Genetic studies of body mass index yield new insights for obesity biology

Adam E. Locke; Bratati Kahali; Sonja I. Berndt; Anne E. Justice; Tune H. Pers; Felix R. Day; Corey Powell; Sailaja Vedantam; Martin L. Buchkovich; Jian Yang; Damien C. Croteau-Chonka; Tonu Esko; Tove Fall; Teresa Ferreira; Stefan Gustafsson; Zoltan Kutalik; Jian'an Luan; Reedik Maegi; Joshua C. Randall; Thomas W. Winkler; Andrew R. Wood; Tsegaselassie Workalemahu; Jessica D. Faul; Jennifer A. Smith; Jing Hua Zhao; Wei Zhao; Jin Chen; Rudolf Fehrmann; Asa K. Hedman; Juha Karjalainen; Ellen M. Schmidt; Devin Absher; Najaf Amin; Denise Anderson; Marian Beekman; Jennifer L. Bolton; L. Bragg-Gresham; Steven Buyske; Ayse Demirkan; Guohong Deng; Georg B. Ehret; Bjarke Feenstra; Mary F. Feitosa; Krista Fischer; Anuj Goel; Jian Gong; Anne U. Jackson; Stavroula Kanoni; Marcus E. Kleber; Kati Kristiansson; Unhee Lim; Vaneet Lotay; Massimo Mangino; Irene Mateo Leach; Carolina Medina-Gomez; Sarah E. Medland; Michael A. Nalls; Cameron D. Palmer; Dorota Pasko; Sonali Pechlivanis; Marjolein J. Peters; Inga Prokopenko; Dmitry Shungin; Alena Stancakova; Rona J. Strawbridge; Yun Ju Sung; Toshiko Tanaka; Alexander Teumer; Stella Trompet; Sander W. van der Laan; Jessica van Settee; Jana V. Van Vliet-Ostaptchouk; Zhaoming Wang; Loic Yengo; Weihua Zhang; Aaron Isaacs; Eva Albrecht; Johan Arnlov; Gillian M. Arscott; Antony P. Attwood; Stefania Bandinelli; Amy Barrett; Isabelita N. Bas; Claire Bellis; Amanda J. Bennett; Christian Berne; Roza Blagieva; Matthias Blueher; Stefan Bohringer; Lori L. Bonnycastle; Yvonne Boettcher; Heather A. Boyd; Marcel Bruinenberg; Ida H. Caspersen; Yii-Der Ida Chen; Robert Clarke; E. Warwick Daw; Anton J. M. de Craen; Graciela Delgado; Maria Dimitriou; Alex S. F. Doney; Niina Eklund; Karol Estrada; Elodie Eury; Lasse Folkersen; Ross M. Fraser; Melissa E. Garcia; Frank Geller; Vilmantas Giedraitis; Bruna Gigante; Alan S. Go; Alain Golay; Alison H. Goodall; Scott D. Gordon; Mathias Gorski; Hans-Joergen Grabe; Harald Grallert; Tanja B. Grammer; Jurgen Graessler; Henrik Gronberg; Christopher J. Groves; Gaeelle Gusto; Jeffrey Haessler; Per Hall; Toomas Haller; Goran Hallmans; Catharina A. Hartman; Maija Hassinen; Caroline Hayward; Nancy L. Heard-Costa; Qinta Helmer; Christian Hengstenberg; Oddgeir Holmen; Jouke-Jan Hottenga; Alan L. James; Janina M. Jeff; Asa Johansson; Jennifer Jolley; Thorhildur Juliusdottir; Leena Kinnunen; Wolfgang Koenig; Markku Koskenvuo; Wolfgang Kratzer; Jaana Laitinen; Claudia Lamina; Karin Leander; Nanette R. Lee; Peter Lichtner; Lars Lind; Jaana Lindstrom; Ken Sin Lo; Stephane Lobbens; Roberto Lorbeer; Yingchang Lu; Francois Mach; Patrik K. E. Magnusson; Anubha Mahajan; Wendy L. McArdle; Stela McLachlan; Cristina Menni; Sigrun Merger; Evelin Mihailov; Lili Milani; Alireza Moayyeri; Keri L. Monda; Mario A. Morken; Antonella Mulas; Gabriele Mueller; Martina Mueller-Nurasyid; Arthur W. Musk; Ramaiah Nagaraja; Markus M. Noethen; Ilja M. Nolte; Stefan Pilz; Nigel W. Rayner; Frida Renstrom; Rainer Rettig; Janina S. Ried; Stephan Ripke; Neil R. Robertson; Lynda M. Rose; Serena Sanna; Hubert Scharnagl; Salome Scholtens; Fredrick R. Schumacher; William R. Scott; Thomas Seufferlein; Jianxin Shi; Albert Vernon Smith; Joanna Smolonska; Alice V. Stanton; Valgerdur Steinthorsdottir; Kathleen Stirrups; Heather M. Stringham; Johan Sundstrom; Morris A. Swertz; Amy J. Swift; Ann-Christine Syvanen; Sian-Tsung Tan; Bamidele O. Tayo; Barbara Thorand; Gudmar Thorleifsson; Jonathan P. Tyrer; Hae-Won Uh; Liesbeth Vandenput; Frank C. Verhulst; Sita H. Vermeulen; Niek Verweij; Judith M. Vonk; Lindsay L. Waite; Helen R. Warren; Dawn Waterworth; Michael N. Weedon; Lynne R. Wilkens; Christina Willenborg; Tom Wilsgaard; Mary K. Wojczynski; Andrew Wong; Alan F. Wrightl; Qunyuan Zhang; Eoin P. Brennan; Murim Choi; Zari Dastani; Alexander W. Drong; Per Eriksson; Anders Franco-Cereceda; Jesper R. Gadin; Ali G. Gharavi; Michael E. Goddard; Robert E. Handsaker; Jinyan Huang; Fredrik Karpe; Sekar Kathiresan; Sarah Keildson; Krzysztof Kiryluk; Michiaki Kubo; Jong-Young Lee; Liming Liang; Richard P. Lifton; Baoshan Ma; Steven A. McCarroll; Amy J. McKnight; Josine L. Min; Miriam