Growth of Mesenchymal Stem Cells on Poly(3-Hydroxybutyrate) Scaffolds Loaded with Simvastatin

E. A. Akoulina; I. V. Demianova; I. I. Zharkova; V. V. Voinova; V. A. Zhuikov; D. D. Khaydapova; D. V. Chesnokova; K. A. Menshikh; A. A. Dudun; T. K. Makhina; G. A. Bonartseva; A. V. Volkov; T. F. Asfarov; S. Y. Ivanov; K. V. Shaitan; A. P. Bonartsev

doi:10.1007/s10517-021-05190-8

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Growth of Mesenchymal Stem Cells on Poly(3-Hydroxybutyrate) Scaffolds Loaded with Simvastatin

Journal article

Peer reviewed

Growth of Mesenchymal Stem Cells on Poly(3-Hydroxybutyrate) Scaffolds Loaded with Simvastatin

E. A. Akoulina, I. V. Demianova, I. I. Zharkova, V. V. Voinova, V. A. Zhuikov, D. D. Khaydapova, D. V. Chesnokova, K. A. Menshikh, A. A. Dudun, T. K. Makhina, …

Bulletin of experimental biology and medicine, Vol.171(1), pp.172-177

01/05/2021

DOI: https://doi.org/10.1007/s10517-021-05190-8

PMID: 34046794

Abstract

Life Sciences & Biomedicine

Medicine, Research & Experimental

Research & Experimental Medicine

Science & Technology

We studied the effect of porous composite scaffolds based on poly(3-hydroxybutyrate) (PHB) loaded with simvastatin on the growth and differentiation of mesenchymal stem cells. The scaffolds have a suitable microstructure (porosity and pore size) and physicochemical properties to support the growth of mesenchymal stem cells. Scaffold loading with simvastatin suppressed cell growth and increased alkaline phosphatase activity, which can attest to their osteoinductive properties.

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Title: Growth of Mesenchymal Stem Cells on Poly(3-Hydroxybutyrate) Scaffolds Loaded with Simvastatin
Creators - without role: E. A. Akoulina - Lomonosov Moscow State University
I. V. Demianova - Lomonosov Moscow State University
I. I. Zharkova - Lomonosov Moscow State University
V. V. Voinova - Lomonosov Moscow State University
V. A. Zhuikov - Federal Center Research Fundamentals of Biotechnology
D. D. Khaydapova - Peoples' Friendship University of Russia
D. V. Chesnokova - Lomonosov Moscow State University
K. A. Menshikh - Lomonosov Moscow State University
A. A. Dudun - Federal Center Research Fundamentals of Biotechnology
T. K. Makhina - Federal Center Research Fundamentals of Biotechnology
G. A. Bonartseva - Federal Center Research Fundamentals of Biotechnology
A. V. Volkov - Peoples' Friendship University of Russia
T. F. Asfarov - Peoples' Friendship University of Russia
S. Y. Ivanov - Sechenov University
K. V. Shaitan - Lomonosov Moscow State University
A. P. Bonartsev - Lomonosov Moscow State University
Publication Details: Bulletin of experimental biology and medicine, Vol.171(1), pp.172-177
Publisher: Springer Nature
Number of pages: 6
Identifiers: 9942936008331
Academic Unit: King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article