer reviewed

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates A beta, tau, immunity and lipid processing

Brian W. Kunkle, Benjamin Grenier-Boley, Rebecca Sims, Joshua C. Bis, Vincent Damotte, Adam C. Naj, Anne Boland, Maria Vronskaya, Sven J. van der Lee, Alexandre Amlie-Wolf, …

Nature genetics, Vol.51(3), pp.414-+

01/03/2019

DOI: https://doi.org/10.1038/s41588-019-0358-2

PMCID: PMC6463297

PMID: 30820047

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinically diagnosed LOAD (94,437 individuals). We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1, and WWOX), two of which (ADAM10, ACE) were identified in a recent genome-wide association (GWAS)-by-familial-proxy of Alzheimer's or dementia. Fine-mapping of the human leukocyte antigen (HLA) region confirms the neurological and immune-mediated disease haplotype HLA-DR15 as a risk factor for LOAD. Pathway analysis implicates immunity, lipid metabolism, tau binding proteins, and amyloid precursor protein (APP) metabolism, showing that genetic variants affecting APP and A beta processing are associated not only with early-onset autosomal dominant Alzheimer's disease but also with LOAD. Analyses of risk genes and pathways show enrichment for rare variants (P = 1.32 x 10(-7)), indicating that additional rare variants remain to be identified. We also identify important genetic correlations between LOAD and traits such as family history of dementia and education.

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Title: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates A beta, tau, immunity and lipid processing
Creators - without role: Brian W. Kunkle - University of Miami
Benjamin Grenier-Boley - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement
Rebecca Sims - Cardiff University
Joshua C. Bis - University of Washington
Vincent Damotte - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement
Adam C. Naj - Supreme Council Of Health
Anne Boland - University of Paris-Saclay
Maria Vronskaya - Cardiff University
Sven J. van der Lee - Erasmus MC
Alexandre Amlie-Wolf - Supreme Council Of Health
Celine Bellenguez - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement
Aura Frizatti - Cardiff University
Vincent Chouraki - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement
Eden R. Martin - University of Miami
Kristel Sleegers - VIB, Ctr Mol Neurol, Neurodegenerat Brain Dis Grp, Antwerp, Belgium
Nandini Badarinarayan - Cardiff University
Johanna Jakobsdottir - Iceland Heart Assoc, Kopavogur, Iceland
Kara L. Hamilton-Nelson - University of Miami
Sonia Moreno-Grau - Fundació ACE
Robert Olaso - University of Paris-Saclay
Rachel Raybould - Cardiff University
Yuning Chen - Boston University
Amanda B. Kuzma - Supreme Council Of Health
Mikko Hiltunen - University of Eastern Finland
Taniesha Morgan - Cardiff University
Shahzad Ahmad - Erasmus MC
Badri N. Vardarajan - Columbia University
Jacques Epelbaum - Université Paris Cité
Per Hoffmann - University of Bonn
Merce Boada - Fundació ACE
Gary W. Beecham - University of Miami
Jean-Guillaume Garnier - University of Paris-Saclay
Denise Harold - Dublin City University
Annette L. Fitzpatrick - University of Washington
Otto Valladares - Supreme Council Of Health
Marie-Laure Moutet - University of Paris-Saclay
Amy Gerrish - UCL Inst Neurol, Dept Neurodegenerat Dis, Dementia Res Ctr, London, England
Albert Smith - Biostat
