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Green High-Yielding One-Pot Approach to Biginelli Reaction under Catalyst-Free and Solvent-Free Ball Milling Conditions
Journal article   Open access  Peer reviewed

Green High-Yielding One-Pot Approach to Biginelli Reaction under Catalyst-Free and Solvent-Free Ball Milling Conditions

Mohamed Ould M'hamed, Abdulrahman G. Alshammari and O. M. Lemine
Applied sciences, Vol.6(12), pp.431-431
01/12/2016
DOI: https://doi.org/10.3390/app6120431

Abstract

Chemistry Chemistry, Multidisciplinary Engineering Engineering, Multidisciplinary Materials Science Materials Science, Multidisciplinary Physical Sciences Physics Physics, Applied Science & Technology Technology
A simple, green, and efficient approach was used to synthesize 3,4-dihydropyrimidines derivatives. We showed that the application of the planetary ball milling method with a ball-to-reagent weight ratio of 8 for the Biginelli reaction provides 3,4-dihydropyrimidines derivatives with excellent yields (>98%) in a short reaction time from the one-pot, three-component condensation of aldehydes, ethyl acetoacetate, and urea (or thiourea).
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https://doi.org/10.3390/app6120431View
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