Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

Jeffrey C. Barrett; Sarah Hansoul; Dan L. Nicolae; Judy H. Cho; Richard H. Duerr; John D. Rioux; Steven R. Brant; Mark S. Silverberg; Kent D. Taylor; M. Michael Barmada; Alain Bitton; Themistocles Dassopoulos; Lisa Wu Datta; Todd Green; Anne M. Griffiths; Emily O. Kistner; Michael T. Murtha; Miguel D. Regueiro; Jerome I. Rotter; L. Philip Schumm; A. Hillary Steinhart; Stephan R. Targan; Ramnik J. Xavier; Cecile Libioulle; Cynthia Sandor; Mark Lathrop; Jacques Belaiche; Olivier Dewit; Ivo Gut; Simon Heath; Debby Laukens; Myriam Mni; Paul Rutgeerts; Andre Van Gossum; Diana Zelenika; Denis Franchimont; Jean-Pierre Hugot; Martine de Vos; Severine Vermeire; Edouard Louis; Lon R. Cardon; Carl A. Anderson; Hazel Drummond; Elaine Nimmo; Tariq Ahmad; Natalie J. Prescott; Clive M. Onnie; Sheila A. Fisher; Jonathan Marchini; Jilur Ghori; Suzannah Bumpstead; Rhian Gwilliam; Mark Tremelling; Panos Deloukas; John Mansfield; Derek Jewell; Jack Satsangi; Christopher G. Mathew; Miles Parkes; Michel Georges; Mark J. Daly; Wellcome Trust Case Control

doi:10.1038/ng.175

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Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

Journal article

Peer reviewed

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

Jeffrey C. Barrett, Sarah Hansoul, Dan L. Nicolae, Judy H. Cho, Richard H. Duerr, John D. Rioux, Steven R. Brant, Mark S. Silverberg, Kent D. Taylor, M. Michael Barmada, …

Nature genetics, Vol.40(8), pp.955-962

01/08/2008

DOI: https://doi.org/10.1038/ng.175

PMID: 18587394

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

Several risk factors for Crohn's disease have been identified in recent genome-wide association studies. To advance gene discovery further, we combined data from three studies on Crohn's disease ( a total of 3,230 cases and 4,829 controls) and carried out replication in 3,664 independent cases with a mixture of population-based and family-based controls. The results strongly confirm 11 previously reported loci and provide genome-wide significant evidence for 21 additional loci, including the regions containing STAT3, JAK2, ICOSLG, CDKAL1 and ITLN1. The expanded molecular understanding of the basis of this disease offers promise for informed therapeutic development.

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Title: Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
Creators - without role: Jeffrey C. Barrett - University of Oxford
Sarah Hansoul - University of Liège
Dan L. Nicolae - University of Chicago
Judy H. Cho - Yale University
Richard H. Duerr - University of Pittsburgh
John D. Rioux - Broad Institute
Steven R. Brant - Johns Hopkins University
Mark S. Silverberg - University of Toronto
Kent D. Taylor - College Station Medical Center
M. Michael Barmada
Alain Bitton - McGill University
Themistocles Dassopoulos - Johns Hopkins University
Lisa Wu Datta
Todd Green - Broad Institute
Anne M. Griffiths - University of Toronto
Emily O. Kistner - University of Chicago
Michael T. Murtha - Yale University
Miguel D. Regueiro
Jerome I. Rotter - College Station Medical Center
L. Philip Schumm
A. Hillary Steinhart - University of Toronto
Stephan R. Targan - College Station Medical Center
Ramnik J. Xavier - Harvard University
Cecile Libioulle - University of Liège
Cynthia Sandor - University of Liège
Mark Lathrop - Evry
Jacques Belaiche
Olivier Dewit - Clin Univ St Luc, Dept Gastroenterol, UCL, B-1200 Brussels, Belgium
Ivo Gut - Evry
Simon Heath - Evry
Debby Laukens - Ghent University
Myriam Mni
Paul Rutgeerts - KU Leuven
Andre Van Gossum - Free Univ Brussels, Erasmus Hosp, Dept Gastroenterol, B-1050 Brussels, Belgium
Diana Zelenika - Evry
Denis Franchimont - Free Univ Brussels, Erasmus Hosp, Dept Gastroenterol, B-1050 Brussels, Belgium
Jean-Pierre Hugot - Inserm
Martine de Vos - Ghent University
Severine Vermeire - KU Leuven
Edouard Louis
Lon R. Cardon - University of Oxford
Carl A. Anderson - University of Oxford
Hazel Drummond - University of Edinburgh
Elaine Nimmo - University of Edinburgh
Tariq Ahmad - Supreme Council Of Health
Natalie J. Prescott - Supreme Council Of Health
Clive M. Onnie - Supreme Council Of Health
Sheila A. Fisher - Supreme Council Of Health
Jonathan Marchini - University of Oxford
Jilur Ghori
Suzannah Bumpstead - Wellcome Sanger Institute
Rhian Gwilliam - Wellcome Sanger Institute
Mark Tremelling - University of Cambridge
Panos Deloukas - Wellcome Sanger Institute
John Mansfield - Newcastle University
Derek Jewell - University of Oxford
Jack Satsangi - University of Edinburgh
Christopher G. Mathew - Supreme Council Of Health
Miles Parkes - University of Cambridge
Michel Georges
Mark J. Daly - Harvard University
Wellcome Trust Case Control
Publication Details: Nature genetics, Vol.40(8), pp.955-962
Publisher: Springer Nature
Number of pages: 8
Grant note: G0600329 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) AI06277; R01 AI062773; R01 AI062773-02 / NIAID NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) 068545/Z/02 / Wellcome Trust; European Commission G0600329; G0000934; G0800759 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission U01 DK062420-06; DK62432; U01 DK062420; U01 DK062431-06; U01 DK062431; P30 DK040561-13; DK62413; U01 DK062413; U01 DK062423; DK62423; P30 DK063491-049004; U01 DK062420-03; P30 DK063491-019004; U01 DK062420-04; P30 DK063491-029004; U01 DK062429-07; DK064869; U01 DK062432; U01 DK062429; U01 DK062422; U01 DK062420-05; DK62431; R01 DK064869-04; R01 DK064869; U01 DK062413-06; P30 DK063491-039004; DK62429; DK62420; P30 DK040561; U01 DK062422-07; U01 DK062420-01; P30 DK063491; U01 DK062423-06; P30 DK063491-05; U01 DK062420-02; DK62422 / NIDDK NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) CZB/4/540 / Chief Scientist Office R01AI062773 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) R01DK064869 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
Identifiers: 9926437508331
Academic Unit: Prince Sattam Bin Abdulaziz University; King Abdulaziz University
Language: English
Resource Type: Journal article