Liming Qu - Supreme Council Of Health
Delphine Bacq - University of Paris-Saclay
Nicola Denning - Cardiff University
Xueqiu Jian - College Station Medical Center
Yi Zhao - Supreme Council Of Health
Maria Del Zompo - University of Cagliari
Nick C. Fox - UCL Inst Neurol, Dept Neurodegenerat Dis, Dementia Res Ctr, London, England
Seung-Hoan Choi - Fundació ACE
Ignacio Mateo - Universidad de Cantabria
Joseph T. Hughes - Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Basic & Clin Neurosci, London, England
Hieab H. Adams - Erasmus MC
John Malamon - Supreme Council Of Health
Florentino Sanchez-Garcia - Hosp Univ Doctor Negrin, Dept Immunol, Las Palmas Gran Canaria, Spain
Yogen Patel - Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Basic & Clin Neurosci, London, England
Jennifer A. Brody - University of Washington
Beth A. Dombroski - Supreme Council Of Health
Maria Candida Deniz Naranjo - Hosp Univ Doctor Negrin, Dept Immunol, Las Palmas Gran Canaria, Spain
Makrina Daniilidou - Aristotle University of Thessaloniki
Gudny Eiriksdottir - Iceland Heart Assoc, Kopavogur, Iceland
Shubhabrata Mukherjee - University of Washington
David Wallon - Inserm
James Uphill - MRC Prion Unit
Thor Aspelund - Iceland Heart Assoc, Kopavogur, Iceland
Laura B. Cantwell - Supreme Council Of Health
Fabienne Garzia - University of Paris-Saclay
Daniela Galimberti - Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Edith Hofer - University of Graz
Mariusz Butkiewicz - Case Western Reserve University
Bertrand Fin - University of Paris-Saclay
Elio Scarpini - Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Chloe Sarnowski - Boston University
Will S. Bush - Case Western Reserve University
Stphane Meslage - University of Paris-Saclay
Johannes Kornhuber - Univ Erlangen Nurnberg, Dept Psychiat & Psychotherapy, Erlangen, Germany
Charles C. White - College Station Medical Center
Yuenjoo Song - Case Western Reserve University
Robert C. Barber - Univ North Texas, Hlth Sci Ctr, Dept Pharmacol & Neurosci, Ft Worth, TX USA
Sebastiaan Engelborghs - University of Antwerp
Sabrina Sordon - Univ Hosp, Dept Psychiat & Psychotherapy, Saarland, Germany
Dina Voijnovic - Erasmus MC
Perrie M. Adams - College Station Medical Center
Rik Vandenberghe - CognIT
Manuel Mayhaus - Univ Hosp, Dept Psychiat & Psychotherapy, Saarland, Germany
L. Adrienne Cupples - Framingham Heart Dis Epidemiol Study, Framingham, MA USA
Marilyn S. Albert - Johns Hopkins University
Peter P. De Deyn - University of Antwerp
Wei Gu - Univ Hosp, Dept Psychiat & Psychotherapy, Saarland, Germany
Jayanadra J. Himali - Framingham Heart Dis Epidemiol Study, Framingham, MA USA
Duane Beekly - University of Washington
Alessio Squassina - University of Cagliari
Annette M. Hartmann - Martin Luther University Halle-Wittenberg
Adelina Orellana - Fundació ACE
Deborah Blacker - Harvard University
Eloy Rodriguez-Rodriguez - Universidad de Cantabria
Simon Lovestone - University of Oxford
Melissa E. Garcia - NIA, Lab Epidemiol & Populat Sci, Bethesda, MD 20892 USA
Rachelle S. Doody - College Station Medical Center
Carmen Munoz-Fernadez - Hosp Univ Doctor Negrin, Dept Immunol, Las Palmas Gran Canaria, Spain
Rebecca Sussams - University of Southampton
Honghuang Lin - Boston University
Thomas J. Fairchild - Univ North Texas, Hlth Sci Ctr, Off Strategy & Measurement, Ft Worth, TX USA
Yolanda A. Benito - Hosp Univ Doctor Negrin, Dept Immunol, Las Palmas Gran Canaria, Spain
