Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

Anubha Mahajan; Min Jin Go; Weihua Zhang; Jennifer E. Below; Kyle J. Gaulton; Teresa Ferreira; Momoko Horikoshi; Andrew D. Johnson; Maggie C. Y. Ng; Inga Prokopenko; Danish Saleheen; Xu Wang; Eleftheria Zeggini; Goncalo R. Abecasis; Linda S. Adair; Peter Almgren; Mustafa Atalay; Tin Aung; Damiano Baldassarre; Beverley Balkau; Yuqian Bao; Anthony H. Barnett; Ines Barroso; Abdul Basit; Latonya F. Been; John Beilby; Graeme I. Bell; Rafn Benediktsson; Richard N. Bergman; Bernhard O. Boehm; Eric Boerwinkle; Lori L. Bonnycastle; Noel Burtt; Qiuyin Cai; Harry Campbell; Jason Carey; Stephane Cauchi; Mark Caulfield; Juliana C. N. Chan; Li-Ching Chang; Tien-Jyun Chang; Yi-Cheng Chang; Guillaume Charpentier; Chien-Hsiun Chen; Han Chen; Yuan-Tsong Chen; Kee-Seng Chia; Manickam Chidambaram; Peter S. Chines; Nam H. Cho; Young Min Cho; Lee-Ming Chuang; Francis S. Collins; Marilyn C. Cornelis; David J. Couper; Andrew T. Crenshaw; Rob M. van Dam; John Danesh; Debashish Das; Ulf de Faire; George Dedoussis; Panos Deloukas; Antigone S. Dimas; Christian Dina; Alex S. F. Doney; Peter J. Donnelly; Mozhgan Dorkhan; Cornelia van Duijn; Josee Dupuis; Sarah Edkins; Paul Elliott; Valur Emilsson; Raimund Erbel; Johan G. Eriksson; Jorge Escobedo; Tonu Esko; Elodie Eury; Jose C. Florez; Pierre Fontanillas; Nita G. Forouhi; Tom Forsen; Caroline Fox; Ross M. Fraser; Timothy M. Frayling; Philippe Froguel; Philippe Frossard; Yutang Gao; Karl Gertow; Christian Gieger; Bruna Gigante; Harald Grallert; George B. Grant; Leif C. Groop; Christopher J. Groves; Elin Grundberg; Candace Guiducci; Anders Hamsten; Bok-Ghee Han; Kazuo Hara; Neelam Hassanali; Andrew T. Hattersley; Caroline Hayward; Asa K. Hedman; Christian Herder; Albert Hofman; Oddgeir L. Holmen; Kees Hovingh; Astradur B. Hreidarsson; Cheng Hu; Frank B. Hu; Jennie Hui; Steve E. Humphries; Sarah E. Hunt; David J. Hunter; Kristian Hveem; Zafar I. Hydrie; Hiroshi Ikegami; Thomas Illig; Erik Ingelsson; Muhammed Islam; Bo Isomaa; Anne U. Jackson; Tazeen Jafar; Alan James; Weiping Jia; Karl-Heinz Joeckel; Anna Jonsson; Jeremy B. M. Jowett; Takashi Kadowaki; Hyun Min Kang; Stavroula Kanoni; Wen Hong L. Kao; Sekar Kathiresan; Norihiro Kato; Prasad Katulanda; Sirkka M. Keinanen-Kiukaanniemi; Ann M. Kelly; Hassan Khan; Kay-Tee Khaw; Chiea-Chuen Khor; Hyung-Lae Kim; Sangsoo Kim; Young Jin Kim; Leena Kinnunen; Norman Klopp; Augustine Kong; Eeva Korpi-Hyovalti; Sudhir Kowlessur; Peter Kraft; Jasmina Kravic; Malene M. Kristensen; S. Krithika; Ashish Kumar; Jesus Kumate; Johanna Kuusisto; Soo Heon Kwak; Markku Laakso; Vasiliki Lagou; Timo A. Lakka; Claudia Langenberg; Cordelia Langford; Robert Lawrence; Karin Leander; Jen-Mai Lee; Nanette R. Lee; Man Li; Xinzhong Li; Yun Li; Junbin Liang; Samuel Liju; Wei-Yen Lim; Lars