Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

Douglas M. Ruderfer; Stephan Ripke; Andrew McQuillin; James Boocock; Eli A. Stahl; Jennifer M. Whitehead Pavlides; Niamh Mullins; Alexander W. Charney; Anil P.S. Ori; Loes M. Olde Loohuis; Enrico Domenici; Arianna Di Florio; Sergi Papiol; Janos L. Kalman; Vassily Trubetskoy; Rolf Adolfsson; Ingrid Agartz; Esben Agerbo; Huda Akil; Diego Albani; Margot Albus; Martin Alda; Madeline Alexander; Ney Alliey-Rodriguez; Thomas D. Als; Farooq Amin; Adebayo Anjorin; Maria J. Arranz; Swapnil Awasthi; Silviu A. Bacanu; Judith A. Badner; Marie Baekvad-Hansen; Steven Bakker; Gavin Band; Jack D. Barchas; Ines Barroso; Nicholas Bass; Michael Bauer; Bernhard T. Baune; Martin Begemann; Celine Bellenguez; Richard A. Belliveau; Frank Bellivier; Stephan Bender; Judit Bene; Sarah E. Bergen; Wade H. Berrettini; Elizabeth Bevilacqua; Joanna M. Biernacka; Tim B. Bigdeli; Donald W. Black; Hannah Blackburn; Jenefer M. Blackwell; Douglas H.R. Blackwood; Carsten Bocker Pedersen; Michael Boehnke; Marco Boks; Anders D. Borglum; Elvira Bramon; Gerome Breen; Matthew A. Brown; Richard Bruggeman; Nancy G. Buccola; Randy L. Buckner; Monika Budde; Brendan Bulik-Sullivan; Suzannah J. Bumpstead; William Bunney; Margit Burmeister; Joseph D. Buxbaum; Jonas Bybjerg-Grauholm; William Byerley; Wiepke Cahn; Guiqing Cai; Murray J. Cairns; Dominique Campion; Rita M. Cantor; Vaughan J. Carr; Noa Carrera; Juan P. Casas; Miquel Casas; Stanley V. Catts; Pablo Cervantes; Kimberley D. Chambert; Raymond C.K. Chan; Eric Y.H. Chen; Ronald Y.L. Chen; Wei Cheng; Eric F.C. Cheung; Siow Ann Chong; Toni-Kim Clarke; C. Robert Cloninger; David Cohen; Nadine Cohen; Jonathan R.I. Coleman; David A. Collier; Paul Cormican; William Coryell; Nicholas Craddock; David W. Craig; Benedicto Crespo-Facorro; James J. Crowley; Cristiana Cruceanu; David Curtis; Piotr M. Czerski; Anders M. Dale; Mark J. Daly; Udo Dannlowski; Ariel Darvasi; Michael Davidson; Kenneth L. Davis; Christiaan A. de Leeuw; Franziska Degenhardt; Jurgen Del Favero; Lynn E. DeLisi; Panos Deloukas; Ditte Demontis; J. Raymond DePaulo; Marta di Forti; Dimitris Dikeos; Timothy Dinan; Srdjan Djurovic; Amanda L. Dobbyn; Peter Donnelly; Gary Donohoe; Elodie Drapeau; Serge Dronov; Jubao Duan; Frank Dudbridge; Audrey Duncanson; Howard Edenberg; Sarah Edkins; Hannelore Ehrenreich; Peter Eichhammer; Torbjorn Elvsashagen; Johan Eriksson; Valentina Escott-Price; Tonu Esko; Laurent Essioux; Bruno Etain; Chun Chieh Fan; Kai-How Farh; Martilias S. Farrell; Matthew Flickinger; Tatiana M. Foroud; Liz Forty; Josef Frank; Lude Franke; Christine Fraser; Robert Freedman; Colin Freeman; Nelson B. Freimer; Joseph I. Friedman; Menachem Fromer; Mark A. Frye; Janice M. Fullerton; Katrin Gade; Julie Garnham; Helena A. Gaspar; Pablo V. Gejman; Giulio Genovese; Lyudmila Georgieva; Claudia Giambartolomei; Eleni Giannoulatou; Ina Giegling; Michael Gill; Matthew Gillman; Marianne Giortz Pedersen; Paola Giusti-Rodriguez; Stephanie Godard; Fernando Goes; Jacqueline I. Goldstein; Srihari Gopal; Scott D. Gordon; Katherine Gordon-Smith; Jacob Gratten; Emma Gray; Elaine