F. Moffatt; Grant W. Montgomery; Joanne M. Murabito; George Nicholson; Dale R. Nyholt; Yukinori Okada; John R. B. Perry; Rajkumar Dorajoo; Eva Reinmaa; Rany M. Salem; Niina Sandholm; Robert A. Scott; Lisette Stolk; Atsushi Takahashi; Toshihiro Tanaka; Ferdinand M. van 't Hooft; Anna A. E. Vinkhuyzen; Harm-Jan Westra; Wei Zheng; Krina T. Zondervan; Andrew C. Heath; Dominique Arveiler; Stephan J. L. Bakker; John Beilby; Richard N. Bergman; John Blangero; Pascal Bovet; Harry Campbell; Mark J. Caulfield; Giancarlo Cesana; Aravinda Chakravarti; Daniel I. Chasman; Peter S. Chines; Francis S. Collins; Dana C. Crawford; L. Adrienne Cupples; Daniele Cusi; John Danesh; Ulf de Faire; Hester M. den Ruijter; Anna F. Dominiczak; Raimund Erbel; Jeanette Erdmann; Johan G. Eriksson; Martin Farrall; Stephan B. Felix; Ele Ferrannini; Jean Ferrieres; Ian Ford; Nita G. Forouhi; Terrence Forrester; Oscar H. Franco; Ron T. Gansevoort; Pablo V. Gejman; Christian Gieger; Omri Gottesman; Vilmundur Gudnason; Ulf Gyllensten; Alistair S. Hall; Tamara B. Harris; Andrew T. Hattersley; Andrew A. Hicks; Lucia A. Hindorff; Aroon D. Hingorani; Albert Hofman; Georg Homuth; G. Kees Hovingh; Steve E. Humphries; Steven C. Hunt; Elina Hypponen; Thomas Illig; Kevin B. Jacobs; Marjo-Riitta Jarvelin; Karl-Heinz Joeckel; Berit Johansen; Pekka Jousilahti; J. Wouter Jukema; Antti M. Jula; Jaakko Kaprio; John J. P. Kastelein; Sirkka M. Keinanen-Kiukaanniemi; Lambertus A. Kiemeney; Paul Knekt; Jaspal S. Kooner; Charles Kooperberg; Peter Kovacs; Aldi T. Kraja; Meena Kumari; Johanna Kuusisto; Timo A. Lakka; Claudia Langenberg; Laic Le Marchand; Terho Lehtimaki; Valeriya Lyssenko; Satu Mannisto; Andre Marette; Tara C. Matise; Colin A. McKenzie; Barbara McKnight; Frans L. Moll; Andrew D. Morris; Andrew P. Morris; Jeffrey C. Murray; Mari Nelis; Claes Ohlsson; Albertine J. Oldehinkel; Ken K. Ong; Pamela A. F. Madden; Gerard Pasterkamp; John F. Peden; Annette Peters; Dirkje S. Postma; Peter P. Pramstaller; Jackie F. Price; Lu Qi; Olli T. Raitakari; Tuomo Rankinen; D. C. Rao; Treva K. Rice; Paul M. Ridker; John D. Rioux; Marylyn D. Ritchie; Igor Rudan; Veikko Salomaa; Nilesh J. Samani; Jouko Saramines; Mark A. Sarzynski; Heribert Schunkert; Peter E. H. Schwarz; Peter Sever; Alan R. Shuldiner; Juha Sinisalo; Ronald P. Stolk; Konstantin Strauch; Anke Toenjes; David-Alexandre Tregouet; Angelo Tremblay; Elena Tremoli; Jarmo Virtamo; Marie-Claude Vohl; Uwe Voelker; Gerard Waeber; Gonneke Willemsen; Jacqueline C. Witteman; M. Carola Zillikens; Linda S. Adair; Philippe Amouyel; Folkert W. Asselbergs; Themistocles L. Assimes; Murielle Bochud; Bernhard O. Boehm; Eric Boerwinkle; Stefan R. Bornstein; Erwin P. Bottinger; Claude Bouchard; Stephane Cauchi; John C. Chambers; Stephen J. Chanock; Richard S. Cooper; Paul I. W. de Bakker; George Dedoussis; Luigi Ferrucci; Paul W. Franks; Philippe Froguel; Leif C. Groop; Christopher A. Haiman; Anders Hamsten; Jennie Hui; David J. Hunter; Kristian Hveem; Robert C. Kaplan; Mika Kivimaki; Diana Kuh; Markku Laakso; Yongmei Liu; Nicholas G. Martin; Winfried Maerz; Mads Melbve; Andres Metspalu; Susanne Moebus; Patricia B. Munroe; Inger Njolstad; Ben A. Oostra; Colin N. A. Palmer; Nancy L. Pedersen; Markus Perola; Louis Perusse; Ulrike Peters; Chris Power; Thomas Quertermous; Rainer Rauramaa; Fernando Rivadeneira; Timo E. Saaristo; Danish Saleheen; Naveed Sattar; Eric E. Schadt; David Schlessinger; P. Eline Slagboom; Harold Snieder; Tim D. Spector; Unnu R. Thorsteinsdottir; Michael Stumvoll; Jaakko Tuomilehto; Andre G. Uitterlinden; Matti Uusitupa; Pim van der Harst; Mark Walker; Henri Wallaschofski; Nicholas J. Wareham; Hugh Watkins; David R. Weir; H-Erich Wichmann; James F. Wilson; Pieter Zanen; Ingrid B. Borecki; Panos Deloukas; Caroline S. Fox; Iris M. Heid; Jeffrey R. O'Connell; David P. Strachan; Kari Stefansson; Cornelia M. van Duijri; Goncalo R. Abecasis; Lude Franke; Timothy M. Frayling; Mark I. McCarthy; Peter M. Visscher; Andre Scherag; Cristen J. Willer; Michael Boehnke; Karen L. Mohlke; Cecilia M. Lindgren; Jacques S. Beckmann; Ines Barroso; Kari E. North; Erik Ingelsson; Joel N. Hirschhorn; Ruth J. F. Loos; Elizabeth K. Speliotes; ADIPOGen Consortium