Lind; Cecilia M. Lindgren; Eero Lindholm; Ching-Ti Liu; Jian Jun Liu; Stephane Lobbens; Jirong Long; Ruth J. F. Loos; Wei Lu; Jian'an Luan; Valeriya Lyssenko; Ronald C. W. Ma; Shiro Maeda; Reedik Maegi; Satu Mannisto; David R. Matthews; James B. Meigs; Olle Melander; Andres Metspalu; Julia Meyer; Ghazala Mirza; Evelin Mihailov; Susanne Moebus; Viswanathan Mohan; Karen L. Mohlke; Andrew D. Morris; Thomas W. Muehleisen; Martina Mueller-Nurasyid; Bill Musk; Jiro Nakamura; Eitaro Nakashima; Pau Navarro; Peng-Keat Ng; Alexandra C. Nica; Peter M. Nilsson; Inger Njolstad; Markus M. Noethen; Keizo Ohnaka; Twee Hee Ong; Katharine R. Owen; Colin N. A. Palmer; James S. Pankow; Kyong Soo Park; Melissa Parkin; Sonali Pechlivanis; Nancy L. Pedersen; Leena Peltonen; John R. B. Perry; Annette Peters; Janani M. Pinidiyapathirage; Carl G. P. Platou; Simon Potter; Jackie F. Price; Lu Qi; Venkatesan Radha; Loukianos Rallidis; Asif Rasheed; Wolfgang Rathmann; Rainer Rauramaa; Soumya Raychaudhuri; N. William Rayner; Simon D. Rees; Emil Rehnberg; Samuli Ripatti; Neil Robertson; Michael Roden; Elizabeth J. Rossin; Igor Rudan; Denis Rybin; Timo E. Saaristo; Veikko Salomaa; Juha Saltevo; Maria Samuel; Dharambir K. Sanghera; Jouko Saramies; James Scott; Laura J. Scott; Robert A. Scott; Ayellet V. Segre; Joban Sehmi; Bengt Sennblad; Nabi Shah; Sonia Shah; A. Samad Shera; Xiao Ou Shu; Alan R. Shuldiner; Gunnar Sigurdsson; Eric Sijbrands; Angela Silveira; Xueling Sim; Suthesh Sivapalaratnam; Kerrin S. Small; Wing Yee So; Alena Stancakova; Kari Stefansson; Gerald Steinbach; Valgerdur Steinthorsdottir; Kathleen Stirrups; Rona J. Strawbridge; Heather M. Stringham; Qi Sun; Chen Suo; Ann-Christine Syvanen; Ryoichi Takayanagi; Fumihiko Takeuchi; Wan Ting Tay; Tanya M. Teslovich; Barbara Thorand; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Emmi Tikkanen; Joseph Trakalo; Elena Tremoli; Mieke D. Trip; Fuu Jen Tsai; Tiinamaija Tuomi; Jaakko Tuomilehto; Andre G. Uitterlinden; Adan Valladares-Salgado; Sailaja Vedantam; Fabrizio Veglia; Benjamin F. Voight; Congrong Wang; Nicholas J. Wareham; Roman Wennauer; Ananda R. Wickremasinghe; Tom Wilsgaard; James F. Wilson; Steven Wiltshire; Wendy Winckler; Tien Yin Wong; Andrew R. Wood; Jer-Yuarn Wu; Ying Wu; Ken Yamamoto; Toshimasa Yamauchi; Mingyu Yang; Loic Yengo; Mitsuhiro Yokota; Robin Young; Delilah Zabaneh; Fan Zhang; Rong Zhang; Wei Zheng; Paul Z. Zimmet; David Altshuler; Donald W. Bowden; Yoon Shin Cho; Nancy J. Cox; Miguel Cruz; Craig L. Hanis; Jaspal Kooner; Jong-Young Lee; Mark Seielstad; Yik Ying Teo; Michael Boehnke; Esteban J. Parra; John C. Chambers; E. Shyong Tai; Mark I. McCarthy; Andrew P. Morris; South Asian Type Diabet SAT2D Cons

doi:10.1038/ng.2897

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Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