K. Green; Melissa J. Green; Tiffany A. Greenwood; Maria Grigoroiu-Serbanescu; Jakob Grove; Weihua Guan; Hugh Gurling; Jose Guzman Parra; Rhian Gwilliam; Lieuwe de Haan; Jeremy Hall; Mei-Hua Hall; Christian Hammer; Naomi Hammond; Marian L. Hamshere; Mark Hansen; Thomas Hansen; Vahram Haroutunian; Annette M. Hartmann; Joanna Hauser; Martin Hautzinger; Urs Heilbronner; Garrett Hellenthal; Frans A. Henskens; Stefan Herms; Maria Hipolito; Joel N. Hirschhorn; Per Hoffmann; Mads V. Hollegaard; David M. Hougaard; Hailiang Huang; Laura Huckins; Christina M. Hultman; Sarah E. Hunt; Masashi Ikeda; Nakao Iwata; Conrad Iyegbe; Assen V. Jablensky; Stephane Jamain; Janusz Jankowski; Alagurevathi Jayakumar; Inge Joa; Ian Jones; Lisa A. Jones; Erik G. Jonsson; Antonio Julia; Anders Jureus; Anna K. Kahler; Rene S. Kahn; Luba Kalaydjieva; Radhika Kandaswamy; Sena Karachanak-Yankova; Juha Karjalainen; Robert Karlsson; David Kavanagh; Matthew C. Keller; Brian J. Kelly; John Kelsoe; James L. Kennedy; Andrey Khrunin; Yunjung Kim; George Kirov; Sarah Kittel-Schneider; Janis Klovins; Jo Knight; Sarah V. Knott; James A. Knowles; Manolis Kogevinas; Bettina Konte; Eugenia Kravariti; Vaidutis Kucinskas; Zita Ausrele Kucinskiene; Ralph Kupka; Hana Kuzelova-Ptackova; Mikael Landen; Cordelia Langford; Claudine Laurent; Jacob Lawrence; Stephen Lawrie; William B. Lawson; Markus Leber; Marion Leboyer; Phil H. Lee; Jimmy Lee Chee Keong; Sophie E. Legge; Todd Lencz; Bernard Lerer; Douglas F. Levinson; Shawn E. Levy; Cathryn M. Lewis; Jun Z. Li; Miaoxin Li; Qingqin S. Li; Tao Li; Kung-Yee Liang; Jennifer Liddle; Jeffrey Lieberman; Svetlana Limborska; Kuang Lin; Don H. Linszen; Jolanta Lissowska; Chunyu Liu; Jianjun Liu; Jouko Lonnqvist; Carmel M. Loughland; Jan Lubinski; Susanne Lucae; Milan Macek; Donald J. MacIntyre; Patrik K.E. Magnusson; Brion S. Maher; Pamela B. Mahon; Wolfgang Maier; Anil K. Malhotra; Jacques Mallet; Ulrik F. Malt; Hugh S. Markus; Sara Marsal; Nicholas G. Martin; Ignacio Mata; Christopher G. Mathew; Manuel Mattheisen; Morten Mattingsdal; Fermin Mayoral; Owen T. McCann; Robert W. McCarley; Steven A. McCarroll; Mark I. McCarthy; Colm McDonald; Susan L. McElroy; Peter McGuffin; Melvin G. McInnis; Andrew M. McIntosh; James D. McKay; Francis J. McMahon; Helena Medeiros; Sarah E. Medland; Sandra Meier; Carin J. Meijer; Bela Melegh; Ingrid Melle; Fan Meng; Raquelle I. Mesholam-Gately; Andres Metspalu; Patricia T. Michie; Lili Milani; Vihra Milanova; Philip B. Mitchell; Younes Mokrab; Grant W. Montgomery; Jennifer L. Moran; Gunnar Morken; Derek W. Morris; Ole Mors; Preben B. Mortensen; Bryan J. Mowry; Thomas W. Mühleisen; Bertram Müller-Myhsok; Kieran C. Murphy; Robin M. Murray; Richard M. Myers; Inez Myin-Germeys; Benjamin M. Neale; Mari Nelis; Igor Nenadic; Deborah A. Nertney; Gerald Nestadt; Kristin K. Nicodemus; Caroline M. Nievergelt; Liene Nikitina-Zake; Vishwajit Nimgaonkar; Laura Nisenbaum; Merete Nordentoft; Annelie Nordin; Markus M. Nöthen; Evaristus A. Nwulia; Eadbhard O’Callaghan; Claire O’Donovan; Colm O’Dushlaine; F. Anthony O’Neill; Ketil J. Oedegaard; Sang-Yun Oh; Ann Olincy; Line