Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults

Mariaelisa Graff; Robert A. Scott; Anne E. Justice; Kristin L. Young; Mary F. Feitosa; Llilda Barata; Thomas W. Winkler; Audrey Y. Chu; Anubha Mahajan; David Hadley; Luting Xue; Tsegaselassie Workalemahu; Nancy L. Heard-Costa; Marcel den Hoed; Tarunveer S. Ahluwalia; Qibin Qi; Julius S. Ngwa; Frida Renstrom; Lydia Quaye; John D. Eicher; James E. Hayes; Marilyn Cornelis; Zoltan Kutalik; Elise Lim; Jian'an Luan; Jennifer E. Huffman; Weihua Zhang; Wei Zhao; Paula J. Griffin; Toomas Haller; Shafqat Ahmad; Pedro M. Marques-Vidal; Stephanie Bien; Loic Yengo; Alexander Teumer; Albert Vernon Smith; Meena Kumari; Marie Neergaard Harder; Johanne Marie Justesen; Marcus E. Kleber; Mette Hollensted; Kurt Lohman; Natalia V. Rivera; John B. Whitfield; Jing Hua Zhao; Heather M. Stringham; Leo-Pekka Lyytikainen; Charlotte Huppertz; Gonneke Willemsen; Wouter J. Peyrot; Ying Wu; Kati Kristiansson; Ayse Demirkan; Myriam Fornage; Maija Hassinen; Lawrence F. Bielak; Gemma Cadby; Toshiko Tanaka; Reedlk Magl; Peter J. Van der Most; Anne U. Jackson; Jennifer L. Bragg-Gresham; Veronique Vitart; Jonathan Marten; Pau Navarro; Claire Bellis; Dorota Pasko; Asa Johansson; Soren Snitker; Yu-Ching Cheng; Joel Eriksson; Unhee Lim; Mette Aadahl; Linda S. Adair; Najaf Amin; Beverley Balkau; Juha Auvinen; John Beilby; Richard N. Bergman; Sven Bergmann; Alain G. Bertoni; John Blangero; Amelle Bonnefond; Lori L. Bonnycastle; Judith B. Borja; Soren Brage; Fabio Busonero; Steve Buyske; Harry Campbell; Peter S. Chines; Francis S. Collins; Tanguy Corre; George Davey Smith; Graciela E. Delgado; Nicole Dueker; Marcus Doerr; Tapani Ebeling; Gudny Eiriksdottir; Tonu Esko; Jessica D. Faul; Mao Fu; Kristine Faerch; Christian Gieger; Sven Glaeser; Jian Gong; Penny Gordon-Larsen; Harald Grallert; Tanja B. Grammer; Niels Grarup; Gerard van Grootheest; Kennet Harald; Nicholas D. Hastie; Aki S. Havulinna; Dena Hernandez; Lucia Hindorff; Lynne J. Hocking; Oddgeir L. Holmens; Christina Holzapfel; Jouke Jan Hottenga; Jie Huang; Tao Huang; Jennie Hui; Cornelia Huth; Nina Hutri-Kahonen; Alan L. James; John-Olov Jansson; Min A. Jhun; Markus Juonala; Leena Kinnunen; Heikki A. Koistinen; Ivana Kolcic; Pirjo Komulainen; Johanna Kuusisto; Kirsti Kvaloy; Mika Kahonen; Timo A. Lakka; Lenore J. Launer; Benjamin Lehne; Cecilia M. Lindgren; Mattias Lorentzon; Robert Luben; Michel Marre; Yuri Milaneschi; Keri L. Monda; Grant W. Montgomery; Marleen H. M. De Moor; Antonella Mulas; Martina Mueller-Nurasyid; A. W. Musk; Reija Mannikko; Satu Mannisto; Narisu Narisu; Matthias Nauck; Jennifer A. Nettleton; Ilja M. Nolte; Albertine J. Oldehinkel; Matthias Olden; Ken K. Ong; Sandosh Padmanabhan; Lavinia Paternoster; Jeremiah Perez; Markus Perola; Annette