Journal article

Peer reviewed

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility

Anubha Mahajan, Min Jin Go, Weihua Zhang, Jennifer E. Below, Kyle J. Gaulton, Teresa Ferreira, Momoko Horikoshi, Andrew D. Johnson, Maggie C. Y. Ng, Inga Prokopenko, …

Nature genetics, Vol.46(3), pp.234-244

01/03/2014

DOI: https://doi.org/10.1038/ng.2897

PMCID: PMC3969612

PMID: 24509480

Abstract

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

To further understanding of the genetic basis of type 2 diabetes (T2D) susceptibility, we aggregated published meta-analyses of genome-wide association studies (GWAS), including 26,488 cases and 83,964 controls of European, east Asian, south Asian and Mexican and Mexican American ancestry. We observed a significant excess in the directional consistency of T2D risk alleles across ancestry groups, even at SNPs demonstrating only weak evidence of association. By following up the strongest signals of association from the trans-ethnic meta-analysis in an additional 21,491 cases and 55,647 controls of European ancestry, we identified seven new T2D susceptibility loci. Furthermore, we observed considerable improvements in the fine-mapping resolution of common variant association signals at several T2D susceptibility loci. These observations highlight the benefits of trans-ethnic GWAS for the discovery and characterization of complex trait loci and emphasize an exciting opportunity to extend insight into the genetic architecture and pathogenesis of human diseases across populations of diverse ancestry.