Olsen; Lilijana Oruc; Jim Van Os; Michael J. Owen; Sara A. Paciga; Colin N.A. Palmer; Aarno Palotie; Christos Pantelis; George N. Papadimitriou; Elena Parkhomenko; Carlos Pato; Michele T. Pato; Tiina Paunio; Richard Pearson; Diana O. Perkins; Roy H. Perlis; Amy Perry; Tune H. Pers; Tracey L. Petryshen; Andrea Pfennig; Marco Picchioni; Olli Pietilainen; Jonathan Pimm; Matti Pirinen; Robert Plomin; Andrew J. Pocklington; Danielle Posthuma; James B. Potash; Simon C. Potter; John Powell; Alkes Price; Ann E. Pulver; Shaun M. Purcell; Digby Quested; Josep Antoni Ramos-Quiroga; Henrik B. Rasmussen; Anna Rautanen; Radhi Ravindrarajah; Eline J. Regeer; Abraham Reichenberg; Andreas Reif; Mark A. Reimers; Marta Ribases; John P. Rice; Alexander L. Richards; Michelle Ricketts; Brien P. Riley; Fabio Rivas; Margarita Rivera; Joshua L. Roffman; Guy A. Rouleau; Panos Roussos; Dan Rujescu; Veikko Salomaa; Cristina Sanchez-Mora; Alan R. Sanders; Stephen J. Sawcer; Ulrich Schall; Alan F. Schatzberg; William A. Scheftner; Peter R. Schofield; Nicholas J. Schork; Sibylle G. Schwab; Edward M. Scolnick; Laura J. Scott; Rodney J. Scott; Larry J. Seidman; Alessandro Serretti; Pak C. Sham; Cynthia Shannon Weickert; Tatyana Shehktman; Jianxin Shi; Paul D. Shilling; Engilbert Sigurdsson; Jeremy M. Silverman; Kang Sim; Claire Slaney; Petr Slominsky; Olav B. Smeland; Jordan W. Smoller; Hon-Cheong So; Janet L. Sobell; Erik Soderman; Christine Soholm Hansen; Chris C.A. Spencer; Anne T. Spijker; David St Clair; Hreinn Stefansson; Kari Stefansson; Stacy Steinberg; Elisabeth Stogmann; Eystein Stordal; Amy Strange; Richard E. Straub; John S. Strauss; Fabian Streit; Eric Strengman; Jana Strohmaier; T. Scott Stroup; Zhan Su; Mythily Subramaniam; Jaana Suvisaari; Dragan M. Svrakic; Jin P. Szatkiewicz; Szabolcs Szelinger; Avazeh Tashakkori-Ghanbaria; Srinivas Thirumalai; Robert C. Thompson; Thorgeir E. Thorgeirsson; Draga Toncheva; Paul A. Tooney; Sarah Tosato; Timothea Toulopoulou; Richard C. Trembath; Jens Treutlein; Gustavo Turecki; Arne E. Vaaler; Helmut Vedder; Eduard Vieta; John Vincent; Peter M. Visscher; Ananth C. Viswanathan; Damjan Vukcevic; John Waddington; Matthew Waller; Dermot Walsh; Muriel Walshe; James T.R. Walters; Dai Wang; Qiang Wang; Weiqing Wang; Yunpeng Wang; Stanley J. Watson; Bradley T. Webb; Thomas W. Weickert; Daniel R. Weinberger; Matthias Weisbrod; Mark Weiser; Thomas Werge; Paul Weston; Pamela Whittaker; Sara Widaa; Durk Wiersma; Dieter B. Wildenauer; Nigel M. Williams; Stephanie Williams; Stephanie H. Witt; Aaron R. Wolen; Emily H.M. Wong; Nicholas W. Wood; Brandon K. Wormley; Jing Qin Wu; Simon Xi; Wei Xu; Allan H. Young; Clement C. Zai; Peter Zandi; Peng Zhang; Xuebin Zheng; Fritz Zimprich; Sebastian Zollner; Aiden Corvin; Ayman H. Fanous; Sven Cichon; Marcella Rietschel; Elliot S. Gershon; Thomas G. Schulze; Alfredo B. Cuellar-Barboza; Andreas J. Forstner; Peter A. Holmans; John I. Nurnberger; Ole A. Andreassen; S. Hong Lee; Michael C. O’Donovan; Patrick F. Sullivan; Roel A. Ophoff; Naomi R. Wray; Pamela Sklar; Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium; Kenneth S. Kendler