doi:10.1038/nature14177

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Genetic studies of body mass index yield new insights for obesity biology

Journal article

Peer reviewed

Genetic studies of body mass index yield new insights for obesity biology

Adam E. Locke, Bratati Kahali, Sonja I. Berndt, Anne E. Justice, Tune H. Pers, Felix R. Day, Corey Powell, Sailaja Vedantam, Martin L. Buchkovich, Jian Yang, …

Nature (London), Vol.518(7538), pp.197-U401

12/02/2015

DOI: https://doi.org/10.1038/nature14177

PMCID: PMC4382211

PMID: 25673413

Abstract

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in upto 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 x 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for similar to 2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous systemin obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.

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Title: Genetic studies of body mass index yield new insights for obesity biology
Creators - without role: Adam E. Locke - Biostat
Bratati Kahali - College Station Medical Center
Sonja I. Berndt - NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
Anne E. Justice - Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27599 USA
Tune H. Pers - Boston Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA
Felix R. Day - University of Cambridge
Corey Powell - College Station Medical Center
Sailaja Vedantam - Boston Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA
Martin L. Buchkovich - Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA
Jian Yang - University of Queensland
Damien C. Croteau-Chonka - Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA
Tonu Esko - Boston Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA
Tove Fall - Karolinska Institutet
Teresa Ferreira - University of Oxford
Stefan Gustafsson - Uppsala University
Zoltan Kutalik - College Station Medical Center
Jian'an Luan - University of Cambridge
Reedik Maegi - University of Tartu
Joshua C. Randall - University of Oxford
Thomas W. Winkler - University of Regensburg
Andrew R. Wood - University of Exeter
Tsegaselassie Workalemahu - Harvard University
Jessica D. Faul - Univ Michigan, Inst Social Res, Survey Res Ctr, Ann Arbor, MI 48104 USA
Jennifer A. Smith - Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA
Jing Hua Zhao - University of Cambridge
Wei Zhao - Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA
Jin Chen - College Station Medical Center
Rudolf Fehrmann - University of Groningen
Asa K. Hedman - Uppsala University
Juha Karjalainen - University of Groningen
Ellen M. Schmidt - College Station Medical Center
Devin Absher - HudsonAlpha Inst Biotechnol, Huntsville, AL 35806 USA
Najaf Amin - Erasmus MC
Denise Anderson - University of Western Australia
Marian Beekman - Leiden University
Jennifer L. Bolton - University of Edinburgh
L. Bragg-Gresham - Biostat
Steven Buyske - Biostat
Ayse Demirkan - Erasmus MC
Guohong Deng - Ealing Hosp NHS Trust, Southall UB1 3HW, Middx, England
Georg B. Ehret - Johns Hopkins University
Bjarke Feenstra - Veterinary Biological and Research Institute
Mary F. Feitosa - Supreme Council Of Health
Krista Fischer - University of Tartu
Anuj Goel - University of Oxford
Jian Gong - Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA
Anne U. Jackson - Biostat
Stavroula Kanoni - Queen Mary University of London
Marcus E. Kleber - Heidelberg University
Kati Kristiansson - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Unhee Lim - University of Hawaii System
Vaneet Lotay - Supreme Council Of Health
Massimo Mangino - Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England
Irene Mateo Leach - University of Groningen
Carolina Medina-Gomez - NCHA, NL-3015 GE Rotterdam, Netherlands
Sarah E. Medland - College Station Medical Center
Michael A. Nalls - NIA, Lab Neurogenet, NIH, Bethesda, MD 20892 USA
Cameron D. Palmer - Boston Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA
Dorota Pasko - University of Exeter
Sonali Pechlivanis - College Station Medical Center
Marjolein J. Peters - NCHA, NL-3015 GE Rotterdam, Netherlands
Inga Prokopenko - University of Oxford
Dmitry Shungin - Skane Univ Hosp, Dept Clin Sci, Genet & Mol Epidemiol Unit, S-20502 Malmo, Sweden
Alena Stancakova - University of Eastern Finland
Rona J. Strawbridge - Karolinska Institutet
Yun Ju Sung - Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA
Toshiko Tanaka - NIA, Translat Gerontol Branch, Baltimore, MD 21225 USA
Alexander Teumer - College Station Medical Center
Stella Trompet - Leiden University
