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Gold‐Catalyzed Intermolecular Oxidative Diyne Cyclizations via 1,6‐Carbene Transfer
Journal article   Open access  Peer reviewed

Gold‐Catalyzed Intermolecular Oxidative Diyne Cyclizations via 1,6‐Carbene Transfer

Qian Wang, Matthias Rudolph, Frank Rominger and A. Stephen K. Hashmi
Advanced synthesis & catalysis, Vol.362(4), pp.755-759
21/02/2020
DOI: https://doi.org/10.1002/adsc.201901318

Abstract

carbene transfer diyne gold carbene gold catalysis N-oxides
A vinyl/α‐oxo carbene is generated via an α‐oxo carbene formation and subsequently transferred across the second alkyne. These highly active species can react with nitriles in an intermolecular fashion to provide substituted oxazoles. This methodology goes through 1,6‐carbene shift and offers a range of valuable products.
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https://doi.org/10.1002/adsc.201901318View
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