Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Sonja I. Berndt; Stefan Gustafsson; Reedik Maegi; Andrea Ganna; Eleanor Wheeler; Mary F. Feitosa; Anne E. Justice; Keri L. Monda; Damien C. Croteau-Chonka; Felix R. Day; Tonu Esko; Tove Fall; Teresa Ferreira; Davide Gentilini; Anne U. Jackson; Jian'an Luan; Joshua C. Randall; Sailaja Vedantam; Cristen J. Willer; Thomas W. Winkler; Andrew R. Wood; Tsegaselassie Workalemahu; Yi-Juan Hu; Sang Hong Lee; Liming Liang; Dan-Yu Lin; Josine L. Min; Benjamin M. Neale; Gudmar Thorleifsson; Jian Yang; Eva Albrecht; Najaf Amin; Jennifer L. Bragg-Gresham; Gemma Cadby; Martin den Heijer; Niina Eklund; Krista Fischer; Anuj Goel; Jouke-Jan Hottenga; Jennifer E. Huffman; Ivonne Jarick; Asa Johansson; Toby Johnson; Stavroula Kanoni; Marcus E. Kleber; Inke R. Koenig; Kati Kristiansson; Zoltn Kutalik; Claudia Lamina; Cecile Lecoeur; Guo Li; Massimo Mangino; Wendy L. McArdle; Carolina Medina-Gomez; Martina Mueller-Nurasyid; Julius S. Ngwa; Ilja M. Nolte; Lavinia Paternoster; Sonali Pechlivanis; Markus Perola; Marjolein J. Peters; Michael Preuss; Lynda M. Rose; Jianxin Shi; Dmitry Shungin; Albert Vernon Smith; Rona J. Strawbridge; Ida Surakka; Alexander Teumer; Mieke D. Trip; Jonathan Tyrer; Jana V. Van Vliet-Ostaptchouk; Liesbeth Vandenput; Lindsay L. Waite; Jing Hua Zhao; Devin Absher; Folkert W. Asselbergs; Mustafa Atalay; Antony P. Attwood; Anthony J. Balmforth; Hanneke Basart; John Beilby; Lori L. Bonnycastle; Paolo Brambilla; Marcel Bruinenberg; Harry Campbell; Daniel I. Chasman; Peter S. Chines; Francis S. Collins; John M. Connell; William O. Cookson; Ulf de Faire; Femmie de Vegt; Mariano Dei; Maria Dimitriou; Sarah Edkins; Karol Estrada; David M. Evans; Martin Farrall; Marco M. Ferrario; Jean Ferrieres; Lude Franke; Francesca Frau; Pablo V. Gejman; Harald Grallert; Henrik Groenberg; Vilmundur Gudnason; Alistair S. Hall; Per Hall; Anna-Liisa Hartikainen; Caroline Hayward; Nancy L. Heard-Costa; Andrew C. Heath; Johannes Hebebrand; Georg Homuth; Frank B. Hu; Sarah E. Hunt; Elina Hyppoenen; Carlos Iribarren; Kevin B. Jacobs; John-Olov Jansson; Antti Jula; Mika Kahonen; Sekar Kathiresan; Frank Kee; Kay-Tee Khaw; Mika Kivimaki; Wolfgang Koenig; Aldi T. Kraja; Meena Kumari; Kari Kuulasmaa; Johanna Kuusisto; Jaana H. Laitinen; Timo A. Lakka; Claudia Langenberg; Lenore J. Launer; Lars Lind; Jaana Lindstrom; Jianjun Liu; Antonio Liuzzi; Marja-Liisa Lokki; Mattias Lorentzon; Pamela A. Madden; Patrik K. Magnusson; Paolo Manunta; Diana Marek; Winfried Maerz; Irene Mateo Leach; Barbara McKnight; Sarah E. Medland; Evelin Mihailov; Lili Milani; Grant W. Montgomery; Vincent Mooser; Thomas W. Muehleisen; Patricia B. Munroe; Arthur W. Musk; Narisu Narisu; Gerjan Navis; George Nicholson; Ellen A. Nohr; Ken K. Ong; Ben A. Oostra; Colin N. A. Palmer; Aarno Palotie; John F. Peden; Nancy Pedersen; Annette Peters; Ozren Polasek; Anneli Pouta; Peter P. Pramstaller; Inga Prokopenko; Carolin Puetter; Aparna Radhakrishnan; Olli Raitakari; Augusto Rendon; Fernando Rivadeneira; Igor Rudan; Timo E. Saaristo; Jennifer G. Sambrook; Alan R. Sanders; Serena