Clive Holmes - University of Southampton
Hata Karamujic-Comic - Erasmus MC
Matthew P. Frosch - Massachusetts Gen Hosp, CS Kub Lab Neuropathol, Charlestown, MA USA
Hakan Thonberg - Karolinska Univ Hosp Solna, Unit Hereditary Dementias, Theme Aging, Stockholm, Sweden
Wolfgang Maier - German Ctr Neurodegenerat Dis, Bonn, Germany
Gena Roschupkin - Erasmus MC
Bernardino Ghetti - Indiana University
Vilmantas Giedraitis - Uppsala University
Amit Kawalia - Univ Hosp Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany
Shuo Li - Boston University
Ryan M. Huebinger - College Station Medical Center
Lena Kilander - Uppsala University
Susanne Moebus - University of Duisburg-Essen
Isabel Hernandez - Fundació ACE
M. Ilyas Kamboh - University of Pittsburgh
Rosemarie Brundin - Uppsala University
James Turton - University of Nottingham
Qiong Yang - Boston University
Mindy J. Katz - Albert Einstein College of Medicine
Letizia Concari - University of Parma
Jenny Lord - University of Nottingham
Alexa S. Beiser - Framingham Heart Dis Epidemiol Study, Framingham, MA USA
C. Dirk Keene - University of Washington
Seppo Helisalmi - University of Eastern Finland
Iwona Kloszewska - College Station Medical Center
Walter A. Kukull - University of Washington
Anne Maria Koivisto - University of Eastern Finland
Aoibhinn Lynch - St James Hosp, Mercers Inst Res Aging, Dublin, Ireland
Lluis Tarraga - Fundació ACE
Eric B. Larson - Kaiser Permanente
Annakaisa Haapasalo - University of Eastern Finland
Brian Lawlor - St James Hosp, Mercers Inst Res Aging, Dublin, Ireland
Thomas H. Mosley - University of Mississippi
Richard B. Lipton - Albert Einstein College of Medicine
Vincenzo Solfrizzi - University of Bari Aldo Moro
Michael Gill - St James Hosp, Mercers Inst Res Aging, Dublin, Ireland
W. T. Longstreth - University of Washington
Thomas J. Montine - University of Washington
Vincenza Frisardi - University of Bari Aldo Moro
Monica Diez-Fairen - Fundacio Recerca Biomed & Social Mutua Terrassa, Barcelona, Spain
Fernando Rivadeneira - Erasmus MC
Ronald C. Petersen - Mayo Clin, Dept Neurol, Rochester, MN USA
Vincent Deramecourt - CHU Lille, Memory Ctr Lille, Ctr Memoire Ressources & Rech, Lille, France
Ignacio Alvarez - Fundacio Recerca Biomed & Social Mutua Terrassa, Barcelona, Spain
Francesca Salani - IRCCS Santa Lucia Fdn, Expt Neuropsychobiol Lab, Dept Clin & Behav Neurol, Rome, Italy
Antonio Ciaramella - IRCCS Santa Lucia Fdn, Expt Neuropsychobiol Lab, Dept Clin & Behav Neurol, Rome, Italy
Eric Boerwinkle - Supreme Council Of Health
Eric M. Reiman - Phoenix
Nathalie Fievet - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement
Jerome Rotter - Biomed Research Institute
Joan S. Reisch - College Station Medical Center
Olivier Hanon - Université Paris Cité
Chiara Cupidi - ASP Catanzaro, Reg Neurogenet Ctr CRN, Lamezia Terme, Italy
A. G. Andre Uitterlinden - Erasmus MC
Donald R. Royall - UT Hlth Sci Ctr San Antonio, South Texas Vet Hlth Adm Geriatr Res Educ & Clin, Dept Psychiat, San Antonio, TX USA
Carole Dufouil - University of Bordeaux
Raffaele Giovanni Maletta - ASP Catanzaro, Reg Neurogenet Ctr CRN, Lamezia Terme, Italy
Itziar de Rojas - Fundació ACE
Mary Sano - Supreme Council Of Health
Alexis Brice - Sorbonne Université
Roberta Cecchetti - University of Perugia
Peter St George-Hyslop - University of Cambridge
Karen Ritchie - Inserm
