Genomic insights into the Ixodes scapularis tick vector of Lyme disease

Monika Gulia-Nuss; Andrew B. Nuss; Jason M. Meyer; Daniel E. Sonenshine; R. Michael Roe; Robert M. Waterhouse; David B. Sattelle; Jose de la Fuente; Jose M. Ribeiro; Karine Megy; Jyothi Thimmapuram; Jason R. Miller; Brian P. Walenz; Sergey Koren; Jessica B. Hostetler; Mathangi Thiagarajan; Vinita S. Joardar; Linda I. Hannick; Shelby Bidwell; Martin P. Hammond; Sarah Young; Qiandong Zeng; Jenica L. Abrudan; Francisca C. Almeida; Nieves Ayllon; Ketaki Bhide; Brooke W. Bissinger; Elena Bonzon-Kulichenko; Steven D. Buckingham; Daniel R. Caffrey; Melissa J. Caimano; Vincent Croset; Timothy Driscoll; Don Gilbert; Joseph J. Gillespie; Gloria I. Giraldo-Calderon; Jeffrey M. Grabowski; David Jiang; Sayed M. S. Khalil; Donghun Kim; Katherine M. Kocan; Juraj Koci; Richard J. Kuhn; Timothy J. Kurtti; Kristin Lees; Emma G. Lang; Ryan C. Kennedy; Hyeogsun Kwon; Rushika Perera; Yumin Qi; Justin D. Radolf; Joyce M. Sakamoto; Alejandro Sanchez-Gracia; Maiara S. Severo; Neal Silverman; Ladislav Simo; Marta Tojo; Cristian Tornador; Janice P. Van Zee; Jesus Vazquez; Filipe G. Vieira; Margarita Villar; Adam R. Wespiser; Yunlong Yang; Jiwei Zhu; Peter Arensburger; Patricia V. Pietrantonio; Stephen C. Barker; Renfu Shao; Evgeny M. Zdobnov; Frank Hauser; Cornelis J. P. Grimmelikhuijzen; Yoonseong Park; Julio Rozas; Richard Benton; Joao H. F. Pedra; David R. Nelson; Maria F. Unger; Jose M. C. Tubio; Zhijian Tu; Hugh M. Robertson; Martin Shumway; Granger Sutton; Jennifer R. Wortman; Daniel Lawson; Stephen K. Wikel; Vishvanath M. Nene; Claire M. Fraser; Frank H. Collins; Bruce Birren; Karen E. Nelson; Elisabet Caler; Catherine A. Hill

doi:10.1038/ncomms10507

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Genomic insights into the Ixodes scapularis tick vector of Lyme disease

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Genomic insights into the Ixodes scapularis tick vector of Lyme disease

Monika Gulia-Nuss, Andrew B. Nuss, Jason M. Meyer, Daniel E. Sonenshine, R. Michael Roe, Robert M. Waterhouse, David B. Sattelle, Jose de la Fuente, Jose M. Ribeiro, Karine Megy, …

Nature communications, Vol.7, p.10507

09/02/2016

DOI: https://doi.org/10.1038/ncomms10507

PMCID: PMC4748124

PMID: 26856261

Abstract

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic anaplasmosis, babesiosis and other diseases. The large genome reflects accumulation of repetitive DNA, new lineages of retro-transposons, and gene architecture patterns resembling ancient metazoans rather than pancrustaceans. Annotation of scaffolds representing similar to 57% of the genome, reveals 20,486 protein-coding genes and expansions of gene families associated with tick-host interactions. We report insights from genome analyses into parasitic processes unique to ticks, including host 'questing', prolonged feeding, cuticle synthesis, blood meal concentration, novel methods of haemoglobin digestion, haem detoxification, vitellogenesis and prolonged off-host survival. We identify proteins associated with the agent of human granulocytic anaplasmosis, an emerging disease, and the encephalitis-causing Langat virus, and a population structure correlated to life-history traits and transmission of the Lyme disease agent.

