Genome-wide association study identifies eight loci associated with blood pressure

Christopher Newton-Cheh; Toby Johnson; Vesela Gateva; Martin D. Tobin; Murielle Bochud; Lachlan Coin; Samer S. Najjar; Jing Hua Zhao; Simon C. Heath; Susana Eyheramendy; Konstantinos Papadakis; Benjamin F. Voight; Laura J. Scott; Feng Zhang; Martin Farrall; Toshiko Tanaka; Chris Wallace; John C. Chambers; Kay-Tee Khaw; Peter Nilsson; Pim van der Harst; Silvia Polidoro; Diederick E. Grobbee; N. Charlotte Onland-Moret; Michiel L. Bots; Louise V. Wain; Katherine S. Elliott; Alexander Teumer; Jian'an Luan; Gavin Lucas; Johanna Kuusisto; Paul R. Burton; David Hadley; Wendy L. McArdle; Morris Brown; Anna Dominiczak; Stephen J. Newhouse; Nilesh J. Samani; John Webster; Eleftheria Zeggini; Jacques S. Beckmann; Sven Bergmann; Noha Lim; Kijoung Song; Peter Vollenweider; Gerard Waeber; Dawn M. Waterworth; Xin Yuan; Leif Groop; Marju Orho-Melander; Alessandra Allione; Alessandra Di Gregorio; Simonetta Guarrera; Salvatore Panico; Fulvio Ricceri; Valeria Romanazzi; Carlotta Sacerdote; Paolo Vineis; Ines Barroso; Manjinder S. Sandhu; Robert N. Luben; Gabriel J. Crawford; Pekka Jousilahti; Markus Perola; Michael Boehnke; Lori L. Bonnycastle; Francis S. Collins; Anne U. Jackson; Karen L. Mohlke; Heather M. Stringham; Timo T. Valle; Cristen J. Willer; Richard N. Bergman; Mario A. Morken; Angela Doering; Christian Gieger; Thomas Illig; Thomas Meitinger; Elin Org; Arne Pfeufer; H. Erich Wichmann; Sekar Kathiresan; Jaume Marrugat; Christopher J. O'Donnell; Stephen M. Schwartz; David S. Siscovick; Isaac Subirana; Nelson B. Freimer; Anna-Liisa Hartikainen; Mark I. McCarthy; Paul F. O'Reilly; Leena Peltonen; Anneli Pouta; Paul E. de Jong; Harold Snieder; Wiek H. van Gilst; Robert Clarke; Anuj Goel; Anders Hamsten; John F. Peden; Udo Seedorf; Ann-Christine Syvanen; Giovanni Tognoni; Edward G. Lakatta; Serena Sanna; Paul Scheet; David Schlessinger; Angelo Scuteri; Marcus Doerr; Florian Ernst; Stephan B. Felix; Georg Homuth; Roberto Lorbeer; Thorsten Reffelmann; Rainer Rettig; Uwe Voelker; Pilar Galan; Ivo G. Gut; Serge Hercberg; G. Mark Lathrop; Diana Zelenika; Panos Deloukas; Nicole Soranzo; Frances M. Williams; Guangju Zhai; Veikko Salomaa; Markku Laakso; Roberto Elosua; Nita G. Forouhi; Henry Volzke; Cuno S. Uiterwaal; Yvonne T. van der Schouw; Mattijs E. Numans; Giuseppe Matullo; Gerjan Navis; Goran Berglund; Sheila A. Bingham; Jaspal S. Kooner; John M. Connell; Stefania Bandinelli; Luigi Ferrucci; Hugh Watkins; Tim D. Spector; Jaakko Tuomilehto; David Altshuler; David P. Strachan; Maris Laan; Pierre Meneton; Nicholas J. Wareham; Manuela Uda; Marjo-Riitta Jarvelin; Vincent Mooser; Olle Melander; Ruth J. F. Loos; Paul Elliott; Goncalo R. Abecasis; Mark Caulfield; Patricia B. Munroe; Wellcome Trust Case Control Consor

doi:10.1038/ng.361

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Genome-wide association study identifies eight loci associated with blood pressure

Journal article

Peer reviewed

Genome-wide association study identifies eight loci associated with blood pressure

Christopher Newton-Cheh, Toby Johnson, Vesela Gateva, Martin D. Tobin, Murielle Bochud, Lachlan Coin, Samer S. Najjar, Jing Hua Zhao, Simon C. Heath, Susana Eyheramendy, …

