Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Louise V. Wain; Germaine C. Verwoert; Paul F. O'Reilly; Gang Shi; Toby Johnson; Andrew D. Johnson; Murielle Bochud; Kenneth M. Rice; Peter Henneman; Albert V. Smith; Georg B. Ehret; Najaf Amin; Martin G. Larson; Vincent Mooser; David Hadley; Marcus Doerr; Joshua C. Bis; Thor Aspelund; Tonu Esko; A. Cecile J. W. Janssens; Jing Hua Zhao; Simon Heath; Maris Laan; Jingyuan Fu; Giorgio Pistis; Jian'an Luan; Pankaj Arora; Gavin Lucas; Nicola Pirastu; Irene Pichler; Anne U. Jackson; Rebecca J. Webster; Feng Zhang; John F. Peden; Helena Schmidt; Toshiko Tanaka; Harry Campbell; Wilmar Igl; Yuri Milaneschi; Jouke-Jan Hottenga; Veronique Vitart; Daniel I. Chasman; Stella Trompet; Jennifer L. Bragg-Gresham; Behrooz Z. Alizadeh; John C. Chambers; Xiuqing Guo; Terho Lehtimaki; Brigitte Kuehnel; Lorna M. Lopez; Ozren Polasek; Mladen Boban; Christopher P. Nelson; Alanna C. Morrison; Vasyl Pihur; Santhi K. Ganesh; Albert Hofman; Suman Kundu; Francesco U. S. Mattace-Raso; Fernando Rivadeneira; Eric J. G. Sijbrands; Andre G. Uitterlinden; Shih-Jen Hwang; Ramachandran S. Vasan; Thomas J. Wang; Sven Bergmann; Peter Vollenweider; Gerard Waeber; Jaana Laitinen; Anneli Pouta; Paavo Zitting; Wendy L. McArdle; Heyo K. Kroemer; Uwe Voelker; Henry Voelzke; Nicole L. Glazer; Kent D. Taylor; Tamara B. Harris; Helene Alavere; Toomas Haller; Aime Keis; Mari-Liis Tammesoo; Yurii Aulchenko; Ines Barroso; Kay-Tee Khaw; Pilar Galan; Serge Hercberg; Mark Lathrop; Susana Eyheramendy; Elin Org; Siim Sober; Xiaowen Lu; Ilja M. Nolte; Brenda W. Penninx; Tanguy Corre; Corrado Masciullo; Cinzia Sala; Leif Groop; Benjamin F. Voight; Olle Melander; Christopher J. O'Donnell; Veikko Salomaa; Adamo Pio d'Adamo; Antonella Fabretto; Flavio Faletra; Sheila Ulivi; Fabiola M. Del Greco; Maurizio Facheris; Francis S. Collins; Richard N. Bergman; John P. Beilby; Joseph Hung; A. William Musk; Massimo Mangino; So-Youn Shin; Nicole Soranzo; Hugh Watkins; Anuj Goel; Anders Hamsten; Pierre Gider; Marisa Loitfelder; Marion Zeginigg; Dena Hernandez; Samer S. Najjar; Pau Navarro; Sarah H. Wild; Anna Maria Corsi; Andrew Singleton; Eco J. C. de Geus; Gonneke Willemsen; Alex N. Parker; Lynda M. Rose; Brendan Buckley; David Stott; Marco Orru; Manuela Uda; Melanie M. van der Klauw; Weihua Zhang; Xinzhong Li; James Scott; Yii-Der Ida Chen; Gregory L. Burke; Mika Kahonen; Jorma Viikari; Angela Doering; Thomas Meitinger; Gail Davies; John M. Starr; Valur Emilsson; Andrew Plump; Jan H. Lindeman; Peter A. C. 't Hoen; Inke R. Koenig; Janine F. Felix; Robert Clarke; Jemma C. Hopewell; Halit Ongen; Monique Breteler; Stephanie Debette; Anita L. DeStefano; Myriam Fornage; Gary F. Mitchell; Nicholas L. Smith; Hilma Holm; Kari Stefansson; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Nilesh J. Samani; Michael Preuss; Igor Rudan; Caroline Hayward; Ian J. Deary; H-Erich Wichmann; Olli T. Raitakari; Walter Palmas; Jaspal S. Kooner; Ronald P. Stolk; J. Wouter Jukema; Alan F. Wright; Dorret I. Boomsma; Stefania Bandinelli; Ulf B. Gyllensten; James F. Wilson; Luigi Ferrucci; Reinhold Schmidt; Martin Farrall; Tim D. Spector; Lyle J. Palmer; Jaakko Tuomilehto; Arne Pfeufer; Paolo Gasparini; David Siscovick; David Altshuler; Ruth J. F. Loos; Daniela Toniolo; Harold Snieder; Christian Gieger; Pierre Meneton; Nicholas J. Wareham; Ben A. Oostra; Andres Metspalu; Lenore Launer; Rainer Rettig; David P. Strachan; Jacques S. Beckmann; Jacqueline C. M. Witteman; Jeanette Erdmann; Ko Willems van Dijk; Eric Boerwinkle; Michael Boehnke; Paul M. Ridker; Marjo-Riitta Jarvelin; Aravinda Chakravarti; Goncalo R. Abecasis; Vilmundur Gudnason; Christopher Newton-Cheh; Daniel Levy; Patricia B. Munroe; Bruce M. Psaty; Mark J. Caulfield; Dabeeru C. Rao; Martin D. Tobin; Paul Elliott; Cornelia M. van Duijn; CHARGE Consortium Heart Failure

