Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

Jaspal S. Kooner; Danish Saleheen; Xueling Sim; Joban Sehmi; Weihua Zhang; Philippe Frossard; Latonya F. Been; Kee-Seng Chia; Antigone S. Dimas; Neelam Hassanali; Tazeen Jafar; Jeremy B. M. Jowett; Xinzhong Li; Venkatesan Radha; Simon D. Rees; Fumihiko Takeuchi; Robin Young; Tin Aung; Abdul Basit; Manickam Chidambaram; Debashish Das; Elin Grundberg; Asa K. Hedman; Zafar I. Hydrie; Muhammed Islam; Chiea-Chuen Khor; Sudhir Kowlessur; Malene M. Kristensen; Samuel Liju; Wei-Yen Lim; David R. Matthews; Jianjun Liu; Andrew P. Morris; Alexandra C. Nica; Janani M. Pinidiyapathirage; Inga Prokopenko; Asif Rasheed; Maria Samuel; Nabi Shah; A. Samad Shera; Kerrin S. Small; Chen Suo; Ananda R. Wickremasinghe; Tien Yin Wong; Mingyu Yang; Fan Zhang; Goncalo R. Abecasis; Anthony H. Barnett; Mark Caulfield; Panos Deloukas; Timothy M. Frayling; Philippe Froguel; Norihiro Kato; Prasad Katulanda; M. Ann Kelly; Junbin Liang; Viswanathan Mohan; Dharambir K. Sanghera; James Scott; Mark Seielstad; Paul Z. Zimmet; Paul Elliott; Yik Ying Teo; Mark I. McCarthy; John Danesh; E. Shyong Tai; John C. Chambers; DIAGRAM

doi:10.1038/ng.921

Back

Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

Journal article

Peer reviewed

Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

Jaspal S. Kooner, Danish Saleheen, Xueling Sim, Joban Sehmi, Weihua Zhang, Philippe Frossard, Latonya F. Been, Kee-Seng Chia, Antigone S. Dimas, Neelam Hassanali, …

Nature genetics, Vol.43(10), pp.984-U94

01/10/2011

DOI: https://doi.org/10.1038/ng.921

PMID: 21874001

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

We carried out a genome-wide association study of type-2 diabetes (T2D) in individuals of South Asian ancestry. Our discovery set included 5,561 individuals with T2D (cases) and 14,458 controls drawn from studies in London, Pakistan and Singapore. We identified 20 independent SNPs associated with T2D at P < 10(-4) for testing in a replication sample of 13,170 cases and 25,398 controls, also all of South Asian ancestry. In the combined analysis, we identified common genetic variants at six loci (GRB14, ST6GAL1, VPS26A, HMG20A, AP3S2 and HNF4A) newly associated with T2D (P = 4.1 x 10(-8) to P = 1.9 x 10(-11)). SNPs at GRB14 were also associated with insulin sensitivity (P = 5.0 x 10(-4)), and SNPs at ST6GAL1 and HNF4A were also associated with pancreatic beta-cell function (P = 0.02 and P = 0.001, respectively). Our findings provide additional insight into mechanisms underlying T2D and show the potential for new discovery from genetic association studies in South Asians, a population with increased susceptibility to T2D.

