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Gold-Catalyzed Highly Diastereoselective Synthesis of Functionalized 3,4-Disubstituted Butyrolactams via Phosphatyloxy or Carbonate Double Migrations
Journal article   Peer reviewed

Gold-Catalyzed Highly Diastereoselective Synthesis of Functionalized 3,4-Disubstituted Butyrolactams via Phosphatyloxy or Carbonate Double Migrations

Weibo Yang, Yang Yu, Tuo Zhang, Max M. Hansmann, Daniel Pflaesterer and A. Stephen K. Hashmi
Advanced synthesis & catalysis, Vol.355(10), pp.2037-2043
08/07/2013
DOI: https://doi.org/10.1002/adsc.201300158

Abstract

Chemistry Chemistry, Applied Chemistry, Organic Physical Sciences Science & Technology
A gold-catalyzed highly diastereoselective synthesis of functionalised 3,4-disubstituted butyrolactams via phosphatyloxy or carbonate double migrations is reported, which is proposed to proceed by a tandem 1,3-phosphatyloxy or carbonate migration and a long-range 1,5-phosphatyloxy or carbonate migration, which overall corresponds to a formal 1,6-migration.

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