doi:10.1038/ng.922

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Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Journal article

Peer reviewed

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure

Louise V. Wain, Germaine C. Verwoert, Paul F. O'Reilly, Gang Shi, Toby Johnson, Andrew D. Johnson, Murielle Bochud, Kenneth M. Rice, Peter Henneman, Albert V. Smith, …

Nature genetics, Vol.43(10), pp.1005-U122

01/10/2011

DOI: https://doi.org/10.1038/ng.922

PMCID: PMC3445021

PMID: 21909110

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans(1-3). We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 x 10(-8) to P = 2.3 x 10(-13)) four new PP loci (at 4q12 near CHIC2, 7q22.3 near PIK3CG, 8q24.12 in NOV and 11q24.3 near ADAMTS8), two new MAP loci (3p21.31 in MAP4 and 10q25.3 near ADRB1) and one locus associated with both of these traits (2q24.3 near FIGN) that has also recently been associated with SBP in east Asians. For three of the new PP loci, the estimated effect for SBP was opposite of that for DBP, in contrast to the majority of common SBP- and DBP-associated variants, which show concordant effects on both traits. These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP.

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Title: Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure
Creators - without role: Louise V. Wain - University of Leicester
Germaine C. Verwoert - Erasmus MC
Paul F. O'Reilly - University of London
Gang Shi - Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA
Toby Johnson - Queen Mary University of London
Andrew D. Johnson - Framingham Heart Study
Murielle Bochud - College Station Medical Center
Kenneth M. Rice - University of Washington
Peter Henneman - Leiden University
Albert V. Smith - Iceland Heart Assoc, Kopavogur, Iceland
Georg B. Ehret - Johns Hopkins University
Najaf Amin - Erasmus MC
Martin G. Larson - Framingham Heart Study
Vincent Mooser - GlaxoSmithKline
David Hadley - University of London
Marcus Doerr - University of Greifswald
Joshua C. Bis - University of Washington
Thor Aspelund - Iceland Heart Assoc, Kopavogur, Iceland
Tonu Esko - University of Tartu
A. Cecile J. W. Janssens - Erasmus MC
Jing Hua Zhao - College Station Medical Center
Simon Heath - Evry
Maris Laan - University of Tartu
Jingyuan Fu - University of Groningen
Giorgio Pistis - Mylan
Jian'an Luan - College Station Medical Center
Pankaj Arora - Massachusetts Gen Hosp, Cardiovasc Res Ctr, Ctr Human Genet Res, Boston, MA 02114 USA
Gavin Lucas - College Station Medical Center
Nicola Pirastu - University of Trieste
Irene Pichler - College Station Medical Center
Anne U. Jackson - Biostat
Rebecca J. Webster - University of Western Australia
Feng Zhang - Kings Coll London, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England
John F. Peden - University of Oxford
Helena Schmidt - University of Graz
Toshiko Tanaka - NIA, Clin Res Branch, Baltimore, MD 21224 USA
Harry Campbell - University of Edinburgh
Wilmar Igl - Uppsala University
Yuri Milaneschi - NIA, Clin Res Branch, Baltimore, MD 21224 USA
Jouke-Jan Hottenga - University of Amsterdam
Veronique Vitart - College Station Medical Center
Daniel I. Chasman - Brigham and Women's Hospital