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Title: Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
Creators - without role: Anubha Mahajan - Wellcome Centre for Human Genetics
Min Jin Go - Korea National Institute of Health
Weihua Zhang - Imperial College London
Jennifer E. Below - Seattle University
Kyle J. Gaulton - Wellcome Centre for Human Genetics
Teresa Ferreira - Wellcome Centre for Human Genetics
Momoko Horikoshi - University of Oxford
Andrew D. Johnson - National Heart Lung and Blood Institute
Maggie C. Y. Ng - Wake Forest University
Inga Prokopenko - Wellcome Centre for Human Genetics
Danish Saleheen - Center for Non-Communicable Diseases
Xu Wang - Duke-NUS Medical School
Eleftheria Zeggini - Wellcome Sanger Institute
Goncalo R. Abecasis - University of Michigan–Ann Arbor
Linda S. Adair - University of North Carolina at Chapel Hill
Peter Almgren - Lund University
Mustafa Atalay - University of Eastern Finland
Tin Aung - Singapore Eye Research Institute
Damiano Baldassarre - Centro Cardiologico Monzino
Beverley Balkau - University of Paris-Sud
Yuqian Bao - Shanghai Sixth People's Hospital
Anthony H. Barnett - University of Birmingham
Ines Barroso - Wellcome Sanger Institute
Abdul Basit - Baqai Institute of Diabetology and Endocrinology
Latonya F. Been - University of Oklahoma Health Sciences Center
John Beilby - Queen Elizabeth II Medical Centre
Graeme I. Bell - University of Chicago
Rafn Benediktsson - University of Iceland
Richard N. Bergman - Cedars-Sinai Medical Center
Bernhard O. Boehm - Nanyang Technological University
Eric Boerwinkle - The University of Texas Health Science Center at Houston
Lori L. Bonnycastle - National Institutes of Health
Noel Burtt - Broad Institute
Qiuyin Cai - Vanderbilt University
Harry Campbell - University of Edinburgh
Jason Carey - Broad Institute
Stephane Cauchi - Pasteur Institute of Lille
Mark Caulfield - Queen Mary University of London
Juliana C. N. Chan - Chinese University of Hong Kong
Li-Ching Chang - Institute of Biomedical Sciences, Academia Sinica
Tien-Jyun Chang - National Taiwan University Hospital
Yi-Cheng Chang - National Taiwan University Hospital
Guillaume Charpentier - Centre Hospitalier Sud Francilien
Chien-Hsiun Chen - Institute of Biomedical Sciences, Academia Sinica
Han Chen - Boston University
Yuan-Tsong Chen - Acad Sinica, Inst Biomed Sci, Taipei, Taiwan
Kee-Seng Chia - National University of Singapore
Manickam Chidambaram - Madras Diabetes Research Foundation
Peter S. Chines - National Institutes of Health
Nam H. Cho - Ajou University
Young Min Cho - Seoul National University
Lee-Ming Chuang - National Taiwan University Hospital
Francis S. Collins - National Institutes of Health
Marilyn C. Cornelis - Harvard University
David J. Couper - University of North Carolina at Chapel Hill
Andrew T. Crenshaw - Broad Institute
Rob M. van Dam - Duke-NUS Medical School
John Danesh - University of Cambridge
Debashish Das - Ealing Hospital
Ulf de Faire - Karolinska Institutet
George Dedoussis - Harokopio University of Athens
Panos Deloukas - Wellcome Sanger Institute
Antigone S. Dimas - Wellcome Centre for Human Genetics
Christian Dina - Inserm
Alex S. F. Doney - University of Dundee
Peter J. Donnelly - University of Oxford
Mozhgan Dorkhan - Lund University
Cornelia van Duijn - Erasmus MC
Josee Dupuis - National Heart Lung and Blood Institute
Sarah Edkins - Wellcome Sanger Institute
Paul Elliott - Imperial College London
Valur Emilsson - Icelandic Heart Association
Raimund Erbel - West German Heart and Vascular Center Essen
Johan G. Eriksson - Finnish Institute for Health and Welfare
Jorge Escobedo - Mexican Social Security Institute
Tonu Esko - University of Tartu
