Genome-wide association study of germline variants and breast cancer-specific mortality

Maria Escala-Garcia; Qi Guo; Thilo Dörk; Sander Canisius; Renske Keeman; Joe Dennis; Jonathan Beesley; Julie Lecarpentier; Manjeet K Bolla; Qin Wang; Jean Abraham; Irene L Andrulis; Hoda Anton-Culver; Volker Arndt; Paul L Auer; Matthias W Beckmann; Sabine Behrens; Javier Benitez; Marina Bermisheva; Leslie Bernstein; Carl Blomqvist; Bram Boeckx; Stig E Bojesen; Bernardo Bonanni; Anne-Lise Børresen-Dale; Hiltrud Brauch; Hermann Brenner; Adam Brentnall; Louise Brinton; Per Broberg; Ian W Brock; Sara Y Brucker; Barbara Burwinkel; Carlos Caldas; Trinidad Caldés; Daniele Campa; Federico Canzian; Angel Carracedo; Brian D Carter; Jose E Castelao; Jenny Chang-Claude; Stephen J Chanock; Georgia Chenevix-Trench; Ting-Yuan David Cheng; Suet-Feung Chin; Christine L Clarke; Emilie Cordina-Duverger; Fergus J Couch; David G Cox; Angela Cox; Simon S Cross; Kamila Czene; Mary B Daly; Peter Devilee; Janet A Dunn; Alison M Dunning; Lorraine Durcan; Miriam Dwek; Helena M Earl; Arif B Ekici; A Heather Eliassen; Carolina Ellberg; Christoph Engel; Mikael Eriksson; D Gareth Evans; Jonine Figueroa; Dieter Flesch-Janys; Henrik Flyger; Marike Gabrielson; Manuela Gago-Dominguez; Eva Galle; Susan M Gapstur; Montserrat García-Closas; José A García-Sáenz; Mia M Gaudet; Angela George; Vassilios Georgoulias; Graham G Giles; Gord Glendon; David E Goldgar; Anna González-Neira; Grethe I Grenaker Alnæs; Mervi Grip; Pascal Guénel; Lothar Haeberle; Eric Hahnen; Christopher A Haiman; Niclas Håkansson; Per Hall; Ute Hamann; Susan Hankinson; Elaine F Harkness; Patricia A Harrington; Steven N Hart; Jaana M Hartikainen; Alexander Hein; Peter Hillemanns; Louise Hiller; Bernd Holleczek; Antoinette Hollestelle; Maartje J Hooning; Robert N Hoover; John L Hopper; Anthony Howell; Guanmengqian Huang; Keith Humphreys; David J Hunter; Wolfgang Janni; Esther M John; Michael E Jones; Arja Jukkola-Vuorinen; Audrey Jung; Rudolf Kaaks; Maria Kabisch; Katarzyna Kaczmarek; Michael J Kerin; Sofia Khan; Elza Khusnutdinova; Johanna I Kiiski; Cari M Kitahara; Julia A Knight; Yon-Dschun Ko; Linetta B Koppert; Veli-Matti Kosma; Peter Kraft; Vessela N Kristensen; Ute Krüger; Tabea Kühl; Diether Lambrechts; Loic Le Marchand; Eunjung Lee; Flavio Lejbkowicz; Lian Li; Annika Lindblom; Sara Lindström; Martha Linet; Jolanta Lissowska; Wing-Yee Lo; Sibylle Loibl; Jan Lubiński; Michael P Lux; Robert J MacInnis; Melanie Maierthaler; Tom Maishman; Enes Makalic; Arto Mannermaa; Mehdi Manoochehri; Siranoush Manoukian; Sara Margolin; Maria Elena Martinez; Dimitrios Mavroudis; Catriona McLean; Alfons Meindl; Pooja Middha; Nicola Miller; Roger L Milne; Fernando Moreno; Anna Marie Mulligan; Claire Mulot; Rami Nassir; Susan L Neuhausen; William T Newman; Sune F Nielsen; Børge G Nordestgaard; Aaron Norman; Håkan Olsson; Nick Orr; V Shane Pankratz; Tjoung-Won Park-Simon; Jose I A Perez; Clara Pérez-Barrios; Paolo Peterlongo; Christos Petridis; Mila Pinchev; Karoliona Prajzendanc; Ross Prentice; Nadege Presneau; Darya Prokofieva; Katri Pylkäs; Brigitte Rack; Paolo Radice; Dhanya Ramachandran; Gadi Rennert; Hedy S Rennert; Valerie Rhenius; Atocha Romero; Rebecca Roylance; Emmanouil Saloustros; Elinor J Sawyer; Daniel F Schmidt; Rita K Schmutzler; Andreas Schneeweiss; Minouk J Schoemaker; Fredrick Schumacher; Lukas Schwentner; Rodney J Scott; Christopher Scott; Caroline Seynaeve; Mitul Shah; Jacques Simard; Ann Smeets; Christof Sohn; Melissa C Southey; Anthony J Swerdlow; Aline Talhouk; Rulla M Tamimi; William J Tapper; Manuel R Teixeira; Maria Tengström; Mary Beth Terry; Kathrin Thöne; Rob A E M Tollenaar; Ian Tomlinson; Diana Torres; Thérèse Truong; Constance Turman; Clare Turnbull; Hans-Ulrich Ulmer; Michael Untch; Celine Vachon; Christi J van Asperen; Ans M W van den Ouweland; Elke M van Veen; Camilla Wendt; Alice S Whittemore; Walter Willett; Robert Winqvist; Alicja Wolk; Xiaohong R Yang; Yan Zhang; Douglas F Easton; Peter A Fasching; Heli Nevanlinna; Diana M Eccles; Paul D P Pharoah; Marjanka K Schmidt; NBCS Collaborators

