Abstract
Alopecia areata (AA) is a common non-scarring hair loss disease of defined patterns with varied patches size and body sites. The etiology of AA has a complex basis of autoimmunity, environment, and genetic variations. The latter factor is found to play a crucial role in AA risk. Thus, this study aimed to investigate the potential impact of specific immune-related gene polymorphisms among a cohort of Jordanian patients, which was previously reported in other populations. Blood samples of AA patients and control subjects were collected for genomic DNA (gDNA) extraction. Targeted single nucleotide polymorphisms (SNPs) of
MASP2, TLR1, CTLA4,
and
C11orf30
were genotyped in duplicate using the Sequenom MassARRAY® system (iPLEX GOLD). Genotype and allele analysis reveals statistical differences in
TLR1
rs4833095 (allele C,
P
= 0.044),
MASP2
rs2273346 (genotype AA,
P
= 0.0026), and
C11orf30
rs2155219 (genotype GG,
P
= 0.0069) distribution. These findings present the significant contribution of genetic variations in AA susceptibility in the Jordanian population, which is infrequently studied.
Alopecia areata; Hair follicles; Autoimmunity; Gene polymorphisms; Genetic markers;
TLR1
.