Sanna; Jouko Saramies; Sabine Schipf; Stefan Schreiber; Heribert Schunkert; So-Youn Shin; Stefano Signorini; Juha Sinisalo; Boris Skrobek; Nicole Soranzo; Alena Stancakova; Klaus Stark; Jonathan C. Stephens; Kathleen Stirrups; Ronald P. Stolk; Michael Stumvoll; Amy J. Swift; Eirini V. Theodoraki; Barbara Thorand; David-Alexandre Tregouet; Elena Tremoli; Melanie M. Van der Klauw; Joyce B. J. van Meurs; Sita H. Vermeulen; Jorma Viikari; Jarmo Virtamo; Veronique Vitart; Gerard Waeber; Zhaoming Wang; Elisabeth Widen; Sarah H. Wild; Gonneke Willemsen; Bernhard R. Winkelmann; Jacqueline C. M. Witteman; Bruce H. R. Wolffenbuttel; Andrew Wong; Alan F. Wright; M. Carola Zillikens; Philippe Amouyel; Bernhard O. Boehm; Eric Boerwinkle; Dorret I. Boomsma; Mark J. Caulfield; Stephen J. Chanock; L. Adrienne Cupples; Daniele Cusi; George V. Dedoussis; Jeanette Erdmann; Johan G. Eriksson; Paul W. Franks; Philippe Froguel; Christian Gieger; Ulf Gyllensten; Anders Hamsten; Tamara B. Harris; Christian Hengstenberg; Andrew A. Hicks; Aroon Hingorani; Anke Hinney; Albert Hofman; Kees G. Hovingh; Kristian Hveem; Thomas Illig; Marjo-Riitta Jarvelin; Karl-Heinz Joeckel; Sirkka M. Keinanen-Kiukaanniemi; Lambertus A. Kiemeney; Diana Kuh; Markku Laakso; Terho Lehtimaki; Douglas F. Levinson; Nicholas G. Martin; Andres Metspalu; Andrew D. Morris; Markku S. Nieminen; Inger Njolstad; Claes Ohlsson; Albertine J. Oldehinkel; Willem H. Ouwehand; Lyle J. Palmer; Brenda Penninx; Chris Power; Michael A. Province; Bruce M. Psaty; Lu Qi; Rainer Rauramaa; Paul M. Ridker; Samuli Ripatti; Veikko Salomaa; Nilesh J. Samani; Harold Snieder; Thorkild I. A. Sorensen; Timothy D. Spector; Kari Stefansson; Anke Tonjes; Jaakko Tuomilehto; Andre G. Uitterlinden; Matti Uusitupa; Pim van der Harst; Peter Vollenweider; Henri Wallaschofski; Nicholas J. Wareham; Hugh Watkins; H-Erich Wichmann; James F. Wilson; Goncalo R. Abecasis; Themistocles L. Assimes; Ines Barroso; Michael Boehnke; Ingrid B. Borecki; Panos Deloukas; Caroline S. Fox; Timothy Frayling; Leif C. Groop; Talin Haritunian; Iris M. Heid; David Hunter; Robert C. Kaplan; Fredrik Karpe; Miriam F. Moffatt; Karen L. Mohlke; Jeffrey R. O'Connell; Yudi Pawitan; Eric E. Schadt; David Schlessinger; Valgerdur Steinthorsdottir; David P. Strachan; Unnur Thorsteinsdottir; Cornelia M. van Duijn; Peter M. Visscher; Anna Maria Di Blasio; Joel N. Hirschhorn; Cecilia M. Lindgren; Andrew P. Morris; David Meyre; Andr Scherag; Mark I. McCarthy; Elizabeth K. Speliotes; Kari E. North; Ruth J. F. Loos; Erik Ingelsson; Göteborgs universitet

doi:10.1038/ng.2606

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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Journal article

Peer reviewed

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Sonja I. Berndt, Stefan Gustafsson, Reedik Maegi, Andrea Ganna, Eleanor Wheeler, Mary F. Feitosa, Anne E. Justice, Keri L. Monda, Damien C. Croteau-Chonka, Felix R. Day, …

Nature genetics, Vol.45(5), pp.501-U69

2013

DOI: https://doi.org/10.1038/ng.2606

PMCID: PMC3973018

PMID: 23563607

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.