doi:10.1016/j.cell.2018.05.046

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Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

Journal article

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Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes

Douglas M. Ruderfer, Stephan Ripke, Andrew McQuillin, James Boocock, Eli A. Stahl, Jennifer M. Whitehead Pavlides, Niamh Mullins, Alexander W. Charney, Anil P.S. Ori, Loes M. Olde Loohuis, …

Cell, Vol.173(7), pp.1705-1715.e16

14/06/2018

DOI: https://doi.org/10.1016/j.cell.2018.05.046

PMCID: PMC6432650

PMID: 29906448

Abstract

bipolar disorder

polygenic risk

psychosis

schizophrenia

subphenotypes

Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology. Understanding the genetic factors contributing to the shared and disorder-specific symptoms will be crucial for improving diagnosis and treatment. In genetic data consisting of 53,555 cases (20,129 bipolar disorder [BD], 33,426 schizophrenia [SCZ]) and 54,065 controls, we identified 114 genome-wide significant loci implicating synaptic and neuronal pathways shared between disorders. Comparing SCZ to BD (23,585 SCZ, 15,270 BD) identified four genomic regions including one with disorder-independent causal variants and potassium ion response genes as contributing to differences in biology between the disorders. Polygenic risk score (PRS) analyses identified several significant correlations within case-only phenotypes including SCZ PRS with psychotic features and age of onset in BD. For the first time, we discover specific loci that distinguish between BD and SCZ and identify polygenic components underlying multiple symptom dimensions. These results point to the utility of genetics to inform symptomology and potential treatment. [Display omitted] •Shared genetic-risk loci between BD and SCZ have varying disorder-specific effects•Specific genetic loci contribute to phenotypic differences between BD and SCZ•Disorder-specific polygenic risk scores correlate with symptom dimensions•Genetic risk could be used to characterize clinically relevant patient outcomes Genetic analysis of multiple bipolar disorder and schizophrenia cohorts reveals loci and polygenic risk scores that differentiate the clinical symptoms of these two highly correlated disorders.