Stella Trompet - Leiden University
Jennifer L. Bragg-Gresham - Biostat
Behrooz Z. Alizadeh - University of Groningen
John C. Chambers - University of London
Xiuqing Guo - College Station Medical Center
Terho Lehtimaki - University of Tampere
Brigitte Kuehnel - Helmholtz Zentrum München
Lorna M. Lopez - University of Edinburgh
Ozren Polasek - University of Split
Mladen Boban - University of Split
Christopher P. Nelson - University of Leicester
Alanna C. Morrison - Supreme Council Of Health
Vasyl Pihur - Johns Hopkins University
Santhi K. Ganesh - College Station Medical Center
Albert Hofman - Erasmus MC
Suman Kundu - Erasmus MC
Francesco U. S. Mattace-Raso - Erasmus MC
Fernando Rivadeneira - Erasmus MC
Eric J. G. Sijbrands - Erasmus MC
Andre G. Uitterlinden - Erasmus MC
Shih-Jen Hwang - Framingham Heart Study
Ramachandran S. Vasan - Framingham Heart Study
Thomas J. Wang - Framingham Heart Study
Sven Bergmann - University of Lausanne
Peter Vollenweider - College Station Medical Center
Gerard Waeber - College Station Medical Center
Jaana Laitinen - Finnish Inst Occupat Hlth, Oulu, Finland
Anneli Pouta - Natl Inst Hlth & Welf, Dept Children Young People & Families, Oulu, Finland
Paavo Zitting - Lapland Cent Hosp, Dept Physiatr, Rovaniemi, Finland
Wendy L. McArdle - University of Bristol
Heyo K. Kroemer - University of Greifswald
Uwe Voelker - University of Greifswald
Henry Voelzke - University of Greifswald
Nicole L. Glazer - Boston University
Kent D. Taylor - College Station Medical Center
Tamara B. Harris - NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA
Helene Alavere - University of Tartu
Toomas Haller - University of Tartu
Aime Keis - University of Tartu
Mari-Liis Tammesoo - University of Tartu
Yurii Aulchenko - Erasmus MC
Ines Barroso - Wellcome Sanger Institute
Kay-Tee Khaw - University of Cambridge
Pilar Galan - Inserm
Serge Hercberg - Inserm
Mark Lathrop - Evry
Susana Eyheramendy - Pontificia Univ Catolica Chile, Dept Stat, Santiago, Chile
Elin Org - University of Tartu
Siim Sober - University of Tartu
Xiaowen Lu - University of Groningen
Ilja M. Nolte - University of Groningen
Brenda W. Penninx - University of Amsterdam
Tanguy Corre - Mylan
Corrado Masciullo - Ist Sci San Raffaele, Div Genet & Cell Biol, I-20132 Milan, Italy
Cinzia Sala - Mylan
Leif Groop - Malmö University
Benjamin F. Voight - Broad Institute
Olle Melander - Malmö University
Christopher J. O'Donnell - Framingham Heart Study
Veikko Salomaa - THL Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland
Adamo Pio d'Adamo - University of Trieste
Antonella Fabretto
Flavio Faletra
Sheila Ulivi
Fabiola M. Del Greco - College Station Medical Center
Maurizio Facheris - College Station Medical Center
Francis S. Collins - NHGRI, NIH, Bethesda, MD 20892 USA
Richard N. Bergman - Supreme Council Of Health
John P. Beilby - College Station Medical Center
Joseph Hung - College Station Medical Center
A. William Musk - College Station Medical Center
Massimo Mangino - Kings Coll London, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England
So-Youn Shin - Kings Coll London, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England