Peters; Ulrike Peters; Patricia A. Peyser; Inga Prokopenko; Hannu Puolijoki; Olli T. Raitakari; Tuomo Rankinen; Laura J. Rasmussen-Torvik; Rajesh Rawal; Paul M. Ridker; Lynda M. Rose; Igor Rudan; Cinzia Sarti; Mark A. Sarzynski; Kai Savonen; William R. Scott; Serena Sanna; Alan R. Shuldiner; Steve Sidney; Guenther Silbernagel; Blair H. Smith; Jennifer A. Smith; Harold Snieder; Alena Stancakova; Barbara Sternfeld; Amy J. Swift; Tuija Tammelin; Sian-Tsung Tan; Barbara Thorand; Dorothee Thuillier; Liesbeth Vandenput; Henrik Vestergaard; Jana V. van Vliet-Ostaptchouk; Marie-Claude Vohl; Uwe Voelker; Gerard Waeber; Mark Walker; Sarah Wild; Andrew Wong; Alan F. Wright; M. Carola Zillikens; Niha Zubair; Christopher A. Haiman; Loic Lemarchand; Ulf Gyllensten; Claes Ohlsson; Albert Hofman; Fernando Rivadeneira; Andre G. Uitterlinden; Louis Perusse; James F. Wilson; Caroline Hayward; Ozren Polasek; Francesco Cucca; Kristian Hveem; Catharina A. Hartman; Anke Toenjes; Stefania Bandinelli; Lyle J. Palmer; Sharon L. R. Kardia; Rainer Rauramaa; Thorkild I. A. Sorensen; Jaakko Tuomilehto; Veikko Salomaa; Brenda W. J. H. Penninx; Eco J. C. de Geus; Dorret I. Boomsma; Terho Lehtimaki; Massimo Mangino; Markku Laakso; Claude Bouchard; Nicholas G. Martin; Diana Kuh; Yongmei Liu; Allan Linneberg; Winfried Maerz; Konstantin Strauch; Mika Kivimaki; Tamara B. Harris; Vilmundur Gudnason; Henry Voelzke; Lu Qi; Marjo-Riitta Jarvelin; John C. Chambers; Jaspal S. Kooner; Philippe Froguel; Charles Kooperberg; Peter Vollenweider; Goran Hallmans; Torben Hansen; Oluf Pedersen; Andres Metspalu; Nicholas J. Wareham; Claudia Langenberg; David R. Weir; David J. Porteous; Eric Boerwinkle; Daniel I. Chasman; Goncalo R. Abecasis; Ines Barroso; Mark I. McCarthy; Timothy M. Frayling; Jeffrey R. O'Connell; Cornelia M. van Duijn; Michael Boehnke; Iris M. Heid; Karen L. Mohlke; David P. Strachan; Caroline S. Fox; Ching-Ti Liu; Joel N. Hirschhorn; Robert J. Klein; Andrew D. Johnson; Ingrid B. Borecki; Paul W. Franks; Kari E. North; L. Adrienne Cupples; Ruth J. F. Loos; Tuomas O. Kilpelainen; PAGE Consortium

doi:10.1371/journal.pgen.1006528

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Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults

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Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults

Mariaelisa Graff, Robert A. Scott, Anne E. Justice, Kristin L. Young, Mary F. Feitosa, Llilda Barata, Thomas W. Winkler, Audrey Y. Chu, Anubha Mahajan, David Hadley, …

PLoS genetics, Vol.13(4), pp.e1006528-e1006528

01/04/2017

DOI: https://doi.org/10.1371/journal.pgen.1006528

PMCID: PMC5407576

PMID: 28448500

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by similar to 30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.