Magda Tsolaki - Aristotle University of Thessaloniki
Debby W. Tsuang - University of Puget Sound
Bruno Dubois - Hop La Pitie Salpetriere, Dept Neurol, Inst Memoire & Malad Alzheimer, Paris, France
David Craig - Queens University
Chuang-Kuo Wu - Texas Tech Univ, Hlth Sci Ctr, Dept Neurol, Lubbock, TX 79409 USA
Hilkka Soininen - University of Eastern Finland
Despoina Avramidou - Aristotle University of Thessaloniki
Roger L. Albin - Univ Michigan, Dept Neurol, Ann Arbor, MI USA
Laura Fratiglioni - Karolinska Institutet
Antonia Germanou - Aristotle University of Thessaloniki
Liana G. Apostolova - Indiana University
Lina Keller - Karolinska Institutet
Maria Koutroumani - Aristotle University of Thessaloniki
Steven E. Arnold - Supreme Council Of Health
Francesco Panza - University of Bari Aldo Moro
Olymbia Gkatzima - Aristotle University of Thessaloniki
Sanjay Asthana - Univ Wisconsin, GRECC, Madison, WI USA
Didier Hannequin - Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Basic & Clin Neurosci, London, England
Patrice Whitehead - University of Miami
Craig S. Atwood - Indiana University
Paolo Caffarra - University of Pittsburgh
Harald Hampel - AXA Research Fund
Ines Quintela - Universidade de Santiago de Compostela
Angel Carracedo - Universidade de Santiago de Compostela
Lars Lannfelt - Uppsala University
David C. Rubinsztein - University of Cambridge
Lisa L. Barnes - Rush University
Florence Pasquier - CHU Lille, Memory Ctr Lille, Ctr Memoire Ressources & Rech, Lille, France
Lutz Froelich - Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Heidelberg, Germany
Sandra Barral - Columbia University
Bernadette McGuinness - Queens University
Thomas G. Beach - Phoenix
Janet A. Johnston - Queens University
James T. Becker - University of Pittsburgh
Peter Passmore - Queens University
Eileen H. Bigio - Northwestern Univ, Feinberg Sch Med, Dept Pathol, Chicago, IL 60611 USA
Jonathan M. Schott - UCL Inst Neurol, Dept Neurodegenerat Dis, Dementia Res Ctr, London, England
Thomas D. Bird - University of Washington
Jason D. Warren - UCL Inst Neurol, Dept Neurodegenerat Dis, Dementia Res Ctr, London, England
Bradley F. Boeve - Mayo Clin, Dept Neurol, Rochester, MN USA
Michelle K. Lupton - Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Basic & Clin Neurosci, London, England
James D. Bowen - College Station Medical Center
Petra Proitsi - Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Basic & Clin Neurosci, London, England
Adam Boxer - Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA
John F. Powell - Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Basic & Clin Neurosci, London, England
James R. Burke - Duke University
John S. K. Kauwe - Brigham Young University
Jeffrey M. Burns - University of Kansas
Michelangelo Mancuso - University of Pisa
Joseph D. Buxbaum - Supreme Council Of Health
Ubaldo Bonuccelli - University of Pisa
Nigel J. Cairns - Washington Univ, Dept Pathol & Immunol, St Louis, MO USA
Andrew McQuillin - UCL, Div Psychiat, London, England
Chuanhai Cao - Univ S Florida, USF Hlth Byrd Alzheimers Inst, Tampa, FL USA
Gill Livingston - UCL, Div Psychiat, London, England
Chris S. Carlson - College Station Medical Center
Nicholas J. Bass - UCL, Div Psychiat, London, England
Cynthia M. Carlsson - Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA
John Hardy - UCL, Dept Mol Neurosci, Inst Neurol, London, England
Regina M. Carney - College Station Medical Center