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Title: Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Creators - without role: Sonja I. Berndt - National Cancer Institute
Stefan Gustafsson - Science for Life Laboratory
Reedik Maegi - University of Oxford
Andrea Ganna - Karolinska Institutet
Eleanor Wheeler - Wellcome Sanger Institute
Mary F. Feitosa - Washington University in St. Louis
Anne E. Justice - University of North Carolina at Chapel Hill
Keri L. Monda - University of North Carolina at Chapel Hill
Damien C. Croteau-Chonka - University of North Carolina at Chapel Hill
Felix R. Day - MRC Epidemiology Unit
Tonu Esko - University of Tartu
Tove Fall - Karolinska Institutet
Teresa Ferreira - University of Oxford
Davide Gentilini - IRCCS Istituto Auxologico Italiano
Anne U. Jackson - University of Michigan–Ann Arbor
Jian'an Luan - MRC Epidemiology Unit
Joshua C. Randall - Wellcome Sanger Institute
Sailaja Vedantam - Boston Children's Hospital
Cristen J. Willer - University of Michigan–Ann Arbor
Thomas W. Winkler - University Hospital Regensburg
Andrew R. Wood - Peninsula College of Medicine and Dentistry
Tsegaselassie Workalemahu - Harvard University
Yi-Juan Hu - Emory University
Sang Hong Lee - Emory University
Liming Liang - Harvard University
Dan-Yu Lin - Biostat
Josine L. Min - Wellcome Centre for Human Genetics
Benjamin M. Neale - Massachusetts General Hospital
Gudmar Thorleifsson - deCODE Genetics
Jian Yang - Princess Alexandra Hospital
Eva Albrecht - Helmholtz Zentrum München
Najaf Amin - Erasmus MC
Jennifer L. Bragg-Gresham - University of Michigan–Ann Arbor
Gemma Cadby - Ontario Institute for Cancer Research
Martin den Heijer - University of Amsterdam
Niina Eklund - Finnish Institute for Health and Welfare
Krista Fischer - University of Tartu
Anuj Goel - Wellcome Centre for Human Genetics
Jouke-Jan Hottenga - Vrije Universiteit Amsterdam
Jennifer E. Huffman - Western General Hospital
Ivonne Jarick - Philipps University of Marburg
Asa Johansson - Uppsala University
Toby Johnson - Queen Mary University of London
Stavroula Kanoni - Wellcome Sanger Institute
Marcus E. Kleber - University of Mannheim
Inke R. Koenig - Heidelberg University
Kati Kristiansson - Finnish Institute for Health and Welfare
Zoltn Kutalik - University of Lausanne
Claudia Lamina - Innsbruck Medical University
Cecile Lecoeur - Pasteur Institute of Lille
Guo Li - University of Washington
Massimo Mangino - King's College London
Wendy L. McArdle - University of Bristol
Carolina Medina-Gomez - Netherlands Consortium for Healthy Ageing
Martina Mueller-Nurasyid - Helmholtz Zentrum München
Julius S. Ngwa - Boston University
Ilja M. Nolte - University Medical Center Groningen
Lavinia Paternoster - University of Bristol
Sonali Pechlivanis - Institut für Medizinische Informatik, Biometrie und Epidemiologie
Markus Perola - University of Helsinki
Marjolein J. Peters - Netherlands Consortium for Healthy Ageing
Michael Preuss - University of Lübeck
Lynda M. Rose - Brigham and Women's Hospital
Jianxin Shi - National Institutes of Health
Dmitry Shungin - Lund University
Albert Vernon Smith - Icelandic Heart Association
Rona J. Strawbridge - Karolinska Institutet
Ida Surakka - University of Helsinki
Alexander Teumer - University of Greifswald
Mieke D. Trip - Academic Medical Center
Jonathan Tyrer - University of Cambridge
Jana V. Van Vliet-Ostaptchouk - University Medical Center Groningen
Liesbeth Vandenput - University of Gothenburg
Lindsay L. Waite - HudsonAlpha Institute for Biotechnology
Jing Hua Zhao - MRC Epidemiology Unit
Devin Absher - HudsonAlpha Institute for Biotechnology
Folkert W. Asselbergs - University Medical Center Utrecht
Mustafa Atalay - University of Eastern Finland
Antony P. Attwood - National Institute for Health Research
Anthony J. Balmforth - University of Leeds
Hanneke Basart - Academic Medical Center
John Beilby - Queen Elizabeth II Medical Centre
