Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013: Findings From the Global Burden of Disease 2013 Study

Hmwe H Kyu; Christine Pinho; Joseph A Wagner; Jonathan C Brown; Amelia Bertozzi-Villa; Fiona J Charlson; Luc Edgar Coffeng; Lalit Dandona; Holly E Erskine; Alize J Ferrari; Christina Fitzmaurice; Thomas D Fleming; Mohammad H Forouzanfar; Nicholas Graetz; Caterina Guinovart; Juanita Haagsma; Hideki Higashi; Nicholas J Kassebaum; Heidi J Larson; Stephen S Lim; Ali H Mokdad; Maziar Moradi-Lakeh; Shaun V Odell; Gregory A Roth; Peter T Serina; Jeffrey D Stanaway; Awoke Misganaw; Harvey A Whiteford; Timothy M Wolock; Sarah Wulf Hanson; Foad Abd-Allah; Semaw Ferede Abera; Laith J Abu-Raddad; Fadia S AlBuhairan; Azmeraw T Amare; Carl Abelardo T Antonio; Al Artaman; Suzanne L Barker-Collo; Lope H Barrero; Corina Benjet; Isabela M Bensenor; Zulfiqar A Bhutta; Boris Bikbov; Alexandra Brazinova; Ismael Campos-Nonato; Carlos A Castañeda-Orjuela; Ferrán Catalá-López; Rajiv Chowdhury; Cyrus Cooper; John A Crump; Rakhi Dandona; Louisa Degenhardt; Robert P Dellavalle; Samath D Dharmaratne; Emerito Jose A Faraon; Valery L Feigin; Thomas Fürst; Johanna M Geleijnse; Bradford D Gessner; Katherine B Gibney; Atsushi Goto; David Gunnell; Graeme J Hankey; Roderick J Hay; John C Hornberger; H Dean Hosgood; Guoqing Hu; Kathryn H Jacobsen; Sudha P Jayaraman; Panniyammakal Jeemon; Jost B Jonas; André Karch; Daniel Kim; Sungroul Kim; Yoshihiro Kokubo; Barthelemy Kuate Defo; Burcu Kucuk Bicer; G Anil Kumar; Anders Larsson; Janet L Leasher; Ricky Leung; Yongmei Li; Steven E Lipshultz; Alan D Lopez; Paulo A Lotufo; Raimundas Lunevicius; Ronan A Lyons; Marek Majdan; Reza Malekzadeh; Taufiq Mashal; Amanda J Mason-Jones; Yohannes Adama Melaku; Ziad A Memish; Walter Mendoza; Ted R Miller; Charles N Mock; Joseph Murray; Sandra Nolte; In-Hwan Oh; Bolajoko Olubukunola Olusanya; Katrina F Ortblad; Eun-Kee Park; Angel J Paternina Caicedo; Scott B Patten; George C Patton; David M Pereira; Norberto Perico; Frédéric B Piel; Suzanne Polinder; Svetlana Popova; Farshad Pourmalek; D Alex Quistberg; Giuseppe Remuzzi; Alina Rodriguez; David Rojas-Rueda; Dietrich Rothenbacher; David H Rothstein; Juan Sanabria; Itamar S Santos; David C Schwebel; Sadaf G Sepanlou; Amira Shaheen; Rahman Shiri; Ivy Shiue; Vegard Skirbekk; Karen Sliwa; Chandrashekhar T Sreeramareddy; Dan J Stein; Timothy J Steiner; Lars Jacob Stovner; Bryan L Sykes; Karen M Tabb; Abdullah Sulieman Terkawi; Alan J Thomson; Andrew L Thorne-Lyman; Jeffrey Allen Towbin; Kingsley Nnanna Ukwaja; Tommi Vasankari; Narayanaswamy Venketasubramanian; Vasiliy Victorovich Vlassov; Stein Emil Vollset; Elisabete Weiderpass; Robert G Weintraub; Andrea Werdecker; James D Wilkinson; Solomon Meseret Woldeyohannes; Charles D A Wolfe; Yuichiro Yano; Paul Yip; Naohiro Yonemoto; Seok-Jun Yoon; Mustafa Z Younis; Chuanhua Yu; Maysaa El Sayed Zaki; Mohsen Naghavi; Christopher J L Murray; Theo Vos; Global Burden of Disease Pediatrics Collaboration

doi:10.1001/jamapediatrics.2015.4276

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Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013: Findings From the Global Burden of Disease 2013 Study

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Peer reviewed

Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013: Findings From the Global Burden of Disease 2013 Study