Metrics

1 Record Views

See more details

Details

Title: Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci
Creators - without role: Jaspal S. Kooner - National Institutes of Health
Danish Saleheen - University of Cambridge
Xueling Sim - National University of Singapore
Joban Sehmi - National Institutes of Health
Weihua Zhang - Imperial College London
Philippe Frossard - Ctr Noncommunicable Dis Pakistan, Karachi, Pakistan
Latonya F. Been - University of Oklahoma
Kee-Seng Chia - National University of Singapore
Antigone S. Dimas - University of Oxford
Neelam Hassanali - University of Oxford
Tazeen Jafar - Aga Khan University
Jeremy B. M. Jowett - The Heart Research Institute
Xinzhong Li - Imperial College London
Venkatesan Radha - Indian Council of Medical Research
Simon D. Rees - University of Birmingham
Fumihiko Takeuchi - College Station Medical Center
Robin Young - University of Cambridge
Tin Aung - Duke-NUS Medical School
Abdul Basit - Baqai Inst Diabetol & Endocrinol, Karachi, Pakistan
Manickam Chidambaram - Indian Council of Medical Research
Debashish Das - National Health Service
Elin Grundberg - King's College London
Asa K. Hedman - University of Oxford
Zafar I. Hydrie - Baqai Inst Diabetol & Endocrinol, Karachi, Pakistan
Muhammed Islam - Aga Khan University
Chiea-Chuen Khor - Agency for Science, Technology and Research
Sudhir Kowlessur - Minist Hlth, Port Louis, Mauritius
Malene M. Kristensen - The Heart Research Institute
Samuel Liju - Indian Council of Medical Research
Wei-Yen Lim - National University of Singapore
David R. Matthews - University of Oxford
Jianjun Liu - Agency for Science, Technology and Research
Andrew P. Morris - University of Oxford
Alexandra C. Nica - University of Geneva
Janani M. Pinidiyapathirage - University of Kelaniya
Inga Prokopenko - University of Oxford
Asif Rasheed - Ctr Noncommunicable Dis Pakistan, Karachi, Pakistan
Maria Samuel - Ctr Noncommunicable Dis Pakistan, Karachi, Pakistan
Nabi Shah - Ctr Noncommunicable Dis Pakistan, Karachi, Pakistan
A. Samad Shera - Diabet Assoc Pakistan, Karachi, Pakistan
Kerrin S. Small - King's College London
Chen Suo - National University of Singapore
Ananda R. Wickremasinghe - University of Kelaniya
Tien Yin Wong - University of Melbourne
Mingyu Yang - Beijing Genom Inst, Shenzhen, Peoples R China
Fan Zhang - BGI Group
Goncalo R. Abecasis - University of Michigan–Ann Arbor
Anthony H. Barnett - University of Birmingham
Mark Caulfield - Queen Mary University of London
Panos Deloukas - Wellcome Sanger Institute
Timothy M. Frayling - University of Exeter
Philippe Froguel - Imperial College London
Norihiro Kato - College Station Medical Center
Prasad Katulanda - University of Oxford
M. Ann Kelly - University of Birmingham
Junbin Liang - BGI Group
Viswanathan Mohan - Indian Council of Medical Research
Dharambir K. Sanghera - University of Oklahoma Health Sciences Center
James Scott - Imperial College London
Mark Seielstad - University of California, San Francisco
Paul Z. Zimmet - Baker Heart and Diabetes Institute
Paul Elliott - Imperial College London
Yik Ying Teo - Natl Univ Singapore, Ctr Mol Epidemiol, Singapore 117548, Singapore
Mark I. McCarthy - National Institute for Health Research
John Danesh - University of Cambridge
E. Shyong Tai - National University of Singapore
John C. Chambers - Imperial College London
DIAGRAM
Publication Details: Nature genetics, Vol.43(10), pp.984-U94
Publisher: Springer Nature
Number of pages: 8
Grant note: SP/04/002 / British Heart Foundation DK-25446; KO1TW006087 / US National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA NMRC/STaR/0003/2008; 1174/2008 / National Medical Research Council Singapore; National Medical Research Council, Singapore; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) G0700931; G0801056; G0601966 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) RP-PG-0407-10371; NF-SI-0508-10272 / National Institute for Health Research; National Institutes of Health Research (NIHR) 07/0003512 / Diabetes UK Ministry of Education, Culture, Sports, Science and Technology of Japan; Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) National Science Foundation of Sri Lanka G0700931 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Oxford NIHR Biomedical Research Centre; National Institutes of Health Research (NIHR) 09/1/35/19/616; 08/1/35/19/550 / Biomedical Research Council Singapore; Agency for Science Technology & Research (A*STAR) National Institute for Health Research Comprehensive Biomedical Research Centre at Imperial College Healthcare NHS Trust R01DK082766 / National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) National Center for Global Health and Medicine; National Center for Global Health & Medicine - Japan G0601966; G0801056B; G0801056; G0700931 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Chennai Wellingdon Corporate Foundation 05/1/21/19/425 / A*STAR Biomedical Research Council; Agency for Science Technology & Research (A*STAR) 070854/Z/03/Z; 080747/Z/06/Z; 083270/Z/07/Z; 084723/Z/08/Z / Wellcome Trust KAKENHI; Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT); Japan Society for the Promotion of Science; Grants-in-Aid for Scientific Research (KAKENHI) RG/08/014/24067 / British Heart Foundation RP-PG-0407-10371 / National Institute for Health Research; National Institutes of Health Research (NIHR)
Identifiers: 9939109608331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article