Jose Bras - UK Dementia Research Institute
Minerva M. Carrasquillo - Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA
Rita Guerreiro - UK Dementia Research Institute
Mariet Allen - Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA
Helena C. Chui - Univ Southern Calif, Dept Neurol, Los Angeles, CA USA
Elizabeth Fisher - UCL Inst Neurol, Dept Neurodegenerat Dis, London, England
Carlo Masullo - Univ Cattolica Sacro Cuore, Dept Neurol, Rome, Italy
Elizabeth A. Crocco - University of Miami
Charles DeCarli - Univ Calif Davis, Dept Neurol, Sacramento, CA 95817 USA
Gina Bisceglio - Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA
Malcolm Dick - Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, Irvine, CA USA
Li Ma - Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA
Ranjan Duara - College Station Medical Center
Neill R. Graff-Radford - Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA
Denis A. Evans - Rush University
Angela Hodges - Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Old Age Psychiat, London, England
Kelley M. Faber - Indiana University
Martin Scherer - Univ Med Ctr Hamburg Eppendorf, Dept Primary Med Care, Hamburg, Germany
Kenneth B. Fallon - University of Alabama
Matthias Riemenschneider - Univ Hosp, Dept Psychiat & Psychotherapy, Saarland, Germany
David W. Fardo - University of Kentucky
Reinhard Heun - University of Bonn
Martin R. Farlow - Indiana University
Heike Koelsch - University of Bonn
Steven Ferris - NYU, Dept Psychiat, 550 1St Ave, New York, NY 10016 USA
Markus Leber - University of Cologne
Tatiana M. Foroud - Indiana University
Isabella Heuser - Charité - Universitätsmedizin Berlin
Douglas R. Galasko - Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
Ina Giegling - Martin Luther University Halle-Wittenberg
Marla Gearing - Emory University
Michael Huell - University of Freiburg
Daniel H. Geschwind - Univ Calif Los Angeles, Neurogenet Program, Los Angeles, CA USA
John R. Gilbert - University of Miami
John Morris - Supreme Council Of Health
Robert C. Green - Brigham and Women's Hospital
Kevin Mayo - Supreme Council Of Health
John H. Growdon - Supreme Council Of Health
Thomas Feulner - Univ Hosp, Dept Psychiat & Psychotherapy, Saarland, Germany
Ronald L. Hamilton - University of Pittsburgh
Lindy E. Harrell - University of Alabama
Dmitriy Drichel - University of Cologne
Lawrence S. Honig - Columbia University
Thomas D. Cushion - Cardiff University
Matthew J. Huentelman - Phoenix
Paul Hollingworth - Cardiff University
Christine M. Hulette - Duke University
Bradley T. Hyman - Supreme Council Of Health
Rachel Marshall - Cardiff University
Gail P. Jarvik - University of Washington
Alun Meggy - Cardiff University
Erin Abner - University of Kentucky
Georgina E. Menzies - Cardiff University
Lee-Way Jin - Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville, Spain
Ganna Leonenko - Cardiff University
Luis M. Real - Hosp Univ Valme, Unidad Clin Enfermedades Infecciosas & Microbiol, Seville, Spain
Gyungah R. Jun - Boston University
Clinton T. Baldwin - Boston University
Detelina Grozeva - Cardiff University
Anna Karydas - College Station Medical Center
Giancarlo Russo - University of Zurich
Jeffrey A. Kaye - Oregon Hlth & Sci Univ, Dept Neurol, Portland, OR 97201 USA
Ronald Kim - College Station Medical Center
Frank Jessen - German Ctr Neurodegenerat Dis, Bonn, Germany
Neil W. Kowall - Boston University
