Abstract
In this work, a highly sensitive non-enzymatic glucose sensor was developed based on NiO hollow cage-like nanostructures (NiO HCs). The novel nanostructures were synthesized using hydrothermal growth route with glycine employed as an effecient growth director. The synthesized NiO HCs were characterized by using scanning electron microscopy (SEM), X-ray photoelectron microscopy (XPS) X-ray diffraction (XRD) and Fourier transform infrared (FTIR) techniques for morphological, compositional and structural determination respectively. The prepared NiO HCs were directly integrated to be structured electrodes exhibiting enhanced electrocatalytic performance toward the oxidation of glucose with high sensitivity (2476.4 mu A mM(-1) cm(-2)), low detection limit (LOD) (0.1 mu M), wide detection range (0.1-5.0 mM) (r(2) = 0.9997) and excellent reproducibility. The developed nonenzymatic glucose sensor further demonstrated excellent anti-interference property in the presence of common interferents such as uric acid (UA), dopamine (DP) and ascorbic acid (AS). The role of glycine molecules as an efficient growth directing agent with a plausible growth mechanism has also been highlighted. In addition, the NiO HCs modified electrode was also used to analyze glucose concentration in human serum samples. The excellent sensing performance can be attributed to the unique morphology, which allowed increased electron transfer passages with lower charge transfer resistance, and enhanced molecular approach during electrochemical sensing offered from nanoscale "hollow cage" units of NiO structures.