doi:10.1038/s41416-019-0393-x

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Genome-wide association study of germline variants and breast cancer-specific mortality

Journal article

Open access

Peer reviewed

Genome-wide association study of germline variants and breast cancer-specific mortality

Maria Escala-Garcia, Qi Guo, Thilo Dörk, Sander Canisius, Renske Keeman, Joe Dennis, Jonathan Beesley, Julie Lecarpentier, Manjeet K Bolla, Qin Wang, …

British journal of cancer, Vol.120(6), pp.647-657

2019

DOI: https://doi.org/10.1038/s41416-019-0393-x

PMCID: PMC6461853

PMID: 30787463

Abstract

Bayes Theorem

Breast Neoplasms - genetics

Breast Neoplasms - metabolism

Breast Neoplasms - mortality

Chromosomes, Human, Pair 7

Female

Genetic Variation

Genome-Wide Association Study

Humans

Prognosis

Proportional Hazards Models

Receptors, Estrogen - genetics

Receptors, Estrogen - metabolism

Whites - genetics

We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry. Meta-analyses included summary estimates based on Cox models of twelve datasets using ~10.4 million variants for 96,661 women with breast cancer and 7697 events (breast cancer-specific deaths). Oestrogen receptor (ER)-specific analyses were based on 64,171 ER-positive (4116) and 16,172 ER-negative (2125) patients. We evaluated the probability of a signal to be a true positive using the Bayesian false discovery probability (BFDP). We did not find any variant associated with breast cancer-specific mortality at P < 5 × 10 . For ER-positive disease, the most significantly associated variant was chr7:rs4717568 (BFDP = 7%, P = 1.28 × 10 , hazard ratio [HR] = 0.88, 95% confidence interval [CI] = 0.84-0.92); the closest gene is AUTS2. For ER-negative disease, the most significant variant was chr7:rs67918676 (BFDP = 11%, P = 1.38 × 10 , HR = 1.27, 95% CI = 1.16-1.39); located within a long intergenic non-coding RNA gene (AC004009.3), close to the HOXA gene cluster. We uncovered germline variants on chromosome 7 at BFDP < 15% close to genes for which there is biological evidence related to breast cancer outcome. However, the paucity of variants associated with mortality at genome-wide significance underpins the challenge in providing genetic-based individualised prognostic information for breast cancer patients.