Nature genetics, Vol.41(6), pp.666-676

01/06/2009

DOI: https://doi.org/10.1038/ng.361

PMID: 19430483

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

Elevated blood pressure is a common, heritable cause of cardiovascular disease worldwide. To date, identification of common genetic variants influencing blood pressure has proven challenging. We tested 2.5 million genotyped and imputed SNPs for association with systolic and diastolic blood pressure in 34,433 subjects of European ancestry from the Global BPgen consortium and followed up findings with direct genotyping (N <= 71,225 European ancestry, N <= 12,889 Indian Asian ancestry) and in silico comparison (CHARGE consortium, N 29,136). We identified association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 x 10(-24)), CYP1A2 (P = 1 x 10(-23)), FGF5 (P = 1 x 10(-21)), SH2B3 (P = 3 x 10(-18)), MTHFR (P = 2 x 10(-13)), c10orf107 (P = 1 x 10(-9)), ZNF652 (P = 5 x 10(-9)) and PLCD3 (P = 1 x 10(-8)) genes. All variants associated with continuous blood pressure were associated with dichotomous hypertension. These associations between common variants and blood pressure and hypertension offer mechanistic insights into the regulation of blood pressure and may point to novel targets for interventions to prevent cardiovascular disease.

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Title: Genome-wide association study identifies eight loci associated with blood pressure
Creators - without role: Christopher Newton-Cheh - Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA
Toby Johnson - University of Lausanne
Vesela Gateva - Biostat
Martin D. Tobin - University of Leicester
Murielle Bochud - College Station Medical Center
Lachlan Coin - University of London
Samer S. Najjar - NIA, Cardiovasc Sci Lab, Intramural Res Program, NIH, Baltimore, MD 21224 USA
Jing Hua Zhao - Massachusetts Rehabilitation Commission
Simon C. Heath - Evry
Susana Eyheramendy - Pontificia Univ Catolica Chile, Fac Matemat, Santiago, Chile
Konstantinos Papadakis - University of London
Benjamin F. Voight - Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA
Laura J. Scott - Biostat
Feng Zhang - Kings Coll London, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England
Martin Farrall - University of Oxford
Toshiko Tanaka - Medstar Res Inst, Baltimore, MD USA
Chris Wallace - Queen Mary University of London
John C. Chambers - University of London
Kay-Tee Khaw - Institut de Recherche en Génie Civil et Mécanique
Peter Nilsson - Malmö University
Pim van der Harst - University of Groningen
Silvia Polidoro - ISI Fdn Inst Sci Interchange, Turin, Italy
Diederick E. Grobbee - College Station Medical Center
N. Charlotte Onland-Moret - College Station Medical Center
Michiel L. Bots - College Station Medical Center
Louise V. Wain - University of Leicester
Katherine S. Elliott - Wellcome Trust
Alexander Teumer - University of Greifswald
Jian'an Luan - Massachusetts Rehabilitation Commission
Gavin Lucas - College Station Medical Center
Johanna Kuusisto - College Station Medical Center
Paul R. Burton - University of Leicester
David Hadley - University of London
Wendy L. McArdle - University of Bristol
Morris Brown - University of Cambridge
Anna Dominiczak - University of Glasgow
Stephen J. Newhouse - Queen Mary University of London
Nilesh J. Samani - University of Leicester
John Webster - Aberdeen Royal Infirm, Aberdeen, Scotland
Eleftheria Zeggini - Wellcome Trust
Jacques S. Beckmann - University of Lausanne
Sven Bergmann - University of Lausanne
Noha Lim - GlaxoSmithKline, Div Genet, King Of Prussia, PA USA
Kijoung Song - GlaxoSmithKline
Peter Vollenweider - College Station Medical Center
Gerard Waeber - College Station Medical Center
Dawn M. Waterworth - GlaxoSmithKline
Xin Yuan - GlaxoSmithKline
Leif Groop - Univ Hosp, Diabet & Endocrinol Res Unit, Dept Clin Sci, Malmo, Sweden
Marju Orho-Melander - Malmö University
Alessandra Allione
Alessandra Di Gregorio - ISI Fdn Inst Sci Interchange, Turin, Italy
Simonetta Guarrera - ISI Fdn Inst Sci Interchange, Turin, Italy
Salvatore Panico - University of Naples Federico II
Fulvio Ricceri - ISI Fdn Inst Sci Interchange, Turin, Italy