Lori L. Bonnycastle - National Institutes of Health
Paolo Brambilla - University of Milano-Bicocca
Marcel Bruinenberg - University Medical Center Groningen
Harry Campbell - University of Edinburgh
Daniel I. Chasman - Brigham and Women's Hospital
Peter S. Chines - National Institutes of Health
Francis S. Collins - National Institutes of Health
John M. Connell - University of Glasgow
William O. Cookson - University of London
Ulf de Faire - Karolinska Institutet
Femmie de Vegt - Radboud University Medical Center
Mariano Dei - Institute of Genetic and Biomedical Research
Maria Dimitriou - Harokopio University of Athens
Sarah Edkins - Wellcome Sanger Institute
Karol Estrada - Netherlands Consortium for Healthy Ageing
David M. Evans - University of Bristol
Martin Farrall - University of Oxford
Marco M. Ferrario - University of Insubria
Jean Ferrieres - Supreme Council Of Health
Lude Franke - University of Groningen
Francesca Frau - University of Milan
Pablo V. Gejman - University of Chicago
Harald Grallert - Helmholtz Zentrum München
Henrik Groenberg - Karolinska Institutet
Vilmundur Gudnason - Iceland Heart Assoc, Kopavogur, Iceland
Alistair S. Hall - University of Leeds
Per Hall - Karolinska Institutet
Anna-Liisa Hartikainen - University of Oulu
Caroline Hayward - College Station Medical Center
Nancy L. Heard-Costa - Boston University
Andrew C. Heath - Supreme Council Of Health
Johannes Hebebrand - University of Duisburg-Essen
Georg Homuth - University of Greifswald
Frank B. Hu - Harvard University
Sarah E. Hunt - Wellcome Sanger Institute
Elina Hyppoenen - Biostat
Carlos Iribarren - Kaiser Permanente
Kevin B. Jacobs - NCI, US Dept HHS, Div Canc Epidemiol & Genet, US Natl Inst Hlth, Bethesda, MD 20892 USA
John-Olov Jansson - University of Gothenburg
Antti Jula - Natl Inst Hlth & Welf, Populat Studies Unit, Dept Chron Dis Prevent, Turku, Finland
Mika Kahonen - University of Tampere
Sekar Kathiresan - Broad Institute
Frank Kee - Queens University
Kay-Tee Khaw - University of Cambridge
Mika Kivimaki - UCL, Dept Epidemiol & Publ Hlth, London, England
Wolfgang Koenig - University of Ulm
Aldi T. Kraja - Supreme Council Of Health
Meena Kumari - UCL, Dept Epidemiol & Publ Hlth, London, England
Kari Kuulasmaa - Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Chron Dis Epidemiol & Prevent Unit, Helsinki, Finland
Johanna Kuusisto - University of Eastern Finland
Jaana H. Laitinen - Finnish Inst Occupat Hlth, Oulu, Finland
Timo A. Lakka - University of Eastern Finland
Claudia Langenberg - Massachusetts Rehabilitation Commission
Lenore J. Launer - NIA, Lab Epidemiol, US Natl Inst Hlth, Bethesda, MD 20892 USA
Lars Lind - Uppsala University
Jaana Lindstrom - Natl Inst Hlth & Welf, Diabet Prevent Unit, Helsinki, Finland
Jianjun Liu - Genome Institute of Singapore
Antonio Liuzzi - College Station Medical Center
Marja-Liisa Lokki - University of Helsinki
Mattias Lorentzon - University of Gothenburg
Pamela A. Madden - Supreme Council Of Health
Patrik K. Magnusson - Karolinska Institutet
Paolo Manunta - Univ Vita Salute San Raffaele, Chair Nephrol San Raffaele Sci Inst, Unite Osped Nephrol & Dialysis, Milan, Italy
Diana Marek - University of Lausanne
Winfried Maerz - Synlab
Irene Mateo Leach - University of Groningen
Barbara McKnight - University of Washington
Sarah E. Medland - College Station Medical Center
Evelin Mihailov - University of Tartu
Lili Milani - University of Tartu
Grant W. Montgomery - College Station Medical Center
Vincent Mooser - GlaxoSmithKline
Thomas W. Muehleisen - University of Bonn
Patricia B. Munroe - Queen Mary University of London
Arthur W. Musk - University of Western Australia
Narisu Narisu - NHGRI, Genome Technol Branch, US Natl Inst Hlth, Bethesda, MD 20892 USA
Gerjan Navis - University of Groningen
George Nicholson - Mary Lyon Centre at MRC Harwell
Ellen A. Nohr - Aarhus University
Ken K. Ong - Massachusetts Rehabilitation Commission
Ben A. Oostra - Erasmus MC