Bruno Vellas - University of Toulouse
Joel H. Kramer - Univ Calif San Francisco, Dept Neuropsychol, San Francisco, CA 94143 USA
Emma Vardy - Newcastle University
Frank M. LaFerla - Univ Calif Irvine, Dept Neurobiol & Behav, Irvine, CA USA
Karl-Heinz Joeckel - University of Duisburg-Essen
James J. Lah - Emory University
Martin Dichgans - Klinikum Univ Munchen, Inst Stroke & Dementia Res, Munich, Germany
James B. Leverenz - Cleveland Clin, Lou Ruvo Ctr Brain Hlth, Cleveland, OH 44106 USA
David Mann - University of Manchester
Allan Levey - Emory University
Stuart Pickering-Brown - University of Manchester
Andrew P. Lieberman - Univ Michigan, Dept Pathol, Ann Arbor, MI 48109 USA
Norman Klopp - Helmholtz Zentrum München
Kathryn L. Lunetta - Boston University
H-Erich Wichmann - Helmholtz Ctr Munich, Inst Epidemiol, Munich, Germany
Constantine G. Lyketsos - Johns Hopkins University
Kevin Morgan - University of Nottingham
Daniel C. Marson - University of Alabama
Kristelle Brown - University of Nottingham
Frank Martiniuk - College Station Medical Center
Christopher Medway - University of Nottingham
Deborah C. Mash - University of Miami
Markus M. Noethen - University of Bonn
Eliezer Masliah - Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
Nigel M. Hooper - University of Manchester
Wayne C. McCormick - University of Washington
Antonio Daniele - Pontifícia Universidade Católica de São Paulo
Susan M. McCurry - University of Washington
Anthony Bayer - Cardiff University
Andrew N. McDavid - Univ S Florida, USF Hlth Byrd Alzheimers Inst, Tampa, FL USA
John Gallacher - University of Oxford
Ann C. McKee - Boston University
Hendrik van den Bussche - Eppendorf
Marsel Mesulam - Northwestern Univ, Feinberg Sch Med, Mesulam Ctr Cognit Neurol & Alzheimers Dis, Chicago, IL 60611 USA
Carol Brayne - University of Cambridge
Bruce L. Miller - Univ Calif San Francisco, Memory & Aging Ctr, Weill Inst Neurosci, San Francisco, CA 94143 USA
Steffi Riedel-Heller - College Station Medical Center
Carol A. Miller - Univ Southern Calif, Dept Pathol, Los Angeles, CA USA
Joshua W. Miller - College Station Medical Center
Ammar Al-Chalabi - Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England
John C. Morris - Washington Univ, Dept Pathol & Immunol, St Louis, MO USA
Christopher E. Shaw - Kings Coll London, Inst Psychiat Psychol & Neurosci, London, England
Amanda J. Myers - University of Miami
Jens Wiltfang - College Station Medical Center
Sid O'Bryant - Univ North Texas, Hlth Sci Ctr, Dept Pharmacol & Neurosci, Ft Worth, TX USA
John M. Olichney - Univ Calif Davis, Dept Neurol, Sacramento, CA 95817 USA
Victoria Alvarez - Univ Cent Asturias, Mol Genet Lab Hosp, Oviedo, Spain
Joseph E. Parisi - College Station Medical Center
Andrew B. Singleton - NIA, Mol Genet Sect, Lab Neurogenet, NIH, Bethesda, MD 20892 USA
Henry L. Paulson - Univ Michigan, Dept Neurol, Ann Arbor, MI USA
John Collinge - MRC Prion Unit
William R. Perry - University of Miami
Simon Mead - MRC Prion Unit
Elaine Peskind - University of Washington
David H. Cribbs - Univ Calif Irvine, Dept Neurol, Irvine, CA 92717 USA
Martin Rossor - UCL Inst Neurol, Dept Neurodegenerat Dis, Dementia Res Ctr, London, England
Aimee Pierce - Univ Calif Irvine, Dept Neurol, Irvine, CA 92717 USA
Natalie S. Ryan - MRC Prion Unit
Wayne W. Poon - Univ Calif Irvine, Inst Memory Impairments & Neurol Disorders, Irvine, CA USA
