Abstract
Because of their renewability and environmental friendliness, the synthesis of nanomaterials with low environmental risk and unique functional features via plant extracts has recently attracted researchers' interest around the world. We synthesized Fe nanoparticles (Fe NPs) from Clove and Green Coffee (G-Coffee) extracts and examined them using a variety of techniques in this study. The hepatoprotective activity of the Fe NPs using Clove or G-Coffee nanoplatform in paracetamol (PCM) in Wistar albino rats was investigated. Simultaneous administration of the Fe NPs from clove or green coffee with PCM significantly attenuated the side changes in the serum, total albumin (TP), Alanine aminotransferase (ALT), Aspartate Alanine aminotransferase (AST), and Alkaline phosphatase (ALP). The liver histopathological examination showed a notable decrease in liver toxicity, and liver tissue was sustained at almost the normal level. The toxicity of the Fe NPs was investigated. The results confirmed that the Fe NPs synthesized from both extracts are potent hepatoprotective agents against PCM-induced hepatotoxicity in rats.