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Title: Genome-wide association study of germline variants and breast cancer-specific mortality
Creators - without role: Maria Escala-Garcia - The Netherlands Cancer Institute
Qi Guo - University of Cambridge
Thilo Dörk - Medizinische Hochschule Hannover
Sander Canisius - The Netherlands Cancer Institute
Renske Keeman - The Netherlands Cancer Institute
Joe Dennis - University of Cambridge
Jonathan Beesley - QIMR Berghofer Medical Research Institute
Julie Lecarpentier - University of Cambridge
Manjeet K Bolla - University of Cambridge
Qin Wang - University of Cambridge
Jean Abraham - University of Cambridge
Irene L Andrulis - University of Toronto
Hoda Anton-Culver - University of California, Irvine
Volker Arndt - Heidelberg
Paul L Auer - University of Wisconsin–Milwaukee
Matthias W Beckmann - Friedrich-Alexander-Universität Erlangen-Nürnberg
Sabine Behrens - Heidelberg
Javier Benitez - Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain
Marina Bermisheva - Ufa Scientific Center of Russian Academy of Sciences, Institute of Biochemistry and Genetics, Ufa, Russia
Leslie Bernstein - Beckman Research Institute
Carl Blomqvist - Örebro University Hospital
Bram Boeckx - KU Leuven
Stig E Bojesen - University of Copenhagen
Bernardo Bonanni - Division of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS Milan, Milan, 20141, Italy
Anne-Lise Børresen-Dale - Oslo University Hospital
Hiltrud Brauch - Heidelberg
Hermann Brenner - National Center for Tumor Diseases
Adam Brentnall - Queen Mary University of London
Louise Brinton - National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA
Per Broberg - Lund University
Ian W Brock - University of Sheffield
Sara Y Brucker - University of Tübingen
Barbara Burwinkel - Heidelberg
Carlos Caldas - Cancer Genetics
Trinidad Caldés - NICO
Daniele Campa - University of Pisa
Federico Canzian - Heidelberg
Angel Carracedo - King Abdulaziz University
Brian D Carter - American Cancer Society, Epidemiology Research Program, Atlanta, GA, USA
Jose E Castelao - Vigo
Jenny Chang-Claude - University Medical Center Hamburg-Eppendorf
Stephen J Chanock - National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA
Georgia Chenevix-Trench - QIMR Berghofer Medical Research Institute
Ting-Yuan David Cheng - Roswell Park Cancer Institute
Suet-Feung Chin - University of Cambridge
Christine L Clarke - University of Sydney
Emilie Cordina-Duverger - University of Paris-Saclay
Fergus J Couch - Mayo Clinic, Department of Laboratory Medicine and Pathology, Rochester, MN, USA
David G Cox - Cancer Research Center of Lyon
Angela Cox - University of Sheffield
Simon S Cross - University of Sheffield
Kamila Czene - Karolinska Institutet
Mary B Daly - Fox Chase Cancer Center
Peter Devilee - Leiden University Medical Center
Janet A Dunn - University of Warwick
Alison M Dunning - University of Cambridge
Lorraine Durcan - University of Southampton
Miriam Dwek - University of Westminster
Helena M Earl - University of Cambridge
Arif B Ekici - Friedrich-Alexander-Universität Erlangen-Nürnberg
A Heather Eliassen - Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA
Carolina Ellberg - Lund University
Christoph Engel - University of Leipzig, LIFE - Leipzig Research Centre for Civilization Diseases, Leipzig, Germany
Mikael Eriksson - Karolinska Institutet
D Gareth Evans - St Marys Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester Centre for Genomic Medicine, Manchester, UK
Jonine Figueroa - Edinburgh Cancer Research
Dieter Flesch-Janys - University Medical Centre Hamburg-Eppendorf, Department of Cancer Epidemiology, Clinical Cancer Registry, Hamburg, Germany
Henrik Flyger - Copenhagen University Hospital