Valeria Romanazzi - ISI Fdn Inst Sci Interchange, Turin, Italy
Carlotta Sacerdote - University of Turin
Paolo Vineis - University of London
Ines Barroso - Institut de Recherche en Génie Civil et Mécanique
Manjinder S. Sandhu - Massachusetts Rehabilitation Commission
Robert N. Luben - Institut de Recherche en Génie Civil et Mécanique
Gabriel J. Crawford - Massachusetts Institute of Technology
Pekka Jousilahti - Natl Inst Welf & Hlth, Helsinki, Finland
Markus Perola - Natl Inst Welf & Hlth, Helsinki, Finland
Michael Boehnke - Biostat
Lori L. Bonnycastle - NHGRI, Genome Technol Branch, Bethesda, MD 20892 USA
Francis S. Collins - NHGRI, Genome Technol Branch, Bethesda, MD 20892 USA
Anne U. Jackson - Biostat
Karen L. Mohlke - Univ N Carolina, Dept Genet, Chapel Hill, NC USA
Heather M. Stringham - Biostat
Timo T. Valle - Natl Publ Hlth Inst, Dept Epidemiol & Hlth Promot, Diabet Unit, Helsinki, Finland
Cristen J. Willer - Biostat
Richard N. Bergman - Supreme Council Of Health
Mario A. Morken - Natl Publ Hlth Inst, Dept Epidemiol & Hlth Promot, Diabet Unit, Helsinki, Finland
Angela Doering - Helmholtz Zentrum München
Christian Gieger - Helmholtz Zentrum München
Thomas Illig - Helmholtz Zentrum München
Thomas Meitinger - Helmholtz Zentrum München
Elin Org - University of Tartu
Arne Pfeufer - Helmholtz Zentrum München
H. Erich Wichmann - Helmholtz Zentrum München
Sekar Kathiresan - Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA
Jaume Marrugat - College Station Medical Center
Christopher J. O'Donnell - Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA
Stephen M. Schwartz - University of Washington
David S. Siscovick - University of Washington
Isaac Subirana - College Station Medical Center
Nelson B. Freimer - Univ Calif Los Angeles, Gonda Ctr, Ctr Neurobehav Genet, Los Angeles, CA USA
Anna-Liisa Hartikainen - University of Oulu
Mark I. McCarthy - Wellcome Trust
Paul F. O'Reilly - University of London
Leena Peltonen - Wellcome Sanger Institute
Anneli Pouta - University of Oulu
Paul E. de Jong - University of Groningen
Harold Snieder - University of Groningen
Wiek H. van Gilst - University of Groningen
Robert Clarke - University of Oxford
Anuj Goel - University of Oxford
Anders Hamsten - Karolinska Institutet
John F. Peden - University of Oxford
Udo Seedorf - University of Münster
Ann-Christine Syvanen - Uppsala University
Giovanni Tognoni - Ist Ric Farmacol Mario Negri, Consorzio Mario Negri Sud, I-66030 Santa Maria Imbaro, Chieti, Italy
Edward G. Lakatta - NIA, Cardiovasc Sci Lab, Intramural Res Program, NIH, Baltimore, MD 21224 USA
Serena Sanna - CNR, Inst Neurogenet & Neurofarmacol, Cagliari, Italy
Paul Scheet - Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Houston, TX 77030 USA
David Schlessinger - NIA, Genet Lab, Intramural Res Program, NIH, Baltimore, MD 21224 USA
Angelo Scuteri - Istituto Nazionale di Riposo e Cura per Anziani
Marcus Doerr - University of Greifswald
Florian Ernst - University of Greifswald
Stephan B. Felix - University of Greifswald
Georg Homuth - University of Greifswald
Roberto Lorbeer - University of Greifswald
Thorsten Reffelmann - University of Greifswald
Rainer Rettig - University of Greifswald
Uwe Voelker - University of Greifswald
Pilar Galan - Université Paris Cité
Ivo G. Gut - Evry
Serge Hercberg - Université Paris Cité
G. Mark Lathrop - Evry
Diana Zelenika - Evry
Panos Deloukas - Institut de Recherche en Génie Civil et Mécanique
Nicole Soranzo - Kings Coll London, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England
Frances M. Williams - Kings Coll London, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England
Guangju Zhai - Kings Coll London, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England
Veikko Salomaa - Natl Inst Welf & Hlth, Helsinki, Finland
Markku Laakso - College Station Medical Center
Roberto Elosua - College Station Medical Center
Nita G. Forouhi - Massachusetts Rehabilitation Commission
Henry Volzke
Cuno S. Uiterwaal - College Station Medical Center
Yvonne T. van der Schouw - College Station Medical Center
Mattijs E. Numans - College Station Medical Center
Giuseppe Matullo - ISI Fdn Inst Sci Interchange, Turin, Italy
Gerjan Navis - University of Groningen
