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Growth Restriction, Osteopenia, Placental Massive Perivillous Fibrin Deposition With (or Without) Intervillous Histiocytes and Renal Tubular Dysgenesis-An Emerging Complex
Journal article   Peer reviewed

Growth Restriction, Osteopenia, Placental Massive Perivillous Fibrin Deposition With (or Without) Intervillous Histiocytes and Renal Tubular Dysgenesis-An Emerging Complex

Sahar Abdulghani, Felipe Moretti, Peter Gj Nikkels, Suonavy Khung-Savatovsky, Julie Hurteau-Miller and David Grynspan
Pediatric and developmental pathology, Vol.21(1), pp.91-94
01/2018
DOI: https://doi.org/10.1177/1093526617697061
PMID: 29187034

Abstract

Abortion, Eugenic Adult Bone Diseases, Metabolic - diagnosis Bone Diseases, Metabolic - pathology Female Fetal Growth Retardation - diagnosis Fetal Growth Retardation - pathology Humans Kidney Tubules, Proximal - abnormalities Kidney Tubules, Proximal - pathology Male Placenta Diseases - diagnosis Placenta Diseases - pathology Pregnancy Syndrome Urogenital Abnormalities - diagnosis Urogenital Abnormalities - pathology
We describe a case of a pregnancy complicated by early onset asymmetric growth restriction with anhydramnios with termination occurring at 21 weeks. Fetal autopsy showed demineralization of bones and renal tubular dysgenesis. Placental pathology showed features of massive perivillous fibrin deposition and chronic histiocytic intervillositis. We review prior documentation of this association and briefly discuss potential pathogenesis.

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