Marike Gabrielson - Karolinska Institutet
Manuela Gago-Dominguez - University of California, San Diego
Eva Galle - KU Leuven
Susan M Gapstur - American Cancer Society, Epidemiology Research Program, Atlanta, GA, USA
Montserrat García-Closas - Institute of Cancer Research, Division of Genetics and Epidemiology, London, UK
José A García-Sáenz - NICO
Mia M Gaudet - American Cancer Society, Epidemiology Research Program, Atlanta, GA, USA
Angela George - Royal Marsden NHS Foundation Trust
Vassilios Georgoulias - University Hospital of Heraklion
Graham G Giles - Monash University
Gord Glendon - Lunenfeld-Tanenbaum Research Institute
David E Goldgar - University of Utah
Anna González-Neira - Spanish National Cancer Research Centre
Grethe I Grenaker Alnæs - Oslo University Hospital
Mervi Grip - Oulu University Hospital
Pascal Guénel - University of Paris-Saclay
Lothar Haeberle - Friedrich-Alexander-Universität Erlangen-Nürnberg
Eric Hahnen - University of Cologne
Christopher A Haiman - University of Southern California, Department of Preventive Medicine, Keck School of Medicine, Los Angeles, CA, USA
Niclas Håkansson - Karolinska Institutet
Per Hall - South General Hospital, Department of Oncology, Stockholm, Sweden
Ute Hamann - Heidelberg
Susan Hankinson - University of Massachusetts Amherst
Elaine F Harkness - Manchester University NHS Foundation Trust
Patricia A Harrington - University of Cambridge
Steven N Hart - Mayo Clinic, Department of Health Sciences Research, Rochester, MN, USA
Jaana M Hartikainen - Kuopio University Hospital
Alexander Hein - Friedrich-Alexander-Universität Erlangen-Nürnberg
Peter Hillemanns - Medizinische Hochschule Hannover
Louise Hiller - University of Warwick
Bernd Holleczek - Saarland Cancer Registry, Saarbruecken, Germany
Antoinette Hollestelle - Erasmus MC Cancer Institute
Maartje J Hooning - Erasmus MC Cancer Institute
Robert N Hoover - National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA
John L Hopper - University of Melbourne
Anthony Howell - University of Manchester
Guanmengqian Huang - Heidelberg
Keith Humphreys - Karolinska Institutet
David J Hunter - University of Oxford
Wolfgang Janni - Edinburgh Cancer Research
Esther M John - Stanford University School of Medicine
Michael E Jones - Institute of Cancer Research, Division of Genetics and Epidemiology, London, UK
Arja Jukkola-Vuorinen - Tampere University Hospital
Audrey Jung - Heidelberg
Rudolf Kaaks - Heidelberg
Maria Kabisch - Heidelberg
Katarzyna Kaczmarek - Pomeranian Medical University
Michael J Kerin - National University of Ireland
Sofia Khan - Helsinki University Hospital
Elza Khusnutdinova - Bashkir State University
Johanna I Kiiski - Helsinki University Hospital
Cari M Kitahara - National Cancer Institute, Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA
Julia A Knight - University of Toronto
Yon-Dschun Ko - Johanniter Krankenhaus, Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Bonn, Germany
Linetta B Koppert - Erasmus MC Cancer Institute
Veli-Matti Kosma - Kuopio University Hospital
Peter Kraft - Harvard T.H. Chan School of Public Health, Program in Genetic Epidemiology and Statistical Genetics, Boston, MA, USA
Vessela N Kristensen - Oslo University Hospital
Ute Krüger - Lund University
Tabea Kühl - University Medical Center Hamburg-Eppendorf
Diether Lambrechts - KU Leuven
Loic Le Marchand - University of Hawaii System
Eunjung Lee - University of Southern California, Department of Preventive Medicine, Keck School of Medicine, Los Angeles, CA, USA
Flavio Lejbkowicz - Carmel Medical Center
Lian Li - Tianjin Medical University Cancer Institute and Hospital
Annika Lindblom - Karolinska Institutet
Sara Lindström - Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, WA, USA