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Title: Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults
Creators - without role: Mariaelisa Graff - University of North Carolina at Chapel Hill
Robert A. Scott - University of Cambridge
Anne E. Justice - University of North Carolina at Chapel Hill
Kristin L. Young - University of North Carolina at Chapel Hill
Mary F. Feitosa - Washington University in St. Louis
Llilda Barata - Washington University in St. Louis
Thomas W. Winkler - University of Regensburg
Audrey Y. Chu - Brigham and Women's Hospital
Anubha Mahajan - Wellcome Centre for Human Genetics
David Hadley - St George's, University of London
Luting Xue - Boston University
Tsegaselassie Workalemahu - Harvard University
Nancy L. Heard-Costa - Framingham Heart Study
Marcel den Hoed - University of Cambridge
Tarunveer S. Ahluwalia - Novo Nordisk Foundation
Qibin Qi - Albert Einstein College of Medicine
Julius S. Ngwa - Howard University
Frida Renstrom - Lund University
Lydia Quaye - King's College London
John D. Eicher - Framingham Heart Study
James E. Hayes - Cornell University
Marilyn Cornelis - Northwestern University
Zoltan Kutalik - Institute of Social and Preventive Medicine
Elise Lim - Boston University
Jian'an Luan - University of Cambridge
Jennifer E. Huffman - Western General Hospital
Weihua Zhang - Imperial College London
Wei Zhao - University of Michigan–Ann Arbor
Paula J. Griffin - Boston University
Toomas Haller - University of Tartu
Shafqat Ahmad - Lund University
Pedro M. Marques-Vidal - University of Lausanne
Stephanie Bien - Fred Hutch Cancer Center
Loic Yengo - Pasteur Institute of Lille
Alexander Teumer - Greifswald University Hospital
Albert Vernon Smith - Icelandic Heart Association
Meena Kumari - University of Essex
Marie Neergaard Harder - University of Copenhagen
Johanne Marie Justesen - Novo Nordisk Foundation
Marcus E. Kleber - University Medical Centre Mannheim
Mette Hollensted - Novo Nordisk Foundation
Kurt Lohman - Wake Forest University
Natalia V. Rivera - Karolinska Institutet
John B. Whitfield - QIMR Berghofer Medical Research Institute
Jing Hua Zhao - MRC Epidemiology Unit
Heather M. Stringham - University of Michigan–Ann Arbor
Leo-Pekka Lyytikainen - Fimlab
Charlotte Huppertz - Vrije Universiteit Amsterdam
Gonneke Willemsen - Vrije Universiteit Amsterdam
Wouter J. Peyrot - GGZ inGeest
Ying Wu - University of North Carolina at Chapel Hill
Kati Kristiansson - Finnish Institute for Health and Welfare
Ayse Demirkan - Leiden University Medical Center
Myriam Fornage - The University of Texas Health Science Center at Houston
Maija Hassinen - University of Eastern Finland
Lawrence F. Bielak - University of Michigan–Ann Arbor
Gemma Cadby - University of Western Australia
Toshiko Tanaka - National Institute on Aging
Reedlk Magl - University of Tartu
Peter J. Van der Most - University Medical Center Groningen
Anne U. Jackson - University of Michigan–Ann Arbor
Jennifer L. Bragg-Gresham - University of Michigan–Ann Arbor
Veronique Vitart - MRC Institute of Genetics and Molecular Medicine
Jonathan Marten - University of Edinburgh
Pau Navarro - University of Edinburgh
Claire Bellis - Agency for Science, Technology and Research
Dorota Pasko - University of Exeter
Asa Johansson - Uppsala University
Soren Snitker - Supreme Council Of Health
Yu-Ching Cheng - University of Maryland, Baltimore
Joel Eriksson - University of Gothenburg
Unhee Lim - University of Hawaii System
Mette Aadahl - University of Copenhagen
Linda S. Adair - University of North Carolina at Chapel Hill
Najaf Amin - Erasmus MC
Beverley Balkau - Inserm
Juha Auvinen - University of Oulu
John Beilby - Sir Charles Gairdner Hospital
Richard N. Bergman - Cedars-Sinai Medical Center
Sven Bergmann - University of Lausanne
Alain G. Bertoni - Wake Forest University
John Blangero - Texas Biomedical Research Institute
Amelle Bonnefond - Univ Lille, CNRS, Inst Pasteur Lille, UMR 8199,EGID, Lille, France
Lori L. Bonnycastle - National Human Genome Research Institute