Sander W. van der Laan - College Station Medical Center
Jessica van Settee - College Station Medical Center
Jana V. Van Vliet-Ostaptchouk - University of Groningen
Zhaoming Wang - NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
Loic Yengo - Inst Pasteur, Ctr Immunol & Biol Parasitaire, CNRS, UMR 8199, F-59019 Lille, France
Weihua Zhang - Ealing Hosp NHS Trust, Southall UB1 3HW, Middx, England
Aaron Isaacs - Erasmus MC
Eva Albrecht - Helmholtz Zentrum München
Johan Arnlov - Uppsala University
Gillian M. Arscott - College Station Medical Center
Antony P. Attwood - University of Cambridge
Stefania Bandinelli - Florence
Amy Barrett - University of Oxford
Isabelita N. Bas - University of San Carlos
Claire Bellis - Texas Biomedical Research Institute
Amanda J. Bennett - University of Oxford
Christian Berne - Uppsala University
Roza Blagieva - University of Ulm
Matthias Blueher - Institute of Inland Fisheries in Potsdam-Sacrow
Stefan Bohringer - Leiden University
Lori L. Bonnycastle - College Station Medical Center
Yvonne Boettcher - Institute of Inland Fisheries in Potsdam-Sacrow
Heather A. Boyd - Veterinary Biological and Research Institute
Marcel Bruinenberg - University of Groningen
Ida H. Caspersen - Norwegian Univ Sci & Technol, Dept Biol, N-7491 Trondheim, Norway
Yii-Der Ida Chen - Univ Calif Los Angeles, Dept Pediat, Torrance, CA 90502 USA
Robert Clarke - University of Oxford
E. Warwick Daw - Supreme Council Of Health
Anton J. M. de Craen - Leiden University
Graciela Delgado - Heidelberg University
Maria Dimitriou - Harokopio University of Athens
Alex S. F. Doney - University of Dundee
Niina Eklund - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Karol Estrada - Massachusetts Institute of Technology
Elodie Eury - Inst Pasteur, Ctr Immunol & Biol Parasitaire, CNRS, UMR 8199, F-59019 Lille, France
Lasse Folkersen - Karolinska Institutet
Ross M. Fraser - University of Edinburgh
Melissa E. Garcia - NIA, Lab Epidemiol & Populat Sci, NIH, Bethesda, MD 20892 USA
Frank Geller - Veterinary Biological and Research Institute
Vilmantas Giedraitis - Uppsala University
Bruna Gigante - Karolinska Institutet
Alan S. Go - Kaiser Permanente
Alain Golay - Univ Hosp Geneva, Serv Therapeut Educ Diabet Obes & Chron Dis, CH-1211 Geneva, Switzerland
Alison H. Goodall - University of Leicester
Scott D. Gordon - College Station Medical Center
Mathias Gorski - University of Regensburg
Hans-Joergen Grabe - Helios
Harald Grallert - Helmholtz Zentrum München
Tanja B. Grammer - Heidelberg University
Jurgen Graessler - College Station Medical Center
Henrik Gronberg - Karolinska Institutet
Christopher J. Groves - University of Oxford
Gaeelle Gusto - Inst Inter Reg Sante, F-37520 La Riche, France
Jeffrey Haessler - Hutchinson
Per Hall - Karolinska Institutet
Toomas Haller - University of Tartu
Goran Hallmans - Umeå University
Catharina A. Hartman - University of Groningen
Maija Hassinen - College Station Medical Center
Caroline Hayward - University of Edinburgh
Nancy L. Heard-Costa - Framingham Heart Study
Qinta Helmer - Leiden University
Christian Hengstenberg - Munich Heart Alliance, German Res Ctr Cardiovasc Res, Deutsch Forschungszentrum Herz Kreislauferkrankun, D-80636 Munich, Germany
Oddgeir Holmen - Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, N-7489 Trondheim, Norway
Jouke-Jan Hottenga - University of Amsterdam
Alan L. James - College Station Medical Center
Janina M. Jeff - Supreme Council Of Health
Asa Johansson - University of Western Australia
Jennifer Jolley - University of Cambridge
Thorhildur Juliusdottir - University of Oxford
Leena Kinnunen - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Wolfgang Koenig - University of Ulm
Markku Koskenvuo - University of Helsinki
Wolfgang Kratzer - University of Ulm
Jaana Laitinen - Finnish Inst Occupat Hlth, FI-90100 Oulu, Finland
Claudia Lamina - College Station Medical Center
Karin Leander - Karolinska Institutet
Nanette R. Lee - University of San Carlos
Peter Lichtner - Helmholtz Zentrum München
Lars Lind - Uppsala University
Jaana Lindstrom - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Ken Sin Lo - Montreal Heart Institute
Stephane Lobbens - Inst Pasteur, Ctr Immunol & Biol Parasitaire, CNRS, UMR 8199, F-59019 Lille, France
Roberto Lorbeer - College Station Medical Center
Yingchang Lu - Supreme Council Of Health
Francois Mach - College Station Medical Center
Patrik K. E. Magnusson - Karolinska Institutet
Anubha Mahajan - University of Oxford
Wendy L. McArdle - University of Bristol
Stela McLachlan - University of Edinburgh
Cristina Menni - Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England