Colin N. A. Palmer - University of Dundee
Aarno Palotie - Wellcome Sanger Institute
John F. Peden - Illumina
Nancy Pedersen - Karolinska Institutet
Annette Peters - Helmholtz Zentrum München
Ozren Polasek - University of Split
Anneli Pouta - University of Oulu
Peter P. Pramstaller - European Acad Bozen Bolzano EURAC, Ctr Biomed, Bolzano, Italy
Inga Prokopenko - University of Oxford
Carolin Puetter - University of Duisburg-Essen
Aparna Radhakrishnan - Wellcome Sanger Institute
Olli Raitakari - University of Turku
Augusto Rendon - Biomed Res Ctr, Natl Inst Hlth Res NIHR, Cambridge, England
Fernando Rivadeneira - Erasmus MC
Igor Rudan - University of Edinburgh
Timo E. Saaristo - Finnish Diabet Assoc, Tampere, Finland
Jennifer G. Sambrook - Cambridge Ctr, Natl Hlth Serv NHS Blood & Transplant, Cambridge, England
Alan R. Sanders - University of Chicago
Serena Sanna - CNR, Ist Ric Genet & Biomed, Monserrato, Italy
Jouko Saramies - South Karelia Cent Hosp, Lappeenranta, Finland
Sabine Schipf - College Station Medical Center
Stefan Schreiber - Univ Kiel, Inst Clin Mol Biol, Kiel, Germany
Heribert Schunkert - Deutsch Herzzentrum Munich, Munich, Germany
So-Youn Shin - Wellcome Sanger Institute
Stefano Signorini - Azienda Osped Desio & Vimercate, Milan, Italy
Juha Sinisalo - University of Helsinki
Boris Skrobek - Univ Lille Nord France, Lille, France
Nicole Soranzo - Wellcome Sanger Institute
Alena Stancakova - University of Eastern Finland
Klaus Stark - College Station Medical Center
Jonathan C. Stephens - Cambridge Ctr, Natl Hlth Serv NHS Blood & Transplant, Cambridge, England
Kathleen Stirrups - Wellcome Sanger Institute
Ronald P. Stolk - University of Groningen
Michael Stumvoll - College Station Medical Center
Amy J. Swift - NHGRI, Genome Technol Branch, US Natl Inst Hlth, Bethesda, MD 20892 USA
Eirini V. Theodoraki - Harokopio University of Athens
Barbara Thorand - Helmholtz Zentrum München
David-Alexandre Tregouet - Université Paris Cité
Elena Tremoli - University of Milan
Melanie M. Van der Klauw - University of Groningen
Joyce B. J. van Meurs - Erasmus MC
Sita H. Vermeulen - Radboud University Nijmegen
Jorma Viikari - University of Turku
Jarmo Virtamo - Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Chron Dis Epidemiol & Prevent Unit, Helsinki, Finland
Veronique Vitart - College Station Medical Center
Gerard Waeber - College Station Medical Center
Zhaoming Wang - NCI, US Dept HHS, Div Canc Epidemiol & Genet, US Natl Inst Hlth, Bethesda, MD 20892 USA
Elisabeth Widen - University of Helsinki
Sarah H. Wild - University of Edinburgh
Gonneke Willemsen - University of Amsterdam
Bernhard R. Winkelmann - Cardiol Grp, Frankfurt, Germany
Jacqueline C. M. Witteman - Erasmus MC
Bruce H. R. Wolffenbuttel - University of Groningen
Andrew Wong - Massachusetts Rehabilitation Commission
Alan F. Wright - College Station Medical Center
M. Carola Zillikens - Erasmus MC
Philippe Amouyel - Univ Lille Nord France, INSERM, Inst Pasteur Lille, U744, F-59019 Lille, France
Bernhard O. Boehm - College Station Medical Center
Eric Boerwinkle - College Station Medical Center
Dorret I. Boomsma - University of Amsterdam
Mark J. Caulfield - Queen Mary University of London
Stephen J. Chanock - NCI, US Dept HHS, Div Canc Epidemiol & Genet, US Natl Inst Hlth, Bethesda, MD 20892 USA
L. Adrienne Cupples - Boston University
Daniele Cusi - University of Milan
George V. Dedoussis - Harokopio University of Athens
Jeanette Erdmann - University of Lübeck
Johan G. Eriksson - University of Helsinki
Paul W. Franks - Harvard University
Philippe Froguel - University of Lille
Christian Gieger - Helmholtz Zentrum München
Ulf Gyllensten - Uppsala University
Anders Hamsten - Karolinska Institutet
Tamara B. Harris - NIA, Lab Epidemiol, US Natl Inst Hlth, Bethesda, MD 20892 USA
Christian Hengstenberg - College Station Medical Center
Andrew A. Hicks - European Acad Bozen Bolzano EURAC, Ctr Biomed, Bolzano, Italy