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Title: Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes
Creators - without role: Douglas M. Ruderfer
Stephan Ripke
Andrew McQuillin
James Boocock
Eli A. Stahl
Jennifer M. Whitehead Pavlides
Niamh Mullins
Alexander W. Charney
Anil P.S. Ori
Loes M. Olde Loohuis
Enrico Domenici
Arianna Di Florio
Sergi Papiol
Janos L. Kalman
Vassily Trubetskoy
Rolf Adolfsson
Ingrid Agartz
Esben Agerbo
Huda Akil
Diego Albani
Margot Albus
Martin Alda
Madeline Alexander
Ney Alliey-Rodriguez
Thomas D. Als
Farooq Amin
Adebayo Anjorin
Maria J. Arranz
Swapnil Awasthi
Silviu A. Bacanu
Judith A. Badner
Marie Baekvad-Hansen
Steven Bakker
Gavin Band
Jack D. Barchas
Ines Barroso
Nicholas Bass
Michael Bauer
Bernhard T. Baune
Martin Begemann
Celine Bellenguez
Richard A. Belliveau
Frank Bellivier
Stephan Bender
Judit Bene
Sarah E. Bergen
Wade H. Berrettini
Elizabeth Bevilacqua
Joanna M. Biernacka
Tim B. Bigdeli
Donald W. Black
Hannah Blackburn
Jenefer M. Blackwell
Douglas H.R. Blackwood
Carsten Bocker Pedersen
Michael Boehnke
Marco Boks
Anders D. Borglum
Elvira Bramon
Gerome Breen
Matthew A. Brown
Richard Bruggeman
Nancy G. Buccola
Randy L. Buckner
Monika Budde
Brendan Bulik-Sullivan
Suzannah J. Bumpstead
William Bunney
Margit Burmeister
Joseph D. Buxbaum
Jonas Bybjerg-Grauholm
William Byerley
Wiepke Cahn
Guiqing Cai
Murray J. Cairns
Dominique Campion
Rita M. Cantor
Vaughan J. Carr
Noa Carrera
Juan P. Casas
Miquel Casas
Stanley V. Catts
Pablo Cervantes
Kimberley D. Chambert
Raymond C.K. Chan
Eric Y.H. Chen
Ronald Y.L. Chen
Wei Cheng
Eric F.C. Cheung
Siow Ann Chong
Toni-Kim Clarke
C. Robert Cloninger
David Cohen
Nadine Cohen
Jonathan R.I. Coleman
David A. Collier
Paul Cormican
William Coryell
Nicholas Craddock
David W. Craig
Benedicto Crespo-Facorro
James J. Crowley
Cristiana Cruceanu
David Curtis
Piotr M. Czerski
Anders M. Dale
Mark J. Daly
Udo Dannlowski
Ariel Darvasi
Michael Davidson
Kenneth L. Davis
Christiaan A. de Leeuw
Franziska Degenhardt
Jurgen Del Favero
Lynn E. DeLisi
Panos Deloukas
Ditte Demontis
J. Raymond DePaulo
Marta di Forti
Dimitris Dikeos
Timothy Dinan
Srdjan Djurovic
Amanda L. Dobbyn
Peter Donnelly
Gary Donohoe
Elodie Drapeau
Serge Dronov
Jubao Duan
Frank Dudbridge
Audrey Duncanson
Howard Edenberg
Sarah Edkins
Hannelore Ehrenreich
Peter Eichhammer
Torbjorn Elvsashagen
Johan Eriksson
Valentina Escott-Price
Tonu Esko
Laurent Essioux
Bruno Etain
Chun Chieh Fan
Kai-How Farh
Martilias S. Farrell
Matthew Flickinger
Tatiana M. Foroud
Liz Forty
Josef Frank
Lude Franke
Christine Fraser
Robert Freedman
Colin Freeman
Nelson B. Freimer
Joseph I. Friedman
Menachem Fromer
Mark A. Frye
Janice M. Fullerton
Katrin Gade
Julie Garnham
Helena A. Gaspar
Pablo V. Gejman
Giulio Genovese
Lyudmila Georgieva
Claudia Giambartolomei
Eleni Giannoulatou
Ina Giegling
Michael Gill
Matthew Gillman
Marianne Giortz Pedersen
Paola Giusti-Rodriguez
Stephanie Godard
Fernando Goes
Jacqueline I. Goldstein
Srihari Gopal
Scott D. Gordon
Katherine Gordon-Smith
Jacob Gratten
Emma Gray