Martha Linet - National Cancer Institute, Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA
Jolanta Lissowska - M. Sklodowska-Curie Cancer Centre, Oncology Institute, Department of Cancer Epidemiology and Prevention, Warsaw, Poland
Wing-Yee Lo - University of Tübingen
Sibylle Loibl - German Breast group
Jan Lubiński - Pomeranian Medical University
Michael P Lux - Friedrich-Alexander-Universität Erlangen-Nürnberg
Robert J MacInnis - University of Melbourne
Melanie Maierthaler - Heidelberg
Tom Maishman - University of Southampton
Enes Makalic - University of Melbourne
Arto Mannermaa - Kuopio University Hospital
Mehdi Manoochehri - Heidelberg
Siranoush Manoukian - Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Unit of Medical Genetics, Department of Medical Oncology and Haematology, Milan, Italy
Sara Margolin - Karolinska Institutet
Maria Elena Martinez - University of California, San Diego
Dimitrios Mavroudis - University Hospital of Heraklion
Catriona McLean - The Alfred Hospital
Alfons Meindl - Ludwig Maximilian University of Munich, Department of Gynaecology and Obstetrics, Munich, Germany
Pooja Middha - Heidelberg
Nicola Miller - National University of Ireland
Roger L Milne - University of Melbourne
Fernando Moreno - NICO
Anna Marie Mulligan - University Health Network, Laboratory Medicine Program, Toronto, ON, Canada
Claire Mulot - Inserm
Rami Nassir - University of California, Davis
Susan L Neuhausen - Beckman Research Institute
William T Newman - University of Manchester
Sune F Nielsen - Copenhagen University Hospital
Børge G Nordestgaard - University of Copenhagen
Aaron Norman - Mayo Clinic, Department of Health Sciences Research, Rochester, MN, USA
Håkan Olsson - Lund University
Nick Orr - Queen's University Belfast
V Shane Pankratz - University of New Mexico, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
Tjoung-Won Park-Simon - Medizinische Hochschule Hannover
Jose I A Perez - Hospital Monte Naranco
Clara Pérez-Barrios - Hospital Universitario Puerta de Hierro, Medical Oncology Department, Madrid, Spain
Paolo Peterlongo - The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, IFOM, Milan, Italy
Christos Petridis - King's College London
Mila Pinchev - Carmel Medical Center
Karoliona Prajzendanc - Pomeranian Medical University
Ross Prentice - Hutchinson
Nadege Presneau - University of Westminster
Darya Prokofieva - Bashkir State University
Katri Pylkäs - Cancer Genetics
Brigitte Rack - Ludwig Maximilian University of Munich, Department of Gynaecology and Obstetrics, Munich, Germany
Paolo Radice - Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Milan, Italy
Dhanya Ramachandran - Medizinische Hochschule Hannover
Gadi Rennert - Carmel Medical Center
Hedy S Rennert - Carmel Medical Center
Valerie Rhenius - University of Cambridge
Atocha Romero - Hospital Universitario Puerta de Hierro, Medical Oncology Department, Madrid, Spain
Rebecca Roylance - UCLH Foundation Trust, Department of Oncology, London, UK
Emmanouil Saloustros - University Hospital of Larissa
Elinor J Sawyer - King's College London
Daniel F Schmidt - University of Melbourne
Rita K Schmutzler - University of Cologne
Andreas Schneeweiss - Heidelberg
Minouk J Schoemaker - The Institute of Cancer Research, Division of Genetics and Epidemiology, London, UK
Fredrick Schumacher - Case Western Reserve University
Lukas Schwentner - Edinburgh Cancer Research
Rodney J Scott - University of Newcastle, Centre for Information Based Medicine, Callaghan, Newcastle, NSW, Australia
Christopher Scott - Mayo Clinic
Caroline Seynaeve - Erasmus MC Cancer Institute
Mitul Shah - University of Cambridge
Jacques Simard - Centre Hospitalier Universitaire de Québec