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Title: Genomic insights into the Ixodes scapularis tick vector of Lyme disease
Creators - without role: Monika Gulia-Nuss - University of Nevada Reno
Andrew B. Nuss - University of Nevada Reno
Jason M. Meyer - Monsanto
Daniel E. Sonenshine - Old Dominion University
R. Michael Roe - North Carolina State University
Robert M. Waterhouse - Massachusetts Institute of Technology
David B. Sattelle - University College London
Jose de la Fuente - Oklahoma State University
Jose M. Ribeiro - Vector Oncology
Karine Megy - European Bioinformatics Institute
Jyothi Thimmapuram - Purdue University West Lafayette
Jason R. Miller - J. Craig Venter Institute
Brian P. Walenz - J. Craig Venter Institute
Sergey Koren - J. Craig Venter Institute
Jessica B. Hostetler - J. Craig Venter Institute
Mathangi Thiagarajan - Leidos
Vinita S. Joardar - J. Craig Venter Institute
Linda I. Hannick - Leidos
Shelby Bidwell - J. Craig Venter Institute
Martin P. Hammond - European Bioinformatics Institute
Sarah Young - Broad Institute
Qiandong Zeng - Broad Institute
Jenica L. Abrudan - University of Nevada, Las Vegas
Francisca C. Almeida - Universitat de Barcelona
Nieves Ayllon - Instituto de Investigación en Recursos Cinegéticos
Ketaki Bhide - Purdue University West Lafayette
Brooke W. Bissinger - Research Triangle Park Foundation
Elena Bonzon-Kulichenko - Spanish National Centre for Cardiovascular Research
Steven D. Buckingham - University College London
Daniel R. Caffrey - University of Massachusetts Chan Medical School
Melissa J. Caimano - University of Connecticut Health Center
Vincent Croset - University of Lausanne
Timothy Driscoll - West Virginia University
Don Gilbert - Indiana University Bloomington
Joseph J. Gillespie - University of Maryland, Baltimore
Gloria I. Giraldo-Calderon - University of Notre Dame
Jeffrey M. Grabowski - Purdue University West Lafayette
David Jiang - Virginia Tech
Sayed M. S. Khalil - Agricultural Genetic Engineering Research Institute
Donghun Kim - Texas A&M Univ, Dept Entomol, College Stn, TX 77843 USA
Katherine M. Kocan - Oklahoma State University
Juraj Koci - University of Maryland, Baltimore
Richard J. Kuhn - Purdue University West Lafayette
Timothy J. Kurtti - University of Minnesota
Kristin Lees - National University of Singapore
Emma G. Lang - Purdue University West Lafayette
Ryan C. Kennedy - University of California, San Francisco
Hyeogsun Kwon - Iowa State University
Rushika Perera - Colorado State University
Yumin Qi - Virginia Tech
Justin D. Radolf - University of Connecticut Health Center
Joyce M. Sakamoto - Pennsylvania State University
Alejandro Sanchez-Gracia - Universitat de Barcelona
Maiara S. Severo - University of California, Riverside
Neal Silverman - University of Massachusetts Chan Medical School
Ladislav Simo - French Agency for Food, Environmental and Occupational Health & Safety
Marta Tojo - Instituto de Investigación Sanitaria de Santiago
Cristian Tornador - Pompeu Fabra University
Janice P. Van Zee - Purdue University West Lafayette
Jesus Vazquez - Spanish National Centre for Cardiovascular Research
Filipe G. Vieira - Universitat de Barcelona
Margarita Villar - Instituto de Investigación en Recursos Cinegéticos
Adam R. Wespiser - University of Massachusetts Chan Medical School
Yunlong Yang - Texas A&M University
Jiwei Zhu - North Carolina State University
Peter Arensburger - California State Polytechnic University
Patricia V. Pietrantonio - Texas A&M University
Stephen C. Barker - University of Queensland
Renfu Shao - University of the Sunshine Coast
Evgeny M. Zdobnov - SIB Swiss Institute of Bioinformatics
Frank Hauser - University of Copenhagen
Cornelis J. P. Grimmelikhuijzen - University of Copenhagen
Yoonseong Park - Kansas State University
Julio Rozas - Universitat de Barcelona
Richard Benton - University of Lausanne
Joao H. F. Pedra - University of Maryland, Baltimore
David R. Nelson - University of Tennessee Health Science Center
Maria F. Unger - University of Notre Dame
Jose M. C. Tubio - Universidade de Vigo
Zhijian Tu - Virginia Tech
Hugh M. Robertson - University of Illinois Urbana-Champaign
Martin Shumway - Max Planck Institute for Infection Biology
Granger Sutton - J. Craig Venter Institute
Jennifer R. Wortman - J. Craig Venter Institute
Daniel Lawson - European Bioinformatics Institute
Stephen K. Wikel - Quinnipiac University
Vishvanath M. Nene - International Livestock Research Institute
Claire M. Fraser - University of Maryland, Baltimore
Frank H. Collins - University of Notre Dame
Bruce Birren - Broad Institute
Karen E. Nelson - J. Craig Venter Institute
Elisabet Caler - National Heart Lung and Blood Institute
Catherine A. Hill - Purdue University West Lafayette
Publication Details: Nature communications, Vol.7, p.10507
Publisher: Springer Nature
Number of pages: 13
Grant note: 1R01AI090062; 1R21AI096268; HHSN272200900040C; R01AI017828; R01AI043006 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 278976 / EU FP7 ANTIGONE; European Union (EU) R83-2011-7610 / Lundbeck Foundation; Lundbeckfonden IOS-0949194 / NSF; National Science Foundation (NSF) N01-AI30071; HHSN272200900007C; HHSN266200400001C; 5R01GM77117-5 / National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services (NIAID, NIH, DHHS) NIAID; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) 205202 / European Research Council Starting Independent Researcher Grant; European Research Council (ERC) HHSN266200400039C; HHSN272200900039C / NIH-NIAID; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) DP120100240 / Australian Research Council Broad Genomics Platform SFRH/BD/22360/2005 / Fundacao para a Ciencia e a Tecnologia, Portugal fellowship BFU2007-6292; BFU2010-15484; BIO2009-07990; BIO2012-37926 / Ministerio de Ciencia e Innovacion of Spain; Spanish Government 2008-35302-18820 / USDA-NRI/CREES; United States Department of Agriculture (USDA) Lundbeck Foundation (Denmark); Lundbeckfonden PIOF-GA-2011-303312 / Marie Curie International Outgoing Fellowship; European Union (EU) 31003A-125350; 31003A-143936 / Swiss National Science Foundation; Swiss National Science Foundation (SNSF) NSF; National Science Foundation (NSF) TL1 TR000162 / NIH-NCATS award SFRH/BD/22360/2005 / Fundao para a Cincia e a Tecnologia; Fundacao para a Ciencia e a Tecnologia (FCT) 10PXIB918057PR / Xunta de Galicia of Spain; Xunta de Galicia Texas AgriLife Research Vector Biology grant
Identifiers: 9949386908331
Academic Unit: King Saud University
Language: English
Resource Type: Journal article