Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

Boris Bikbov; Carrie Purcell; Andrew S. Levey; Mari Smith; Amir Abdoli; Molla Abebe; Oladimeji M. Adebayo; Mohsen Afarideh; Sanjay Kumar Agarwal; Marcela Agudelo-Botero; Elham Ahmadian; Ziyad Al-Aly; Vahid Alipour; Amir Almasi-Hashiani; Rajaa M. Al-Raddadi; Nelson Alvis-Guzman; Saeed Amini; Tudorel Andrei; Catalina Liliana Andrei; Zewudu Andualem; Mina Anjomshoa; Jalal Arabloo; Alebachew Fasil Ashagre; Daniel Asmelash; Zerihun Ataro; Maha Moh'd Wahbi Atout; Martin Amogre Ayanore; Alaa Badawi; Ahad Bakhtiari; Shoshana H. Ballew; Abbas Balouchi; Maciej Banach; Simon Barquera; Sanjay Basu; Mulat Tirfie Bayih; Neeraj Bedi; Aminu K. Bello; Isabela M. Bensenor; Ali Bijani; Archith Boloor; Antonio M. Borzi; Luis Alberto Camera; Juan J. Carrero; Felix Carvalho; Franz Castro; Ferran Catala-Lopez; Alex R. Chang; Ken Lee Chin; Sheng-Chia Chung; Massimo Cirillo; Ewerton Cousin; Lalit Dandona; Rakhi Dandona; Ahmad Daryani; Rajat Das Gupta; Feleke Mekonnen Demeke; Gebre Teklemariam Demoz; Desilu Mahari Desta; Huyen Phuc Do; Bruce B. Duncan; Aziz Eftekhari; Alireza Esteghamati; Syeda Sadia Fatima; Joao C. Fernandes; Eduarda Fernandes; Florian Fischer; Marisa Freita; Mohamed M. Gad; Gebreamlak Gebremedhn Gebremeskel; Begashaw Melaku Gebresillassie; Birhanu Geta; Mansour Ghafourifard; Alireza Ghajar; Nermin Ghith; Paramjit Singh Gill; Ibrahim Abdelmageed Ginawi; Rajeev Gupta; Nima Hafezi-Nejad; Arvin Haj-Mirzaian; Arya Haj-Mirzaian; Ninuk Hariyani; Mehedi Hasan; Milad Hasankhani; Amir Hasanzadeh; Hamid Yimam Hassen; Simon I. Hay; Behnam Heidari; Claudiu Herteliu; Chi Linh Hoang; Mostafa Hosseini; Mihaela Hostiuc; Seyed Sina Naghibi Irvani; Sheikh Mohammed Shariful Islam; Nader Jafari Balalami; Spencer L. James; Simerjot K. Jassal; Vivekanand Jha; Jost B. Jonas; Farahnaz Joukar; Jacek Jerzy Jozwiak; Ali Kabir; Amaha Kahsay; Amir Kasaeian; Tesfaye Dessale Kassa; Hagazi Gebremedhin Kassaye; Yousef Saleh Khader; Rovshan Khalilov; Ejaz Ahmad Khan; Mohammad Saud Khan; Young-Ho Khang; Adnan Kisa; Csaba