Benedetta Nacmias - University of Florence
Huntington Potter - Supreme Council Of Health
Sandro Sorbi - University of Florence
Joseph F. Quinn - Eppendorf
Eleonora Sacchinelli - IRCCS Santa Lucia Fdn, Expt Neuropsychobiol Lab, Dept Clin & Behav Neurol, Rome, Italy
Ashok Raj - Univ S Florida, USF Hlth Byrd Alzheimers Inst, Tampa, FL USA
Gianfranco Spalletta - IRCCS Santa Lucia Fdn, Lab Neuropsychiat, Rome, Italy
Murray Raskind - University of Washington
Carlo Caltagirone - IRCCS Santa Lucia Fdn, Lab Neuropsychiat, Rome, Italy
Paola Bossu - IRCCS Santa Lucia Fdn, Expt Neuropsychobiol Lab, Dept Clin & Behav Neurol, Rome, Italy
Maria Donata Orfei - IRCCS Santa Lucia Fdn, Lab Neuropsychiat, Rome, Italy
Barry Reisberg - NYU, Dept Psychiat, 550 1St Ave, New York, NY 10016 USA
Robert Clarke - University of Oxford
Christiane Reitz - Columbia University
A. David Smith - University of Oxford
John M. Ringman - Supreme Council Of Health
Donald Warden - University of Oxford
Erik D. Roberson - University of Alabama
Gordon Wilcock - University of Oxford
Ekaterina Rogaeva - University of Toronto
Amalia Cecilia Bruni - ASP Catanzaro, Reg Neurogenet Ctr CRN, Lamezia Terme, Italy
Howard J. Rosen - Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA
Maura Gallo - ASP Catanzaro, Reg Neurogenet Ctr CRN, Lamezia Terme, Italy
Roger N. Rosenberg - College Station Medical Center
Yoav Ben-Shlomo - University of Bristol
Mark A. Sager - College Station Medical Center
Patrizia Mecocci - University of Perugia
Andrew J. Saykin - Indiana University
Pau Pastor - University Hospital Mútua de Terrassa
Michael L. Cuccaro - University of Miami
Jeffery M. Vance - University of Miami
Julie A. Schneider - Rush University
Lori S. Schneider - Univ Southern Calif, Dept Neurol, Los Angeles, CA USA
Susan Slifer - University of Miami
William W. Seeley - Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA
Amanda G. Smith - Univ S Florida, USF Hlth Byrd Alzheimers Inst, Tampa, FL USA
Joshua A. Sonnen - University of Washington
Salvatore Spina - Indiana University
Robert A. Stern - Boston University
Russell H. Swerdlow - University of Kansas
Mitchell Tang - Supreme Council Of Health
Rudolph E. Tanzi - Supreme Council Of Health
John Q. Trojanowski - Supreme Council Of Health
Juan C. Troncoso - Johns Hopkins University
Vivianna M. Van Deerlin - Supreme Council Of Health
Linda J. Van Eldik - University of Kentucky
Harry V. Vinters - Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90024 USA
Jean Paul Vonsattel - Columbia University
Sandra Weintraub - Northwestern Univ, Feinberg Sch Med, Mesulam Ctr Cognit Neurol & Alzheimers Dis, Chicago, IL 60611 USA
Kathleen A. Welsh-Bohmer - Duke University
Kirk C. Wilhelmsen - Univ N Carolina, Dept Genet, Chapel Hill, NC 27515 USA
Jennifer Williamson - Columbia University
Thomas S. Wingo - Emory University
Randall L. Woltjer - Oregon Hlth & Sci Univ, Dept Pathol, Portland, OR 97201 USA
Clinton B. Wright - NINDS, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA
Chang-En Yu - University of Washington
Lei Yu - Rush University
Yasaman Saba - University of Graz
Alberto Pilotto - CASA
Maria J. Bullido - Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Oliver Peters - Charité - Universitätsmedizin Berlin
Paul K. Crane - University of Washington
David Bennett - Rush University
Paola Bosco - SRL
Eliecer Coto - Univ Cent Asturias, Mol Genet Lab Hosp, Oviedo, Spain
