Global, regional, and national burden of bone fractures in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019

Ai-Min Wu; Catherine Bisignano; Spencer L. James; Gdiom Gebreheat Abady; Aidin Abedi; Eman Abu-Gharbieh; Robert Kaba Alhassan; Vahid Alipour; Jalal Arabloo; Malke Asaad; Wondwossen Niguse Asmare; Atalel Fentahun Awedew; Maciej Banach; Srikanta K. Banerjee; Ali Bijani; Tesega Tesega Mengistu Birhanu; Srinivasa Rao Bolla; Luis Alberto Camera; Jung-Chen Chang; Daniel Youngwhan Cho; Michael T. Chung; Rosa A. S. Couto; Xiaochen Dai; Lalit Dandona; Rakhi Dandona; Farshad Farzadfar; Irina Filip; Florian Fischer; Artem Alekseevich Fomenkov; Tiffany K. Gill; Bhawna Gupta; Juanita A. Haagsma; Arvin Haj-Mirzaian; Samer Hamidi; Simon Hay; Irena M. Ilic; Milena D. Ilic; Rebecca Q. Ivers; Mikk Jurisson; Rohollah Kalhor; Tanuj Kanchan; Taras Kavetskyy; Rovshan Khalilov; Ejaz Ahmad Khan; Maseer Khan; Cameron J. Kneib; Vijay Krishnamoorthy; G. Anil Kumar; Narinder Kumar; Ratilal Lalloo; Savita Lasrado; Stephen S. Lim; Zichen Liu; Ali Manafi; Navid Manafi; Ritesh G. Menezes; Tuomo J. Meretoja; Bartosz Miazgowski; Ted R. Miller; Yousef Mohammad; Abdollah Mohammadian-Hafshejani; Ali H. Mokdad; Christopher J. L. Murray; Mehdi Naderi; Mukhammad David Naimzada; Vinod C. Nayak; Cuong Tat Nguyen; Rajan Nikbakhsh; Andrew T. Olagunju; Nikita Otstavnov; Stanislav S. Otstavnov; Jagadish Rao Padubidri; Jeevan Pereira; Hai Quang Pham; Marina Pinheiro; Suzanne Polinder; Hadis Pourchamani; Navid Rabiee; Amir Radfar; Mohammad Hifz Ur Rahman; David Laith Rawaf; Salman Rawaf; Mohammad Reza Saeb; Abdallah M. Samy; Lidia Sanchez Riera; David C. Schwebel; Saeed Shahabi; Masood Ali Shaikh; Amin Soheili; Rafael Tabares-Seisdedos; Marcos Roberto Tovani-Palone; Bach Xuan Tran; Ravensara S. Travillian; Pascual R. Valdez; Tommi Juhani Vasankari; Diana Zuleika Velazquez; Narayanaswamy Venketasubramanian; Giang Thu Vu; Zhi-Jiang Zhang; Theo Vos; GBD 2019 Fracture Collaborators

doi:10.1016/S2666-7568(21)00172-0

$Global, regional, and national burden of bone fractures in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019$

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Global, regional, and national burden of bone fractures in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019

Ai-Min Wu, Catherine Bisignano, Spencer L. James, Gdiom Gebreheat Abady, Aidin Abedi, Eman Abu-Gharbieh, Robert Kaba Alhassan, Vahid Alipour, Jalal Arabloo, Malke Asaad, …