Elaine K. Green
Melissa J. Green
Tiffany A. Greenwood
Maria Grigoroiu-Serbanescu
Jakob Grove
Weihua Guan
Hugh Gurling
Jose Guzman Parra
Rhian Gwilliam
Lieuwe de Haan
Jeremy Hall
Mei-Hua Hall
Christian Hammer
Naomi Hammond
Marian L. Hamshere
Mark Hansen
Thomas Hansen
Vahram Haroutunian
Annette M. Hartmann
Joanna Hauser
Martin Hautzinger
Urs Heilbronner
Garrett Hellenthal
Frans A. Henskens
Stefan Herms
Maria Hipolito
Joel N. Hirschhorn
Per Hoffmann
Mads V. Hollegaard
David M. Hougaard
Hailiang Huang
Laura Huckins
Christina M. Hultman
Sarah E. Hunt
Masashi Ikeda
Nakao Iwata
Conrad Iyegbe
Assen V. Jablensky
Stephane Jamain
Janusz Jankowski
Alagurevathi Jayakumar
Inge Joa
Ian Jones
Lisa A. Jones
Erik G. Jonsson
Antonio Julia
Anders Jureus
Anna K. Kahler
Rene S. Kahn
Luba Kalaydjieva
Radhika Kandaswamy
Sena Karachanak-Yankova
Juha Karjalainen
Robert Karlsson
David Kavanagh
Matthew C. Keller
Brian J. Kelly
John Kelsoe
James L. Kennedy
Andrey Khrunin
Yunjung Kim
George Kirov
Sarah Kittel-Schneider
Janis Klovins
Jo Knight
Sarah V. Knott
James A. Knowles
Manolis Kogevinas
Bettina Konte
Eugenia Kravariti
Vaidutis Kucinskas
Zita Ausrele Kucinskiene
Ralph Kupka
Hana Kuzelova-Ptackova
Mikael Landen
Cordelia Langford
Claudine Laurent
Jacob Lawrence
Stephen Lawrie
William B. Lawson
Markus Leber
Marion Leboyer
Phil H. Lee
Jimmy Lee Chee Keong
Sophie E. Legge
Todd Lencz
Bernard Lerer
Douglas F. Levinson
Shawn E. Levy
Cathryn M. Lewis
Jun Z. Li
Miaoxin Li
Qingqin S. Li
Tao Li
Kung-Yee Liang
Jennifer Liddle
Jeffrey Lieberman
Svetlana Limborska
Kuang Lin
Don H. Linszen
Jolanta Lissowska
Chunyu Liu
Jianjun Liu
Jouko Lonnqvist
Carmel M. Loughland
Jan Lubinski
Susanne Lucae
Milan Macek
Donald J. MacIntyre
Patrik K.E. Magnusson
Brion S. Maher
Pamela B. Mahon
Wolfgang Maier
Anil K. Malhotra
Jacques Mallet
Ulrik F. Malt
Hugh S. Markus
Sara Marsal
Nicholas G. Martin
Ignacio Mata
Christopher G. Mathew
Manuel Mattheisen
Morten Mattingsdal
Fermin Mayoral
Owen T. McCann
Robert W. McCarley
Steven A. McCarroll
Mark I. McCarthy
Colm McDonald
Susan L. McElroy
Peter McGuffin
Melvin G. McInnis
Andrew M. McIntosh
James D. McKay
Francis J. McMahon
Helena Medeiros
Sarah E. Medland
Sandra Meier
Carin J. Meijer
Bela Melegh
Ingrid Melle
Fan Meng
Raquelle I. Mesholam-Gately
Andres Metspalu
Patricia T. Michie
Lili Milani
Vihra Milanova
Philip B. Mitchell
Younes Mokrab
Grant W. Montgomery
Jennifer L. Moran
Gunnar Morken
Derek W. Morris
Ole Mors
Preben B. Mortensen
Bryan J. Mowry
Thomas W. Mühleisen
Bertram Müller-Myhsok
Kieran C. Murphy
Robin M. Murray
Richard M. Myers
Inez Myin-Germeys
Benjamin M. Neale
Mari Nelis
Igor Nenadic
Deborah A. Nertney
Gerald Nestadt
Kristin K. Nicodemus
Caroline M. Nievergelt
Liene Nikitina-Zake
Vishwajit Nimgaonkar
Laura Nisenbaum
Merete Nordentoft
Annelie Nordin
Markus M. Nöthen
Evaristus A. Nwulia
Eadbhard O’Callaghan
Claire O’Donovan
Colm O’Dushlaine
F. Anthony O’Neill
Ketil J. Oedegaard
Sang-Yun Oh
Ann Olincy
Line Olsen
Lilijana Oruc
Jim Van Os
Michael J. Owen
Sara A. Paciga
Colin N.A. Palmer