Sigrun Merger - University of Ulm
Evelin Mihailov - University of Tartu
Lili Milani - University of Tartu
Alireza Moayyeri - Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England
Keri L. Monda - Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27599 USA
Mario A. Morken - College Station Medical Center
Antonella Mulas - CNR, IRGB, I-09042 Cagliari, Sardinia, Italy
Gabriele Mueller - Evidence
Martina Mueller-Nurasyid - Helmholtz Zentrum München
Arthur W. Musk - College Station Medical Center
Ramaiah Nagaraja - NIA, Lab Genet, Baltimore, MD 21224 USA
Markus M. Noethen - University of Bonn
Ilja M. Nolte - University of Groningen
Stefan Pilz - University of Amsterdam
Nigel W. Rayner - University of Oxford
Frida Renstrom - Skane Univ Hosp, Dept Clin Sci, Genet & Mol Epidemiol Unit, S-20502 Malmo, Sweden
Rainer Rettig - College Station Medical Center
Janina S. Ried - Helmholtz Zentrum München
Stephan Ripke - Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA
Neil R. Robertson - University of Oxford
Lynda M. Rose - Brigham and Women's Hospital
Serena Sanna - CNR, IRGB, I-09042 Cagliari, Sardinia, Italy
Hubert Scharnagl - University of Graz
Salome Scholtens - University of Groningen
Fredrick R. Schumacher - Supreme Council Of Health
William R. Scott - Ealing Hosp NHS Trust, Southall UB1 3HW, Middx, England
Thomas Seufferlein - University of Ulm
Jianxin Shi - NCI, Bethesda, MD 20892 USA
Albert Vernon Smith - Inst Pasteur, Ctr Immunol & Biol Parasitaire, CNRS, UMR 8199, F-59019 Lille, France
Joanna Smolonska - University of Groningen
Alice V. Stanton - Royal Coll Surgeons Ireland, Dublin 2, Ireland
Valgerdur Steinthorsdottir - Amgen
Kathleen Stirrups - Wellcome Sanger Institute
Heather M. Stringham - Biostat
Johan Sundstrom - Uppsala University
Morris A. Swertz - University of Groningen
Amy J. Swift - College Station Medical Center
Ann-Christine Syvanen - Uppsala University
Sian-Tsung Tan - Ealing Hosp NHS Trust, Southall UB1 3HW, Middx, England
Bamidele O. Tayo - Loyola University Chicago
Barbara Thorand - German Ctr Diabet Res DZD, D-85764 Neuherberg, Germany
Gudmar Thorleifsson - Amgen
Jonathan P. Tyrer - University of Cambridge
Hae-Won Uh - Leiden University
Liesbeth Vandenput
Frank C. Verhulst - Erasmus MC
Sita H. Vermeulen - Radboud University Nijmegen
Niek Verweij - University of Groningen
Judith M. Vonk - University of Groningen
Lindsay L. Waite - HudsonAlpha Inst Biotechnol, Huntsville, AL 35806 USA
Helen R. Warren - Queen Mary University of London
Dawn Waterworth - GlaxoSmithKline
Michael N. Weedon - University of Exeter
Lynne R. Wilkens - University of Hawaii System
Christina Willenborg - Partner Site Hamburg Lubeck Kiel, German Ctr Cardiovasc Res, D-23562 Lubeck, Germany
Tom Wilsgaard - UiT The Arctic University of Norway
Mary K. Wojczynski - Supreme Council Of Health
Andrew Wong - Massachusetts Rehabilitation Commission
Alan F. Wrightl - University of Edinburgh
Qunyuan Zhang - Supreme Council Of Health
Eoin P. Brennan - Supreme Council Of Health
Murim Choi - College Station Medical Center
Zari Dastani - McGill University
Alexander W. Drong - University of Oxford
Per Eriksson - Karolinska Institutet
Anders Franco-Cereceda - Karolinska Institutet
Jesper R. Gadin - Karolinska Institutet
Ali G. Gharavi - Columbia University
Michael E. Goddard - Dept Primary Ind, Biosci Res Div, Bundoora, Vic 3083, Australia
Robert E. Handsaker - Massachusetts Institute of Technology
Jinyan Huang - Harvard University
Fredrik Karpe - University of Oxford
Sekar Kathiresan - Massachusetts Institute of Technology
Sarah Keildson - University of Oxford
Krzysztof Kiryluk - Columbia University
Michiaki Kubo - RIKEN
Jong-Young Lee - Natl Inst Hlth, Ctr Genome Sci, Chungcheongbuk Do 363951, Chungbuk, South Korea
Liming Liang - Harvard University
Richard P. Lifton - Yale University
Baoshan Ma - Harvard University
Steven A. McCarroll - Massachusetts Institute of Technology
Amy J. McKnight - Queens University
Josine L. Min - University of Bristol
Miriam F. Moffatt - University of London
Grant W. Montgomery - College Station Medical Center
Joanne M. Murabito - Framingham Heart Study
George Nicholson - University of Oxford
Dale R. Nyholt - College Station Medical Center
Yukinori Okada - RIKEN
John R. B. Perry - University of Oxford
Rajkumar Dorajoo - Genome Institute of Singapore
Eva Reinmaa - University of Tartu
Rany M. Salem - Boston Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA
Niina Sandholm - Aalto University
Robert A. Scott - University of Cambridge
Lisette Stolk - Leiden University