Elodie Eury - Pasteur Institute of Lille
Jose C. Florez - Broad Institute
Pierre Fontanillas - Broad Institute
Nita G. Forouhi - MRC Epidemiology Unit
Tom Forsen - University of Helsinki
Caroline Fox - Framingham Heart Study
Ross M. Fraser - University of Edinburgh
Timothy M. Frayling - University of Exeter
Philippe Froguel - Pasteur Institute of Lille
Philippe Frossard - Center for Non-Communicable Diseases
Yutang Gao - Shanghai Cancer Institute
Karl Gertow - Karolinska Institutet
Christian Gieger - Helmholtz Zentrum München
Bruna Gigante - Karolinska Institutet
Harald Grallert - Helmholtz Zentrum München
George B. Grant - Broad Institute
Leif C. Groop - Scania
Christopher J. Groves - University of Oxford
Elin Grundberg - King's College London
Candace Guiducci - Broad Institute
Anders Hamsten - Karolinska Institutet
Bok-Ghee Han - Korea National Institute of Health
Kazuo Hara - The University of Tokyo
Neelam Hassanali - University of Oxford
Andrew T. Hattersley - University of Exeter
Caroline Hayward - University of Edinburgh
Asa K. Hedman - University of Oxford
Christian Herder - Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Ctr, Inst Clin Diabetol, Dusseldorf, Germany
Albert Hofman - College Station Medical Center
Oddgeir L. Holmen - Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, HUNT Res Ctr, Levanger, Norway
Kees Hovingh - University of Amsterdam
Astradur B. Hreidarsson - Landspitali Univ Hosp, Reykjavik, Iceland
Cheng Hu - Shanghai Jiao Tong University
Frank B. Hu - Harvard University
Jennie Hui - College Station Medical Center
Steve E. Humphries - UCL, Inst Cardiovasc Sci, London, England
Sarah E. Hunt - Wellcome Sanger Institute
David J. Hunter - Harvard University
Kristian Hveem - Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, HUNT Res Ctr, Levanger, Norway
Zafar I. Hydrie - Baqai Inst Diabetol & Endocrinol, Karachi, Pakistan
Hiroshi Ikegami - Kindai University
Thomas Illig - Helmholtz Zentrum Muenchen, Res Unit Mol Epidemiol, Neuherberg, Germany
Erik Ingelsson - University of Oxford
Muhammed Islam - Aga Khan Univ, Dept Community Hlth Sci, Karachi, Pakistan
Bo Isomaa - Folkhalsan Res Ctr, Helsinki, Finland
Anne U. Jackson - Biostat
Tazeen Jafar - Aga Khan University
Alan James - College Station Medical Center
Weiping Jia - Shanghai Jiao Tong University
Karl-Heinz Joeckel - College Station Medical Center
Anna Jonsson - Lund University
Jeremy B. M. Jowett - Heart & Diabet Inst, Baker Int Diabet Inst IDI, Melbourne, Australia
Takashi Kadowaki - The University of Tokyo
Hyun Min Kang - Biostat
Stavroula Kanoni - Wellcome Sanger Institute
Wen Hong L. Kao - Supreme Council Of Health
Sekar Kathiresan - Massachusetts Institute of Technology
Norihiro Kato - College Station Medical Center
Prasad Katulanda - University of Oxford
Sirkka M. Keinanen-Kiukaanniemi - University of Oulu
Ann M. Kelly - University of Birmingham
Hassan Khan - University of Cambridge
Kay-Tee Khaw - University of Cambridge
Chiea-Chuen Khor - Singapore Eye Research Institute
Hyung-Lae Kim - Ewha Womans University
Sangsoo Kim - Soongsil University
Young Jin Kim - Natl Inst Hlth, Ctr Genome Sci, Gangoe Myeon, Yeonje Ri, South Korea
Leena Kinnunen - Natl Inst Hlth & Welf, Diabet Prevent Unit, Helsinki, Finland
Norman Klopp - Helmholtz Zentrum Muenchen, Res Unit Mol Epidemiol, Neuherberg, Germany
Augustine Kong - deCODE Genet, Reykjavik, Iceland
Eeva Korpi-Hyovalti - South Ostrobothnia Cent Hosp, Seinajoki, Finland
Sudhir Kowlessur - Minist Hlth, Port Louis, Mauritius
Peter Kraft - Harvard University
Jasmina Kravic - Lund University
Malene M. Kristensen - Heart & Diabet Inst, Baker Int Diabet Inst IDI, Melbourne, Australia