Virginia Boccardi - University of Perugia
Phil L. De Jager - Columbia University
Alberto Lleo - Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Nick Warner - Tioga County Partnership for Community Health
Oscar L. Lopez - University of Pittsburgh
Martin Ingelsson - Uppsala University
Panagiotis Deloukas - Wellcome Sanger Institute
Carlos Cruchaga - Supreme Council Of Health
Caroline Graff - Karolinska Univ Hosp Solna, Unit Hereditary Dementias, Theme Aging, Stockholm, Sweden
Rhian Gwilliam - Wellcome Sanger Institute
Myriam Fornage - College Station Medical Center
Alison M. Goate - Supreme Council Of Health
Pascual Sanchez-Juan - Universidad de Cantabria
Patrick G. Kehoe - University of Bristol
Najaf Amin - Erasmus MC
Nilifur Ertekin-Taner - Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA
Claudine Berr - Inserm
Stphanie Debette - Sorbonne Université
Seth Love - University of Bristol
Lenore J. Launer - NIA, Lab Epidemiol & Populat Sci, Bethesda, MD 20892 USA
Steven G. Younkin - Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA
Jean-Francois Dartigues - CMRR Bordeaux, Memory Res & Resources Ctr, Bordeaux, France
Chris Corcoran - Utah State University
M. Arfan Ikram - Erasmus MC
Dennis W. Dickson - Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA
Gael Nicolas - Inserm
Dominique Campion - Inserm
JoAnn Tschanz - Utah State University
Helena Schmidt - University of Graz
Hakon Hakonarson - Supreme Council Of Health
Jordi Clarimon - Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
Ron Munger - Utah State University
Reinhold Schmidt - University of Graz
Lindsay A. Farrer - Boston University
Christine Van Broeckhoven - VIB, Ctr Mol Neurol, Neurodegenerat Brain Dis Grp, Antwerp, Belgium
Michael C. O'Donovan - Cardiff University
Anita L. DeStefano - Boston University
Lesley Jones - Cardiff University
Jonathan L. Haines - Case Western Reserve University
Jean-Francois Deleuze - University of Paris-Saclay
Michael J. Owen - Cardiff University
Vilmundur Gudnason - Iceland Heart Assoc, Kopavogur, Iceland
Richard Mayeux - Columbia University
Valentina Escott-Price - Cardiff University
Bruce M. Psaty - University of Washington
Alfredo Ramirez - Univ Hosp Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Bonn, Germany
Li-San Wang - Supreme Council Of Health
Agustin Ruiz - Fundació ACE
Cornelia M. van Duijn - Erasmus MC
Peter A. Holmans - Cardiff University
Sudha Seshadri - Framingham Heart Dis Epidemiol Study, Framingham, MA USA
Julie Williams - Cardiff University
Phillippe Amouyel - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement
Gerard D. Schellenberg - Supreme Council Of Health
Jean-Charles Lambert - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement
Margaret A. Pericak-Vance - University of Miami
Cohorts Heart Aging Res Genomic Ep
Publication Details: Nature genetics, Vol.51(3), pp.414-+
Publisher: NATURE PORTFOLIO
Number of pages: 20
Grant note: MR/L023784/2; G9810900; MR/L023784/1; MC_U123160657; MC_PC_18025; MR/R024804/1; G0900421; G0900688; UKDRI-3003; MC_PC_14095; G0902227; MR/L021803/1; G0600974; G0500289; G0701075; MR/M024784/1; UKDRI-1009; MC_UU_00024/9; MC_UU_00024/1; MR/N026004/1; G0300429; G0901254; G0801418; UKDRI-1001; MR/K013041/1; G0600237; MR/M009076/1; MR/K01417X/1 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC)
Identifiers: 9938607908331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article