Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma

Eranga N. Vithana; Chiea-Chuen Khor; Chunyan Qiao; Monisha E. Nongpiur; Ronnie George; Li-Jia Chen; Tan Do; Khaled K. Abu-Amero; Chor Kai Huang; Sancy Low; Liza-Sharmini A. Tajudin; Shamira A. Perera; Ching-Yu Cheng; Liang Xu; Hongyan Jia; Ching-Lin Ho; Kar Seng Sim; Ren-Yi Wu; Clement C. Y. Tham; Paul T. K. Chew; Daniel H. Su; Francis T. Oen; Sripriya Sarangapani; Nagaswamy Soumittra; Essam A. Osman; Hon-Tym Wong; Guangxian Tang; Sujie Fan; Hailin Meng; Dao T. L. Huong; Hua Wang; Bo Feng; Mani Baskaran; Balekudaru Shantha; Vedam L. Ramprasad; Govindasamy Kumaramanickavel; Sudha K. Iyengar; Alicia C. How; Kelvin Y. Lee; Theru A. Sivakumaran; Victor H. K. Yong; Serena M. L. Ting; Yang Li; Ya-Xing Wang; Wan-Ting Tay; Xueling Sim; Raghavan Lavanya; Belinda K. Cornes; Ying-Feng Zheng; Tina T. Wong; Seng-Chee Loon; Vernon K. Y. Yong; Naushin Waseem; Azhany Yaakub; Kee-Seng Chia; R. Rand Allingham; Michael A. Hauser; Dennis S. C. Lam; Martin L. Hibberd; Shomi S. Bhattacharya; Mingzhi Zhang; Yik Ying Teo; Donald T. Tan; Jost B. Jonas; E-Shyong Tai; Seang-Mei Saw; Do Nhu Hon; Saleh A. Al-Obeidan; Jianjun Liu; Tran Nguyen Bich Chau; Cameron P. Simmons; Jin-Xin Bei; Yi-Xin Zeng; Paul J. Foster; Lingam Vijaya; Tien-Yin Wong; Chi-Pui Pang; Ningli Wang; Tin Aung

doi:10.1038/ng.2390

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Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma

Journal article

Peer reviewed

Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma

Eranga N. Vithana, Chiea-Chuen Khor, Chunyan Qiao, Monisha E. Nongpiur, Ronnie George, Li-Jia Chen, Tan Do, Khaled K. Abu-Amero, Chor Kai Huang, Sancy Low, …

Nature genetics, Vol.44(10), pp.1142-1146

01/10/2012

DOI: https://doi.org/10.1038/ng.2390

PMCID: PMC4333205

PMID: 22922875

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

Primary angle closure glaucoma (PACG) is a major cause of blindness worldwide. We conducted a genome-wide association study including 1,854 PACG cases and 9,608 controls across 5 sample collections in Asia. Replication experiments were conducted in 1,917 PACG cases and 8,943 controls collected from a further 6 sample collections. We report significant associations at three new loci: rs11024102 in PLEKHA7 (per-allele odds ratio (OR) = 1.22; P = 5.33 x 10(-12)), rs3753841 in COL11A1 (per-allele OR = 1.20; P = 9.22 x 10(-10)) and rs1015213 located between PCMTD1 and ST18 on chromosome 8q (per-allele OR = 1.50; P = 3.29 x 10(-9)). Our findings, accumulated across these independent worldwide collections, suggest possible mechanisms explaining the pathogenesis of PACG.