P. Kovesdy; Barthelemy Kuate Defo; G. Anil Kumar; Anders O. Larsson; Lee-Ling Lim; Alan D. Lopez; Paulo A. Lotufo; Azeem Majeed; Reza Malekzadeh; Winfried Marz; Anthony Masaka; Hailemariam Abiy Alemu Meheretu; Tomasz Miazgowski; Andreea Mirica; Erkin M. Mirrakhimov; Prasanna Mithra; Babak Moazen; Dara K. Mohammad; Reza Mohammadpourhodki; Shafiu Mohammed; Ali H. Mokdad; Linda Morales; Ilais Moreno Velasquez; Seyyed Meysam Mousavi; Satinath Mukhopadhyay; Jean B. Nachega; Girish N. Nadkarni; Jobert Richie Nansseu; Gopalakrishnan Natarajan; Javad Nazari; Bruce Neal; Ruxandra Irina Negoi; Cuong Tat Nguyen; Rajan Nikbakhsh; Jean Jacques Noubiap; Christoph Nowak; Andrew T. Olagunju; Alberto Ortiz; Mayowa Ojo Owolabi; Raffaele Palladino; Mona Pathak; Norberto Perico; Hossein Poustchi; Swayam Prakash; Narayan Prasad; Alireza Rafiei; Sree Bhushan Raju; Kiana Ramezanzadeh; Salman Rawaf; David Laith Rawaf; Lal Rawal; Robert C. Reiner; Aziz Rezapour; Daniel Cury Ribeiro; Leonardo Roever; Dietrich Rothenbacher; Godfrey M. Rwegerera; Seyedmohammad Saadatagah; Saeed Safari; Berhe Weldearegawi Sahle; Hosni Salem; Juan Sanabria; Itamar S. Santos; Arash Sarveazad; Monika Sawhney; Elke Schaeffner; Maria Ines Schmidt; Aletta Elisabeth Schutte; Sadaf G. Sepanlou; Masood Ali Shaikh; Zeinab Sharafi; Mehdi Sharif; Amrollah Sharifi; Diego Augusto Santos Silva; Jasvinder A. Singh; Narinder Pal Singh; Malede Mequanent M. Sisay; Amin Soheili; Ipsita Sutradhar; Berhane Fseha Teklehaimanot; Berhe Etsay Tesfay; Getnet Fetene Teshome; Jarnail Singh Thakur; Marcello Tonelli; Khanh Bao Tran; Bach Xuan Tran; Candide Tran Ngoc; Irfan Ullah; Pascual R. Valdez; Santosh Varughese; Linh Gia Vu; Yasir Waheed; Andrea Werdecker; Haileab Fekadu Wolde; Adam Belay Wondmieneh; Sarah Wulf Hanson; Tomohide Yamada; Yigizie Yeshaw; Naohiro Yonemoto; Hasan Yusefzadeh; Zoubida Zaidi; Leila Zaki; Sojib Bin Zaman; Nelson Zamora; Afshin Zarghi; Kaleab Alemayehu Zewdie; Johan Arnlov; Josef Coresh; Giuseppe Remuzzi; Christopher J. L. Murray; Theo Vos; GBD Chronic Kidney Dis Collaborat