Judith B. Borja - University of San Carlos
Soren Brage - University of Cambridge
Fabio Busonero - Institute of Genetic and Biomedical Research
Steve Buyske - Rutgers, The State University of New Jersey
Harry Campbell - Centre for Global Health Research
Peter S. Chines - National Human Genome Research Institute
Francis S. Collins - National Human Genome Research Institute
Tanguy Corre - University of Lausanne
George Davey Smith - University of Bristol
Graciela E. Delgado - University Medical Centre Mannheim
Nicole Dueker - University of Maryland, Baltimore
Marcus Doerr - DZHK, German Ctr Cardiovasc Res, Greifswald, Germany
Tapani Ebeling - Oulu University Hospital
Gudny Eiriksdottir - Icelandic Heart Association
Tonu Esko - University of Tartu
Jessica D. Faul - University of Michigan–Ann Arbor
Mao Fu - Supreme Council Of Health
Kristine Faerch - Steno Diabet Ctr, Gentofte, Denmark
Christian Gieger - Helmholtz Zentrum München
Sven Glaeser - College Station Medical Center
Jian Gong - Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA
Penny Gordon-Larsen - Univ N Carolina, Carolina Populat Ctr, Chapel Hill, NC USA
Harald Grallert - Helmholtz Zentrum München
Tanja B. Grammer - Heidelberg University
Niels Grarup - University of Copenhagen
Gerard van Grootheest - GGZ inGeest
Kennet Harald - Natl Inst Hlth & Welf, Dept Hlth, Helsinki, Finland
Nicholas D. Hastie - University of Edinburgh
Aki S. Havulinna - Natl Inst Hlth & Welf, Dept Hlth, Helsinki, Finland
Dena Hernandez - Institute of Aging
Lucia Hindorff - College Station Medical Center
Lynne J. Hocking - University of Aberdeen
Oddgeir L. Holmens - Trondheim Reg & Univ Hosp, St Olav Hosp, Trondheim, Norway
Christina Holzapfel - Helmholtz Zentrum München
Jouke Jan Hottenga - Vrije Univ, Dept Biol Psychol, Amsterdam, Netherlands
Jie Huang - Wellcome Sanger Institute
Tao Huang - Supreme Council Of Health
Jennie Hui - College Station Medical Center
Cornelia Huth - Helmholtz Zentrum München
Nina Hutri-Kahonen - Tampere University
Alan L. James - College Station Medical Center
John-Olov Jansson - University of Gothenburg
Min A. Jhun - Supreme Council Of Health
Markus Juonala - University of Turku
Leena Kinnunen - Natl Inst Hlth & Welf, Dept Hlth, Helsinki, Finland
Heikki A. Koistinen - Natl Inst Hlth & Welf, Dept Hlth, Helsinki, Finland
Ivana Kolcic - University of Split
Pirjo Komulainen - College Station Medical Center
Johanna Kuusisto - University of Eastern Finland
Kirsti Kvaloy - Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, HUNT Res Ctr, Levanger, Norway
Mika Kahonen - Tampere University
Timo A. Lakka - College Station Medical Center
Lenore J. Launer - Institute of Aging
Benjamin Lehne - Supreme Council Of Health
Cecilia M. Lindgren - University of Oxford
Mattias Lorentzon - University of Gothenburg
Robert Luben - University of Cambridge
Michel Marre - Ctr Rech Cordeliers, NSERM U1138, Equipe Pathophysiol & Therapeut Vasc & Renal Diab, Paris, France
Yuri Milaneschi - GGZ inGeest
Keri L. Monda - Supreme Council Of Health
Grant W. Montgomery - College Station Medical Center
Marleen H. M. De Moor - Vrije Univ, EMGO Inst, Amsterdam, Netherlands
Antonella Mulas - Cittadella Univ Monserrato, Consiglio Nazl Ric CNR, IRGB, Monserrato, Italy
Martina Mueller-Nurasyid - Helmholtz Zentrum München
A. W. Musk - College Station Medical Center
Reija Mannikko - College Station Medical Center
Satu Mannisto - Natl Inst Hlth & Welf, Dept Hlth, Helsinki, Finland
Narisu Narisu - College Station Medical Center
Matthias Nauck - DZHK, German Ctr Cardiovasc Res, Greifswald, Germany
Jennifer A. Nettleton - Univ Texas Hlth Sci Ctr Houston, Div Epidemiol Human Genet & Environm Sci, Houston, TX 77030 USA
Ilja M. Nolte - University of Groningen
Albertine J. Oldehinkel - University of Groningen
Matthias Olden - University of Regensburg
Ken K. Ong - University of Cambridge
Sandosh Padmanabhan - University of Edinburgh
Lavinia Paternoster - University of Bristol
Jeremiah Perez - Boston University