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Title: Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma
Creators - without role: Eranga N. Vithana - Singapore Eye Research Institute
Chiea-Chuen Khor - National University Health System
Chunyan Qiao - Beijing Tongren Hospital
Monisha E. Nongpiur - Singapore National Eye Center
Ronnie George - Sankara Nethralaya
Li-Jia Chen - Chinese University of Hong Kong
Tan Do - Vietnam Natl Inst Ophthalmol, Hanoi, Vietnam
Khaled K. Abu-Amero - King Saud University
Chor Kai Huang - Chinese University of Hong Kong
Sancy Low - National Institute for Health Research
Liza-Sharmini A. Tajudin - Supreme Council Of Health
Shamira A. Perera - Singapore Eye Research Institute
Ching-Yu Cheng - Singapore National Eye Center
Liang Xu - Beijing Tongren Hospital
Hongyan Jia - Beijing Tongren Hospital
Ching-Lin Ho - Singapore National Eye Center
Kar Seng Sim - Genome Institute of Singapore
Ren-Yi Wu - Singapore Eye Research Institute
Clement C. Y. Tham - Chinese University of Hong Kong
Paul T. K. Chew - Natl Univ Hlth Syst, Dept Ophthalmol, Singapore, Singapore
Daniel H. Su - Singapore National Eye Center
Francis T. Oen - Singapore National Eye Center
Sripriya Sarangapani - Sankara Nethralaya
Nagaswamy Soumittra - Sankara Nethralaya
Essam A. Osman - King Saud University
Hon-Tym Wong - Tan Tock Seng Hospital
Guangxian Tang - Hebei Eye Hospital
Sujie Fan - Han Dan City Eye Hospital - The Third Hospital of Handan
Hailin Meng - Anyang Eye Hosp, Anyang, Peoples R China
Dao T. L. Huong - National Hospital of Pediatrics
Hua Wang - Beijing Tongren Hospital
Bo Feng - Beijing Tongren Hospital
Mani Baskaran - Singapore National Eye Center
Balekudaru Shantha - Sankara Nethralaya
Vedam L. Ramprasad - Sankara Nethralaya
Govindasamy Kumaramanickavel - Sankara Nethralaya
Sudha K. Iyengar - Case Western Reserve University
Alicia C. How - Singapore National Eye Center
Kelvin Y. Lee - Singapore National Eye Center
Theru A. Sivakumaran - Case Western Reserve University
Victor H. K. Yong - Singapore National Eye Center
Serena M. L. Ting - Singapore National Eye Center
Yang Li - Supreme Council Of Health
Ya-Xing Wang - College Station Medical Center
Wan-Ting Tay - Singapore National Eye Center
Xueling Sim - National University of Singapore
Raghavan Lavanya - Singapore National Eye Center
Belinda K. Cornes - Singapore National Eye Center
Ying-Feng Zheng - Singapore Eye Research Institute
Tina T. Wong - Singapore National Eye Center
Seng-Chee Loon - National University Health System
Vernon K. Y. Yong - Tan Tock Seng Hosp, Dept Ophthalmol, Singapore, Singapore
Naushin Waseem - Moorfields Eye Hospital
Azhany Yaakub - Hospital Universiti Sains Malaysia
Kee-Seng Chia - Supreme Council Of Health
R. Rand Allingham - Duke University
Michael A. Hauser - Duke University
Dennis S. C. Lam - Chinese University of Hong Kong
Martin L. Hibberd - National University Health System
Shomi S. Bhattacharya - Moorfields Eye Hosp, NIHR, Biomed Res Ctr Ophthalmol, London, England
Mingzhi Zhang - Chinese University of Hong Kong
Yik Ying Teo - Duke-NUS Medical School
Donald T. Tan - National University Health System
Jost B. Jonas - Heidelberg University
E-Shyong Tai - National University Health System
Seang-Mei Saw - Singapore Eye Research Institute
Do Nhu Hon - Vietnam Natl Inst Ophthalmol, Hanoi, Vietnam
Saleh A. Al-Obeidan - King Saud University
Jianjun Liu - Genome Institute of Singapore
Tran Nguyen Bich Chau - University of Oxford
Cameron P. Simmons - Oxford University Clinical Research Unit
Jin-Xin Bei - Sun Yat-sen University Cancer Center
Yi-Xin Zeng - Southern Medical University
Paul J. Foster - National Institute for Health Research
Lingam Vijaya - Sankara Nethralaya
Tien-Yin Wong - Singapore National Eye Center
Chi-Pui Pang - Chinese University of Hong Kong
Ningli Wang - College Station Medical Center
Tin Aung - Singapore Eye Research Institute
Publication Details: Nature genetics, Vol.44(10), pp.1142-1146
Publisher: Springer Nature
Number of pages: 6
Grant note: BMRC 09/1/35/19/616; 08/1/35/19/550 / Biomedical Research Council, Singapore; Agency for Science Technology & Research (A*STAR) 81030016 / Key Project of the National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC) Genome Institute of Singapore NMRC/TCR/002-SERI/2008; R626/47/2008TCR; CSA R613/34/2008; NMRC 0796/2003; STaR/0003/2008 / National Medical Research Council, Singapore; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) 7102036 / Beijing Municipal Natural Science Foundation; Beijing Natural Science Foundation National Research Foundation of Singapore; National Research Foundation, Singapore 7081001 / Key Project of the Beijing Municipal Natural Science Foundation
Identifiers: 9949898408331
Academic Unit: King Saud University
Language: English
Resource Type: Journal article