doi:10.1016/S0140-6736(20)30045-3

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Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

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Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017

Boris Bikbov, Carrie Purcell, Andrew S. Levey, Mari Smith, Amir Abdoli, Molla Abebe, Oladimeji M. Adebayo, Mohsen Afarideh, Sanjay Kumar Agarwal, Marcela Agudelo-Botero, …

The Lancet (British edition), Vol.395(10225), pp.709-733

29/02/2020

DOI: https://doi.org/10.1016/S0140-6736(20)30045-3

PMCID: PMC7049905

PMID: 32061315

Abstract

General & Internal Medicine

Life Sciences & Biomedicine

Medicine, General & Internal

Science & Technology

Background Health system planning requires careful assessment of chronic kidney disease (CKD) epidemiology, but data for morbidity and mortality of this disease are scarce or non-existent in many countries. We estimated the global, regional, and national burden of CKD, as well as the burden of cardiovascular disease and gout attributable to impaired kidney function, for the Global Burden of Diseases, Injuries, and Risk Factors Study 2017. We use the term CKD to refer to the morbidity and mortality that can be directly attributed to all stages of CKD, and we use the term impaired kidney function to refer to the additional risk of CKD from cardiovascular disease and gout. Methods The main data sources we used were published literature, vital registration systems, end-stage kidney disease registries, and household surveys. Estimates of CKD burden were produced using a Cause of Death Ensemble model and a Bayesian meta-regression analytical tool, and induded incidence, prevalence, years lived with disability, mortality, years of life lost, and disability-adjusted life-years (DALYs). A comparative risk assessment approach was used to estimate the proportion of cardiovascular diseases and gout burden attributable to impaired kidney function. Findings Globally, in 2017,1.2 million (95% uncertainty interval [UI] 1.2 to 1.3) people died from CKD. The global all-age mortality rate from CKD increased 41.5% (95% UI 35.2 to 46.5) between 1990 and 2017, although there was no significant change in the age-standardised mortality rate (2.8%, -1.5 to 6.3). In 2017,697.5 million (95% UI 649.2 to 752.0) cases of all-stage CKD were recorded, for a global prevalence of 9.1% (8.5 to 9.8). The global all-age prevalence of CKD increased 29.3% (95% UI 26.4 to 32.6) since 1990, whereas the age-standardised prevalence remained stable (1.2%, -1.1 to 3.5). CKD resulted in 35.8 million (95% UI 33.7 to 38.0) DALYs in 2017, with diabetic nephropathy accounting for almost a third of DALYs. Most of the burden of CKD was concentrated in the three lowest quintiles of Socio-demographic Index (SDI). In several regions, particularly Oceania, sub-Saharan Africa, and Latin America, the burden of CKD was much higher than expected for the level of development, whereas the disease burden in western, eastern, and central sub-Saharan Africa, east Asia, south Asia, central and eastern Europe, Australasia, and western Europe was lower than expected. 1.4 million (95% UI 1.2 to 1.6) cardiovascular disease-related deaths and 25.3 million (22.2 to 28.9) cardiovascular disease DALYs were attributable to impaired kidney function. Interpretation Kidney disease has a major effect on global health, both as a direct cause of global morbidity and mortality and as an important risk factor for cardiovascular disease. CKD is largely preventable and treatable and deserves greater attention in global health policy decision making, particularly in locations with low and middle SDI. Copyright (C) 2020 The Author(s). Published by Elsevier Ltd.