Markus Perola - Natl Inst Hlth & Welf, Dept Hlth, Helsinki, Finland
Annette Peters - Helmholtz Zentrum München
Ulrike Peters - Hutchinson
Patricia A. Peyser - Supreme Council Of Health
Inga Prokopenko - Imperial Coll London, Genom Common Dis, London, England
Hannu Puolijoki - South Ostrobothnia Cent Hosp, Seinajoki, Finland
Olli T. Raitakari - College Station Medical Center
Tuomo Rankinen - Pennington Biomed Res Ctr, Human Genom Lab, 6400 Perkins Rd, Baton Rouge, LA 70808 USA
Laura J. Rasmussen-Torvik - Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA
Rajesh Rawal - Helmholtz Zentrum München
Paul M. Ridker - Brigham and Women's Hospital
Lynda M. Rose - Brigham and Women's Hospital
Igor Rudan - Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland
Cinzia Sarti - City Helsinki, Social Serv & Hlth Care Dept, Helsinki, Finland
Mark A. Sarzynski - Pennington Biomed Res Ctr, Human Genom Lab, 6400 Perkins Rd, Baton Rouge, LA 70808 USA
Kai Savonen - College Station Medical Center
William R. Scott - Supreme Council Of Health
Serena Sanna - Cittadella Univ Monserrato, Consiglio Nazl Ric CNR, IRGB, Monserrato, Italy
Alan R. Shuldiner - Supreme Council Of Health
Steve Sidney - Kaiser Permanente
Guenther Silbernagel - University of Graz
Blair H. Smith - University of Edinburgh
Jennifer A. Smith - Supreme Council Of Health
Harold Snieder - University of Groningen
Alena Stancakova - University of Eastern Finland
Barbara Sternfeld - Kaiser Permanente
Amy J. Swift - College Station Medical Center
Tuija Tammelin - LIKES Res Ctr Sport & Hlth Sci, Jyvaskyla, Finland
Sian-Tsung Tan - Lung Institute
Barbara Thorand - Helmholtz Zentrum München
Dorothee Thuillier - University of Lille
Liesbeth Vandenput - University of Gothenburg
Henrik Vestergaard - University of Copenhagen
Jana V. van Vliet-Ostaptchouk - University of Groningen
Marie-Claude Vohl - Inst Nutr & Funct Foods, Quebec City, PQ, Canada
Uwe Voelker - DZHK, German Ctr Cardiovasc Res, Greifswald, Germany
Gerard Waeber - College Station Medical Center
Mark Walker - University of Newcastle Australia
Sarah Wild - Usher Inst Populat Hlth Sci & Informat, Ctr Populat Hlth Sci, Teviot Pl, Edinburgh, Midlothian, Scotland
Andrew Wong - Massachusetts Rehabilitation Commission
Alan F. Wright - University of Edinburgh
M. Carola Zillikens - Erasmus MC
Niha Zubair - Hutchinson
Christopher A. Haiman - Supreme Council Of Health
Loic Lemarchand - University of Hawaii System
Ulf Gyllensten - Uppsala University
Claes Ohlsson - University of Gothenburg
Claes Ohlsson
Albert Hofman - Erasmus MC
Fernando Rivadeneira - Erasmus MC
Andre G. Uitterlinden - Erasmus MC
Louis Perusse - Inst Nutr & Funct Foods, Quebec City, PQ, Canada
James F. Wilson - University of Edinburgh
Caroline Hayward - University of Edinburgh
Ozren Polasek - Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland
Francesco Cucca - Cittadella Univ Monserrato, Consiglio Nazl Ric CNR, IRGB, Monserrato, Italy
Kristian Hveem - Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, HUNT Res Ctr, Levanger, Norway
Catharina A. Hartman - University of Groningen
Anke Toenjes - College Station Medical Center
Stefania Bandinelli - Florence
Lyle J. Palmer - University of Adelaide
Sharon L. R. Kardia - Supreme Council Of Health
Rainer Rauramaa - College Station Medical Center
Thorkild I. A. Sorensen - University of Copenhagen
Jaakko Tuomilehto - Natl Inst Hlth & Welf, Dept Hlth, Helsinki, Finland
Veikko Salomaa - Natl Inst Hlth & Welf, Dept Hlth, Helsinki, Finland
Brenda W. J. H. Penninx - GGZ inGeest
Eco J. C. de Geus - Vrije Univ, Dept Biol Psychol, Amsterdam, Netherlands
Dorret I. Boomsma - Vrije Univ, Dept Biol Psychol, Amsterdam, Netherlands
Terho Lehtimaki - Fimlab
Massimo Mangino - Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England
Markku Laakso - University of Eastern Finland
Claude Bouchard - Pennington Biomed Res Ctr, Human Genom Lab, 6400 Perkins Rd, Baton Rouge, LA 70808 USA
Nicholas G. Martin - College Station Medical Center
Diana Kuh - Massachusetts Rehabilitation Commission
