Genome-wide association analysis identifies 13 new risk loci for schizophrenia

Stephan Ripke; Colm O'Dushlaine; Kimberly Chambert; Jennifer L. Moran; Anna K. Kaehler; Susanne Akterin; Sarah E. Bergen; Ann L. Collins; James J. Crowley; Menachem Fromer; Yunjung Kim; Sang Hong Lee; Patrik K. E. Magnusson; Nick Sanchez; Eli A. Stahl; Stephanie Williams; Naomi R. Wray; Kai Xia; Francesco Bettella; Anders D. Borglum; Brendan K. Bulik-Sullivan; Paul Cormican; Nick Craddock; Christiaan de Leeuw; Naser Durmishi; Michael Gill; Vera Golimbet; Marian L. Hamshere; Peter Holmans; David M. Hougaard; Kenneth S. Kendler; Kuang Lin; Derek W. Morris; Ole Mors; Preben B. Mortensen; Benjamin M. Neale; Francis A. O'Neill; Michael J. Owen; Milica Pejovic Milovancevic; Danielle Posthuma; John Powell; Alexander L. Richards; Brien P. Riley; Douglas Ruderfer; Dan Rujescu; Engilbert Sigurdsson; Teimuraz Silagadze; August B. Smit; Hreinn Stefansson; Stacy Steinberg; Jaana Suvisaari; Sarah Tosato; Matthijs Verhage; James T. Walters; Elvira Bramon; Aiden P. Corvin; Michael C. O'Donovan; Kari Stefansson; Edward Scolnick; Shaun Purcell; Steven A. McCarroll; Pamela Sklar; Christina M. Hultman; Patrick F. Sullivan; Multictr Genetic Studies Schizophr; Panos Deloukas

doi:10.1038/ng.2742

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Genome-wide association analysis identifies 13 new risk loci for schizophrenia

Journal article

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Genome-wide association analysis identifies 13 new risk loci for schizophrenia

Stephan Ripke, Colm O'Dushlaine, Kimberly Chambert, Jennifer L. Moran, Anna K. Kaehler, Susanne Akterin, Sarah E. Bergen, Ann L. Collins, James J. Crowley, Menachem Fromer, …

Nature genetics, Vol.45(10), pp.1150-1159

01/10/2013

DOI: https://doi.org/10.1038/ng.2742

PMID: 23974872

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and 6,243 controls) followed by meta-analysis with previous schizophrenia GWAS (8,832 cases and 12,067 controls) and finally by replication of SNPs in 168 genomic regions in independent samples (7,413 cases, 19,762 controls and 581 parent-offspring trios). We identified 22 loci associated at genome-wide significance; 13 of these are new, and 1 was previously implicated in bipolar disorder. Examination of candidate genes at these loci suggests the involvement of neuronal calcium signaling. We estimate that 8,300 independent, mostly common SNPs (95% credible interval of 6,300-10,200 SNPs) contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability. Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder.