Nicole Soranzo - Kings Coll London, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England
Hugh Watkins - University of Oxford
Anuj Goel - University of Oxford
Anders Hamsten - Karolinska Institutet
Pierre Gider - University of Graz
Marisa Loitfelder - University of Graz
Marion Zeginigg - University of Graz
Dena Hernandez - NIA, Neurogenet Lab, Bethesda, MD 20892 USA
Samer S. Najjar - NIA, Cardiovasc Sci Lab, Intramural Res Program, NIH, Baltimore, MD 21224 USA
Pau Navarro - College Station Medical Center
Sarah H. Wild - University of Edinburgh
Anna Maria Corsi - Florence
Andrew Singleton - NIA, Neurogenet Lab, Bethesda, MD 20892 USA
Eco J. C. de Geus - University of Amsterdam
Gonneke Willemsen - University of Amsterdam
Alex N. Parker - Amgen
Lynda M. Rose - Brigham and Women's Hospital
Brendan Buckley - Univ Coll Cork, Dept Pharmacol & Therapeut, Cork, Ireland
David Stott - University of Glasgow
Marco Orru - CNR, Ist Neurogenet & Neurofarmacol, Monserrato, Italy
Manuela Uda - CNR, Ist Neurogenet & Neurofarmacol, Monserrato, Italy
Melanie M. van der Klauw - University of Groningen
Weihua Zhang - University of London
Xinzhong Li - University of London
James Scott - University of London
Yii-Der Ida Chen - College Station Medical Center
Gregory L. Burke - Wake Forest University
Mika Kahonen - University of Tampere
Jorma Viikari - University of Turku
Angela Doering - Helmholtz Zentrum München
Thomas Meitinger - Helmholtz Zentrum München
Gail Davies - University of Edinburgh
John M. Starr - University of Edinburgh
Valur Emilsson - Iceland Heart Assoc, Kopavogur, Iceland
Andrew Plump - Merck Res Lab, Rahway, NJ USA
Jan H. Lindeman - Leiden University
Peter A. C. 't Hoen - Leiden University
Inke R. Koenig - University of Lübeck
Janine F. Felix - Erasmus MC
Robert Clarke - University of Oxford
Jemma C. Hopewell - University of Oxford
Halit Ongen - University of Oxford
Monique Breteler - Erasmus MC
Stephanie Debette - Boston University
Anita L. DeStefano - Boston University
Myriam Fornage - College Station Medical Center
Gary F. Mitchell - Cardiovasc Engn Inc, Norwood, MA USA
Nicholas L. Smith - University of Washington
Hilma Holm - deCODE Genet Inc, Reykjavik, Iceland
Kari Stefansson - deCODE Genet Inc, Reykjavik, Iceland
Gudmar Thorleifsson - deCODE Genet Inc, Reykjavik, Iceland
Unnur Thorsteinsdottir - deCODE Genet Inc, Reykjavik, Iceland
Nilesh J. Samani - University of Leicester
Michael Preuss - University of Lübeck
Igor Rudan - University of Edinburgh
Caroline Hayward - College Station Medical Center
Ian J. Deary - University of Edinburgh
H-Erich Wichmann - Helmholtz Zentrum München
Olli T. Raitakari - University of Turku
Walter Palmas - Columbia University
Jaspal S. Kooner - Ealing Hosp Natl Hlth Serv NHS Trust, Middlesex, England
Ronald P. Stolk
J. Wouter Jukema - Leiden University
Alan F. Wright - College Station Medical Center
Dorret I. Boomsma - University of Amsterdam
Stefania Bandinelli - Florence
Ulf B. Gyllensten - Uppsala University
James F. Wilson - University of Edinburgh
Luigi Ferrucci - NIA, Clin Res Branch, Baltimore, MD 21224 USA
Reinhold Schmidt - University of Graz
Martin Farrall - University of Oxford
Tim D. Spector - Kings Coll London, Dept Twin Res & Genet Epidemiol, London WC2R 2LS, England