Yongmei Liu - Supreme Council Of Health
Allan Linneberg - Glostrup Univ Hosp, Res Ctr Prevent & Hlth, Glostrup, Denmark
Winfried Maerz - Heidelberg University
Konstantin Strauch - Helmholtz Zentrum München
Mika Kivimaki - UCL, Dept Epidemiol & Publ Hlth, London, England
Tamara B. Harris - NIA, Lab Epidemiol & Populat Sci, Bethesda, MD 20892 USA
Vilmundur Gudnason - Iceland Heart Assoc, Kopavogur, Iceland
Henry Voelzke - College Station Medical Center
Lu Qi - Supreme Council Of Health
Marjo-Riitta Jarvelin - Supreme Council Of Health
John C. Chambers - Supreme Council Of Health
Jaspal S. Kooner - Ealing Hosp HNS Trust, Dept Cardiol, Middlesex, England
Philippe Froguel - University of Lille
Charles Kooperberg - Hutchinson
Peter Vollenweider - College Station Medical Center
Goran Hallmans - Umeå University
Torben Hansen - University of Copenhagen
Oluf Pedersen - University of Copenhagen
Andres Metspalu - University of Tartu
Nicholas J. Wareham - University of Cambridge
Claudia Langenberg - University of Cambridge
David R. Weir - Univ Michigan, Inst Social Res, Survey Res Ctr, Ann Arbor, MI 48109 USA
David J. Porteous - University of Edinburgh
Eric Boerwinkle - Univ Texas Hlth Sci Ctr Houston, Div Epidemiol Human Genet & Environm Sci, Houston, TX 77030 USA
Daniel I. Chasman - Brigham and Women's Hospital
Goncalo R. Abecasis - Biostat
Ines Barroso - Wellcome Sanger Institute
Mark I. McCarthy - University of Oxford
Timothy M. Frayling - University of Exeter
Jeffrey R. O'Connell - Supreme Council Of Health
Cornelia M. van Duijn - Erasmus MC
Michael Boehnke - Biostat
Iris M. Heid - University of Regensburg
Karen L. Mohlke - Univ N Carolina, Dept Genet, Chapel Hill, NC USA
David P. Strachan - University of London
Caroline S. Fox - Framingham Heart Study
Ching-Ti Liu - Boston University
Joel N. Hirschhorn - Supreme Council Of Health
Robert J. Klein - Supreme Council Of Health
Andrew D. Johnson - Framingham Heart Dis Epidemiol Study, Natl Heart Lung & Blood Inst, Framingham, MA USA
Ingrid B. Borecki - Supreme Council Of Health
Paul W. Franks - Supreme Council Of Health
Kari E. North - Supreme Council Of Health
L. Adrienne Cupples - Framingham Heart Dis Epidemiol Study, Natl Heart Lung & Blood Inst, Framingham, MA USA
Ruth J. F. Loos - University of Cambridge
Tuomas O. Kilpelainen - University of Cambridge
PAGE Consortium
Publication Details: PLoS genetics, Vol.13(4), pp.e1006528-e1006528
Publisher: Public Library Science
Number of pages: 26
Grant note: Genetic Association Information Network of the Foundation for the National Institutes of Health RP-PG 0407 -10371 / UK National Institute for Health Research; National Institutes of Health Research (NIHR) ALK-Abello' NS (Horsholm, Denmark) CZD/16/6 / Scottish Executive Health Department Dutch Ministry of Justice German Diabetes Association Federation Francaise de Cardiologie Research Centre for Prevention and Health, the Capital Region for Denmark Danish Diabetes Academy Center for Medical Systems Biology Vastra Gotaland Foundation P30 DK72488 / Mid-Atlantic Nutrition Obesity Research Center Cardionics NHS Foundation Trust 4/26/2010 / Social Insurance Institution of Finland Emil Aaltonen Foundation FP-006; EU/QLRT-2001-01254 / European Science Foundation; European Science Foundation (ESF); European Commission 904-61-090; 985-10002; 904-61-193; 480-04-004; 400-05-717; Addiction-31160008; Middelgroot-911-09-032; Spinozapremie 56-464-14192; 2010/31471/ZONMVV / Netherlands Organisation for Health Research and Development; Netherlands Organization for Health Research and Development Sanofi-Aventis Wissenschaftsoffensive TMO Medical Research Council of Canada; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Agence Nationale de la Recherche; Agence Nationale de la Recherche (ANR) Merck Sante Swedish Foundation for Strategic Research; Swedish Foundation for Humanities & Social Sciences UK National Institute for Health Research BioResource Clinical Research Facility and Biomedical