Atsushi Takahashi - RIKEN
Toshihiro Tanaka - Supreme Council Of Health
Ferdinand M. van 't Hooft - Karolinska Institutet
Anna A. E. Vinkhuyzen - University of Queensland
Harm-Jan Westra - University of Groningen
Wei Zheng - Vanderbilt University
Krina T. Zondervan - University of Oxford
Andrew C. Heath - Supreme Council Of Health
Dominique Arveiler - University of Strasbourg
Stephan J. L. Bakker - University of Groningen
John Beilby - College Station Medical Center
Richard N. Bergman - Cedars Sinai Diabet & Obes Res Inst, Los Angeles, CA 90048 USA
John Blangero - Texas Biomedical Research Institute
Pascal Bovet - College Station Medical Center
Harry Campbell - University of Edinburgh
Mark J. Caulfield - Queen Mary University of London
Giancarlo Cesana - University of Milan
Aravinda Chakravarti - Johns Hopkins University
Daniel I. Chasman - Brigham and Women's Hospital
Peter S. Chines - College Station Medical Center
Francis S. Collins - College Station Medical Center
Dana C. Crawford - Vanderbilt University
L. Adrienne Cupples - Framingham Heart Study
Daniele Cusi - University of Milan
John Danesh - University of Cambridge
Ulf de Faire - Karolinska Institutet
Hester M. den Ruijter - College Station Medical Center
Anna F. Dominiczak - University of Glasgow
Raimund Erbel - Univ Hosp Essen, Clin Cardiol, West German Heart Ctr, D-45147 Essen, Germany
Jeanette Erdmann - Partner Site Hamburg Lubeck Kiel, German Ctr Cardiovasc Res, D-23562 Lubeck, Germany
Johan G. Eriksson - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Martin Farrall - University of Oxford
Stephan B. Felix - College Station Medical Center
Ele Ferrannini - University of Pisa
Jean Ferrieres - Supreme Council Of Health
Ian Ford - University of Glasgow
Nita G. Forouhi - University of Cambridge
Terrence Forrester - Univ W Indies, UWI Solut Developing Countries, Kingston 7, Jamaica
Oscar H. Franco - NCHA, NL-3015 GE Rotterdam, Netherlands
Ron T. Gansevoort - University of Groningen
Pablo V. Gejman - NorthShore Univ HealthSyst, Evanston, IL 60201 USA
Christian Gieger - Helmholtz Zentrum München
Omri Gottesman - Supreme Council Of Health
Vilmundur Gudnason - Iceland Heart Assoc, IS-201 Kopavogur, Iceland
Ulf Gyllensten - University of Western Australia
Alistair S. Hall - University of Leeds
Tamara B. Harris - NIA, Lab Epidemiol & Populat Sci, NIH, Bethesda, MD 20892 USA
Andrew T. Hattersley - University of Exeter
Andrew A. Hicks - Bolzano EURAC, European Acad Bozen, Ctr Biomed, I-39100 Bolzano, Italy
Lucia A. Hindorff - College Station Medical Center
Aroon D. Hingorani - UCL, Inst Cardiovasc Sci, London WC1E 6BT, England
Albert Hofman - NCHA, NL-3015 GE Rotterdam, Netherlands
Georg Homuth - College Station Medical Center
G. Kees Hovingh - University of Amsterdam
Steve E. Humphries - UCL, Inst Cardiovasc Sci, Ctr Cardiovasc Genet, London WC1E 6JJ, England
Steven C. Hunt - University of Utah
Elina Hypponen - Univ S Australia, Sansom Inst Hlth Res, Adelaide, SA 5000, Australia
Thomas Illig - Helmholtz Zentrum München
Kevin B. Jacobs - NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
Marjo-Riitta Jarvelin - University of London
Karl-Heinz Joeckel - College Station Medical Center
Berit Johansen - Norwegian Univ Sci & Technol, Dept Biol, N-7491 Trondheim, Norway
Pekka Jousilahti - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
J. Wouter Jukema - Leiden University
Antti M. Jula - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Jaakko Kaprio - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
John J. P. Kastelein - University of Amsterdam
Sirkka M. Keinanen-Kiukaanniemi - University of Oulu
Lambertus A. Kiemeney - Radboud University Nijmegen
Paul Knekt - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Jaspal S. Kooner - Ealing Hosp NHS Trust, Southall UB1 3HW, Middx, England
Charles Kooperberg - Hutchinson
Peter Kovacs - Institute of Inland Fisheries in Potsdam-Sacrow
Aldi T. Kraja - Supreme Council Of Health
Meena Kumari - UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England
Johanna Kuusisto - College Station Medical Center
Timo A. Lakka - College Station Medical Center
Claudia Langenberg - University of Cambridge
Laic Le Marchand - University of Hawaii System
Terho Lehtimaki - University of Tampere
Valeriya Lyssenko - Steno Diabet Ctr AS, DK-2820 Gentofte, Denmark
Satu Mannisto - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Andre Marette - MED Institute
Tara C. Matise - Rutgers, The State University of New Jersey
Colin A. McKenzie - Univ W Indies, UWI Solut Developing Countries, Kingston 7, Jamaica
