Abstract
Derivatives of pyrazolo[4,3-c]cinnoline were synthesized, through green and sustainable procedures, and their antibacterial activities were evaluated against selected bacterial strains. A green and sustainable methodology was employed for the synthesis through grinding three components in one pot in absence of solvent, and then refluxing through means of sunlight reflector as a benign and renewable source of energy. Eight derivatives of pyrazolo[4,3-c]cinnoline heterocyclic ring system were synthesized and their structures were confirmed through spectroscopic analysis. The green and sustainable context of the synthetic procedure was outlined and impacted higher atom economy, lower energy consumption, optimum conversion, excellent yields, and least auxiliaries. Antibacterial potencies of the prepared derivatives were evaluated and revealed highly significant potencies that encouraged further pharmaceutical investigations.