Research Centre ICS110.1/RF97.71 / Italian Ministry of Health; Ministry of Health, Italy 241944; 339462; 389927; 389875; 389891; 389892; 389938; 442915; 442981; 496739; 552485; 552498 / Australian National Health and Medical Research Council; National Health and Medical Research Council (NHMRC) of Australia Contrat de Projets Etat-Region European Regional Development Fund; European Commission Velux Foundation; Velux Fonden Neuroscience Campus Amsterdam FRN-CCT-83028 / Canadian Institutes of Health Research; Canadian Institutes of Health Research (CIHR) U.S. Department of Health and Human Services PahIssons Foundation Yrjo Jahnsson Foundation Marcus Borgstrom Foundation University Medical Center Groningen Federal State of Mecklenburg - West Pomerania Ministry of Cultural Affairs of the Federal State of Mecklenburg-West Pomerania Lundberg Foundation Siemens Healthcare; Siemens AG 2008.024 / Netherlands Bioinformatics Centre Pierre Fabre MC_U106179471; G0500539; G0600705; G0601966; G0700931; G1002319; K013351; MC_UU_12019/1 / UK Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Arthritis Research UK; Versus Arthritis Roche; Roche Holding K2007-66X-20270-013; 2011-2354 / Swedish Medical Research Council; Swedish Medical Research Council (SMRC) 108-1080315-0302 / Republic of Croatia Ministry of Science, Education and Sport Australian Associated Brewers Heart Foundation of Northern Sweden Canada Foundation for Innovation; CGIAR; Spanish Government Erasmus University John D and Catherine T MacArthur Foundation MC_UU_12015/2; MC_UU_12015/3; MC_UU_12015/1; MC_UU_12019/1; MC_U106179473; MR/K002414/1; MC_UU_12013/1; MR/K013351/1 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Association Diabete Risque Vasculaire Paivikki and Sakari Sohlberg Foundation ALFEDIAM Paavo Nurmi Foundation SFB-1052; SPP 1629 TO 718/2-1 / German Research Council; German Research Foundation (DFG) UK Department of Health; National Institutes of Health Research (NIHR) Finnish Cultural Foundation; Finnish IT center for science Swedish Society for Medical Research IUT20-60; IUT24-6 / Estonian Government 014-93-015; RIDE2 / Research Institute for Diseases in the Elderly 13P0ST16500011; 10SDG269004 / American Heart Association Social Ministry of the Federal State of Mecklenburg-West Pomerania 084723/Z/08/Z; 088869/B/09/ Z; 090532; 091551; 098051; 098381 / Wellcome Trust 627 / Ministry of Education and Culture of Finland 20140543 / Swedish Heart-Lung Foundation NF-SI-0611-10099 / National Institute for Health Research; National Institutes of Health Research (NIHR) HS06516 / Agency for Health Care Policy Research; United States Department of Health & Human Services; Agency for Healthcare Research & Quality Cohortes Sante TGIR Leiden University Medical Center 2015-03657 / Swedish Research Council; Swedish Research Council for Health Working Life & Welfare (Forte); Swedish Research Council Formas MC_UU_12013/1; MC_UU_12015/3; MC_UU_12019/1; MC_PC_13048; MR/K013351/1; MC_UU_12015/2; MC_UU_12015/1; MC_PC_13046; MR/K002414/1; MC_U106179473 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) NNF14OC0011039; NNF17OC0026828; NNF15OC0016220; NNF14OC0010513; NNF13OC0004839; NNF14OC0009883; NNF16OC0021214; NNF13OC0005785 / Novo Nordisk Fonden; Novo Nordisk Foundation 1 IK2 BX001823 / Veterans Affairs; US Department of Veterans Affairs Icelandic Parliament Lundbeck Foundation; Lundbeckfonden National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 129619 / Academy of Finland (AKA); Research Council of Finland; Finnish Funding Agency for Technology & Innovation (TEKES) Netherlands Genomics Initiative Becton Dickinson Office National Interprofessionel des Vins King's College London; General Electric X51001 / Kuopio, Tampere and Turku University Hospital Medical Funds SP1GVARENG / University of Tartu NIMH U24 MH068457-06 / Rutgers University Cell and DNA Repository Stroke Association AG13196; 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Medical Research Council UK (MRC) Kjell