The Lancet. Healthy longevity, Vol.2(9), pp.E580-E592

01/09/2021

DOI: https://doi.org/10.1016/S2666-7568(21)00172-0

PMID: 34723233

Abstract

Geriatrics & Gerontology

Life Sciences & Biomedicine

Science & Technology

Background Bone fractures are a global public health issue; however, to date, no comprehensive study of their incidence and burden has been done. We aimed to measure the global, regional, and national incidence, prevalence, and years lived with disability (YLDs) of fractures from 1990 to 2019. Methods Using the framework of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we compared numbers and age-standardised rates of global incidence, prevalence, and YLDs of fractures across the 21 GBD regions and 204 countries and territories, by age, sex, and year, from 1990 to 2019. We report estimates with 95% uncertainty intervals (UIs). Findings Globally, in 2019, there were 178 million (95% UI 162-196) new fractures (an increase of 33.4% [30.1-37.0] since 1990), 455 million (428-484) prevalent cases of acute or long-term symptoms of a fracture (an increase of 70.1% [67.5-72.5] since 1990), and 25.8 million (17.8-35.8) YLDs (an increase of 65.3% [62.4-68.0] since 1990). The age-standardised rates of fractures in 2019 were 2296.2 incident cases (2091.1-2529.5) per 100 000 population (a decrease of 9.6% [8.1-11.1] since 1990), 5614.3 prevalent cases (5286.1-5977.5) per 100 000 population (a decrease of 6.7% [5.7-7.6] since 1990), and 319.0 YLDs (220.1-442.5) per 100 000 population (a decrease of 8.4% [7.2-9.5] since 1990). Lower leg fractures of the patella, tibia or fibula, or ankle were the most common and burdensome fracture in 2019, with an age-standardised incidence rate of 419.9 cases (345.8-512.0) per 100 000 population and an age-standardised rate of YLDs of 190.4 (125.0-276.9) per 100 000 population. In 2019, age-specific rates of fracture incidence were highest in the oldest age groups, with, for instance, 15 381.5 incident cases (11 245.3-20 651.9) per 100 000 population in those aged 95 years and older. Interpretation The global age-standardised rates of incidence, prevalence, and YLDs for fractures decreased slightly from 1990 to 2019, but the absolute counts increased substantially. Older people have a particularly high risk of fractures, and more widespread injury-prevention efforts and access to screening and treatment of osteoporosis for older individuals should help to reduce the overall burden. Copyright (C) 2021 The Author(s). Published by Elsevier Ltd.