Hmwe H Kyu, Christine Pinho, Joseph A Wagner, Jonathan C Brown, Amelia Bertozzi-Villa, Fiona J Charlson, Luc Edgar Coffeng, Lalit Dandona, Holly E Erskine, Alize J Ferrari, …

JAMA pediatrics, Vol.170(3), pp.267-287

01/03/2016

DOI: https://doi.org/10.1001/jamapediatrics.2015.4276

PMCID: PMC5076765

PMID: 26810619

Abstract

Adolescent

Adolescent Health - statistics & numerical data

Adolescent Health - trends

Bayes Theorem

Child

Child Health - statistics & numerical data

Child Health - trends

Child Mortality - trends

Child, Preschool

Cost of Illness

Developed Countries - statistics & numerical data

Developing Countries - statistics & numerical data

Female

Global Health - statistics & numerical data

Global Health - trends

Humans

Male

Prevalence

Public Health Surveillance

Quality-Adjusted Life Years

Wounds and Injuries - epidemiology

The literature focuses on mortality among children younger than 5 years. Comparable information on nonfatal health outcomes among these children and the fatal and nonfatal burden of diseases and injuries among older children and adolescents is scarce. To determine levels and trends in the fatal and nonfatal burden of diseases and injuries among younger children (aged <5 years), older children (aged 5-9 years), and adolescents (aged 10-19 years) between 1990 and 2013 in 188 countries from the Global Burden of Disease (GBD) 2013 study. Data from vital registration, verbal autopsy studies, maternal and child death surveillance, and other sources covering 14,244 site-years (ie, years of cause of death data by geography) from 1980 through 2013 were used to estimate cause-specific mortality. Data from 35,620 epidemiological sources were used to estimate the prevalence of the diseases and sequelae in the GBD 2013 study. Cause-specific mortality for most causes was estimated using the Cause of Death Ensemble Model strategy. For some infectious diseases (eg, HIV infection/AIDS, measles, hepatitis B) where the disease process is complex or the cause of death data were insufficient or unavailable, we used natural history models. For most nonfatal health outcomes, DisMod-MR 2.0, a Bayesian metaregression tool, was used to meta-analyze the epidemiological data to generate prevalence estimates. Of the 7.7 (95% uncertainty interval [UI], 7.4-8.1) million deaths among children and adolescents globally in 2013, 6.28 million occurred among younger children, 0.48 million among older children, and 0.97 million among adolescents. In 2013, the leading causes of death were lower respiratory tract infections among younger children (905.059 deaths; 95% UI, 810,304-998,125), diarrheal diseases among older children (38,325 deaths; 95% UI, 30,365-47,678), and road injuries among adolescents (115,186 deaths; 95% UI, 105,185-124,870). Iron deficiency anemia was the leading cause of years lived with disability among children and adolescents, affecting 619 (95% UI, 618-621) million in 2013. Large between-country variations exist in mortality from leading causes among children and adolescents. Countries with rapid declines in all-cause mortality between 1990 and 2013 also experienced large declines in most leading causes of death, whereas countries with the slowest declines had stagnant or increasing trends in the leading causes of death. In 2013, Nigeria had a 12% global share of deaths from lower respiratory tract infections and a 38% global share of deaths from malaria. India had 33% of the world's deaths from neonatal encephalopathy. Half of the world's diarrheal deaths among children and adolescents occurred in just 5 countries: India, Democratic Republic of the Congo, Pakistan, Nigeria, and Ethiopia. Understanding the levels and trends of the leading causes of death and disability among children and adolescents is critical to guide investment and inform policies. Monitoring these trends over time is also key to understanding where interventions are having an impact. Proven interventions exist to prevent or treat the leading causes of unnecessary death and disability among children and adolescents. The findings presented here show that these are underused and give guidance to policy makers in countries where more attention is needed.