och Marta Beijers Foundation Icelandic Heart Association Food Standards Agency Ardix Medical Health and Safety Executive State of Bavaria Bayer Diagnostics; Bayer AG Ministere de l'Economie, de l'Innovation et des Exportations; Ministry for Health, Welfare and Sports of the Netherlands 2011036 / United States - Israel Binational Science Foundation Grant; US-Israel Binational Science Foundation HEALTH-F4-2007-201413) / VU University's Institute for Health and Care Research (EMGO+) and Neuroscience Campus Amsterdam Goran Gustafssons Foundation 01ER1206; 01ER1507 / German Federal Ministry of Education and Research; Federal Ministry of Education & Research (BMBF) 10-000-1002; GB -MW 940-38-011; 100-001-004; 60-60600-97-118, 26198-710; GB-MaGW 480-01-006; GB-MaGW 480-07-001; GB-MaGW 452-04-314; GB-MaGW 45206-004; 175.010.2003.005; 175.010.2005.011; 481-08-013; 480-05-003; 911-03-012 / Netherlands Organisation for Scientific Research; Netherlands Organization for Scientific Research (NWO) RG/10/12/28456; SP/04/002 / British Heart Foundation Goteborg Medical Society Age UK Research into Ageing Fund 102318; 104781; 120315; 123885; 129619; 286284; 134309; 126925; 121584; 124282; 129378; 117787; 250207; 258753; 41071; 77299; 124243; 1114194; 24300796 / Academy of Finland; Research Council of Finland Novo Nordisk; Novo Nordisk Foundation RG/10/12/28456 / British Heart Foundation National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) Royal Society Avera Research Institute Finnish Foundation of Cardiovascular Research Municipality of Rotterdam Chief Scientist Office of the Scottish Government NWO-RFBR 047.017.043 / Russian Foundation for Basic Research; Russian Foundation for Basic Research (RFBR); Spanish Government 75617 / University Hospital Oulu Finnish Diabetes Association LMUinnovativ INSERM, Reseaux en Sante Publique, Interactions entre les determinants de la sante; Institut National de la Sante et de la Recherche Medicale (Inserm) UK National Institute for Health Research (NIHR) Comprehensive Biomedical Research Centre; National Institutes of Health Research (NIHR) Ministry of Education, Culture and Science of the Netherlands; MRC Human Genetics Unit; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Ake Wiberg Foundation UK Diabetes Association Department of Psychology and Education of the VU University Amsterdam; Diabetes Hilfs- und Forschungsfonds Deutschland Kuopio University Hospital 8875 / Croatian Science Foundation Danish Agency for Science, Technology and Innovation Fondation de France AstraZeneca Novartis Pharmaceuticals; Novartis ALF/LUA Research Grant in Gothenburg Center of Excellence in Complex Disease Genetics and SALVECenter of Excellence in Genomics (EXCEGEN) 3.2.0304.11-0312 / Estonian Ministry of Education and Research; Ministry of Education and Research, Estonia 01ZZ9603; 01ZZ0103; 01ZZ0403; 03ZIK012; 031S2061A / Federal Ministry of Education and Research; Federal Ministry of Education & Research (BMBF) 230374; 284167; 323195; 692145; FP7 EurHEALTHAgeing-277849; FP7 BBMRI-LPC 313010; 602633; HEALTH-F2-2008-201865-GEFOS; HEALTH-F4-2007-201413; FP6 LSHM-CT-2004-005272; FP5 QLG2-CT-2002-01254 / European Commission; European Commission Joint Research Centre DFF-1333-00124; DFF-1331-007308 / Danish Council for Independent Research; Det Frie Forskningsrad (DFF) Finnish Heart Association Lilly; Eli Lilly DK46200 / Biocentrum Helsinki; Boston Obesity Nutrition Research Center 33CSC0-122661; 33CS30-139468; 33CS30-148401 / Swiss National Science Foundation; Swiss National Science Foundation (SNSF) Topcon; Torsten and Ragnar Soderberg's Foundation Cancer Research UK Vleugels Foundation Timber Merchant Vilhelm Bangs Foundation GlaxoSmithKline Italian Ministry of Economy and Finance Umea University Career Development Award Juho Vainio Foundation Swedish Diabetes Association Ejner Danielsens Foundation MEKOS Laboratories (Denmark) Fonds Sante
Identifiers: 9937550708331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article