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Gold(I)-Catalyzed Hydroxy Group Assisted C(sp(2))-H Alkylation of Enaminones with Diazo Compounds To Access 3-Alkyl Chromones
Journal article   Peer reviewed

Gold(I)-Catalyzed Hydroxy Group Assisted C(sp(2))-H Alkylation of Enaminones with Diazo Compounds To Access 3-Alkyl Chromones

Pradip N. Bagle, Manoj V. Mane, Shashank P. Sancheti, Amol B. Gade, Samir R. Shaikh, Mu-Hyun Baik and Nitin T. Patil
Organic letters, Vol.21(1), pp.335-339
04/01/2019
DOI: https://doi.org/10.1021/acs.orglett.8b03989
PMID: 30586309

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
A strategy for expedient synthesis of 3-substituted chromones from easily available o-hydroxyarylenaminones and diazo compounds has been developed. Carefully conducted experimental and computational studies led us to propose an uncommon mechanistic pathway involving the hydroxyl group assisted alkylation of enaminones with in situ generated gold carbenes.

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