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Title: Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017
Creators - without role: Boris Bikbov - IRCCS, Ist Ric Farmacol Mario Negri, Ranica, Italy
Carrie Purcell - University of Washington
Andrew S. Levey - College Station Medical Center
Mari Smith - University of Washington
Amir Abdoli - Jahrom University
Molla Abebe - University of Gondar
Oladimeji M. Adebayo - College Station Medical Center
Mohsen Afarideh - University of Tehran
Sanjay Kumar Agarwal - College Station Medical Center
Marcela Agudelo-Botero - Supreme Council Of Health
Elham Ahmadian - College Station Medical Center
Ziyad Al-Aly - College Station Medical Center
Vahid Alipour - College Station Medical Center
Amir Almasi-Hashiani - Arak University
Rajaa M. Al-Raddadi - King Abdulaziz University
Nelson Alvis-Guzman - University of Cartagena
Saeed Amini - Arak University
Tudorel Andrei - Bucharest Univ Econ Studies, Dept Stat & Econometr, Bucharest, Romania
Catalina Liliana Andrei - College Station Medical Center
Zewudu Andualem - University of Gondar
Mina Anjomshoa - College Station Medical Center
Jalal Arabloo - College Station Medical Center
Alebachew Fasil Ashagre - University of Gondar
Daniel Asmelash - University of Gondar
Zerihun Ataro - Haramaya University
Maha Moh'd Wahbi Atout - University of Nottingham
Martin Amogre Ayanore - Univ Hlth & Allied Sci, Dept Hlth Policy Planning & Management, Ho, Ghana
Alaa Badawi - Publ Hlth Agcy Canada, Publ Hlth Risk Sci Div, Toronto, ON, Canada
Ahad Bakhtiari - University of Tehran
Shoshana H. Ballew - Johns Hopkins University
Abbas Balouchi - Supreme Council Of Health
Maciej Banach - College Station Medical Center
Simon Barquera - Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico
Sanjay Basu - Supreme Council Of Health
Mulat Tirfie Bayih - Bahir Dar University
Neeraj Bedi - College Station Medical Center
Aminu K. Bello - University of Alberta
Isabela M. Bensenor - College Station Medical Center
Ali Bijani - College Station Medical Center
Archith Boloor - College Station Medical Center
Antonio M. Borzi - University of Catania
Luis Alberto Camera - College Station Medical Center
Juan J. Carrero - Karolinska Institutet
Felix Carvalho - Universidade do Porto
Franz Castro - Mécanique et Engrenage Moderne
Ferran Catala-Lopez - Supreme Council Of Health
Alex R. Chang - Geisinger Hlth Syst, Kidney Hlth Res Inst, Danville, PA USA
Ken Lee Chin - Monash University
Sheng-Chia Chung - UCL, Dept Hlth Informat, London, England
Massimo Cirillo - University of Salerno
Ewerton Cousin - Federal Reserve
Lalit Dandona - University of Washington
Rakhi Dandona - University of Washington
Ahmad Daryani - College Station Medical Center
Rajat Das Gupta - University of South Carolina
Feleke Mekonnen Demeke - Bahir Dar University
Gebre Teklemariam Demoz - Aksum University
Desilu Mahari Desta - Mekelle University
Huyen Phuc Do - Trường ĐH Nguyễn Tất Thành
Bruce B. Duncan - Univ Fed Rio Grande do Sul, Postgrad Program Epidemiol, Porto Alegre, RS, Brazil
Aziz Eftekhari - College Station Medical Center
Alireza Esteghamati - University of Tehran
Syeda Sadia Fatima - Aga Khan Univ, Biol & Biomed Sci, Karachi, Pakistan
Joao C. Fernandes - Universidade Católica Portuguesa
Eduarda Fernandes - Universidade do Porto
Florian Fischer - College Station Medical Center
Marisa Freita - Universidade do Porto
Mohamed M. Gad - College Station Medical Center
Gebreamlak Gebremedhn Gebremeskel - Aksum University
Begashaw Melaku Gebresillassie - University of Gondar
Birhanu Geta - Wollo University
Mansour Ghafourifard - College Station Medical Center
Alireza Ghajar - University of Tehran
Nermin Ghith - Tech Univ Denmark, Grp Genom Epidemiol, Lyngby, Denmark
Paramjit Singh Gill - University of Warwick