Aroon Hingorani - UCL, Dept Epidemiol & Publ Hlth, London, England
Anke Hinney - University of Duisburg-Essen
Albert Hofman - Erasmus MC
Kees G. Hovingh - University of Amsterdam
Kristian Hveem - Norwegian Univ Sci & Technol, Helseundersokelsen Nord Trondelag HUNT Res Ctr, Dept Publ Hlth & Gen Practice, Levanger, Norway
Thomas Illig - Helmholtz Zentrum München
Marjo-Riitta Jarvelin - Natl Inst Hlth & Welf, Oulu, Finland
Karl-Heinz Joeckel - University of Duisburg-Essen
Sirkka M. Keinanen-Kiukaanniemi - University of Oulu
Lambertus A. Kiemeney - Radboud University Nijmegen
Diana Kuh - Massachusetts Rehabilitation Commission
Markku Laakso - University of Eastern Finland
Terho Lehtimaki - University of Tampere
Douglas F. Levinson - Stanford University
Nicholas G. Martin - College Station Medical Center
Andres Metspalu - University of Tartu
Andrew D. Morris - University of Dundee
Markku S. Nieminen - University of Helsinki
Inger Njolstad - College Station Medical Center
Claes Ohlsson - Association of Local Public Health Agencies
Albertine J. Oldehinkel - University of Groningen
Willem H. Ouwehand - Wellcome Sanger Institute
Lyle J. Palmer - Ontario Inst Canc Res, Toronto, ON, Canada
Brenda Penninx - University of Groningen
Chris Power - Biostat
Michael A. Province - Supreme Council Of Health
Bruce M. Psaty - University of Washington
Lu Qi - Harvard University
Rainer Rauramaa - College Station Medical Center
Paul M. Ridker - Brigham and Women's Hospital
Samuli Ripatti - Wellcome Sanger Institute
Veikko Salomaa - Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Chron Dis Epidemiol & Prevent Unit, Helsinki, Finland
Nilesh J. Samani - University of Leicester
Harold Snieder - University of Groningen
Thorkild I. A. Sorensen - College Station Medical Center
Timothy D. Spector - Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England
Kari Stefansson - deCODE Genet, Reykjavik, Iceland
Anke Tonjes - College Station Medical Center
Jaakko Tuomilehto - Natl Inst Hlth & Welf, Diabet Prevent Unit, Helsinki, Finland
Andre G. Uitterlinden - Erasmus MC
Matti Uusitupa - University of Eastern Finland
Pim van der Harst - University of Groningen
Peter Vollenweider - College Station Medical Center
Henri Wallaschofski - College Station Medical Center
Nicholas J. Wareham - Massachusetts Rehabilitation Commission
Hugh Watkins - University of Oxford
H-Erich Wichmann - College Station Medical Center
James F. Wilson - University of Edinburgh
Goncalo R. Abecasis - Biostat
Themistocles L. Assimes - Stanford University
Ines Barroso - Wellcome Sanger Institute
Michael Boehnke - Biostat
Ingrid B. Borecki - Supreme Council Of Health
Panos Deloukas - Wellcome Sanger Institute
Caroline S. Fox - Framingham Heart Study
Timothy Frayling - University of Exeter
Leif C. Groop - Lund University
Talin Haritunian - College Station Medical Center
Iris M. Heid - University of Regensburg
David Hunter - Harvard University
Robert C. Kaplan - Albert Einstein College of Medicine
Fredrik Karpe - University of Oxford
Miriam F. Moffatt - University of London
Karen L. Mohlke - Univ N Carolina, Dept Genet, Chapel Hill, NC USA
Jeffrey R. O'Connell - Supreme Council Of Health
Yudi Pawitan - Karolinska Institutet
Eric E. Schadt - Supreme Council Of Health
David Schlessinger - NIA, Genet Lab, Baltimore, MD 21224 USA
Valgerdur Steinthorsdottir - deCODE Genet, Reykjavik, Iceland
David P. Strachan - University of London
Unnur Thorsteinsdottir - deCODE Genet, Reykjavik, Iceland
Cornelia M. van Duijn - Erasmus MC
Peter M. Visscher - Emory University
Anna Maria Di Blasio - Ist Auxol Italiano, Dept Mol Biol, Milan, Italy
Joel N. Hirschhorn - Childrens Hosp, Div Genet, Ctr Basic & Translat Obes Res, Boston, MA 02115 USA
Cecilia M. Lindgren - University of Oxford
Andrew P. Morris - University of Oxford
David Meyre - Univ Lille Nord France, Lille, France
Andr Scherag - University of Duisburg-Essen