Barbara McKnight - University of Washington
Frans L. Moll - College Station Medical Center
Andrew D. Morris - University of Dundee
Andrew P. Morris - University of Tartu
Jeffrey C. Murray - University of Iowa
Mari Nelis - University of Tartu
Claes Ohlsson
Albertine J. Oldehinkel - University of Groningen
Ken K. Ong - University of Cambridge
Pamela A. F. Madden - Supreme Council Of Health
Gerard Pasterkamp - College Station Medical Center
John F. Peden - Illumina
Annette Peters - Helmholtz Zentrum München
Dirkje S. Postma - University of Groningen
Peter P. Pramstaller - Bolzano EURAC, European Acad Bozen, Ctr Biomed, I-39100 Bolzano, Italy
Jackie F. Price - University of Edinburgh
Lu Qi - Brigham and Women's Hospital
Olli T. Raitakari - College Station Medical Center
Tuomo Rankinen - Pennington Biomed Res Ctr, Human Genom Lab, Baton Rouge, LA 70808 USA
D. C. Rao - Supreme Council Of Health
Treva K. Rice - Biostat
Paul M. Ridker - Brigham and Women's Hospital
John D. Rioux - Montreal Heart Institute
Marylyn D. Ritchie - Pennsylvania State University
Igor Rudan - University of Edinburgh
Veikko Salomaa - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Nilesh J. Samani - University of Leicester
Jouko Saramines - South Carelia Cent Hosp, Lappeenranta 53130, Finland
Mark A. Sarzynski - Pennington Biomed Res Ctr, Human Genom Lab, Baton Rouge, LA 70808 USA
Heribert Schunkert - Munich Heart Alliance, German Res Ctr Cardiovasc Res, Deutsch Forschungszentrum Herz Kreislauferkrankun, D-80636 Munich, Germany
Peter E. H. Schwarz - College Station Medical Center
Peter Sever - University of London
Alan R. Shuldiner - Supreme Council Of Health
Juha Sinisalo - University of Helsinki
Ronald P. Stolk - University of Groningen
Konstantin Strauch - Helmholtz Zentrum München
Anke Toenjes
David-Alexandre Tregouet - Sorbonne Université
Angelo Tremblay - Univ Laval, Dept Kinesiol, Quebec City, PQ G1V 0A6, Canada
Elena Tremoli - University of Milan
Jarmo Virtamo - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Marie-Claude Vohl - Univ Laval, Dept Food Sci & Nutr, Quebec City, PQ G1V 0A6, Canada
Uwe Voelker - College Station Medical Center
Gerard Waeber - College Station Medical Center
Gonneke Willemsen - University of Amsterdam
Jacqueline C. Witteman - Erasmus MC
M. Carola Zillikens - NCHA, NL-3015 GE Rotterdam, Netherlands
Linda S. Adair - Univ N Carolina, Dept Nutr, Chapel Hill, NC 27599 USA
Philippe Amouyel - Inst Pasteur, F-59000 Lille, France
Folkert W. Asselbergs - UCL, Inst Cardiovasc Sci, London WC1E 6BT, England
Themistocles L. Assimes - Stanford University
Murielle Bochud - College Station Medical Center
Bernhard O. Boehm - University of London
Eric Boerwinkle - Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA
Stefan R. Bornstein - College Station Medical Center
Erwin P. Bottinger - Supreme Council Of Health
Claude Bouchard - Pennington Biomed Res Ctr, Human Genom Lab, Baton Rouge, LA 70808 USA
Stephane Cauchi - Inst Pasteur, Ctr Immunol & Biol Parasitaire, CNRS, UMR 8199, F-59019 Lille, France
John C. Chambers - Ealing Hosp NHS Trust, Southall UB1 3HW, Middx, England
Stephen J. Chanock - NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
Richard S. Cooper - Loyola University Chicago
Paul I. W. de Bakker - College Station Medical Center
George Dedoussis - Harokopio University of Athens
Luigi Ferrucci - NIA, Translat Gerontol Branch, Baltimore, MD 21225 USA
Paul W. Franks - Harvard University
Philippe Froguel - University of London
Leif C. Groop - University of Helsinki
Christopher A. Haiman - Supreme Council Of Health
Anders Hamsten - Karolinska Institutet
Jennie Hui - College Station Medical Center
David J. Hunter - Brigham and Women's Hospital
Kristian Hveem - Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, N-7489 Trondheim, Norway
Robert C. Kaplan - Albert Einstein College of Medicine
Mika Kivimaki - UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England
Diana Kuh - Massachusetts Rehabilitation Commission
Markku Laakso - College Station Medical Center
Yongmei Liu - Supreme Council Of Health
Nicholas G. Martin - College Station Medical Center
Winfried Maerz - Heidelberg University
Mads Melbve - Stanford University
Andres Metspalu - University of Tartu
Susanne Moebus - College Station Medical Center
Patricia B. Munroe - Queen Mary University of London
Inger Njolstad - UiT The Arctic University of Norway
Ben A. Oostra - Erasmus MC
Colin N. A. Palmer - University of Dundee
Nancy L. Pedersen - Karolinska Institutet
Markus Perola - University of Tartu
Louis Perusse - Univ Laval, Dept Kinesiol, Quebec City, PQ G1V 0A6, Canada