Ibrahim Abdelmageed Ginawi - University of Ha'il
Rajeev Gupta - Rajasthan Univ Hlth Sci, Acad & Res Dept, Jaipur, Rajasthan, India
Nima Hafezi-Nejad - University of Tehran
Arvin Haj-Mirzaian - University of Tehran
Arya Haj-Mirzaian - University of Tehran
Ninuk Hariyani - College Station Medical Center
Mehedi Hasan - BRAC University
Milad Hasankhani - Supreme Council Of Health
Amir Hasanzadeh - University of Tehran
Hamid Yimam Hassen - Mizan Tepi University
Simon I. Hay - University of Washington
Behnam Heidari - University of Tehran
Claudiu Herteliu - Bucharest Univ Econ Studies, Dept Stat & Econometr, Bucharest, Romania
Chi Linh Hoang - Trường ĐH Nguyễn Tất Thành
Mostafa Hosseini - University of Tehran
Mihaela Hostiuc - College Station Medical Center
Seyed Sina Naghibi Irvani - Shahid Beheshti University
Sheikh Mohammed Shariful Islam - Deakin University
Nader Jafari Balalami - Babol Noshirvani University of Technology
Spencer L. James - University of Washington
Simerjot K. Jassal - College Station Medical Center
Vivekanand Jha - George Institute for Global Health
Jost B. Jonas - Heidelberg University
Farahnaz Joukar - College Station Medical Center
Jacek Jerzy Jozwiak - College Station Medical Center
Ali Kabir - College Station Medical Center
Amaha Kahsay - Mekelle University
Amir Kasaeian - University of Tehran
Tesfaye Dessale Kassa - Mekelle University
Hagazi Gebremedhin Kassaye - Adigrat University
Yousef Saleh Khader - College Station Medical Center
Rovshan Khalilov - Baku State University
Ejaz Ahmad Khan - Biostat
Mohammad Saud Khan - Brown University
Young-Ho Khang - Seoul Natl Univ, Div Hlth Policy & Management, Seoul, South Korea
Adnan Kisa - Supreme Council Of Health
Csaba P. Kovesdy - University of Tennessee at Knoxville
Barthelemy Kuate Defo - Univ Montreal, Dept Demog, Montreal, PQ, Canada
G. Anil Kumar - Publ Hlth Fdn India, Gurugram, India
Anders O. Larsson - Uppsala University
Lee-Ling Lim - Univ Malaya, Dept Med, Kuala Lumpur, Malaysia
Alan D. Lopez - University of Washington
Paulo A. Lotufo - College Station Medical Center
Azeem Majeed - Imperial Coll London, Dept Primary Care and Publ Hlth, London, England
Reza Malekzadeh - University of Tehran
Winfried Marz - Heidelberg Univ, Med Clin 5, Mannheim, Germany
Anthony Masaka - Botho University
Hailemariam Abiy Alemu Meheretu - Bahir Dar University
Tomasz Miazgowski - College Station Medical Center
Andreea Mirica - Bucharest Univ Econ Studies, Dept Stat & Econometr, Bucharest, Romania
Erkin M. Mirrakhimov - College Station Medical Center
Prasanna Mithra - College Station Medical Center
Babak Moazen - Heidelberg Univ, Heidelberg Inst Global Hlth, Mannheim, Germany
Dara K. Mohammad - Karolinska Institutet
Reza Mohammadpourhodki - College Station Medical Center
Shafiu Mohammed - Heidelberg Univ, Heidelberg Inst Global Hlth, Mannheim, Germany
Ali H. Mokdad - University of Washington
Linda Morales - Ctr Populat Hlth Res, Cuernavaca, Morelos, Mexico
Ilais Moreno Velasquez - Mécanique et Engrenage Moderne
Seyyed Meysam Mousavi - University of Tehran
Satinath Mukhopadhyay - College Station Medical Center
Jean B. Nachega - Johns Hopkins University
Girish N. Nadkarni - Supreme Council Of Health
Jobert Richie Nansseu - Minist Publ Hlth, Dept Dis Epidem & Pandem Control, Yaounde, Cameroon
Gopalakrishnan Natarajan - College Station Medical Center
Javad Nazari - Arak University
Bruce Neal - Cardiometab Grp, New Delhi, India
Ruxandra Irina Negoi - College Station Medical Center
Cuong Tat Nguyen - Duy Tan University
Rajan Nikbakhsh - University of Tehran
Jean Jacques Noubiap - University of Cape Town
Christoph Nowak - Karolinska Institutet
Andrew T. Olagunju - McMaster University
Alberto Ortiz - Autonomous University of Madrid
Mayowa Ojo Owolabi - University of Ibadan
Raffaele Palladino - Imperial Coll London, Dept Primary Care and Publ Hlth, London, England