Aarno Palotie
Christos Pantelis
George N. Papadimitriou
Elena Parkhomenko
Carlos Pato
Michele T. Pato
Tiina Paunio
Richard Pearson
Diana O. Perkins
Roy H. Perlis
Amy Perry
Tune H. Pers
Tracey L. Petryshen
Andrea Pfennig
Marco Picchioni
Olli Pietilainen
Jonathan Pimm
Matti Pirinen
Robert Plomin
Andrew J. Pocklington
Danielle Posthuma
James B. Potash
Simon C. Potter
John Powell
Alkes Price
Ann E. Pulver
Shaun M. Purcell
Digby Quested
Josep Antoni Ramos-Quiroga
Henrik B. Rasmussen
Anna Rautanen
Radhi Ravindrarajah
Eline J. Regeer
Abraham Reichenberg
Andreas Reif
Mark A. Reimers
Marta Ribases
John P. Rice
Alexander L. Richards
Michelle Ricketts
Brien P. Riley
Fabio Rivas
Margarita Rivera
Joshua L. Roffman
Guy A. Rouleau
Panos Roussos
Dan Rujescu
Veikko Salomaa
Cristina Sanchez-Mora
Alan R. Sanders
Stephen J. Sawcer
Ulrich Schall
Alan F. Schatzberg
William A. Scheftner
Peter R. Schofield
Nicholas J. Schork
Sibylle G. Schwab
Edward M. Scolnick
Laura J. Scott
Rodney J. Scott
Larry J. Seidman
Alessandro Serretti
Pak C. Sham
Cynthia Shannon Weickert
Tatyana Shehktman
Jianxin Shi
Paul D. Shilling
Engilbert Sigurdsson
Jeremy M. Silverman
Kang Sim
Claire Slaney
Petr Slominsky
Olav B. Smeland
Jordan W. Smoller
Hon-Cheong So
Janet L. Sobell
Erik Soderman
Christine Soholm Hansen
Chris C.A. Spencer
Anne T. Spijker
David St Clair
Hreinn Stefansson
Kari Stefansson
Stacy Steinberg
Elisabeth Stogmann
Eystein Stordal
Amy Strange
Richard E. Straub
John S. Strauss
Fabian Streit
Eric Strengman
Jana Strohmaier
T. Scott Stroup
Zhan Su
Mythily Subramaniam
Jaana Suvisaari
Dragan M. Svrakic
Jin P. Szatkiewicz
Szabolcs Szelinger
Avazeh Tashakkori-Ghanbaria
Srinivas Thirumalai
Robert C. Thompson
Thorgeir E. Thorgeirsson
Draga Toncheva
Paul A. Tooney
Sarah Tosato
Timothea Toulopoulou
Richard C. Trembath
Jens Treutlein
Gustavo Turecki
Arne E. Vaaler
Helmut Vedder
Eduard Vieta
John Vincent
Peter M. Visscher
Ananth C. Viswanathan
Damjan Vukcevic
John Waddington
Matthew Waller
Dermot Walsh
Muriel Walshe
James T.R. Walters
Dai Wang
Qiang Wang
Weiqing Wang
Yunpeng Wang
Stanley J. Watson
Bradley T. Webb
Thomas W. Weickert
Daniel R. Weinberger
Matthias Weisbrod
Mark Weiser
Thomas Werge
Paul Weston
Pamela Whittaker
Sara Widaa
Durk Wiersma
Dieter B. Wildenauer
Nigel M. Williams
Stephanie Williams
Stephanie H. Witt
Aaron R. Wolen
Emily H.M. Wong
Nicholas W. Wood
Brandon K. Wormley
Jing Qin Wu
Simon Xi
Wei Xu
Allan H. Young
Clement C. Zai
Peter Zandi
Peng Zhang
Xuebin Zheng
Fritz Zimprich
Sebastian Zollner
Aiden Corvin
Ayman H. Fanous
Sven Cichon
Marcella Rietschel
Elliot S. Gershon
Thomas G. Schulze
Alfredo B. Cuellar-Barboza
Andreas J. Forstner
Peter A. Holmans
John I. Nurnberger
Ole A. Andreassen
S. Hong Lee
Michael C. O’Donovan
Patrick F. Sullivan
Roel A. Ophoff
Naomi R. Wray
Pamela Sklar
Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium
Kenneth S. Kendler
Publication Details: Cell, Vol.173(7), pp.1705-1715.e16
Publisher: Elsevier Inc
Identifiers: 9937884208331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article