Abstract
Four ursane-type triterpenoid glycosides (1-4), two benzophenone glycosides (5 and 6), and one iridoid glucoside (7) were isolated and characterized from the dried roots of Vangueria agrestis. Compounds 1 (3-O-[alpha-L-rhamnopyranosyl-(1 -> 2)-beta-D-xylopyranosyl]pomolic acid 28-O-beta-D-glucopyranosyl ester) and 5 (2-O-[beta-D-apiofuranosyl-(1 -> 6)-beta-D-glucopyranosyl]-6,4 '-dihydroxy-4-methoxy benzophenone) were found to be new metabolites. The identity of all compounds has been accomplished, primarily, based on 1 D and 2 D NMR and HRESMS analysis. Compounds 6 and 2, showed inhibitory effect against Trypanosoma brucei with IC50 22.3 mu M for 6 and IC50 11.1 mu M, IC90 12.3 mu M for 2.