Mona Pathak - College Station Medical Center
Norberto Perico - IRCCS, Ist Ric Farmacol Mario Negri, Ranica, Italy
Hossein Poustchi - University of Tehran
Swayam Prakash - College Station Medical Center
Narayan Prasad - College Station Medical Center
Alireza Rafiei - College Station Medical Center
Sree Bhushan Raju - College Station Medical Center
Kiana Ramezanzadeh - Shahid Beheshti University
Salman Rawaf - Imperial Coll London, Dept Primary Care and Publ Hlth, London, England
David Laith Rawaf - Imperial Coll London, WHO Collaborating Ctr Publ Hlth Educ & Training, London, England
Lal Rawal - Supreme Council Of Health
Robert C. Reiner - University of Washington
Aziz Rezapour - College Station Medical Center
Daniel Cury Ribeiro - University of Otago
Leonardo Roever - Federal Reserve
Dietrich Rothenbacher - College Station Medical Center
Godfrey M. Rwegerera - University of Botswana
Seyedmohammad Saadatagah - University of Tehran
Saeed Safari - Shahid Beheshti University
Berhe Weldearegawi Sahle - Western Sydney University
Hosni Salem - Cairo University
Juan Sanabria - Marshall University
Itamar S. Santos - College Station Medical Center
Arash Sarveazad - College Station Medical Center
Monika Sawhney - Univ N Carolina, Dept Publ Hlth Sci, Charlotte, NC USA
Elke Schaeffner - Charité - Universitätsmedizin Berlin
Maria Ines Schmidt - Univ Fed Rio Grande do Sul, Postgrad Program Epidemiol, Porto Alegre, RS, Brazil
Aletta Elisabeth Schutte - North West Univ, Hypertens Africa Res Team, Potchefstroom, South Africa
Sadaf G. Sepanlou - University of Tehran
Masood Ali Shaikh
Zeinab Sharafi - Lorestan University
Mehdi Sharif - Islamic Azad University, Tehran
Amrollah Sharifi - Golestan University
Diego Augusto Santos Silva - Supreme Council Of Health
Jasvinder A. Singh - University of Alabama
Narinder Pal Singh - Max
Malede Mequanent M. Sisay - University of Gondar
Amin Soheili - Urmia University
Ipsita Sutradhar - BRAC University
Berhane Fseha Teklehaimanot - Adigrat University
Berhe Etsay Tesfay - Adigrat University
Getnet Fetene Teshome - University of Gondar
Jarnail Singh Thakur - Supreme Council Of Health
Marcello Tonelli - University of Calgary
Khanh Bao Tran - University of Auckland
Bach Xuan Tran - College Station Medical Center
Candide Tran Ngoc - University of Manchester
Irfan Ullah - Gomal University
Pascual R. Valdez - College Station Medical Center
Santosh Varughese - College Station Medical Center
Linh Gia Vu - Trường ĐH Nguyễn Tất Thành
Yasir Waheed - College Station Medical Center
Andrea Werdecker - Federal Reserve
Haileab Fekadu Wolde - University of Gondar
Adam Belay Wondmieneh - Addis Ababa University
Sarah Wulf Hanson - University of Washington
Tomohide Yamada - The University of Tokyo
Yigizie Yeshaw - University of Gondar
Naohiro Yonemoto - Natl Ctr Neurol & Psychiat, Dept Psychopharmacol, Tokyo, Japan
Hasan Yusefzadeh - Urmia University
Zoubida Zaidi - Univ Hosp Setif, Dept Epidemiol, Setif, Algeria
Leila Zaki - Tarbiat Modares University
Sojib Bin Zaman - Monash University
Nelson Zamora - College Station Medical Center
Afshin Zarghi - Shahid Beheshti University
Kaleab Alemayehu Zewdie - Mekelle University
Johan Arnlov - Dalarna University
Josef Coresh - Johns Hopkins University
Giuseppe Remuzzi - IRCCS, Ist Ric Farmacol Mario Negri, Ranica, Italy
Christopher J. L. Murray - University of Washington
Theo Vos - University of Washington
GBD Chronic Kidney Dis Collaborat
Publication Details: The Lancet (British edition), Vol.395(10225), pp.709-733
Publisher: Elsevier
Number of pages: 25
Grant note: Bill AMP; Melinda Gates Foundation; CGIAR MR/M015084/1 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC)
Identifiers: 9938381008331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article