Abstract
Acrylamide (AA) is a human carcinogen generated in carbohydrate-rich foodstuffs upon heating. It has been shown to cause neurotoxic effects in humans, and genotoxic and carcinogenic effects in laboratory animals. The aim of this study was to assess the effects of AA on the frequency of chromosomal aberrations (CA), frequency of micronuclei (MN) and mitotic index (MI). Four groups of four mice, each weighing approximately 20-25 g, were orally administered AA once daily for 30 days with doses of 0, 2, 4, 8,16, and 32 mg kg(-1) body weight of AA. The control group consisted of four animals orally administered deionized water. Bone marrow was collected 24 h after the last treatment following standard protocols. AA significantly increased (p < 0.05) the number of CA and the frequency of micronucleated cells and decreased the MI in exposed groups compared to the negative control. The results obtained in this study further support that AA induces genotoxicity in mouse bone marrow cells.