Lyle J. Palmer - University of Western Australia
Jaakko Tuomilehto - Natl Inst Hlth & Welf, Diabet Prevent Unit, Helsinki, Finland
Arne Pfeufer - College Station Medical Center
Paolo Gasparini - University of Trieste
David Siscovick - University of Washington
David Altshuler - Broad Institute
Ruth J. F. Loos - College Station Medical Center
Daniela Toniolo - Ist Sci San Raffaele, Div Genet & Cell Biol, I-20132 Milan, Italy
Harold Snieder - University of Groningen
Christian Gieger - Helmholtz Zentrum München
Pierre Meneton - Inserm
Nicholas J. Wareham - College Station Medical Center
Ben A. Oostra - Erasmus MC
Andres Metspalu - University of Tartu
Lenore Launer - NIA, Lab Epidemiol Demog & Biometry, Bethesda, MD 20892 USA
Rainer Rettig - University of Greifswald
David P. Strachan - University of London
Jacques S. Beckmann - University of Lausanne
Jacqueline C. M. Witteman - Erasmus MC
Jeanette Erdmann - University of Lübeck
Ko Willems van Dijk - Leiden University
Eric Boerwinkle - Ctr Human Genet, Houston, TX USA
Michael Boehnke - Biostat
Paul M. Ridker - Brigham and Women's Hospital
Marjo-Riitta Jarvelin - University of London
Aravinda Chakravarti - Johns Hopkins University
Goncalo R. Abecasis - Biostat
Vilmundur Gudnason - Iceland Heart Assoc, Kopavogur, Iceland
Christopher Newton-Cheh - Massachusetts Gen Hosp, Cardiovasc Res Ctr, Ctr Human Genet Res, Boston, MA 02114 USA
Daniel Levy - Framingham Heart Study
Patricia B. Munroe - Queen Mary University of London
Bruce M. Psaty - University of Washington
Mark J. Caulfield - Queen Mary University of London
Dabeeru C. Rao - Washington Univ, Sch Med, Div Biostat, St Louis, MO 63110 USA
Martin D. Tobin - University of Leicester
Paul Elliott - University of London
Cornelia M. van Duijn - Erasmus MC
CHARGE Consortium Heart Failure
Publication Details: Nature genetics, Vol.43(10), pp.1005-U122
Publisher: Springer Nature
Number of pages: 8
Grant note: G0700704 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) P 20545 / Austrian Science Fund (FWF) National Heart, Lung, and Blood Institute, European US National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA BB/F019394/1 / Biotechnology and Biological Sciences Research Council; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC) BB/F019394/1 / BBSRC; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC) R01MD009164 / National Institute on Minority Health and Health Disparities; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Minority Health & Health Disparities (NIMHD) R01HL043851 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) RP24/2/2006 / Kidney Research UK; Kidney Research UK (KRUK) N01HC025195 / DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Eye Institute (NEI) CZB/4/505 / Chief Scientist Office NF-SI-0507-10315 / National Institute for Health Research; National Institute for Health Research (NIHR) G0701863 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission ZIAHG000024 / NATIONAL HUMAN GENOME RESEARCH INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) ZIAAG007480 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
Identifiers: 9936821708331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article