Mark I. McCarthy - University of Oxford
Elizabeth K. Speliotes - College Station Medical Center
Kari E. North - Supreme Council Of Health
Ruth J. F. Loos - Massachusetts Rehabilitation Commission
Erik Ingelsson - Karolinska Institutet
Göteborgs universitet
Publication Details: Nature genetics, Vol.45(5), pp.501-U69
Publisher: Springer Nature
Number of pages: 14
Grant note: Heinz Nixdorf Foundation British Heart Foundation Dutch Ministry of Justice German Diabetes Association Finska Lakaresallskapet Republic of Croatia Ministry of Science, Education and Sport Chief Scientist Office of the Scottish government German Ministry of Cultural Affairs Nordic Center of Cardiovascular Research ES/G007438/1; ES/J023299/1 / Economic and Social Research Council; UK Research & Innovation (UKRI); Economic & Social Research Council (ESRC) BioSHaRE Consortium Vastra Gotaland Foundation Aarno Koskelo Foundation Emil Aaltonen Foundation Swedish Foundation for Strategic Research; Swedish Foundation for Humanities & Social Sciences G0600237; G0401527; G0801056B; MC_U106188470; MC_U106179471; G9521010; MR/K013351/1; G1002084; MC_U106179472; MC_UU_12015/1; MC_PC_U127561128; G1000143; MR/K006584/1; MC_U123092720; MC_U105260558; MC_UU_12015/2; G0601261 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Municipal Health Care Center and Hospital in Jakobstad NNF13OC0005785 / Novo Nordisk Fonden; Novo Nordisk Foundation Finnish Ministry of Health and Social Affairs Eleanor Nichols endowments Helmholtz Zentrum Munchen-German Research Center for Environmental Health; Helmholtz Association Swiss National Science Foundation; Swiss National Science Foundation (SNSF) European Research Council; European Research Council (ERC); European Commission German National Genome Research Network European Regional Development Fund; European Commission Genetic Association Information Network Yrjo Jahnsson Foundation Signe and Ane Gyllenberg Foundation University Medical Center Groningen French Ministry of Research; Ministry of Research, France Finnish National Institute for Health and Welfare Agency for Science, Technology and Research of Singapore; Agency for Science Technology & Research (A*STAR) Lundberg Foundation Dutch Kidney Foundation National Alliance for Research on Schizophrenia and Depression Young Investigator Awards; NARSAD Nordic Centre of Excellence on Systems Biology in Controlled Dietary Interventions and Cohort Studies Wellcome Trust Petrus and Augusta Hedlunds Foundation Erasmus University UK MRCUK NIHR, Biomedical Research Centre; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) March of Dimes Novo Nordisk Foundation; Novocure Limited Paivikki and Sakari Sohlberg Foundation G0601261; MC_U123092720; MC_PC_U127561128; MC_UU_12015/2; G9521010; MR/K013351/1; G1002084; MC_U105260558; MC_U106188470; MC_U106179472; G0600237; MC_UU_12015/1 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Swedish Ministry of Education Centre of Excellence in Genomics Paavo Nurmi Foundation Finnish Cultural Foundation; Finnish IT center for science Ollqvist Foundation Northern Netherlands Collaboration of Provinces Australian National Health and Medical Research Council; National Health and Medical Research Council (NHMRC) of Australia Swedish Society for Medical Research Australian Research Council 14136 / Cancer Research UK Social Ministry of the Federal State of Mecklenburg-West Pomerania Finnish Funding Agency for Technology and Innovation; Finnish Funding Agency for Technology & Innovation (TEKES) Leducq Foundation Narpes Health Care Foundation UK NHSBT Swedish Heart-Lung Foundation University of Groningen Finnish Ministry of Education and Culture RP-PG-0310-1002; NF-SI-0512-10113; NF-SI-0611-10099 / National Institute for Health Research; National Institutes of Health Research (NIHR) Icelandic Parliament Swedish Royal Academy of Science European Science Foundation; European Science Foundation (ESF); European Commission Netherlands Genomics Initiative University and Research of the Autonomous Province of Bolzano Gyllenberg Foundation Finland's Slot Machine Association University of Tartu Italian Ministry of Education, Universities and Research; Ministry of Education, Universities and Research (MIUR) Dutch Inter-University Cardiology Institute Orion-Farmos Research Foundation Dutch Diabetes Research Foundation Faculty of Biology and Medicine of Lausanne French National Research Agency; Agence Nationale de la Recherche (ANR) Tampere Tuberculosis Foundation City of Kuopio Estonian government Dutch Brain Foundation Dutch Ministry for Health, Welfare and Sports US National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA BDA Research Perklen Foundation Strategic Support for Epidemiological Research at Karolinska Institutet Greek General Secretary of Research and Technology Dutch Centre for Medical Systems Biology Munich Center of Health Sciences as part of LMUinnovativ CZB/4/710 / Chief Scientist Office Intramural Research Program of the Division of Cancer Epidemiology and Genetics, the National Cancer Institute, NIH Icelandic Heart Association Sigrid Juselius Foundation Paul Michael Donovan Charitable Foundation German Research Foundation; German Research Foundation (DFG) Stockholm County Council European Commission; European Commission Joint Research Centre Folkhalsan Research Foundation UK West Anglia Primary and Community Care Social Insurance Institution of Finland Finnish Medical Society Juvenile Diabetes Research Foundation International; Juvenile Diabetes Research Foundation Dutch Government Economic Structure-Enhancing Fund Goteborg Medical Society Nordic Center of Excellence in Disease Genetics Health Care Centers in Vasa, Narpes and Korsholm Dutch Research Institute for Diseases in the Elderly ES/J023299/1; ES/G007438/1 / ESRC; UK Research & Innovation (UKRI); Economic & Social Research Council (ESRC) Royal Society Finnish Diabetes Research Foundation Municipality of Rotterdam South Tyrolean Sparkasse Foundation Swedish Ministry for Higher Education Dutch Ministry of Education, Culture and Science Reynold's Foundation Swedish Society of Medicine Finnish Social Insurance Institution UK Diabetes Association Dutch Ministry of Economic Affairs; Ministry of Economic Affairs, Netherlands Italian Ministry of Health; Ministry of Health, Italy Finnish Foundation for Cardiovascular Research Donald W. Reynolds Foundation UK Heart Foundation Foundation for Life and Health in Finland Department of Educational Assistance Sophia Foundation for Medical Research Knut and Alice Wallenberg Foundation; Knut & Alice Wallenberg Foundation Kuopio, Tampere and Turku University Hospital Medical Funds Torsten and Ragnar Soderberg Foundation Centre for Clinical Research at the University of Leipzig Dutch BBRMI-NL Netherlands Organization for Health Research and Development Swedish Cultural Foundation in Finland Strategic Cardiovascular Program of Karolinska Institutet Finnish Heart Association Samfundet Folkhalsan Swedish Research Council; Swedish Research Council for Health Working Life & Welfare (Forte); Swedish Research Council Formas Swedish Cancer Society Swedish Medical Research Council; Swedish Medical Research Council (SMRC) Cancer Research UK German Federal Ministry of Education and Research; Federal Ministry of Education & Research (BMBF) Province of Groningen GlaxoSmithKline Juho Vainio Foundation Susan G. Komen Breast Cancer Foundation Swedish Diabetes Association Cedars-Sinai Board of Governors' Chair in Medical Genetics VU University: the Institute for Health and Care Research and the Neuroscience Campus Amsterdam Southern California Diabetes Endocrinology Research Center Great Wine Estates of the Margaret River Region of Western Australia Erasmus Medical Center
Identifiers: 9936773808331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article