Ann Smeets - University Hospitals Leuven, Department of Surgical Oncology, Leuven, Belgium
Christof Sohn - Heidelberg
Melissa C Southey - University of Melbourne
Anthony J Swerdlow - Korean Breast Cancer Society
Aline Talhouk - University of British Columbia
Rulla M Tamimi - Harvard T.H. Chan School of Public Health, Program in Genetic Epidemiology and Statistical Genetics, Boston, MA, USA
William J Tapper - University of Southampton
Manuel R Teixeira - Universidade do Porto
Maria Tengström - University of Eastern Finland
Mary Beth Terry - Columbia University
Kathrin Thöne - University Medical Center Hamburg-Eppendorf
Rob A E M Tollenaar - Leiden University
Ian Tomlinson - University of Oxford
Diana Torres - Pontificia Universidad Javeriana
Thérèse Truong - University of Paris-Saclay
Constance Turman - Harvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA
Clare Turnbull - The Institute of Cancer Research, Division of Genetics and Epidemiology, London, UK
Hans-Ulrich Ulmer - Klinikum Mittelbaden
Michael Untch - Helios
Celine Vachon - Mayo Clinic, Department of Health Sciences Research, Rochester, MN, USA
Christi J van Asperen - Leiden University
Ans M W van den Ouweland - Erasmus University Medical Centre, Department of Clinical Genetics, Rotterdam, The Netherlands
Elke M van Veen - St Marys Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester Centre for Genomic Medicine, Manchester, UK
Camilla Wendt - Karolinska Institutet
Alice S Whittemore - Stanford University School of Medicine
Walter Willett - Brigham and Women's Hospital
Robert Winqvist - Cancer Genetics
Alicja Wolk - Karolinska Institutet
Xiaohong R Yang - National Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA
Yan Zhang - Heidelberg
Douglas F Easton - University of Cambridge
Peter A Fasching - University of California, Los Angeles
Heli Nevanlinna - Helsinki University Hospital
Diana M Eccles - University of Southampton
Paul D P Pharoah - University of Cambridge
Marjanka K Schmidt - The Netherlands Cancer Institute
NBCS Collaborators
Publication Details: British journal of cancer, Vol.120(6), pp.647-657
Grant note: HHSN268201100004I / NHLBI NIH HHS R01 CA177150 / NCI NIH HHS R01 CA054281 / NCI NIH HHS 10119 / Cancer Research UK R01 CA192393 / NCI NIH HHS R01 CA097396 / NCI NIH HHS HHSN268201100004C / WHI NIH HHS U19 CA148537 / NCI NIH HHS HHSN268201100002C / WHI NIH HHS R01 CA128978 / NCI NIH HHS R01 CA140286 / NCI NIH HHS U01 CA199277 / NCI NIH HHS P30 CA006927 / NCI NIH HHS HHSN268201100003C / WHI NIH HHS R01 CA077398 / NCI NIH HHS UM1 CA164973 / NCI NIH HHS RP-PG-1214-20016 / Department of Health U01 CA058860 / NCI NIH HHS R01 CA063464 / NCI NIH HHS P50 CA116201 / NCI NIH HHS G0700491 / Medical Research Council UM1 CA164917 / NCI NIH HHS U01 CA063464 / NCI NIH HHS K07 CA092044 / NCI NIH HHS P01 CA087969 / NCI NIH HHS P50 CA058223 / NCI NIH HHS HHSN268201100046C / NHLBI NIH HHS R37 CA054281 / NCI NIH HHS U54 CA156733 / NCI NIH HHS HHSN271201100004C / NIA NIH HHS R01 CA058860 / NCI NIH HHS UM1 CA176726 / NCI NIH HHS UM1 CA164920 / NCI NIH HHS R01 CA132839 / NCI NIH HHS HHSN268201100003I / NHLBI NIH HHS U19 CA148065 / NCI NIH HHS 14136 / Cancer Research UK 10124 / Cancer Research UK U19 CA148112 / NCI NIH HHS U01 CA164973 / NCI NIH HHS RP-PG-0707-10031 / Department of Health HHSN268201100002I / NHLBI NIH HHS U01 CA098758 / NCI NIH HHS HHSN268201100001C / WHI NIH HHS R01 CA116167 / NCI NIH HHS U01 CA116167 / NCI NIH HHS UM1 CA186107 / NCI NIH HHS U01 CA179715 / NCI NIH HHS R01 CA128931 / NCI NIH HHS R01 CA176785 / NCI NIH HHS HHSN268201100001I / NHLBI NIH HHS 10118 / Cancer Research UK
Identifiers: 9931570208331
Academic Unit: Umm Al Qura University
Language: English
Resource Type: Journal article