S. Krithika - University of Toronto
Ashish Kumar - University of Oxford
Jesus Kumate - Fdn IMSS, Mexico City, DF, Mexico
Johanna Kuusisto - University of Eastern Finland
Soo Heon Kwak - College Station Medical Center
Markku Laakso - University of Eastern Finland
Vasiliki Lagou - University of Oxford
Timo A. Lakka - University of Eastern Finland
Claudia Langenberg - Massachusetts Rehabilitation Commission
Cordelia Langford - Wellcome Sanger Institute
Robert Lawrence - University of Western Australia
Karin Leander - Karolinska Institutet
Jen-Mai Lee - Natl Univ Singapore, Dept Epidemiol & Publ Hlth, Singapore 117548, Singapore
Nanette R. Lee - University of San Carlos
Man Li - Supreme Council Of Health
Xinzhong Li - University of London
Yun Li - Univ N Carolina, Dept Genet, Chapel Hill, NC USA
Junbin Liang - Beijing Genom Inst, Shenzhen, Peoples R China
Samuel Liju - College Station Medical Center
Wei-Yen Lim - Natl Univ Singapore, Ctr Mol Epidemiol, Singapore 117548, Singapore
Lars Lind - Uppsala University
Cecilia M. Lindgren - University of Oxford
Eero Lindholm - Lund University
Ching-Ti Liu - Boston University
Jian Jun Liu - Genome Institute of Singapore
Stephane Lobbens - CNRS, Unite Mixte Rech UMR 8199, Inst Biol, Lille, France
Jirong Long - Vanderbilt University
Ruth J. F. Loos - Massachusetts Rehabilitation Commission
Wei Lu - College Station Medical Center
Jian'an Luan - Massachusetts Rehabilitation Commission
Valeriya Lyssenko - Lund University
Ronald C. W. Ma - Chinese University of Hong Kong
Shiro Maeda - Supreme Council Of Health
Reedik Maegi - University of Tartu
Satu Mannisto - Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland
David R. Matthews - University of Oxford
James B. Meigs - Harvard University
Olle Melander - Lund University
Andres Metspalu - University of Tartu
Julia Meyer - Helmholtz Zentrum Muenchen, Inst Genet Epidemiol, Neuherberg, Germany
Ghazala Mirza - University of Oxford
Evelin Mihailov - University of Tartu
Susanne Moebus - College Station Medical Center
Viswanathan Mohan - College Station Medical Center
Karen L. Mohlke - Univ N Carolina, Dept Genet, Chapel Hill, NC USA
Andrew D. Morris - University of Dundee
Thomas W. Muehleisen - University of Bonn
Martina Mueller-Nurasyid - Helmholtz Zentrum Muenchen, Inst Genet Epidemiol, Neuherberg, Germany
Bill Musk - College Station Medical Center
Jiro Nakamura - Nagoya University
Eitaro Nakashima - Nagoya University
Pau Navarro - University of Edinburgh
Peng-Keat Ng - Natl Univ Singapore, Dept Epidemiol & Publ Hlth, Singapore 117548, Singapore
Alexandra C. Nica - University of Geneva
Peter M. Nilsson - Lund University
Inger Njolstad - College Station Medical Center
Markus M. Noethen - University of Bonn
Keizo Ohnaka - Kyushu University
Twee Hee Ong - Natl Univ Singapore, Dept Epidemiol & Publ Hlth, Singapore 117548, Singapore
Katharine R. Owen - University of Oxford
Colin N. A. Palmer - University of Dundee
James S. Pankow - University of Minnesota
Kyong Soo Park - College Station Medical Center
Melissa Parkin - Massachusetts Institute of Technology
Sonali Pechlivanis - College Station Medical Center
Nancy L. Pedersen - Karolinska Institutet
Leena Peltonen - Wellcome Sanger Institute
John R. B. Perry - University of Oxford
Annette Peters - Helmholtz Zentrum Muenchen, Inst Epidemiol 2, Neuherberg, Germany
Janani M. Pinidiyapathirage - University of Kelaniya
Carl G. P. Platou - Norwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, HUNT Res Ctr, Levanger, Norway
Simon Potter - Wellcome Sanger Institute
Jackie F. Price - University of Edinburgh
Lu Qi - Harvard University
Venkatesan Radha - College Station Medical Center
Loukianos Rallidis - Univ Gen Hosp Attikon, Athens, Greece