Ulrike Peters - Hutchinson
Chris Power - UCL, Inst Child Hlth, London WC1N 1EH, England
Thomas Quertermous - Stanford University
Rainer Rauramaa - College Station Medical Center
Fernando Rivadeneira - NCHA, NL-3015 GE Rotterdam, Netherlands
Timo E. Saaristo - Finnish Diabet Assoc, FI-33680 Tampere, Finland
Danish Saleheen - University of Cambridge
Naveed Sattar - University of Glasgow
Eric E. Schadt - Supreme Council Of Health
David Schlessinger - NIA, Lab Genet, Baltimore, MD 21224 USA
P. Eline Slagboom - Leiden University
Harold Snieder - University of Groningen
Tim D. Spector - Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England
Unnu R. Thorsteinsdottir - Amgen Inc, deCODE Genet, IS-101 Reykjavik, Iceland
Michael Stumvoll - Institute of Inland Fisheries in Potsdam-Sacrow
Jaakko Tuomilehto - Natl Inst Hlth & Welf, FI-00271 Helsinki, Finland
Andre G. Uitterlinden - NCHA, NL-3015 GE Rotterdam, Netherlands
Matti Uusitupa - University of Eastern Finland
Pim van der Harst - University of Groningen
Mark Walker - University of Newcastle Australia
Henri Wallaschofski - Partner Site Greifswald, DZHK, D-17475 Greifswald, Germany
Nicholas J. Wareham - University of Cambridge
Hugh Watkins - University of Oxford
David R. Weir - Univ Michigan, Inst Social Res, Survey Res Ctr, Ann Arbor, MI 48104 USA
H-Erich Wichmann - College Station Medical Center
James F. Wilson - University of Edinburgh
Pieter Zanen - College Station Medical Center
Ingrid B. Borecki - Supreme Council Of Health
Panos Deloukas - Wellcome Sanger Institute
Caroline S. Fox - Framingham Heart Study
Iris M. Heid - University of Regensburg
Jeffrey R. O'Connell - Supreme Council Of Health
David P. Strachan - University of London
Kari Stefansson - Amgen
Cornelia M. van Duijri - Erasmus MC
Goncalo R. Abecasis - Biostat
Lude Franke - University of Groningen
Timothy M. Frayling - University of Exeter
Mark I. McCarthy - University of Oxford
Peter M. Visscher - University of Queensland
Andre Scherag - College Station Medical Center
Cristen J. Willer - College Station Medical Center
Michael Boehnke - Biostat
Karen L. Mohlke - Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA
Cecilia M. Lindgren - Massachusetts Institute of Technology
Jacques S. Beckmann - Swiss Inst Bioinformat, CH-1015 Lausanne, Switzerland
Ines Barroso - Wellcome Sanger Institute
Kari E. North - Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27599 USA
Erik Ingelsson - Uppsala University
Joel N. Hirschhorn - Boston Childrens Hosp, Div Endocrinol, Boston, MA 02115 USA
Ruth J. F. Loos - University of Cambridge
Elizabeth K. Speliotes - College Station Medical Center
ADIPOGen Consortium
Publication Details: Nature (London), Vol.518(7538), pp.197-U401
Publisher: NATURE PORTFOLIO
Number of pages: 23
Grant note: NF-SI-0512-10114; NF-SI-0513-10109; NF-SI-0611-10099; NF-SI-0611-10219; NF-SI-0512-10113; NF-SI-0514-10027; NF-SI-0512-10165; NF-SI-0611-10170; NF-SI-0507-10380; NF-SI-0513-10059 / National Institute for Health Research; National Institute for Health Research (NIHR) NNF12OC1016467; NNF13OC0005785; NNF13OC0004839; NNF14OC0010513; NNF15OC0016416; NNF14OC0009883 / Novo Nordisk Fonden; Novo Nordisk Foundation 14136 / Cancer Research UK CZB/4/672; CZB/4/710 / Chief Scientist Office R190-2014-3904 / Lundbeck Foundation; Lundbeckfonden ES/F02679X/1; ES/J023299/1 / ESRC; UK Research & Innovation (UKRI); Economic & Social Research Council (ESRC) RG/07/008/23674; RG/08/014/24067; RG/10/12/28456; RG/08/008/25291; FS/14/55/30806 / British Heart Foundation ES/J023299/1; ES/F02679X/1 / Economic and Social Research Council; UK Research & Innovation (UKRI); Economic & Social Research Council (ESRC) Pers Group / NNF Center for Basic Metabolic Research; Novo Nordisk Foundation G0902037; MC_UU_12019/1; MC_UU_12015/2; MR/K002414/1; MC_PC_U127561128; MC_UU_12013/1; MR/K013351/1; MC_UP_A100_1003; MR/L003120/1; G1001799; G9521010; MC_U106179472; MC_UU_12015/5; G0600717; G0601261; MC_UU_12015/1; MC_UU_12012/1; MR/N01104X/1; G1000616 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) G0600717; MC_UU_12012/5/B; G0401527; G19/35; MC_UU_12015/1; G0601261; G1000616; MC_UU_12015/2; MC_UU_12012/1; G0902037; MR/K006584/1; G1000143; MC_PC_U127561128; MC_UU_12019/1; G0600717B; G0100222; MC_UU_12015/5; MC_U106179472; MR/K013351/1; G9521010; G1001799; MC_U106179471; MR/N01104X/1; MC_UP_A100_1003; MR/K002414/1; G8802774; MC_UU_12013/1; MR/L003120/1 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC)
Identifiers: 9937754308331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article