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Title: Global and National Burden of Diseases and Injuries Among Children and Adolescents Between 1990 and 2013: Findings From the Global Burden of Disease 2013 Study
Creators - without role: Hmwe H Kyu - University of Washington
Christine Pinho - University of Washington
Joseph A Wagner - University of Washington
Jonathan C Brown - University of Washington
Amelia Bertozzi-Villa - University of Washington
Fiona J Charlson - University of Queensland
Luc Edgar Coffeng - University of Washington
Lalit Dandona - University of Washington
Holly E Erskine - University of Queensland
Alize J Ferrari - University of Queensland
Christina Fitzmaurice - University of Washington
Thomas D Fleming - University of Washington
Mohammad H Forouzanfar - University of Washington
Nicholas Graetz - University of Washington
Caterina Guinovart - University of Washington
Juanita Haagsma - University of Washington
Hideki Higashi - University of Washington
Nicholas J Kassebaum - University of Washington
Heidi J Larson - University of Washington
Stephen S Lim - University of Washington
Ali H Mokdad - University of Washington
Maziar Moradi-Lakeh - Iran University of Medical Sciences
Shaun V Odell - University of Washington Medical Center
Gregory A Roth - University of Washington
Peter T Serina - University of Washington
Jeffrey D Stanaway - University of Washington
Awoke Misganaw - University of Washington
Harvey A Whiteford - University of Queensland
Timothy M Wolock - University of Washington
Sarah Wulf Hanson - University of Washington
Foad Abd-Allah - Cairo University
Semaw Ferede Abera - Mekelle University
Laith J Abu-Raddad - Weill Cornell Medical College in Qatar
Fadia S AlBuhairan - King Saud bin Abdulaziz University for Health Sciences
Azmeraw T Amare - Bahir Dar University
Carl Abelardo T Antonio - University of the Philippines Manila
Al Artaman - Consultant, Windsor, Ontario, Canada
Suzanne L Barker-Collo - University of Auckland
Lope H Barrero - Pontificia Universidad Javeriana
Corina Benjet - National Institute of Psychiatry Ramon de la Fuente, Mexico City, Mexico
Isabela M Bensenor - University of São Paulo, São Paulo, Brazil
Zulfiqar A Bhutta - Aga Khan University
Boris Bikbov - Moscow State University of Medicine and Dentistry
Alexandra Brazinova - University of Trnava
Ismael Campos-Nonato - Harvard University
Carlos A Castañeda-Orjuela - Universidad Nacional de Colombia
Ferrán Catalá-López - Universitat de València
Rajiv Chowdhury - University of Cambridge
Cyrus Cooper - University Hospital Southampton NHS Foundation Trust
John A Crump - University of Otago
Rakhi Dandona - Public Health Foundation of India
Louisa Degenhardt - UNSW Sydney
Robert P Dellavalle - Colorado School of Public Health
Samath D Dharmaratne - University of Peradeniya
Emerito Jose A Faraon - University of the Philippines Manila
Valery L Feigin - Auckland University of Technology
Thomas Fürst - Imperial College London
Johanna M Geleijnse - Division of Human Nutrition, Wageningen University, Wageningen, the Netherlands
Bradford D Gessner - Agence de Médecine Préventive
Katherine B Gibney - Monash University
Atsushi Goto - Tokyo Women's Medical University
David Gunnell - University of Bristol
Graeme J Hankey - University of Western Australia
Roderick J Hay - International Foundation for Dermatology, London, England62King's College London, London, England
John C Hornberger - Menlo School
H Dean Hosgood - Albert Einstein College of Medicine
Guoqing Hu - Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha, China
Kathryn H Jacobsen - George Mason University
Sudha P Jayaraman - Virginia Commonwealth University
Panniyammakal Jeemon - Centre for Chronic Disease Control
Jost B Jonas - Heidelberg
André Karch - GBF German Research Centre for Biotechnology
Daniel Kim - Department of Health Sciences, Northeastern University, Boston, Massachusetts
Sungroul Kim - Soonchunhyang University
Yoshihiro Kokubo - National Cerebral and Cardiovascular Center
Barthelemy Kuate Defo - Department of Social and Preventive Medicine, School of Public Health, University of Montreal, Montreal, Québec, Canada78Department of Demography, University of Montreal, Montreal, Québec, Canada79Public Health Research Institute, University of Montreal
Burcu Kucuk Bicer - Hacettepe University
G Anil Kumar - Public Health Foundation of India
Anders Larsson - Uppsala University
Janet L Leasher - Nova Southeastern University
Ricky Leung - State University of New York at Albany, Rensselaer
Yongmei Li - Genentech
Steven E Lipshultz - Wayne State University
