Genome of the Host-Cell Transforming Parasite Theileria annulata Compared with T. parva

Arnab Pain; Hubert Renauld; Matthew Berriman; Lee Murphy; Corin A. Yeats; William Weir; Arnaud Kerhornou; Martin Aslett; Richard Bishop; Christiane Bouchier; Madeleine Cochet; Richard M. R. Coulson; Ann Cronin; Etienne P. de Villiers; Audrey Fraser; Nigel Fosker; Malcolm Gardner; Arlette Goble; Sam Griffiths-Jones; David E. Harris; Frank Katzer; Natasha Larke; Angela Lord; Pascal Maser; Sue McKellar; Paul Mooney; Fraser Morton; Vishvanath Nene; Susan O'Neil; Claire Price; Michael A. Quail; Ester Rabbinowitsch; Neil D. Rawlings; Simon Rutter; David Saunders; Kathy Seeger; Trushar Shah; Robert Squares; Steven Squares; Adrian Tivey; Alan R. Walker; John Woodward; Dirk A. E. Dobbelaere; Gordon Langsley; Marie-Adele Rajandream; Declan McKeever; Brian Shiels; Andrew Tait; Bart Barrell; Neil Hall

doi:10.1126/science.1110418

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Genome of the Host-Cell Transforming Parasite Theileria annulata Compared with T. parva

Journal article

Peer reviewed

Genome of the Host-Cell Transforming Parasite Theileria annulata Compared with T. parva

Arnab Pain, Hubert Renauld, Matthew Berriman, Lee Murphy, Corin A. Yeats, William Weir, Arnaud Kerhornou, Martin Aslett, Richard Bishop, Christiane Bouchier, …

Science (American Association for the Advancement of Science), Vol.309(5731), pp.131-133

01/07/2005

DOI: https://doi.org/10.1126/science.1110418

PMID: 15994557

Abstract

Theileria annulata and T. parva are closely related protozoan parasites that cause lymphoproliferative diseases of cattle. We sequenced the genome of T. annulata and compared it with that of T. parva to understand the mechanisms underlying transformation and tropism. Despite high conservation of gene sequences and synteny, the analysis reveals unequally expanded gene families and species-specific genes. We also identify divergent families of putative secreted polypeptides that may reduce immune recognition, candidate regulators of host-cell transformation, and a Theileria -specific protein domain [frequently associated in Theileria (FAINT)] present in a large number of secreted proteins.

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Title: Genome of the Host-Cell Transforming Parasite Theileria annulata Compared with T. parva
Creators - without role: Arnab Pain - Wellcome Sanger Institute
Hubert Renauld - Wellcome Sanger Institute
Matthew Berriman - Wellcome Sanger Institute
Lee Murphy - Wellcome Sanger Institute
Corin A. Yeats - Wellcome Sanger Institute
William Weir - Wellcome Sanger Institute
Arnaud Kerhornou - Wellcome Sanger Institute
Martin Aslett - Wellcome Sanger Institute
Richard Bishop - International Livestock Research Institute
Christiane Bouchier - Wellcome Sanger Institute
Madeleine Cochet - Wellcome Sanger Institute
Richard M. R. Coulson - Wellcome Sanger Institute
Ann Cronin - Wellcome Sanger Institute
Etienne P. de Villiers - International Livestock Research Institute
Audrey Fraser - Wellcome Sanger Institute
Nigel Fosker - Wellcome Sanger Institute
Malcolm Gardner - International Livestock Research Institute
Arlette Goble - Wellcome Sanger Institute
Sam Griffiths-Jones - Wellcome Sanger Institute
David E. Harris - Wellcome Sanger Institute
Frank Katzer - Wellcome Sanger Institute
Natasha Larke - Wellcome Sanger Institute
Angela Lord - Wellcome Sanger Institute
Pascal Maser - Wellcome Sanger Institute
Sue McKellar - Wellcome Sanger Institute
Paul Mooney - Wellcome Sanger Institute
Fraser Morton - Wellcome Sanger Institute
Vishvanath Nene - International Livestock Research Institute
Susan O'Neil - Wellcome Sanger Institute
Claire Price - Wellcome Sanger Institute
Michael A. Quail - Wellcome Sanger Institute
Ester Rabbinowitsch - Wellcome Sanger Institute
Neil D. Rawlings - Wellcome Sanger Institute
Simon Rutter - Wellcome Sanger Institute
David Saunders - Wellcome Sanger Institute
Kathy Seeger - Wellcome Sanger Institute
Trushar Shah - Wellcome Sanger Institute
Robert Squares - Wellcome Sanger Institute
Steven Squares - Wellcome Sanger Institute
Adrian Tivey - Wellcome Sanger Institute
Alan R. Walker - Wellcome Sanger Institute
John Woodward - Wellcome Sanger Institute
Dirk A. E. Dobbelaere - Wellcome Sanger Institute
Gordon Langsley - Institut Pasteur
Marie-Adele Rajandream - Wellcome Sanger Institute
Declan McKeever - Wellcome Sanger Institute
Brian Shiels - Wellcome Sanger Institute
Andrew Tait - Wellcome Sanger Institute
Bart Barrell - Wellcome Sanger Institute
Neil Hall - Wellcome Sanger Institute
Publication Details: Science (American Association for the Advancement of Science), Vol.309(5731), pp.131-133
Identifiers: 9943201308331
Academic Unit: King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article