Asif Rasheed - Ctr Noncommunicable Dis Pakistan, Karachi, Pakistan
Wolfgang Rathmann - Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Ctr, Inst Biometr & Epidemiol, Dusseldorf, Germany
Rainer Rauramaa - College Station Medical Center
Soumya Raychaudhuri - Massachusetts Institute of Technology
N. William Rayner - University of Oxford
Simon D. Rees - University of Birmingham
Emil Rehnberg - Karolinska Institutet
Samuli Ripatti - Wellcome Sanger Institute
Neil Robertson - University of Oxford
Michael Roden - Univ Dusseldorf, Leibniz Ctr Diabet Res, German Diabet Ctr, Inst Clin Diabetol, Dusseldorf, Germany
Elizabeth J. Rossin - Massachusetts Institute of Technology
Igor Rudan - University of Edinburgh
Denis Rybin - Boston University
Timo E. Saaristo - Finnish Diabet Assoc, Tampere, Finland
Veikko Salomaa - Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland
Juha Saltevo - College Station Medical Center
Maria Samuel - Ctr Noncommunicable Dis Pakistan, Karachi, Pakistan
Dharambir K. Sanghera - University of Oklahoma
Jouko Saramies - South Karelia Cent Hosp, Lappeenranta, Finland
James Scott - University of London
Laura J. Scott - Biostat
Robert A. Scott - Massachusetts Rehabilitation Commission
Ayellet V. Segre - Massachusetts Institute of Technology
Joban Sehmi - Ealing Hosp NHS Trust, Southall, Middx, England
Bengt Sennblad - Karolinska Institutet
Nabi Shah - Ctr Noncommunicable Dis Pakistan, Karachi, Pakistan
Sonia Shah - UCL, Dept Genet Evolut & Environm, Genet Inst, London, England
A. Samad Shera - Diabet Assoc Pakistan, Karachi, Pakistan
Xiao Ou Shu - Vanderbilt University
Alan R. Shuldiner - Supreme Council Of Health
Gunnar Sigurdsson - Landspitali Univ Hosp, Reykjavik, Iceland
Eric Sijbrands - College Station Medical Center
Angela Silveira - Karolinska Institutet
Xueling Sim - Biostat
Suthesh Sivapalaratnam - University of Amsterdam
Kerrin S. Small - Wellcome Sanger Institute
Wing Yee So - Chinese University of Hong Kong
Alena Stancakova - University of Eastern Finland
Kari Stefansson - University of Iceland
Gerald Steinbach - University of Ulm
Valgerdur Steinthorsdottir - deCODE Genet, Reykjavik, Iceland
Kathleen Stirrups - Wellcome Sanger Institute
Rona J. Strawbridge - Karolinska Institutet
Heather M. Stringham - Biostat
Qi Sun - Harvard University
Chen Suo - Natl Univ Singapore, Ctr Mol Epidemiol, Singapore 117548, Singapore
Ann-Christine Syvanen - Uppsala University
Ryoichi Takayanagi - Kyushu University
Fumihiko Takeuchi - College Station Medical Center
Wan Ting Tay - Singapore Eye Research Institute
Tanya M. Teslovich - Biostat
Barbara Thorand - Helmholtz Zentrum Muenchen, Inst Epidemiol 2, Neuherberg, Germany
Gudmar Thorleifsson - deCODE Genet, Reykjavik, Iceland
Unnur Thorsteinsdottir - University of Iceland
Emmi Tikkanen - Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland
Joseph Trakalo - University of Oxford
Elena Tremoli - Centro Cardiologico Monzino
Mieke D. Trip - University of Amsterdam
Fuu Jen Tsai - Supreme Council Of Health
Tiinamaija Tuomi - Folkhalsan Res Ctr, Helsinki, Finland
Jaakko Tuomilehto - Natl Inst Hlth & Welf, Diabet Prevent Unit, Helsinki, Finland
Andre G. Uitterlinden - College Station Medical Center
Adan Valladares-Salgado - College Station Medical Center
Sailaja Vedantam - Broad Institute
Fabrizio Veglia - Centro Cardiologico Monzino
Benjamin F. Voight - Massachusetts Institute of Technology
Congrong Wang - Shanghai Jiao Tong University
Nicholas J. Wareham - Massachusetts Rehabilitation Commission
Roman Wennauer - College Station Medical Center
Ananda R. Wickremasinghe - University of Kelaniya
Tom Wilsgaard - College Station Medical Center
