Abstract
The nature of binding between Terazosin (TR) and gold nanoparticles (Au-Nps) is investigated using UV-vis and fluorescence spectroscopies, cyclic voltammetry, SEM, and EIS. The results suggest that Au-Nps are effective carriers for TR. An electrochemical sensor for TR is introduced using Au-Nps electrodeposited on carbon paste electrode. The effect of parameters including pH and scan rate on the response was investigated. A linear range from 8.0 x 10(-9) to 5.4 x 10(-5) mol?L-1 with correlation coefficient of 0.9995 and detection limit of 1.2 x 10(-10) mol?L-1 was obtained. This sensor was used for determining TR spiked in urine, and excellent recovery results are achieved.