Abstract
A highly efficient gold(I)- and platinum(II)-catalyzed process for formal Markownikoffs double hydroamination of alkynes tethered with hydroxyl group has been developed. The method was shown to be applicable to a broad range of 2-aminobenzamides and alkynols leading to the formation of multiply substituted tetrahydro-quinazolinones. Interestingly, when Pt(IV)Cl-4 catalyst was employed, cyclic angularly fused compound was obtained.