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Title: Genome-wide association analysis identifies 13 new risk loci for schizophrenia
Creators - without role: Stephan Ripke - Massachusetts General Hospital
Colm O'Dushlaine - Broad Institute
Kimberly Chambert - Broad Institute
Jennifer L. Moran - Broad Institute
Anna K. Kaehler - Univ N Carolina, Dept Genet, Chapel Hill, NC 27515 USA
Susanne Akterin - Karolinska Institutet
Sarah E. Bergen - Karolinska Institutet
Ann L. Collins - University of North Carolina at Chapel Hill
James J. Crowley - University of North Carolina at Chapel Hill
Menachem Fromer - Massachusetts General Hospital
Yunjung Kim - University of North Carolina at Chapel Hill
Sang Hong Lee - University of Queensland
Patrik K. E. Magnusson - Karolinska Institutet
Nick Sanchez - Broad Institute
Eli A. Stahl - Icahn School of Medicine at Mount Sinai
Stephanie Williams - University of North Carolina at Chapel Hill
Naomi R. Wray - University of Queensland
Kai Xia - University of North Carolina at Chapel Hill
Francesco Bettella - deCODE Genetics
Anders D. Borglum - Aarhus University Hospital
Brendan K. Bulik-Sullivan - Massachusetts General Hospital
Paul Cormican - Trinity College Dublin
Nick Craddock - Cardiff University
Christiaan de Leeuw - Amsterdam UMC Location VUmc
Naser Durmishi - University Clinic of Traumatology
Michael Gill - Trinity College Dublin
Vera Golimbet - Mental Health Research Center of Russian Academy of Medical Sciences
Marian L. Hamshere - Cardiff University
Peter Holmans - Cardiff University
David M. Hougaard - Statens Serum Institut
Kenneth S. Kendler - Virginia Commonwealth University
Kuang Lin - King's College London
Derek W. Morris - Trinity College Dublin
Ole Mors - Lundbeck Foundation
Preben B. Mortensen - Lundbeck Foundation
Benjamin M. Neale - Massachusetts General Hospital
Francis A. O'Neill - Queen's University Belfast
Michael J. Owen - Cardiff University
Milica Pejovic Milovancevic - University of Belgrade
Danielle Posthuma - Amsterdam UMC Location VUmc
John Powell - King's College London
Alexander L. Richards - Cardiff University
Brien P. Riley - Virginia Commonwealth University
Douglas Ruderfer - Icahn School of Medicine at Mount Sinai
Dan Rujescu - Ludwig-Maximilians-Universität München
Engilbert Sigurdsson - University of Iceland
Teimuraz Silagadze - Tbilisi State Medical University
August B. Smit - Amsterdam Neuroscience
Hreinn Stefansson - deCODE Genetics
Stacy Steinberg - deCODE Genetics
Jaana Suvisaari - Finnish Institute for Health and Welfare
Sarah Tosato - University of Verona
Matthijs Verhage - Amsterdam UMC Location VUmc
James T. Walters - Cardiff University
Elvira Bramon - King's College London
Aiden P. Corvin - Trinity College Dublin
Michael C. O'Donovan - Cardiff University
Kari Stefansson - deCODE Genetics
Edward Scolnick - Broad Institute
Shaun Purcell - Broad Institute
Steven A. McCarroll - Broad Institute
Pamela Sklar - Icahn School of Medicine at Mount Sinai
Christina M. Hultman - Karolinska Institutet
Patrick F. Sullivan - University of North Carolina at Chapel Hill
Multictr Genetic Studies Schizophr
Panos Deloukas - King Abdulaziz University
Publication Details: Nature genetics, Vol.45(10), pp.1150-1159
Publisher: Springer Nature
Number of pages: 12
Grant note: NWO 645-000-003 / Netherlands Scientific Organization H. Lundbeck A/S; Lundbeck Corporation 085475/B/08/Z; 085475/Z/08/Z / Wellcome Trust Soderstrom Konigska Foundation Lundbeck Foundation; Lundbeckfonden Friedman Brain Institute at the Mount Sinai School of Medicine G1100583; G0601635; G1000718; G0600429; G0400126; G0701420; G0901310; G0800509 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Stanley Research Foundation Swedish Research Council; Swedish Research Council for Health Working Life & Welfare (Forte); Swedish Research Council Formas Swedish County Council NF-SI-0507-10379; PDA/02/06/016 / National Institute for Health Research; National Institutes of Health Research (NIHR) Faculty of Health Sciences at Aarhus University Stanley Center for Psychiatric Research HEALTH-F2-2009-223423 / European Union; European Commission; Spanish Government Danish Strategic Research Council; Danske Strategiske Forskningsrad (DSF) G0701420; G0400126; G0800509; G0801418B; G0901310; G0601635; G0600429; G1100583; G1000718 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) R01 MH077139; R01 MH095034 / NIMH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) Sylvan Herman Foundation Karolinska Institutet, Karolinska University Hospital; Karolinska Institutet
Identifiers: 9937968808331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article