James F. Wilson - University of Edinburgh
Steven Wiltshire - University of Oxford
Wendy Winckler - Massachusetts Institute of Technology
Tien Yin Wong - Singapore Eye Research Institute
Andrew R. Wood - University of Exeter
Jer-Yuarn Wu - Acad Sinica, Inst Biomed Sci, Taipei, Taiwan
Ying Wu - Univ N Carolina, Dept Genet, Chapel Hill, NC USA
Ken Yamamoto - Kyushu University
Toshimasa Yamauchi - The University of Tokyo
Mingyu Yang - Beijing Genom Inst, Shenzhen, Peoples R China
Loic Yengo - CNRS, Unite Mixte Rech UMR 8199, Inst Biol, Lille, France
Mitsuhiro Yokota - Aichi Gakuin University
Robin Young - University of Cambridge
Delilah Zabaneh - UCL, Dept Genet Evolut & Environm, Genet Inst, London, England
Fan Zhang - Beijing Genom Inst, Shenzhen, Peoples R China
Rong Zhang - Shanghai Jiao Tong University
Wei Zheng - Vanderbilt University
Paul Z. Zimmet - Heart & Diabet Inst, Baker Int Diabet Inst IDI, Melbourne, Australia
David Altshuler - Massachusetts Institute of Technology
Donald W. Bowden - Supreme Council Of Health
Yoon Shin Cho - Hallym University
Nancy J. Cox - University of Chicago
Miguel Cruz - College Station Medical Center
Craig L. Hanis - Univ Texas Hlth Sci Ctr Houston, Ctr Human Genet, Houston, TX 77030 USA
Jaspal Kooner - Ealing Hosp NHS Trust, Southall, Middx, England
Jong-Young Lee - Natl Inst Hlth, Ctr Genome Sci, Gangoe Myeon, Yeonje Ri, South Korea
Mark Seielstad - Genome Institute of Singapore
Yik Ying Teo - Natl Univ Singapore, Dept Epidemiol & Publ Hlth, Singapore 117548, Singapore
Michael Boehnke - Biostat
Esteban J. Parra - University of Toronto
John C. Chambers - University of London
E. Shyong Tai - Natl Univ Singapore, Dept Epidemiol & Publ Hlth, Singapore 117548, Singapore
Mark I. McCarthy - University of Oxford
Andrew P. Morris - University of Oxford
South Asian Type Diabet SAT2D Cons
Publication Details: Nature genetics, Vol.46(3), pp.234-244
Publisher: NATURE PORTFOLIO
Number of pages: 13
Grant note: SSA/IMMS/ISSSTE-CONACYT 2012-2; clave 150352; IMSS R-2011-785-018; CONACYT Salud-2007-C01-71068 / Mexico Convocatoria G0601261 / Medical Research Council UK; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) NNF14OC0009819; NNF13OC0005339; NNF12OC1016467 / Novo Nordisk Fonden; Novo Nordisk Foundation HEALTH-F4-2007-201413 / European Commission (ENGAGE FP7); European Commission MR/L003120/1; MC_PC_U127592696; G9521010; G1002084; G0801056; MC_UU_12015/5; MC_UU_12015/1; G0601261; MC_UU_12015/2; MR/K006584/1; MC_UP_A100_1003; MC_U106179471 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) 24591346; 23591327; 24591347; 24390169; 23591328 / Grants-in-Aid for Scientific Research; Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT); Japan Society for the Promotion of Science; Grants-in-Aid for Scientific Research (KAKENHI) RG/08/008/25291; RG/08/014/24067 / British Heart Foundation NF-SI-0512-10165; NF-SI-0512-10113; NF-SI-0611-10136; NF-SI-0611-10219; NF-SI-0611-10099 / National Institute for Health Research; National Institute for Health Research (NIHR) WT098017; WT090532; WT090367; WT098381; WT081682; WT085475 / Wellcome Trust DK062370; HG000376; DK085584; DK085545; DK073541; DK085501 / US National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA CZB/4/710; CZB/4/672 / Chief Scientist Office G9521010; G0801056; MR/L003120/1; MC_UP_A100_1003; MC_UU_12015/2; MC_PC_U127592696; MC_UU_12015/1; G0601261; MC_UU_12015/5; G1002084 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) Canadian Institutes of Health Research; Canadian Institutes of Health Research (CIHR)
Identifiers: 9937225108331
Academic Unit: King Abdulaziz University; King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article