Alan D Lopez - University of Melbourne
Paulo A Lotufo - University of São Paulo, São Paulo, Brazil
Raimundas Lunevicius - Aintree University Hospital
Ronan A Lyons - Swansea University
Marek Majdan - University of Trnava
Reza Malekzadeh - Tehran University of Medical Sciences
Taufiq Mashal - Ministry of Public Health, Kabul, Afghanistan
Amanda J Mason-Jones - Department of Health Sciences, University of York, York, England
Yohannes Adama Melaku - Mekelle University
Ziad A Memish - Alfaisal University
Walter Mendoza - United Nations Population Fund
Ted R Miller - Curtin University
Charles N Mock - University of Washington
Joseph Murray - University of Cambridge
Sandra Nolte - Deakin University
In-Hwan Oh - Kyung Hee University
Bolajoko Olubukunola Olusanya - Healthy Start
Katrina F Ortblad - Harvard University
Eun-Kee Park - Kosin University
Angel J Paternina Caicedo - Universidad de Cartagena, Cartagena, Colombia
Scott B Patten - University of Calgary
George C Patton - University of Melbourne
David M Pereira - REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal
Norberto Perico - Mario Negri Institute for Pharmacological Research
Frédéric B Piel - University of Oxford
Suzanne Polinder - Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands
Svetlana Popova - University of Toronto
Farshad Pourmalek - University of British Columbia
D Alex Quistberg - University of Washington
Giuseppe Remuzzi - Mario Negri Institute for Pharmacological Research
Alina Rodriguez - Imperial College London
David Rojas-Rueda - Barcelona Institute for Global Health
Dietrich Rothenbacher - University of Ulm
David H Rothstein - University at Buffalo, State University of New York
Juan Sanabria - Rosalind Franklin University of Medicine and Science
Itamar S Santos - Internal Medicine Department, University of São Paulo, São Paulo, Brazil
David C Schwebel - University of Alabama at Birmingham
Sadaf G Sepanlou - Tehran University of Medical Sciences
Amira Shaheen - An-Najah National University
Rahman Shiri - University of Tampere
Ivy Shiue - Newcastle University
Vegard Skirbekk - Columbia University
Karen Sliwa - University of Cape Town
Chandrashekhar T Sreeramareddy - University of Kuala Lumpur
Dan J Stein - University of Cape Town
Timothy J Steiner - Norwegian University of Science and Technology
Lars Jacob Stovner - Norwegian University of Science and Technology
Bryan L Sykes - University of California, Irvine
Karen M Tabb - University of Illinois Urbana-Champaign
Abdullah Sulieman Terkawi - University of Virginia
Alan J Thomson - Adaptive Knowledge Management, Victoria, British Columbia, Canada
Andrew L Thorne-Lyman - Harvard University
Jeffrey Allen Towbin - Le Bonheur Children's Hospital
Kingsley Nnanna Ukwaja - Federal Teaching Hospital Abakaliki
Tommi Vasankari - UKK Institute for Health Promotion Research, Tampere, Finland
Narayanaswamy Venketasubramanian - Raffles Neuroscience Centre, Raffles Hospital, Singapore, Singapore
Vasiliy Victorovich Vlassov - National Research University Higher School of Economics, Moscow, Russia
Stein Emil Vollset - University of Bergen
Elisabete Weiderpass - Cancer Registry of Norway
Robert G Weintraub - University of Melbourne
Andrea Werdecker - Federal Institute for Population Research
James D Wilkinson - Wayne State University
Solomon Meseret Woldeyohannes - University of Gondar
Charles D A Wolfe - King's College London
Yuichiro Yano - Northwestern University
Paul Yip - University of Hong Kong
Naohiro Yonemoto - National Center of Neurology and Psychiatry
Seok-Jun Yoon - University of Seoul
Mustafa Z Younis - Jackson State University
Chuanhua Yu - Wuhan University
Maysaa El Sayed Zaki - Faculty
Mohsen Naghavi - University of Washington
Christopher J L Murray - University of Washington
Theo Vos - University of Washington
Global Burden of Disease Pediatrics Collaboration
Publication Details: JAMA pediatrics, Vol.170(3), pp.267-287
Grant note: 089963 / Wellcome Trust T32 HL007093 / NHLBI NIH HHS MC_U147585824 / Medical Research Council MC_U147585819 / Medical Research Council MC_PC_13043 / Medical Research Council RP-PG-0407-10184 / Department of Health 5T32HL007093-40 / NHLBI NIH HHS MC_U147585827 / Medical Research Council MR/L003120/1 / Medical Research Council MR/K006525/1 / Medical Research Council G0400491 / Medical Research Council IA/CPHI/14/1/501497 / DBT-Wellcome Trust India Alliance RG/08/014/24067 / British Heart Foundation 089963/Z/09/Z / Wellcome Trust
Identifiers: 9913360508331
Academic Unit: Alfaisal University
Language: English
Resource Type: Journal article