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Title: Global, regional, and national burden of bone fractures in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019
Creators - without role: Ai-Min Wu - College Station Medical Center
Catherine Bisignano - University of Washington
Spencer L. James - Genentech
Gdiom Gebreheat Abady - Adigrat University
Aidin Abedi - Univ Southern Calif, Dept Orthopaed Surg, Los Angeles, CA 90007 USA
Eman Abu-Gharbieh - University of Sharjah
Robert Kaba Alhassan - Univ Hlth & Allied Sci, Inst Hlth Res, Ho, Ghana
Vahid Alipour - College Station Medical Center
Jalal Arabloo - College Station Medical Center
Malke Asaad - Univ Texas Houston, Dept Plast Surg, Houston, TX USA
Wondwossen Niguse Asmare - MizanTepi Univ, Dept Nursing, Mizan Teferi, Ethiopia
Atalel Fentahun Awedew - Addis Ababa University
Maciej Banach - College Station Medical Center
Srikanta K. Banerjee - Walden University
Ali Bijani - College Station Medical Center
Tesega Tesega Mengistu Birhanu - Amhara Publ Hlth Inst, Planning Monitoring & Evaluat Directorate, Bahir Dar, Ethiopia
Srinivasa Rao Bolla - Nazarbayev University
Luis Alberto Camera - College Station Medical Center
Jung-Chen Chang - College Station Medical Center
Daniel Youngwhan Cho - University of Washington
Michael T. Chung - Wayne State University
Rosa A. S. Couto - Universidade do Porto
Xiaochen Dai - University of Washington
Lalit Dandona - University of Washington
Rakhi Dandona - University of Washington
Farshad Farzadfar - University of Tehran
Irina Filip - Kaiser Permanente
Florian Fischer - Ravensburg Weingarten Univ Appl Sci, Inst Gerontol Hlth Serv & Nursing Res, Weingarten, Germany
Artem Alekseevich Fomenkov - Plant
Tiffany K. Gill - University of Adelaide
Bhawna Gupta - Torrens Univ, Dept Publ Hlth, Melbourne, Vic, Australia
Juanita A. Haagsma - Erasmus MC
Arvin Haj-Mirzaian - University of Tehran
Samer Hamidi - Hamdan Bin Mohammed Smart University
Simon Hay - University of Washington
Irena M. Ilic - University of Belgrade
Milena D. Ilic - University of Kragujevac
Rebecca Q. Ivers - UNSW Sydney
Mikk Jurisson - University of Tartu
Rohollah Kalhor - College Station Medical Center
Tanuj Kanchan - College Station Medical Center
Taras Kavetskyy - John Paul II Catholic University of Lublin
Rovshan Khalilov - Baku State University
Ejaz Ahmad Khan - Biostat
Maseer Khan - Jazan University
Cameron J. Kneib - University of Washington
Vijay Krishnamoorthy - University of Washington
G. Anil Kumar - Publ Hlth Fdn India, Gurugram, India
Narinder Kumar - Medanta Hosp, Dept Orthopaed, Lucknow, Uttar Pradesh, India
Ratilal Lalloo - University of Queensland
Savita Lasrado - College Station Medical Center
Stephen S. Lim - University of Washington
Zichen Liu - University of Washington
Ali Manafi - College Station Medical Center
Navid Manafi - Supreme Council Of Health
Ritesh G. Menezes - Imam Abdulrahman Bin Faisal University
Tuomo J. Meretoja - Helsinki Univ Hosp, Breast Surg Unit, Helsinki, Finland
Bartosz Miazgowski - College Station Medical Center
Ted R. Miller - Pacific Inst Res & Evaluat, Calverton, MD USA
Yousef Mohammad - King Saud University
Abdollah Mohammadian-Hafshejani - Shahrekord University
Ali H. Mokdad - University of Washington
Christopher J. L. Murray - University of Washington
Mehdi Naderi - College Station Medical Center
Mukhammad David Naimzada - Moscow Inst Phys & Technol, Lab Publ Hlth Indicators Anal & Hlth Digitalizat, Dolgoprudnyi, Russia
Vinod C. Nayak - College Station Medical Center
Cuong Tat Nguyen - Duy Tan University
Rajan Nikbakhsh - Shahid Beheshti University
Andrew T. Olagunju - McMaster University
Nikita Otstavnov - Moscow Inst Phys & Technol, Lab Publ Hlth Indicators Anal & Hlth Digitalizat, Dolgoprudnyi, Russia
Stanislav S. Otstavnov - Moscow Inst Phys & Technol, Lab Publ Hlth Indicators Anal & Hlth Digitalizat, Dolgoprudnyi, Russia
Jagadish Rao Padubidri - College Station Medical Center
Jeevan Pereira - Yenepoya University
Hai Quang Pham - Duy Tan University
Marina Pinheiro - Universidade do Porto
Suzanne Polinder - Erasmus MC
Hadis Pourchamani - College Station Medical Center
Navid Rabiee - Sharif University of Technology
Amir Radfar - College Station Medical Center
Mohammad Hifz Ur Rahman - College Station Medical Center
David Laith Rawaf - Imperial Coll London, WHO Collaborating Ctr Publ Hlth Educ & Training, London, England
Salman Rawaf - Imperial Coll London, Dept Primary Care & Publ Hlth, London, England
Mohammad Reza Saeb - Supélec
Abdallah M. Samy - Ain Shams University
Lidia Sanchez Riera - Avon
David C. Schwebel - University of Alabama
Saeed Shahabi - Shiraz University
Masood Ali Shaikh
Amin Soheili - Semnan University
Rafael Tabares-Seisdedos - Universitat de València
Marcos Roberto Tovani-Palone - College Station Medical Center
Bach Xuan Tran - College Station Medical Center
Ravensara S. Travillian - University of Washington
Pascual R. Valdez - Velez Sarsfield Hosp, Buenos Aires, DF, Argentina
Tommi Juhani Vasankari - UKK Inst, Tampere, Finland
Diana Zuleika Velazquez - Autonomous University of Sinaloa
Narayanaswamy Venketasubramanian - Raffles Hosp, Raffles Neurosci Ctr, Singapore, Singapore
Giang Thu Vu - Trường ĐH Nguyễn Tất Thành
Zhi-Jiang Zhang - Wuhan University
Theo Vos - University of Washington
GBD 2019 Fracture Collaborators
Publication Details: The Lancet. Healthy longevity, Vol.2(9), pp.E580-E592
Publisher: Elsevier
Number of pages: 13
Grant note: 075-15-2019-1882 / Megagrant project Walden University Social Change Grant Egyptian Fulbright Mission Program
Identifiers: 9915318608331
Academic Unit: Imam Abdulrahman Bin Faisal University; King Saud University; Jazan University; Alfaisal University
Language: English
Resource Type: Journal article