Genome Sequence of Theileria parva , a Bovine Pathogen That Transforms Lymphocytes

Malcolm J. Gardner; Richard Bishop; Trushar Shah; Etienne P. de Villiers; Jane M. Carlton; Neil Hall; Qinghu Ren; Ian T. Paulsen; Arnab Pain; Matthew Berriman; Robert J. M. Wilson; Shigeharu Sato; Stuart A. Ralph; David J. Mann; Zikai Xiong; Shamira J. Shallom; Janice Weidman; Lingxia Jiang; Jeffery Lynn; Bruce Weaver; Azadeh Shoaibi; Alexander R. Domingo; Delia Wasawo; Jonathan Crabtree; Jennifer R. Wortman; Brian Haas; Samuel V. Angiuoli; Todd H. Creasy; Charles Lu; Bernard Suh; Joana C. Silva; Teresa R. Utterback; Tamara V. Feldblyum; Mihaela Pertea; Jonathan Allen; William C. Nierman; Evans L. N. Taracha; Steven L. Salzberg; Owen R. White; Henry A. Fitzhugh; Subhash Morzaria; J. Craig Venter; Claire M. Fraser; Vishvanath Nene

doi:10.1126/science.1110439

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Genome Sequence of Theileria parva , a Bovine Pathogen That Transforms Lymphocytes

Journal article

Peer reviewed

Genome Sequence of Theileria parva , a Bovine Pathogen That Transforms Lymphocytes

Malcolm J. Gardner, Richard Bishop, Trushar Shah, Etienne P. de Villiers, Jane M. Carlton, Neil Hall, Qinghu Ren, Ian T. Paulsen, Arnab Pain, Matthew Berriman, …

Science (American Association for the Advancement of Science), Vol.309(5731), pp.134-137

01/07/2005

DOI: https://doi.org/10.1126/science.1110439

PMID: 15994558

Abstract

We report the genome sequence of Theileria parva , an apicomplexan pathogen causing economic losses to smallholder farmers in Africa. The parasite chromosomes exhibit limited conservation of gene synteny with Plasmodium falciparum , and its plastid-like genome represents the first example where all apicoplast genes are encoded on one DNA strand. We tentatively identify proteins that facilitate parasite segregation during host cell cytokinesis and contribute to persistent infection of transformed host cells. Several biosynthetic pathways are incomplete or absent, suggesting substantial metabolic dependence on the host cell. One protein family that may generate parasite antigenic diversity is not telomere-associated.

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Title: Genome Sequence of Theileria parva , a Bovine Pathogen That Transforms Lymphocytes
Creators - without role: Malcolm J. Gardner - International Livestock Research Institute
Richard Bishop - International Livestock Research Institute
Trushar Shah - International Livestock Research Institute
Etienne P. de Villiers - International Livestock Research Institute
Jane M. Carlton - International Livestock Research Institute
Neil Hall - Wellcome Sanger Institute
Qinghu Ren - International Livestock Research Institute
Ian T. Paulsen - International Livestock Research Institute
Arnab Pain - Wellcome Sanger Institute
Matthew Berriman - Wellcome Sanger Institute
Robert J. M. Wilson - Wellcome Sanger Institute
Shigeharu Sato - International Livestock Research Institute
Stuart A. Ralph - International Livestock Research Institute
David J. Mann - International Livestock Research Institute
Zikai Xiong - Wellcome Sanger Institute
Shamira J. Shallom - International Livestock Research Institute
Janice Weidman - International Livestock Research Institute
Lingxia Jiang - International Livestock Research Institute
Jeffery Lynn - International Livestock Research Institute
Bruce Weaver - International Livestock Research Institute
Azadeh Shoaibi - International Livestock Research Institute
Alexander R. Domingo - International Livestock Research Institute
Delia Wasawo - International Livestock Research Institute
Jonathan Crabtree - International Livestock Research Institute
Jennifer R. Wortman - International Livestock Research Institute
Brian Haas - International Livestock Research Institute
Samuel V. Angiuoli - International Livestock Research Institute
Todd H. Creasy - International Livestock Research Institute
Charles Lu - International Livestock Research Institute
Bernard Suh - International Livestock Research Institute
Joana C. Silva - International Livestock Research Institute
Teresa R. Utterback - International Livestock Research Institute
Tamara V. Feldblyum - International Livestock Research Institute
Mihaela Pertea - International Livestock Research Institute
Jonathan Allen - International Livestock Research Institute
William C. Nierman - International Livestock Research Institute
Evans L. N. Taracha - Wellcome Sanger Institute
Steven L. Salzberg - International Livestock Research Institute
Owen R. White - International Livestock Research Institute
Henry A. Fitzhugh - International Livestock Research Institute
Subhash Morzaria - International Livestock Research Institute
J. Craig Venter - International Livestock Research Institute
Claire M. Fraser - International Livestock Research Institute
Vishvanath Nene - International Livestock Research Institute
Publication Details: Science (American Association for the Advancement of Science), Vol.309(5731), pp.134-137
Identifiers: 9941779908331
Academic Unit: King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article