Goran Berglund - Malmö University
Sheila A. Bingham - Institut de Recherche en Génie Civil et Mécanique
Jaspal S. Kooner - University of London
John M. Connell - University of Glasgow
Stefania Bandinelli - Florence
Luigi Ferrucci - NIA, Clin Res Branch, Baltimore, MD 21224 USA
Hugh Watkins - University of Oxford
Tim D. Spector - Kings Coll London, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England
Jaakko Tuomilehto - Natl Publ Hlth Inst, Dept Epidemiol & Hlth Promot, Diabet Unit, Helsinki, Finland
David Altshuler - Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA
David P. Strachan - University of London
Maris Laan - University of Tartu
Pierre Meneton - Descartes
Nicholas J. Wareham - Massachusetts Rehabilitation Commission
Manuela Uda - CNR, Inst Neurogenet & Neurofarmacol, Cagliari, Italy
Marjo-Riitta Jarvelin - University of London
Vincent Mooser - GlaxoSmithKline
Olle Melander - Malmö University
Ruth J. F. Loos - Massachusetts Rehabilitation Commission
Paul Elliott - University of London
Goncalo R. Abecasis - Biostat
Mark Caulfield - Queen Mary University of London
Patricia B. Munroe - Queen Mary University of London
Wellcome Trust Case Control Consor
Publication Details: Nature genetics, Vol.41(6), pp.666-676
Publisher: NATURE PORTFOLIO
Number of pages: 11
Grant note: U54 RR020278; U54RR020278 / NCRR NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) U01 DK062370; U01DK062418; R56 DK062370; R01 DK062370; DK072193; U01 DK062418; R01 DK072193; DK062370 / NIDDK NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) P30ES007033; P30 ES007033 / NIEHS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) N01HD013107 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) R01HL087676; K23 HL080025; R01 HL056931-03; R01HL056931; R01 HL056931-04; R01HL087679; R01 HL056931-02; R01 HL087679; R01 HL087676; K23HL80025; K23HL083102; K23 HL080025-04; K23 HL083102 / NHLBI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) 070191/Z/03/Z; 079557; 090532; 089061; WT088885/Z/09/Z; 076113; 077016/Z/05/Z; 076113/B/04/Z; 077011; 068545/Z/02; 088885; 079895; 077016; 061858 / Wellcome Trust; European Commission K23HL080025 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) P30ES007033 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) U54RR020278 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) MC_qA137934 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) RL1 MH083268; RL1MH083268 / NIMH NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) 263MD821336; 263MD916413 / NIMHD NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Minority Health & Health Disparities (NIMHD) RL1MH083268 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) N01AG-821336; N01AG-916413; N01-AG-1-2109 / NIA NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) MC_qA137934 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission 1Z01HG000024 / NHGRI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) 263-MA-410953 / PHS HHS; United States Department of Health & Human Services; United States Public Health Service G9521010; G0801056; MC_U106188470; MC_QA137934; G0000934; G0401527; MC_U137686857; G0501942; G0400874; G0800675; MC_U105630924; G0600329; G9521010D; G0800759; G0701863; 85374 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission U54 DA021519; U54DA021519 / NIDA NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA) FS/05/061/19501; PG02/128; SP/04/002 / British Heart Foundation U01DK062370 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) CZB/4/540 / Chief Scientist Office N01-HD-1-3107 / NICHD NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) ZIAAG000675 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) 10589 / Cancer Research UK U54DA021519 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission Associazione Italiana per la Ricerca sul Cancro; Fondazione AIRC per la ricerca sul cancro Z01 HG000024 / Intramural NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA ZIAHG000024 / NATIONAL HUMAN GENOME RESEARCH INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI)
Identifiers: 9937238508331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article