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Gold meets rhodium: tandem one-pot synthesis of β-disubstituted ketones via Meyer-Schuster rearrangement and asymmetric 1,4-addition
Journal article   Peer reviewed

Gold meets rhodium: tandem one-pot synthesis of β-disubstituted ketones via Meyer-Schuster rearrangement and asymmetric 1,4-addition

Max M Hansmann, A Stephen K Hashmi and Mark Lautens
Organic letters, Vol.15(13), pp.3226-3229
05/07/2013
DOI: https://doi.org/10.1021/ol4011739
PMID: 23777565

Abstract

Alkynes - chemistry Catalysis Coordination Complexes - chemistry Gold - chemistry Ketones - chemical synthesis Ketones - chemistry Ligands Molecular Structure Propanols - chemistry Rhodium - chemistry Stereoisomerism
An asymmetric one-pot tandem Au/Rh-catalyzed synthesis of highly enantioenriched β-disubstituted ketones starting from racemic propargyl alcohols is disclosed. The compatibility of the two metal complexes (Au/Rh) and their orthogonal ligand systems (NHC/diene) in this bimetallic catalytic system is investigated.

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